We went on a hiking trip to Sognsvann, our first since the pandemic (not counting a smaller one in the winter). We took the metro (about 10 min from the lab) to the Sognsvann lake and hiked through the forest (approximately 3 hours) up to Holmenkollen. Fahri served us a very nice late lunch at his place and we sat around chatting for a long time. Everyone agreed that we need to do this more often!
Events
STAMP2 Suppresses Autophagy in Prostate Cancer Cells by Modulating the Integrated Stress Response Pathway
Sikkeland J, Ng MYW, Nenseth HZ, Unal B, Qu S, Jin Y, Simonsen A, Saatcioglu F
PMID: 35141021 PMCID: PMC8822275
Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression
Pällmann N, Deng K, Livgård M, Tesikova M, Jin Y, Frengen NS, Kahraman N, Mokhlis HM, Ozpolat B, Kildal W, Danielsen HE, Fazli L, Rennie PS, Banerjee PP, Üren A, Jin Y, Kuzu OF, Saatcioglu F
PMID: 34183356 DOI: 10.1158/0008-5472.CAN-20-3956
STAMP2 Expression Mediated by Cytokines Attenuates Their Growth-Limiting Effects in Prostate Cancer Cells
Pihlstrøm N, Jin Y, Nenseth HZ, Kuzu OF, Saatcioglu F
PMID: 33808059 PMCID: PMC8036285 DOI: 10.3390/cancers13071579
Targeting the Unfolded Protein Response in Hormone-Regulated Cancers
Jin, Y., and Saatcioglu, F. 2020 Feb;6(2):160-171. doi: 10.1016/j.trecan.2019.12.001.
Together with NBS Oslo, and the group of Hesso Farhan, we have assembled some of the leading voices in the ER proteostasis field for a one day symposium in Oslo
Regulation of the Integrated Stress Response through ATF4 and FAM129A is Critical for Prostate Cancer
Pallmann N, Livgard M, Nenseth, HZ, Xi Y, Koc D, Kahraman N, Mokhlis HM, Ozpolat B, Fazli L, Rennie P, Danielsen H, Jin Y, Saatcioglu F, Oncogene, Jul 16. doi: 10.1038/s41388-019-0879-2
In this paper we show a link between ER stress and quantitative and functional STAMP2-deficiency in adipocytes
We have found that the newly developed IRE1-alpha inhibitor small molecule MKC8866 has potent anti-prostate cancer activity. We have also shown that the mechanism of action for MKC8866 is via inhibition of c-MYC oncoprotein expression, the first time ER stress activation was linked to oncogene activation. Our study is now published in Nature Communications. It also attracted attention in national and international media.
