News

October 2023, a new paper in Nucleic Acids Research

LIN-41/TRIM71 is a well-studied member of the TRMI-NHL family, which includes critical regulators of the self-renewal versus differentiation decision implicated in a range of disorders. In the C. elegans germline, LIN-41 functions as a “roadblock” to cellular reprogramming. Frustratingly, the nature of relevant mRNA targets remained elusive. Our analysis suggests that CFP-1, an important chromatin regulator, may be a long-sought LIN-41 target whose regulation during the oocyte-to-embryo transition facilitates the epigenetic reprogramming underlying for the switch from germ- to somatic cell identity.

 

August 2022, a new paper in Nature Communications

July 2022, a new paper in Nucleic Acids Research