Trond Berg

• Mousavi, Darbi Seyed Ali; Fønhus, Marita Sporstøl; Kindberg, Grete Mørk; Tolleshaug, Helge & Berg, Trond (2013). Enhanced activity of lysosomal proteases in activated rat hepatic stellate cells is associated with a concomitant increase in the number of the mannose-6-phosphate/insulin-like growth factor II receptor. Cell Biology International.  ISSN 1065-6995.  37(7), s 703- 712 . doi: 10.1002/cbin.10085
• Sørensen, Karen Kristine; McCourt, Peter Anthony; Berg, Trond; Crossley, Clive; LeCouteur, David; Wake, Kenjiro & Smedsrød, Bård (2012). The scavenger endothelial cell - a new player in homeostasis and immunity. American Journal of Physiology. Regulatory Integrative and Comparative Physiology.  ISSN 0363-6119.  303(12), s R1217- R1230 . doi: 10.1152/ajpregu.00686.2011
• Mousavi, Darbi Seyed Ali; Berge, Knut Erik; Berg, Trond & Leren, Trond Paul (2011). Affinity and kinetics of proprotein convertase subtilisin/kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells. The FEBS Journal.  ISSN 1742-464X.  278(16), s 2938- 2950 . doi: 10.1111/j.1742-4658.2011.08219.x
• Martinsson, Klara; Skogh, Thomas; Mousavi, Darbi Seyed Ali; Berg, Trond; Jonsson, Jan-Ingvar & Hultman, Per (2010). Deficiency of Activating Fc gamma-Receptors Reduces Hepatic Clearance and Deposition of IC and Increases CIC Levels in Mercury-Induced Autoimmunity. PLOS ONE.  ISSN 1932-6203.  5(10) . doi: 10.1371/journal.pone.0013413
• Mousavi, Darbi Seyed Ali; Sporstol, Marita & Berg, Trond (2009). Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different species. BMC Cell Biology.  ISSN 1471-2121.  10 . doi: 10.1186/1471-2121-10-39
• Mousavi, Darbi Seyed Ali; Sporstol, Marita; Fladeby, Cathrine; Kjeken, R; Barois, Nicolas & Berg, Trond (2007). Receptor-mediated endocytosis of immune complexes in rat liver sinusoidal endothelial cells is mediated by Fc gamma RIIb2. Hepatology.  ISSN 0270-9139.  46
• Sporstol, Marita; Mousavi, Darbi Seyed Ali; Eskild, Winnie; Roos, Norbert & Berg, Trond (2007). ABCAI, ABCGI and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. BMC Molecular Biology.  ISSN 1471-2199.  8 . doi: 10.1186/1471-2199-8-5
• Berntzen, G; Brekke, OH; Mousavi, SA; Andersen, JT; Michaelsen, Terje Einar; Berg, T; Sandlie, I & Lauvrak, V (2006). Characterization of an Fc gamma RI-binding peptide selected by phage display. Protein Engineering Design & Selection.  ISSN 1741-0126.  19(3), s 121- 128 . doi: 10.1093/protein/gzj011
• Malerød, Lene; Sporstol, Marita; Juvet, Lene Kristine; Mousavi, Darbi Seyed Ali; Gjøen, Tor; Berg, Trond; Roos, Norbert & Eskild, Winnie (2005). Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  336(4), s 1096- 1105
• Mousavi, SA; Sato, M; Sporstol, M; Sporstøl, Marita; Smedsrød, Bård; Smedsrod, B; Berg, Trond; Kojima, N & Senoo, H (2005). Uptake of denatured collagen into hepatic stellate cells: evidence for the involvement of urokinase plasminogen activator receptor-associated protein/Endo180. Biochemical Journal.  ISSN 0264-6021.  387, s 39- 46
• Sporstøl, Marita; Tapia, German; Malerød, Lene; Mousavi, Seyed Ali & Berg, Trond (2005). Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  331
• Berg, Trond; Norum, Kaare Reidar; Roos, Norbert & Blomhoff, Rune (2004). Intralobular distribution of vitamin A-storing lipid droplets in hepatic stellate cells. Special reference to polar bear and arctic fox. Comparative Hepatology.  ISSN 1476-5926.  3, s 16
• Braathen, Henrik; Mousavi, Darbi Seyed Ali; Berg, Trond & Kjeken, R (2004). Fc gamma receptors in the hepatic sinusoid. Comparative Hepatology.  ISSN 1476-5926.  3, s 23
• Mousavi, Darbi Seyed Ali; Sporstol, Marita; Smedsrød, Bård & Berg, Trond (2004). Uptake of denatured collagen into hepatic stellate cells: Evidence for the involvement of urokinase plasminogen activator associated protein/Endo180. Biochemical Journal.  ISSN 0264-6021.
• Briley-Saebo, K; Bjørnerud, Atle; Grant, D; Ahlstrom, H; Berg, Trond & Kindberg, GM (2004). Hepatic cellular distribution and degradation of iron oxide nanoparticles following single intravenous injection in rats: implications for magnetic resonance imaging. Cell and Tissue Research.  ISSN 0302-766X.  316(3), s 315- 323
• Higashi, Nobuyo; Imai, Katsuyuki; Sato, Mitsuru; Sato, Takeya; Kojima, Naosuke; Miura, Mitsutaka; Wold, Heidi Libæk; Moskaug, Jan Øivind; Berg, Trond; Norum, Kaare Reidar; Roos, Norbert; Wake, Kenjiro; Blomhoff, Rune & Senoo, Haruki (2004). Intralobular Distribution of Vitamin A-Storing Lipid Droplets in Hepatic Stellate Cells with Special Reference to Polar Bear and Arctic Fox. Comparative Hepatology.  ISSN 1476-5926.  3(1)
• Mousavi, Seyed Ali; Malerød, Lene; Kjeken, Rune & Berg, Trond (2004). Clathrin-dependent endocytosis. Biochemical Journal.  ISSN 0264-6021.  377, s 1- 16
• Senoo, Haruki; Wake, Kenjiro; Wold, Heidi Libæk; Higashi, Nobuyo; Imai, Katsuyuki; Moskaug, Jan Øivind; Kojima, Naosuke; Miura, Mitsutaka; Sato, Takeya; Sato, Mitsuru; Roos, Norbert; Berg, Trond; Norum, Kaare Reidar & Blomhoff, Rune (2004). Decreased Capacity for Vitamin A Storage in Hepatic Stellate Cells for Arctic Animals. Comparative Hepatology.  ISSN 1476-5926.  3(1), s 18- 18
• Malerød, Lene; Sporstol, Marita; Juvet, Lene K.; Mousavi, Seyed Ali; Gjøen, Tor & Berg, Trond (2003). Hepatic scavenger receptor class B, type I is stimulated by peroxisome proliferator-activated receptor gamma and hepatocyte nuclear factor 4alpha. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  305(3), s 557- 565
• Malerød, Lene; Sporstøl, Marita; Juvet, Lene Kristine; Mousavi, Seyed Ali; Gjøen, Tor & Berg, Trond (2003). Hepatic scavenger receptor class B type I, is stimulated by peroxisome proliferator-activated receptor gamma and hepatocyte nuclear factor 4-alpha. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  305, s 557- 565
• Mousavi, Seyed Ali; Brech, Andreas; Berg, Trond & Kjeken, Rune (2003). Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes. Biochemical Journal.  ISSN 0264-6021.  372, s 861- 869
• Frøystad, Marianne Kristin; Volden, Vivi; Berg, Trond & Gjøen, Tor (2002). Metabolism of oxidized and chemically modified low density lipoproteins in rainbow trout - clearance via scavenger receptors. Developmental and Comparative Immunology.  ISSN 0145-305X.  26, s 723- 733
• Grønlien, Heidi Kristine; Berg, Trond & Løvlie, Arne Mathias (2002). In the polymorphic ciliate Tetrahymena vorax the nonselective phagocytosis seen in microstomes changes to a highly selective process in macrostomes. Journal of Experimental Biology.  ISSN 0022-0949.  205, s 2089- 2097
• Malerød, Lene; Juvet, Lene Kristine; Gjøen, Tor & Berg, Trond (2002). The expression of scavenger receptor class B, type I (SR-BI) and caveolin-1 in parenchymal and nonparenchymal liver cells. Cell and Tissue Research.  ISSN 0302-766X.  307, s 173- 180
• Malerød, Lene; Juvet, Lene Kristine; Hanssen-Bauer, Audun; Eskild, Winnie & Berg, Trond (2002). Oxysterol-activated LXR-alpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  299, s 916- 923
• Mousavi, Seyed A.; Kjeken, Rune; Berg, Trond O.; Seglen, Per O.; Berg, Trond & Brech, Andreas (2001). Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy. Biochimica et Biophysica Acta.  ISSN 0006-3002.  1510, s 243- 257
• Egeberg, Morten; Kjeken, Rune; Kolset, Svein Olav; Berg, Trond & Prydz, Kristian (2001). Internalization and stepwise degradation of heparan sulfate proteoglycans in rat hepatocytes. Biochimica et Biophysica Acta.  ISSN 0006-3002.  1541, s 135- 149
• Kjeken, Rune; Mousavi, Seyed Ali; Brech, Andreas; Gjøen, Tor & Berg, Trond (2001). Fluid phase endocytosis of 125I-iodixanol in rat liver parenchymal, endothelial and Kupffer cells. Cell and Tissue Research.  ISSN 0302-766X.  304, s 221- 230
• Kjeken, Rune; Mousavi, Seyed Ali; Brech, Andreas; Griffiths, Gareth O. & Berg, Trond (2001). Wortmannin-sensitive trafficking steps in the endocytic pathways in rat liver endothelial cells. Biochemical Journal.  ISSN 0264-6021.  357, s 497- 503 Vis sammendrag

  Liver endothelial cells (LECs) play an important homoeostatic role by removing potentially harmful macromolecules from blood. The extremely efficient endocytosis in LECs makes these cells an interesting model for the study of the involvement of phosphoinositides in the different steps of the endocytic process. In the present investigation we have studied the effect of wortmannin, an inhibitor of phosphatidylinositol kinases, on uptake, recycling and intracellular transport of (125)I-labelled ovalbumin, which is taken up in LECs via mannose-receptor-mediated endocytosis. Wortmannin was found to inhibit both uptake and degradation of ovalbumin. Further studies indicated that the reduced uptake via the mannose receptor was due both to a reduction of the number of surface receptors and a reduction in the rate of receptor-ligand internalization. Transport of ligand from endosomes to lysosomes was prevented, leading to increased recycling of internalized ligand. Wortmannin treatment released the Rab5 effector EEA1 from the endosomes and caused reduced size of early endosomes.

• Løvdal, Torunn & Berg, Trond (2001). Transcription of Fcgamma-receptors in different rat liver cells. Cell Biology International.  ISSN 1065-6995.  25, s 821- 824 Vis sammendrag

  Expression of Fc(gamma)-receptors (Fc(gamma)Rs) in different liver cells is poorly characterised. In the present study, transcription of Fc(gamma)Rs in different rat liver cells was examined by means of Northern blot analysis and reverse transcriptase-polymerase chain reactions. We found that both Kupffer and liver endothelial cells produce mRNA for Fc(gamma)RIIB2, Fc(gamma)RIII and the gamma-chain, whereas the level of Fc(gamma)RIIB1 mRNA is negligible. In contrast, parenchymal cells produce no Fc(gamma)R mRNA. Copyright 2001 Academic Press.

• Løvdal, Torunn; Brech, Andreas; Kjeken, Rune & Berg, Trond (2001). Receptor-mediated and fluid phase endocytosis in hepatic sinusoidal cells, In E Wisse; D.L. Knook; R De Zanger & K. Arthur (ed.),  Cells of the hepatic sinusoid.  Kupffer Cell Foundation, Leiden, The Netherlands.  s 125 - 131
• Løvdal, Torunn; Brech, Andreas; Kjeken, Rune; Smedsrød, Bård & Berg, Trond (2001). Receptor-mediated and fluid phase endocytosis in hepatic sinusoidal cells, In  Cells of the hepatic sinusoid.  Kupffer Cell Foundation.  Kapittel.  s 125 - 131
• Sato, Mitsuru; Miura, Mitsutaka; Kojima, Naosuke; Higashi, Nobyuo; Imamura, Kazuyuki; Sato, Takeya; Wold, Heidi Libæk; Moshaug, Jan Øivind; Blomhoff, Rune; Wake, Kenjiro; Roos, Norbert; Berg, Trond; Norum, Kaare Reidar & Senoo, Haruki (2001). Nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces in artcic animals. Cell structure and function.  ISSN 0386-7196.  26, s 71- 77
• Senoo, Haruki; Imamura, Kazuyuki; Higashi, Nobyuo; Wake, Kenjiro; Nojima, N.; Miura, Mitsutaka; Wold, Heidi Libæk; Moshaug, Jan Øivind; Sato, Takeya; Roos, Norbert; Berg, Trond; Norum, Kaare Reidar & Blomhoff, Rune (2001). Transport and hepatic storage of vitamin A in arctic animals, In E Wisse; D.L. Knook; R De Zanger & K. Arthur (ed.),  Cells of the hepatic sinusoid.  Kupffer Cell Foundation, Leiden, The Netherlands.  -.  s 207 - 209
• Berg, Trond (2000). Cell separation: A practical approach. Cell Biology International.  ISSN 1065-6995.  24, s 406- 406
• Kjeken, Rune; Kindberg, Grete Mørk & Berg, Trond (2000). Distribution of liposome-encapsulated iodixanol in rat liver cells. Biochemical Pharmacology.  ISSN 0006-2952.  60, s 553- 559
• Løvdal, Torunn; Andersen, Elin; Brech, Andreas & Berg, Trond (2000). Fc receptor mediated endocytosis of small soluble immunoglobulin G immune complexes in Kupffer and endothelial cells from rat liver. Journal of Cell Science.  ISSN 0021-9533.  113, s 3255- 3266
• Tjelle, Torunn Elisabet; Løvdal, Torunn & Berg, Trond (2000). Phagosome dynamics and function. Bioessays.  ISSN 0265-9247.  22, s 255- 263
• Volle, Jan M.; Tolleshaug, Helge & Berg, Trond (2000). Phagocytosis and chemiluminescence response of granulocytes to monodisperse latex particles of varying sizes and surface coats. Inflammation.  ISSN 0360-3997.  24(6), s 571- 582
• Berg, Trond (1999). Anders Jahres Pris for 1999: Søren Kragh Moestrup, Aarhus. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  (23), s 3472- 3473
• Berg, Trond; Hagen, Egil; Myhre, Anita Margareth; Tjelle, Torunn Elisabet & Norum, Kaare Reidar (1999). Retinyl esters are hydrolyzed in early endosomes of J774 macrophages. Journal of Lipid Research.  ISSN 0022-2275.  40, s 309- 317
• Berg, Trond & Prydz, Kristian (1999). Anders Jahres Pris for 1999: Harald Stenmark. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  (23), s 3473- 3474
• Guren, Tormod Kyrre; Abrahamsen, Hilde; Thoresen, G. Hege; Babaie, Eshrat; Berg, Trond & Christoffersen, Thoralf (1999). EGF-induced activation of stat1, stat3, and stat5b is unrelated to the stimulation of DNA synthesis in cultured hepatocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  258, s 565- 571 Vis sammendrag

  Transcription factors of the STAT family have been implicated in regulation of cell proliferation. EGF activates several STAT proteins in liver. We have studied the relationship between STAT activation and the growth-stimulatory effect of EGF in rat hepatocytes, assessing specific DNA-binding activity of STAT proteins in electrophoretic mobility-shift and supershift assays. In freshly isolated hepatocytes, EGF activated Stat1, Stat3, and, particularly, Stat5b. However, the ability of EGF to produce this activation was rapidly attenuated when the cells were cultured, while the activation by IFN-gamma (Stat1) and IL-6 (Stat3) was sustained. Hepatocytes cultured for 24-48 h are highly sensitive to the stimulatory effect of EGF on S phase entry. In these cells EGF did not detectably activate Stat1, Stat3, or Stat5b but markedly stimulated MAP kinase (Erk1/2). Thus, although EGF has the ability to activate several STAT proteins, this did not seem to be part of the mitogenic mechanisms used by the EGF receptor in hepatocytes.

• Senoo, H; Imai, K; Wake, K; Wold, Heidi Libæk; Moskaug, Jan Øivind; Kojima, N; Matano, Y.; Miura, M.; Sato, M; Roos, Norbert; Berg, Trond; Langvatn, R; Norum, Kaare & Blomhoff, Rune (1999). Vitamin A-storing system in mammals and birds in arctic area: a study in the Svalbard archipelego, In E Wisse; D.L. Knook; R de Zanger & R Fraser (ed.),  Cells of the hepatic sinusoid.  Kupffer Cell Foundation.  ISBN 90-803856-2-X.  12.  s 34 - 35
• Synnes, Marianne; Prydz, Kristian; Løvdal, Torunn; Brech, Andreas & Berg, Trond (1999). Fluid phase endocytosis and galactosyl-receptor mediated endocytosis employ different early endosomes. Biochimica et Biophysica Acta - Biomembranes.  ISSN 0005-2736.  1421, s 317- 328 Vis sammendrag

  Endocytosis may originate both in coated pits and in uncoated regions of the plasma membrane. In hepatocytes it has been shown that fluid phase endocytosis (here defined as 'pinocytosis') is unaffected by treatments that arrest coated pit-mediated endocytosis, indicating that pinocytosis is primarily a clathrin-independent process. In this study we have tried to determine possible connections between pinocytosis and clathrin-dependent endocytosis in rat hepatocytes by means of subcellular fractionation, electron microscopy, and by assessing the influence of inhibitors of clathrin-dependent endocytosis on pinocytosis. As marker for clathrin-dependent endocytosis was used asialoorosomucoid (AOM) labelled with [(125)I]tyramine cellobiose ([(125)I]TC). [(125)I]TC-labelled bovine serum albumin ([(125)I]TC-BSA) was found to be a useful marker for pinocytosis. Its uptake in the cells is not saturable, and any remnants of [(125)I]TC-BSA associated with the cell surface could be removed by incubating the cells with 0.3% pronase at 0 degrees C for 60 min. The data obtained by electron microscopy and by subcellular fractionation suggested that early after initiation of uptake (<15 min) [(125)I]TC-BSA and [(125)I]TC-AOM were present in different endocytic vesicles. The two probes probably join prior to their entrance in the lysosomal compartment. The relation between endocytosis via coated pits and pinocytosis was also studied with techniques that induced a selective density shift either in the clathrin-dependent pathway (by AOM-HRP) or in the pinocytic pathway (by allowing uptake of AuBSA). Both treatments indicated that the two probes ([(125)I]TC-AOM and [(125)I]TC-BSA) were early after uptake, at least partly, in separate endocytic compartments. The different distribution of the fluid phase marker and the ligand (internalised via coated pits) was not due to a difference in the rate at which they enter a later compartment, since a lowering of the incubation temperature to 18 degrees C, which should keep the probes in the early endosomes, did not affect their early density distribution. Incubation of cells in a hypertonic medium reduced uptake both of [(125)I]TC-AOM and [(125)I]TC-BSA; the uptake of [(125)I]TC-AOM was, however, reduced much more than that of the fluid phase marker. This finding supports the notion that the two probes enter the cells via different routes.

• Berg, Trond O.; Fengsrud, Monica; Strømhaug, Per E.; Berg, Trond & Seglen, Per O. (1998). Isolation and characterization of rat liver amphisomes: Evidence for fusion of autophagosomes with both early and late endosomes. Journal of Biological Chemistry.  ISSN 0021-9258.  273, s 21883- 21892
• Brech, Andreas; Kjeken, Rune; Synnes, Marianne; Berg, Trond; Roos, Norbert & Prydz, Kristian (1998). Endocytosed ricin and asialoorosomucoid follow different intracellular pathways in hepatocytes. Biochimica et Biophysica Acta.  ISSN 0006-3002.  1373(1), s 195- 208 Vis sammendrag

  Earlier studies have suggested that fluid phase endocytosis in rat hepatocytes takes place via a clathrin-independent mechanism [1,2]. This observation suggests that a relatively large amount of plasma membrane outside coated pits may be involved in hepatic endocytosis. Ricin, which binds to galactose residues on glycoproteins and glycolipids, has, in this report, been used as a general marker for the plasma membrane of hepatocytes. The endocytosis of ricin was compared with that of asialoorosomucoid (AOM) which is taken up exclusively via clathrin-coated pits. Hypertonic medium has been shown to inhibit uptake via coated pits more effectively than clathrin-independent uptake [3-5]. It was found, in this study, that the addition of 100 mM sucrose to the incubation medium inhibited the uptake of 125I-tyramine- cellobiose-asialoorosomucoid (125I-TC-AOM) more extensively than that of 125I-tyramine-cellobiose-ricin (125I-TC-ricin), compatible with the notion that the two probes are internalised via different mechanisms. Subcellular fractionation experiments indicated that 125I-TC-ricin entered a denser endocytic organelle than that receiving 125I-TC-AOM. To determine whether the separation of the two probes was due to a different transport kinetics (i.e. that 125I-TC-ricin is transported more rapidly to a later, denser compartment than 125I-TC-AOM) the cells were incubated at 18 degreesC to allow a slower internalisation/transport of the labelled probes. The results obtained showed, again, that the early endosomes containing 125I-TC-ricin were significantly denser than those containing 125I-TC-AOM. We also employed the horseradish peroxidase (HRP)-diaminobenzidine (DAB) density shift technique of Courtoy et al. [6] to determine whether 125I- TC-ricin and 125I-TC-AOM were in separate endosomes early after their uptake. The results showed that early endosomes containing 125I-TC-AOM were density shifted whereas those containing 125I-TC-ricin were unaffected by the density shift procedure. The use of probes labelled with 125I-TC allowed us to identify compartments involved in the degradation of 125I-TC-AOM and 125I-TC-ricin, by measuring acid soluble radioactivities in the gradient fractions. It was found that 125I-TC- ricin was degraded mainly in endosomes, whereas 125I-TC-AOM, as expected, was degraded mainly in lysosomes.

• Gjøen, Tor; Frøystad, Marianne Kristin; Rode, Marit & Berg, Trond (1998). A role for scavenger receptors in phagocytosis of protein-coated particles in rainbow trout head kidney macrophages. Developmental and Comparative Immunology.  ISSN 0145-305X.  22, s 533- 549
• Gjøen, Tor & Berg, Trond (1997). Lysosomes and endocytosis, In J Graham & D Rickwood (ed.),  Subcellular fractionation:A practical Approach.  IRL Press.
• Gjøen, Tor; Juvet, Lene Kristine & Berg, Trond (1997). The expression of endosomal rab proteins correlate withendocytic rate in rat liver cells. Hepatology.  ISSN 0270-9139.  25, s 1204- 1212
• Gjøen, Tor; Rode, Marit & Berg, Trond (1997). Effect of temperature on endocytosis and intracellular transport in the cell line SHK-1 derived from salmon head kidney. Comparative Biochemistry and Physiology A.  ISSN 1095-6433.  117A, s 531- 537
• Gjøen, Tor; Rode, Marit; Berg, Trond; Stensvåg, K. & Jørgensen, Theodor (1997). MHC class II expression in different tissues from Atlantic salmon (Salmo salar). Karger biobehavioral medicine series.  ISSN 0254-5373.  90, s 433
• Kjeken, Rune; Berg, Trond; Seljelid, rolf & Smedsrød, Bård (1997). Phagocytosis of undegradable particles affect receptor-mediated endocytosis in rat Kupffer cells, In Eddie Wisse; D.L. Knook & C. Balabaud (ed.),  Cells of the Hepatic Sinusoid.  The Kupffer Cell Foundation.  ISBN 90-803856-1-1.  Kapittel.  s 375 - 377
• Brech, Andreas; Løvdahl, T; Kjekken, Rune; Roos, Norbert & Berg, Trond (1996). Density shift of endocytic vesicles induced by uptake of colloidal gold particles in rat hepatocytes. Zeitschrift für Gastroenterologie - German Journal of Gastroenterology.  ISSN 0044-2771.  34, s 79- 80
• Nenseter, Marit Sofie; Volden, Vivi; Berg, Trond; Drevon, Christian A; Ose, Leiv & Tonstad, Serena (1996). Effect of hormone replacement therapy on the susceptibility of low density lipoprotein to oxidation among postmenopausal hypercholesterolaemic women. European Journal of Clinical Investigation.  ISSN 0014-2972.  26, s 1062- 1068 Vis sammendrag

  Abstract. The effect of sequential combined hormone replacement therapy on the susceptibility of low density lipoprotein to oxidative modification was investigated in a double-blind, randomized placebo-controlled study. Hypercholesterolemic, postmenopausal women were supplemented with 17ß-estradiol and norethisterone acetate (n=13 subjects) or placebo capsules (n=15 subjects) for 12 weeks. They were instructed to follow the American Heart Association step one diet. Low density lipoprotein, isolated before and after treatment was subjected to copper-catalysed lipid peroxidation. There were no significant differences between low density lipoprotein from the hormone replacement therapy and placebo groups, as assessed by measuring the lag time for formation of conjugated dienes, the rate of formation and the amount of conjugated dienes formed, the amount of lipid peroxides generated, and the relative electrophoretic mobility at baseline and after treatment. Dietary records showed that the subjects were consuming similar amounts of fat and vitamins. No major differences were found in the fatty acid pattern of low density lipoprotein from the two groups. In conclusion, the results indicated that hormone replacement therapy with 17ß-estradiol sequentially combined with norethisterone acetate in non-smoking, hypercholesterolemic, postmenopausal women had no protective effect on the susceptibility of low density lipoprotein to copper-catalysed modification in vitro.

• Fengsrud, Monica; Roos, Norbert; Berg, Trond; Liou, Willisa; Slot, Jan W & Seglen, Per O. (1995). Ultrastructural and immunocytochemical characterization of autophagic vacoules in isolated hepatocytes: Effects of vinblastine and asparagine on vacoule distributions. Experimental Cell Research.  ISSN 0014-4827.  221, s 504- 519
• Gjøen, Tor; Berg, Trond & Bakke, Oddmund (1995). Physiological fuction of endosomal proteolysis. Biochemical Journal.  ISSN 0264-6021.  307, s 313- 326
• Gjøen, Tor; Løvdal, Torunn; Hollås, H.; Johansson, A.; Skogh, T.; Sandlie, Inger & Berg, Trond (1995). Fc-receptor-mediated endocytosis of immune complexes in cells of the hepatic inusoid, In E Wisse; D.L. Knook & K. Decker (ed.),  Cells of the hepatic sinusoid Vol 5.  The Kupffer cell foundation, Leiden, The Netherlands.  s 316 - 317
• Holen, Ingunn; Gordon, Paul B.; Strømhaug, Per E.; Berg, Trond Olav; Fengsrud, Monica; Brech, Andreas; Roos, Norbert; Berg, Trond & Seglen, Per O. (1995). Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors. Biochemical Journal.  ISSN 0264-6021.  311, s 317- 326
• Kjekken, Rune; Brech, Andreas; Løvdal, Torunn; Roos, Norbert & Berg, Trond (1995). Involvement of early amd late lysosomes in the degradation of mannosylated ligands by rat liver endothelial cells. Experimental Cell Research.  ISSN 0014-4827.  216, s 290- 298
• Gjøen, Tor; Røsjø, Camilla; Berg, Trond; Manum, K.; Magnusson, S. & Thomassen, M. S. (1994). Effects of temperature and dietary n-3 and n-6 fatty acids on endocytic processes in isolated rainbow troeut (Oncorhynchus mykiss, Walbaum)hepatocytes. Fish Physiology & Biochemistry.  ISSN 0920-1742.  13, s 119- 132
• Gjøen, Tor & Berg, Trond (1994). Metabolism of a2-macroglubulin in rainbow trout. Fish and Shellfish Immunology.  ISSN 1050-4648.  4:3, s 189- 199
• Gjøen, Tor; Løvhøiden, N.C. & Berg, Trond (1994). The effect of temperature on intracellular transport of asialoglycoproteins in rainbow trout liver. Journal of Fish Biology.  ISSN 0022-1112.  45, s 75- 86
• Gjøen, Tor; Walday, Per; Tolleshaug, Helge; Kindberg, Grete Mørk; Berg, Trond; Skotland, Tore & Holtz, E. (1994). Biodistributions of air-filled albumin microspheres in rats and pigs. Biochemical Journal.  ISSN 0264-6021.  299, s 437- 443
• Nenseter, Marit Sofie; Gudmundsen, Ola; Malterud, Karl Egil; Berg, Trond & Drevon, Christian A (1994). Effect of cholesterol feeding on the susceptibility of lipoproteins to oxidative modification. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism.  ISSN 0005-2760.  1213, s 207- 214
• Berg, Trond; Brech, Andreas; Kjeken, Rune & Roos, Norbert (1993). Prelysosomal degradation in rat liver endothelial cells, In D.L. Knook & E Wisse (ed.),  Cells of the hepatic sinusoid.  The Kupffer Cell Foundation.  ISBN 90-800079-5-1.  122.  s 426 - 430
• Brech, Andreas; Magnusson, Sigurdur; Stang, Espen; Berg, Trond & Roos, Norbert (1993). Receptor-mediated endocytosis of ricin in rat liver endothelial cells: An immonocytochemical study. European Journal of Cell Biology.  ISSN 0171-9335.  60, s 154- 162
• Gjøen, Tor & Berg, Trond (1993). Hepatic uptake and intracellular processing of LDL in rainbow trout. Biochimica et Biophysica Acta.  ISSN 0006-3002.  1169, s 225- 230
• Gjøen, Tor & Berg, Trond (1993). Interaction of low density lipproteins with liver cells in rainbow trout. Fish Physiology & Biochemistry.  ISSN 0920-1742.  10, s 465- 473
• Gjøen, Tor; Smedsrød, Bård; Sveinbjørnsson, B. & Berg, Trond (1993). Catabolism of circulating collagen in the atlantic salmon. Journal of Fish Biology.  ISSN 0022-1112.  42, s 279- 291
• Gudmundsen, Ola; Berg, Trond; Roos, Norbert & Nenseter, Marit Sofie (1993). Hepatic uptake of beta-VLDL in cholesterol-fed rabbits. Journal of Lipid Research.  ISSN 0022-2275.  34, s 589- 600
• Gudmundsen, Ola; Roos, Norbert; Berg, Trond & Nenseter, Marit Sofie (1993). The role of nonparenchymal liver cells in the uptake of plasma LDL and beta-VLDL in cholesterol-fed rabbits, In D.L. Knook & E Wisse (ed.),  Cells of the hepatic sinusoid.  The Kupffer Cell Foundation.  ISBN 90-800079-5-1.  132.  s 461 - 464
• Senoo, H; Smeland, Sigbjørn; Stang, Espen; Roos, Norbert; Berg, Trond; Norum, Kaare & Blomhoff, Rune (1993). Stellate cells take up retinol-binding protein, In D.L. Knook & E Wisse (ed.),  Cells of the hepatic sinusoid.  The Kupffer Cell Foundation.  ISBN 90-800079-5-1.  121.  s 423 - 425
• Senoo, Haruki; Smeland, Sigbjørn; Malaba, Lucie; Bjerknes, Tove; Stang, Espen; Roos, Norbert; Berg, Trond; Norum, Kaare R & Blomhoff, Rune (1993). Transfer or retinol-binding protein from HepG2 human hepatoma cells to cocultured rat stellate cells. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  90, s 3616- 3620
• Smedsrød, Bård; Gjøen, Tor; Sveinbjørnson, Baldur & Berg, Trond (1993). Catabolism of circulating collagen in the atlantic salmon. Journal of Fish Biology.  ISSN 0022-1112.  42, s 279- 291
• Berg, Trond; Magnusson, Sigurdur; Stang, Espen & Roos, Norbert (1992). Receptor-mediated endocytosis in liver endothelial cells. Evidence of lysosomal heterogeneity, In Pierre J. Courtoy (ed.),  Endocytosis: From cell biology to health, disease and therapy.  Springer.  ISBN 3-540-53146-7.  1.8.  s 239 - 245
• Gjøen, Tor & Berg, Trond (1992). Metabolism of high density lipoproteins in rainbow trout. Biochimica et Biophysica Acta.  ISSN 0006-3002.  1125, s 8- 12
• Nenseter, Marit Sofie; Gudmundsen, O.; Roos, Norbert; Mælandsmo, Gunhild Mari; Drevon, Christian A & Berg, Trond (1992). Role of liver endothelial and Kupffer cells in clearing low density lipoprotein from blood in hypercholesterolemic rabbits. Journal of Lipid Research.  ISSN 0022-2275.  s 867- 877
• Stang, Espen; Krause, Jürgen; Seydel, W; Berg, Trond & Roos, Norbert (1992). Endocytosis and intracellular processing of tissue-type plasminogen activator by rat liver cells in vivo. Biochemical Journal.  ISSN 0264-6021.  282, s 841- 851
• Stang, Espen; Roos, Norbert; Schlüter, Michael; Berg, Trond & Krause, Jürgen (1992). Evidence for carbohydrate-independent endocytosis of tissue-type plasminogen activator by liver cells. Biochemical Journal.  ISSN 0264-6021.  285, s 799- 804
• Gjøen, Tor & Berg, Trond (1991). Metabolism of low density lipoproteins in rainbow trout. Fish Physiology & Biochemistry.  ISSN 0920-1742.  9, s 453- 461
• Gjøen, Tor; Kindberg, Grete Mørk; Tolleshaug, Helge & Berg, Trond (1991). Lysosomal and endosomal heterogeneity in the liver:A comparizon of the intracelular pathways of endocytosis in liver cells. Hepatology.  ISSN 0270-9139.  13, s 254- 259
• V. Synstad, Anne; Stang, Espen; Magnusson, Sigurdur; Berg, Trond & Roos, Norbert (1991). Endocytosis of a mannose terminated glycoprotein in rainbow trout (Oncorhynchus mykiss) liver and kidney. Micron and Microscopica Acta.  ISSN 0739-6260.  22(1/2), s 95- 96
• Kindberg, GM; Stang, Espen; Andersen, KJ; Roos, Norbert & Berg, Trond (1990). Intracellular transort of endocytosed proteins in rat liver endothelial cells. Biochemical Journal.  ISSN 0264-6021.  270, s 205- 211

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• Løset, Geir Åge; Mousavi, Seyed A. & Berg, Trond (2008). Sinusoidal liver cells and liver tolerance. Transworld Research Network.  ISBN 8178953641.  11 s.
• Sporstol, Marita; Mousavi, Seyed A. & Berg, Trond (2008). Hepatic Endocytosis. Research Signpost.  ISBN 978-81-7895-364-9.  282 s. Vis sammendrag

  Endocytosis is a mechanism for uptake of material into cells by invagination of the plasma membrane and formation of intracellular endocytic vesicles. The endocytic process may be divided into pinocytosis and phagocytosis. Pinocytosis (“cell drinking”) is a type of endocytosis in which soluble materials are internalized, whereas phagocytosis (“cell eating”) is endocytosis of particulate material. In the present book the term endocytosis is equivalent to “pinocytosis”, whereas phagocytosis means uptake of particles such as bacteria. The endocytic pathway consists of several transport routes: Endocytosed material may be recycled back to the cell surface, it may be transported across the cells, or it may be brought to the lysosomes for degradation. The hepatocytes are polarized cells with a basolateral surface facing the Space of Disse and an apical membrane surrounding the bile canaliculi. Transport of selected material takes place from basolateral to apical side of the cells. Transcytosis in hepatocytes will be discussed in chapter 1. A physiologically important type of recycling is mediated by the neonatal Fc receptor. It binds endocytosed IgG and serum albumin at low pH in endosomes and brings these ligands back to the cell surface. This process, which explains the long half life of these proteins, is examined and explained in chapter 2. The molecular mechanisms whereby transport via the endocytic pathway from the basolateral membrane to the lysosome of hepatocytes takes place is described and discussed (chapter 3), and Prof. Seglen, who discovered and coined the name amphisome, examines and discusses the relation between the endocytic and the autophagic pathways (chapter 4). The liver plays a key role in lipoprotein metabolism. In addition to synthesizing lipoproteins it also express receptors that mediate endocytosis of lipoproteins such as low density lipoproteins and chylomicron remnants. The role of the liver in regulating turnover of lipoproteins is examined and discussed (chapter 5). The liver is the only organ that can rid the blood of cholesterol. High density lipoprotein (HDL) transfers cholesterol from peripheral tissues to the liver (reverse cholesterol transport). Hepatic endocytosis may be involved in the release of cholesterol esters from HDL into hepatocytes. Reverse cholesterol transport is the topic of chapter 6. Hepatic endocytosis plays important roles both in innate and adaptive immunity. Liver cells cooperate to remove unwanted and potentially harmful material from blood. The material may be modified self molecules, foreign molecules or cells entering portal blood from the intestines. Hepatic endocytosis of desialylated glycoproteins were among the very first studies of receptor-mediated endocytosis. Dr. Tolleshaug who did pioneering work in this field reviews work done on receptor-mediated endocytosis of asialoglycoproteins (chapter 7). The liver holds the largest resident macrophage population in the body, the Kupffer cells, which are professional phagocytes. Phagocytosis in Kupffer cells, and the consequent inflammatory and anti-inflammatory processes, are described and discussed (chapter 8). The sinusoidal endothelial cells are very active endocytic cells and express receptors that mediate endocytosis of a large number of modified endogenous molecules and exogenous harmful material. Receptor-mediated endocytosis of the endogenous ligand, hyaluronan, has been studied in great detail, and this work, and endocytosis of other biomolecules, is discussed and reviewed (chapter 9). In chapter 10 the editors try to give an overview of the endocytic function of liver sinusoidal endothelial cells. Kupffer cells, stellate cells, and sinusoidal endothelial cells express both MHC class I and II and are able to prime T cells. Moreover they contribute to hepatic immune tolerance, an issue that is discussed in chapter 11.

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• Lystad, Alf Håkon; Sporstol, Marita; Foroughi, Masoud; Roos, Norbert; Berg, Trond & Eskild, Winnie (2009). Regulation of VEGF expression by vitamin D i hepatic stellate cells - possible attenuation by the nuclear receptor coregulator NCY-G1.
• Lystad, Alf Håkon; Sporstol, Marita; Foroughi, Masoud; Roos, Norbert; Berg, Trond & Eskild, Winnie (2009). Regulation of VEGF expression by vitamin D in hepatic stellate cells - possible attenuation by the nuclear receptor coregulator NCU-G1.
• Kåsi, Cecilie; Sporstol, Marita; Roos, Norbert; Berg, Trond & Eskild, Winnie (2007). NUCLEAR RECEPTORS IN HEPATIC STELLATE CELL ACTIVATION.
• Grønlien, Heidi Kristine; Sand, Olav & Berg, Trond (2005). Phagocytosis in the polymorphic ciliate Tetrahymena vorax. Acta Physiologica Scandinavica.  ISSN 0001-6772.  183, s A422
• Andersen, A.; Berg, Trond & Warren, David J. (1999). SPE-HPLC bestemmelse av paclitaxel (Taxol) i plasma.
• Berg, Trond & Storaas, Torstein (1998). Den brysomme elgen : ut i naturen. [Radio]. Vis sammendrag

  Elgen er ein verdfull utmarksressurs som kan skada plantefelt og traf fikantar. Ved samarbeid og innsats kan verdien aukast og skadane begr ensast.

• Senoo, Haruki; Imamura, Kazuyuki; Wake, Kenjiro; Wold, Heidi L.; Moshaug, Jan Øivind; Kojima, Naosuke; Matanao, Y.; Miura, Mitsutaka; Sato, M.; Roos, Norbert; Berg, Trond; Langvatn, Rolf; Norum, Kaare Reidar & Blomhoff, Rune (1998). Vitamin A-storing system in mammals and birds in the arctic area - a study in the Svalbard archipelago. Vis sammendrag

  Arctic animals (polar bears, polar foxes, ringed seals etc) store large amounts of vitamin A in hepatic stellate cells. These animals do not show hypervitaminosis A.

• Juvet, Lene Kristine; Gjøen, Tor; Løvdal, Torunn & Berg, Trond (1998). Expression of scavenger receptors and Fc-receptors in liver parenchymal and nonparenchymal cells. Vis sammendrag

  Kupffer cells and liver endothelial cells express scavenger receptors, mannose receptors and Fc-receptors that mediate rapid uptake of ligands in coated pits

• Brech, Andreas; Løvdahl, T; Kjeken, R; Roos, Norbert & Berg, Trond (1996). Density shift of endocytic vesicles induced by uptake of colloidal gold particles in rat hepatocytes. Zeitschrift für Gastroenterologie - German Journal of Gastroenterology.  ISSN 0044-2771.  34, s 79- 80
• Gjøen, Tor; Gudmundsen, O.; Brech, Andreas; Kjeken, Rune & Berg, Trond (1996). Clathrin dependent and clathrin independent endocytosis in liver cells.
• Gjøen, Tor; Juvet, Lene Kristine & Berg, Trond (1996). Rab 5 correlates with endocytic rate in different liver cells.
• Brech, Andreas; Stang, Espen; Magnusson, S; Berg, Trond & Roos, Norbert (1991). Endocytosis of ricin in rat liver endothelial cells. Micron and Microscopica Acta.  ISSN 0739-6260.  22(1/2), s 27- 28
• Gjøen, Tor & Berg, Trond (1991). Hepatic metabolism of LDL in rainbow trout.
• Stang, Espen; Krause, J.; Berg, Trond & Roos, Norbert (1991). Tissue-type plasminogen activator and ovalbumin show colocalization after endocytosis in hepatic cells. Micron and Microscopica Acta.  ISSN 0739-6260.  22(1/2), s 89- 90

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