Marianne Hafting Fyhn

Associate Professor

English version of this page

E-post marianne.fyhn {a t} imbv.uio.no

Mobiltelefon (+47) 95 75 35 42

Rom 2523

Brukernavn

Besøksadresse Kristine Bonnevies hus (Biologibygget) Blindernveien 31 0371 Oslo

Postadresse Postboks 1041 Blindern 0316 Oslo

Last ned visittkort

Academic Interests

The brain has a remarkable ability to adapt to changing environments but the mechanisms underlying these processes in the brain of animals interacting with its environment remain elusive. In my research I want to identify the neural fingerprint that reflects learning of sensory experiences in cortical circuits from structural changes of synapses to changes in the population code of neural ensembles in behaving animals. To achieve this we use large scale extracellular recordings of populations of neurons and transcranial two photon laser scanning microscopy (2PLSM) to identify structural and functional changes of identified neurons. Understanding mechanisms underlying basic cortical plasticity and function will untangle how experience modifies cortical circuits to form long-lasting memories and have great impact on our understanding of normal brain function and help our understanding of what fails in the diseased brain.

Teaching

The Programme for Physiology

Education:

2000-2005 Ph.D. in Neuroscience, Norwegian University of Science and Technology (NTNU), Norway.

PhD supervisors: professor May-Britt Moser and professor Edvard Moser.

1997-1999 Master of Science in Physiology, University of Tromsø, Norway.

1995-1996 Bachelor in Arctic Biology, The University Courses on Svalbard, Norway.

1992-1995 Bachelor in Biology, University of Bergen and University of Oslo, Norway.

Work experience & scientific training:

2008-2010 Post doctoral researcher at University of California San Francisco (UCSF), USA.
In the lab of Dr. Michael P. Stryker I studied the effects of activity-dependent plasticity in visual cortex of mice by intrinsic optical imaging and two-photon laser-scanning microscopy (2PLSM). I performed genetic labelling of subclasses of neurons with fluorescent markers and genetically encoded Ca²⁺ sensors using in utero electroporation, single-cell electroporation, and viral vectors. I implemented the technique and built equipment for in vivo 2PLSM imaging of identified neurons in head-restrained mice running on a styro-foam ball floating on air. I established the technique of shadow-patch for single-cell electroporation in the lab for chronic 2PLSM of sub-cellular structures.

2005-2008 Postdoctoral researcher at KI-CBM, NTNU, Norway.
I followed up my PhD work with large-scale electrophysiological recordings in entorhinal cortex and hippocampus in free-roaming rats and mice. I recorded for the first time grid cells in mice. I developed methods for simultaneous recordings of cell ensembles from two brain areas in combination with intrahippocampal infusions of pharmaca.

2000-2005 Graduate research fellow at KI-CBM, NTNU, Norway.
In the lab of Drs. May-Britt and Edvard Moser I performed electrophysiological recordings of cell ensembles with single unit resolution in entorhinal cortex and hippocampal subfields in behaving rats. I did hippocampal lesions and recorded from hippocamectomized rats. I developed the technique of extracellular recordings in medial entorhinal cortex leading to my discovery of grid cells.

2000-2003 Lecturer in undergraduate courses in biological psychology, NTNU, Norway.

1999-2000 Research assistant at Norwegian Polar Institute and at Institute of Medical Biology, University of Tromsø, Norway.

Honoraria

2008: Award for outstanding contribution to behavioural neuroscience, European Brain and Behaviour Society.

2007: Runner-up winner for the Eppendorf-Science prize in Neurobiology (read the essay at Science online).

2007: Norwegian Academy of Sciences and Letters for young researchers (Nansen award).

2006: Donald B. Lindsley’s Prize in Behavioural Neuroscience. Award for the best PhD thesis in behavioural neuroscience in 2005.

2006: Royal Norwegian Society of Sciences and Letters prize for young researchers in natural sciences (I.K. Lykke’s award).

Emneord: Nevrobiologi, Nevrovitenskap, Fysiologi, Entorhinal cortex, Hippocampus

Beshkov, Kosio; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute (2024). Topological structure of population activity in mouse visual cortex encodes densely sampled stimulus rotations. iScience. ISSN 2589-0042. 27(4). doi: 10.1016/j.isci.2024.109370.
Beshkov, Kosio; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute Tomas (2023). Topological Structure of Population Activity in Mouse Visual Cortex Encodes Densely Sampled Visual Scene Rotations. Social Science Research Network (SSRN). ISSN 1556-5068. doi: 10.2139/ssrn.4495668.
Lepperød, Mikkel Elle; Stöber, Tristan Manfred; Hafting, Torkel; Fyhn, Marianne & Kording, Konrad Paul (2023). Inferring causal connectivity from pairwise recordings and optogenetics. PLoS Computational Biology. ISSN 1553-734X. 19(11). doi: 10.1371/journal.pcbi.1011574. Fulltekst i vitenarkiv
Schøyen, Vemund Sigmundson; Pettersen, Markus Borud; Holzhausen, Konstantin; Fyhn, Marianne; Malthe-Sørenssen, Anders & Lepperød, Mikkel Elle (2023). Coherently remapping toroidal cells but not Grid cells are responsible for path integration in virtual agents. iScience. ISSN 2589-0042. 26(11), s. 1–17. doi: 10.1016/j.isci.2023.108102. Fulltekst i vitenarkiv
Hanssen, Kine Ødegård; Grødem, Sverre; Fyhn, Marianne; Hafting, Torkel; Einevoll, Gaute & Ness, Torbjørn V [Vis alle 7 forfattere av denne artikkelen] (2023). Responses in fast-spiking interneuron firing rates to parameter variations associated with degradation of perineuronal nets. Journal of Computational Neuroscience. ISSN 0929-5313. 51, s. 283–298. doi: 10.1007/s10827-023-00849-9. Fulltekst i vitenarkiv
Grødem, Sverre; Nymoen, Ingeborg; Vatne, Guro Helén; Rogge, Frederik Sebastian; Björnsdottir, Valgerdur & Lensjø, Kristian [Vis alle 7 forfattere av denne artikkelen] (2023). An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice. Nature Communications. ISSN 2041-1723. 14(1), s. 608–1. doi: 10.1038/s41467-023-36324-3. Fulltekst i vitenarkiv
Hanssen, Kine Ødegård; Grødem, Sverre; Fyhn, Marianne; Hafting, Torkel; Einevoll, Gaute & Ness, Torbjørn Vefferstad [Vis alle 7 forfattere av denne artikkelen] (2022). Effects of perineuronal nets on neural ring properties. Research Square. ISSN 2693-5015. doi: 10.21203/rs.3.rs-2198467/v1.
Fawcett, James W.; Fyhn, Marianne; Jendelova, Pavla; Kwok, Jessica C. F.; Ruzicka, Jiri & Sorg, Barbara A. (2022). The extracellular matrix and perineuronal nets in memory. Molecular Psychiatry. ISSN 1359-4184. 27, s. 3192–3203. doi: 10.1038/s41380-022-01634-3. Fulltekst i vitenarkiv
Lehr, Andrew; Kumar, Arvind; Tezlaff, Christian; Hafting, Torkel; Fyhn, Marianne & Stöber, Tristan Manfred (2021). CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing. Neuroscience and Biobehavioral Reviews. ISSN 0149-7634. 126, s. 398–412. doi: 10.1016/j.neubiorev.2021.03.020. Fulltekst i vitenarkiv Vis sammendrag
Hippocampal region CA2 has received increased attention due to its importance in social recognition memory. While its specific function remains to be identified, there are indications that CA2 plays a major role in a variety of situations, widely extending beyond social memory. In this targeted review, we highlight lines of research which have begun to converge on a more fundamental role for CA2 in hippocampus-dependent memory processing. We discuss recent proposals that speak to the computations CA2 may perform within the hippocampal circuit.
Lepperød, Mikkel Elle; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Buccino, Alessio Paolo; Yu, Jai & Fyhn, Marianne [Vis alle 7 forfattere av denne artikkelen] (2021). Optogenetic pacing of medial septum parvalbumin-positive cells disrupts temporal but not spatial firing in grid cells. Science Advances. ISSN 2375-2548. 7(19). doi: 10.1126/sciadv.abd5684. Fulltekst i vitenarkiv
Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Sutterud, Hallvard & Blackstad, Jan Sigurd [Vis alle 8 forfattere av denne artikkelen] (2021). Perineuronal nets stabilize the grid cell network. Nature Communications. ISSN 2041-1723. 12. doi: 10.1038/s41467-020-20241-w. Fulltekst i vitenarkiv
Stöber, Tristan Manfred; Lehr, Andrew B; Hafting, Torkel; Kumar, Arvind & Fyhn, Marianne (2020). Selective neuromodulation and mutual inhibition within the CA3-CA2 system can prioritize sequences for replay. Hippocampus. ISSN 1050-9631. doi: 10.1002/hipo.23256. Fulltekst i vitenarkiv
Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Buccino, Alessio Paolo; Mobarhan, Milad; Malthe-Sørenssen, Anders & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2020). Experimental Pipeline (Expipe): A Lightweight Data Management Platform to Simplify the Steps From Experiment to Data Analysis. Frontiers in Neuroinformatics. ISSN 1662-5196. 14. doi: 10.3389/fninf.2020.00030. Fulltekst i vitenarkiv Vis sammendrag
As experimental neuroscience is moving toward more integrative approaches, with a variety of acquisition techniques covering multiple spatiotemporal scales, data management is becoming increasingly challenging for neuroscience laboratories. Often, datasets are too large to practically be stored on a laptop or a workstation. The ability to query metadata collections without retrieving complete datasets is therefore critical to efficiently perform new analyses and explore the data. At the same time, new experimental paradigms lead to constantly changing specifications for the metadata to be stored. Despite this, there is currently a serious lack of agile software tools for data management in neuroscience laboratories. To meet this need, we have developed Expipe, a lightweight data management framework that simplifies the steps from experiment to data analysis. Expipe provides the functionality to store and organize experimental data and metadata for easy retrieval in exploration and analysis throughout the experimental pipeline. It is flexible in terms of defining the metadata to store and aims to solve the storage and retrieval challenges of data/metadata due to ever changing experimental pipelines. Due to its simplicity and lightweight design, we envision Expipe as an easy-to-use data management solution for experimental laboratories, that can improve provenance, reproducibility, and sharing of scientific projects.
Raheel, Tayyaba Qureshi; Sørensen, Christina; Berghuis, Paul; Jensen, Vidar; Dobszay, Marton B. & Farkas, Tamás [Vis alle 14 forfattere av denne artikkelen] (2019). The glutamine transporter Slc38a1 regulates GABAergic neurotransmission and synaptic plasticity. Cerebral Cortex. ISSN 1047-3211. 29(12), s. 5166–5179. doi: 10.1093/cercor/bhz055. Fulltekst i vitenarkiv
Christensen, Ane Charlotte; Lepperød, Mikkel; Lensjø, Kristian Kinden; Dragly, Svenn-Arne; Blackstad, Jan Sigurd Beddari & Fyhn, Marianne [Vis alle 7 forfattere av denne artikkelen] (2019). Perineuronal nets stabilize the grid cell network. bioRxiv. ISSN 2692-8205. doi: 10.1101/796342.
Mäki-Marttunen, Tuomo; Kaufmann, Tobias; Elvsåshagen, Torbjørn; Devor, Anna; Djurovic, Srdjan & Westlye, Lars Tjelta [Vis alle 23 forfattere av denne artikkelen] (2019). Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders. Frontiers in Psychiatry. ISSN 1664-0640. 10. doi: 10.3389/fpsyt.2019.00534. Fulltekst i vitenarkiv
Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig & Ness, Torbjørn V [Vis alle 16 forfattere av denne artikkelen] (2019). Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex. ISSN 1047-3211. 29(2), s. 875–891. doi: 10.1093/cercor/bhy291. Fulltekst i vitenarkiv
Buccino, Alessio Paolo; Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Häfliger, Philipp; Fyhn, Marianne & Hafting, Torkel (2018). Open source modules for tracking animal behavior and closed-loop stimulation based on Open Ephys and Bonsai. Journal of Neural Engineering. ISSN 1741-2560. 15, s. 1–12. doi: 10.1088/1741-2552/aacf45. Fulltekst i vitenarkiv
Buccino, Alessio Paolo; Kordovan, Michael; Ness, Torbjørn V; Merkt, Benjamin; Häfliger, Philipp & Fyhn, Marianne [Vis alle 9 forfattere av denne artikkelen] (2018). Combining biophysical modeling and deep learning for multielectrode array neuron localization and classification. Journal of Neurophysiology. ISSN 0022-3077. 120(3), s. 1212–1232. doi: 10.1152/jn.00210.2018. Fulltekst i vitenarkiv
Rowlands, Daire; Lensjø, Kristian Kinden; Dinh, Tovy; Yang, Sujeon; Andrews, Melissa & Hafting, Torkel [Vis alle 9 forfattere av denne artikkelen] (2018). Aggrecan directs extracellular matrix mediated neuronal plasticity. Journal of Neuroscience. ISSN 0270-6474. 38(47), s. 10102–10113. doi: 10.1523/JNEUROSCI.1122-18.2018. Vis sammendrag
In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains elusive. Here, we genetically targeted the Acan gene encoding for aggrecan utilizing a novel animal model. This allowed for conditional and targeted loss of aggrecan in vivo, which ablated the PNN structure and caused a shift in the population of parvalbumin expressing inhibitory interneurons towards a high plasticity state. Selective deletion of the Acan gene in the visual cortex of male adult mice reinstated juvenile ocular dominance plasticity, which was mechanistically identical to critical period plasticity. Brain-wide targeting improved object recognition memory.
Dragly, Svenn-Arne; Mobarhan, Milad; Lepperød, Mikkel Elle; Tennøe, Simen; Fyhn, Marianne & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2018). Experimental directory structure (Exdir): An alternative to HDF5 without introducing a new file format. Frontiers in Neuroinformatics. ISSN 1662-5196. 12. doi: 10.3389/fninf.2018.00016.
Mobarhan, Milad; Halnes, Geir; Martínez-Cañada, Pablo; Hafting, Torkel; Fyhn, Marianne & Einevoll, Gaute (2018). Firing-rate based network modeling of the dLGN circuit: Effects of cortical feedback on spatiotemporal response properties of relay cells. PLoS Computational Biology. ISSN 1553-734X. 14(5). doi: 10.1371/journal.pcbi.1006156. Fulltekst i vitenarkiv
Martínez-Cañada, Pablo; Mobarhan, Milad; Halnes, Geir; Fyhn, Marianne; Morillas, Christian & Pelayo, Francisco [Vis alle 7 forfattere av denne artikkelen] (2018). Biophysical network modeling of the dLGN circuit: Effects of cortical feedback on spatial response properties of relay cells. PLoS Computational Biology. ISSN 1553-734X. 14(1), s. 1–45. doi: 10.1371/journal.pcbi.1005930. Fulltekst i vitenarkiv
Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Malthe-sørenssen, Anders; Hafting, Torkel & Fyhn, Marianne (2018). Removal of perineuronal nets disrupts recall of a remote fear memory. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(3), s. 607–612. doi: 10.1073/pnas.1713530115. Fulltekst i vitenarkiv
Dragly, Svenn-Arne; Mobarhan, Milad; Solbrå, Andreas Våvang; Tennøe, Simen; Hafreager, Anders & Malthe-Sørenssen, Anders [Vis alle 9 forfattere av denne artikkelen] (2017). Neuronify: An educational simulator for neural circuits. eNeuro. ISSN 2373-2822. 4(2:e0022-17.2017), s. 1–13. doi: 10.1523/ENEURO.0022-17.2017. Fulltekst i vitenarkiv
Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Tennøe, Simen; Fyhn, Marianne & Hafting, Torkel (2017). Differential Expression and Cell-Type Specificity of Perineuronal Nets in Hippocampus, Medial Entorhinal Cortex and Visual Cortex Examined in the Rat and Mouse. eNeuro. ISSN 2373-2822. 4(3), s. 1–18. doi: 10.1523/ENEURO.0379-16.2017. Fulltekst i vitenarkiv
Aasebø, Ida E. J.; Lepperød, Mikkel Elle; Stavrinou, Maria; Nøkkevangen, Sandra; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2017). Temporal processing in the visual cortex of the awake and anesthetized rat. eNeuro. ISSN 2373-2822. 4:e0059-17.2017(4), s. 1–26. doi: 10.1523/ENEURO.0059-17.2017. Fulltekst i vitenarkiv Vis sammendrag
The activity pattern and temporal dynamics within and between neuron ensembles are essential features of information processing and believed to be profoundly affected by anesthesia. Much of our general understanding of sensory information processing, including computational models aimed at mathematically simulating sensory information processing, rely on parameters derived from recordings conducted on animals under anesthesia. Due to the high variety of neuronal subtypes in the brain, population-based estimates of the impact of anesthesia may conceal unit- or ensemble-specific effects of the transition between states. Using chronically implanted tetrodes into primary visual cortex (V1) of rats, we conducted extracellular recordings of single units and followed the same cell ensembles in the awake and anesthetized states. We found that the transition from wakefulness to anesthesia involves unpredictable changes in temporal response characteristics. The latency of single-unit responses to visual stimulation was delayed in anesthesia, with large individual variations between units. Pair-wise correlations between units increased under anesthesia, indicating more synchronized activity. Further, the units within an ensemble show reproducible temporal activity patterns in response to visual stimuli that is changed between states, suggesting state-dependent sequences of activity. The current dataset, with recordings from the same neural ensembles across states, is well suited for validating and testing computational network models. This can lead to testable predictions, bring a deeper understanding of the experimental findings and improve models of neural information processing. Here, we exemplify such a workflow using a Brunel network model.
Wigestrand, Mattis B; Schiff, Hillary C.; Fyhn, Marianne; LeDoux, Joseph E & Sears, Robert M. (2017). Primary auditory cortex regulates threat memory specificity. Learning & memory (Cold Spring Harbor, N.Y.). ISSN 1072-0502. 24(1), s. 55–58. doi: 10.1101/lm.044362.116.
Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2017). Removal of perineuronal nets unlocks juvenile plasticity through network mechanisms of decreased inhibition and increased gamma Activity. Journal of Neuroscience. ISSN 0270-6474. 37(5), s. 1269–1283. doi: 10.1523/JNEUROSCI.2504-16.2016.
Hagen, Espen; Ness, Torbjørn; Khosrowshahi, Amir; Sørensen, Christina; Fyhn, Marianne & Hafting, Torkel [Vis alle 8 forfattere av denne artikkelen] (2015). ViSAPy: A Python tool for biophysics-based generation of virtual spiking activity for evaluation of spike-sorting algorithms. Journal of Neuroscience Methods. ISSN 0165-0270. 245, s. 182–204. doi: 10.1016/j.jneumeth.2015.01.029.
Bonnevie, Tora; Dunn, Benjamin Adric; Fyhn, Marianne; Hafting, Torkel; Derdikman, Dori Moshe & Kubie, J. L. [Vis alle 9 forfattere av denne artikkelen] (2013). Grid cells require excitatory drive from the hippocampus. Nature Neuroscience. ISSN 1097-6256. 16(3), s. 309–317. doi: 10.1038/nn.3311.
Derdikman, Dori Moshe; Bonnevie, Tora; Whitlock, Jonathan; Fyhn, Marianne; Hafting, Torkel & Moser, May-Britt [Vis alle 7 forfattere av denne artikkelen] (2011). A brain full of maps. Journal of Molecular Neuroscience. ISSN 0895-8696. 45, s. S29–S30.

Se alle arbeider i Cristin

Beshkov, Kosio; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute Tomas (2023). Topological Structure of Population Activity in Mouse Visual Cortex Encodes Densely Sampled Visual Scene Rotations.
Beshkov, Kosio; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute Tomas (2023). Topological Structure of Population Activity in Mouse Visual Cortex Encodes Densely Sampled Visual Scene Rotations.
Banono, Nancy Saana; Gawel, Kinga Aurelia; Mäki-Marttunen, Tuomo; van der Ent, Wietske; Kukula-Koch, Wirginia & Fyhn, Marianne [Vis alle 10 forfattere av denne artikkelen] (2023). Novel zebrafish model for studying neurodevelopment in Timothy syndrome.
Elle Lepperød, Mikkel; Stöber, Tristan; Hafting, Torkel; Fyhn, Marianne & Kording, Konrad (2022). Inferring causal connectivity from pairwise recordings and optogenetics. bioRxiv. ISSN 2692-8205. doi: 10.1101/463760.
Schøyen, Vemund Sigmundson; Pettersen, Markus Borud; Holzhousen, Konstantin; Fyhn, Marianne; Malthe-Sørenssen, Anders & Elle Lepperød, Mikkel (2022). Coherently Remapping Toroidal Cells But Not Grid Cells are Responsible for Path Integration in Virtual Agents. bioRxiv. ISSN 2692-8205. doi: 10.1101/2022.08.18.504379.
Schlegel, Ulrike; Hjallar, Viktor A.; Lensjø, Kristian; Uggerud, Ida Margrethe; Bjaalie, Jan G. & Hvoslef-Eide, Martha [Vis alle 8 forfattere av denne artikkelen] (2022). Mapping of parahippocampal and visual neural networks in mice: Preliminary evidence for feedback projections from perirhinal cortex to visual areas. Vis sammendrag
Feedback projections from higher-order processing areas to lower-order areas within the visual system havebeen observed in several species. While much is known about the function of feedforward connections in thevisual processing pathway, feedback connections are not as well studied. They are thought to cause behaviorssuch as (selective) attention or expectations, but the exact mechanism and underlying neural connectivity isstill unknown. The perirhinal cortex (PRH) forms the intersection between perceptual and mnemonic areas ofthe visual processing pathway. Evidence from rats, monkeys and humans suggests that it is involved in bothobject memory and perceptual tasks, which is reflected in its connectivity. PRH forms numerous feedforwardand feedback projections with other areas of the visual processing pathway. However, little is known about thefunction and organization of feedback projections from PRH, and other parahippocampal regions, to visualareas in mice. Given the widespread availability of genetic and molecular tools, novel opportunities toinvestigate the function of these feedback projections would be enabled by mapping them in mice. Here wepresent preliminary data from anterograde and retrograde tract tracing experiments showing feedbackprojections from PRH, and other parahippocampal regions, to visual areas. We have found first evidence forfeedback projections from PRH to lower-order visual areas that were assumed to be exclusive to higher-developed animals such as monkeys or humans. Further, we have identified feedback projections from otherparahippocampal regions with specific subregional distribution.
Banono, Nancy Saana; van der Ent, Wietske; Gawel, Kinga Aurelia; Marttunen, Tuomo; Kukula, Wirginia Koch & Fyhn, Marianne [Vis alle 9 forfattere av denne artikkelen] (2022). Zebrafish larvae with cacna1c mutations display both shared and distinct phenotypes.
Thon, Sarah Kriebel; Christensen, Ane Charlotte; Fjeldstad, Maria P; Schøyen, Vemund Sigmundson; Olsen, Elise Reppe & Lepperød, Mikkel Elle [Vis alle 8 forfattere av denne artikkelen] (2022). Social and spatial codes in hippocampus CA2 and entorhinal cortex.
Engebretsen, Solveig; Goodwin, Morten; Fyhn, Marianne & Jemterud, Torkild (2022). Abels tårn. [Radio]. NRK P2.
Banono, Nancy Saana; van der Ent, Wietske; Gawel, Kinga Aurelia; Mäki-Marttunen, Tuomo; Kukula-Koch, Wirginia & Einevoll, Gaute [Vis alle 9 forfattere av denne artikkelen] (2021). Functional characterisation of cacna1c mutations in zebrafish larvae.
Sørensen, Christina; Qureshi, Tayyaba; Fyhn, Marianne; Hafting, Torkel & Chaudhry, Farrukh Abbas (2021). GABA er essensielt for normal hjerneutvikling og synaptisk plastisitet. NBS-nytt. ISSN 0801-3535.
Iannella, Nicolangelo Libero; Prydz, Kristian; Malthe-Sørensen, Anders; Einevoll, Gaute & Fyhn, Marianne (2020). A framework for modelling neuronal-ECM signalling.
Fyhn, Marianne; Malthe-Sørenssen, Anders; Mørken, Knut Martin; Nederbragt, Alexander Johan; Odden, Tor Ole & Sundnes, Joakim (2019). Beregningsorientering og utdanningsutvikling.
Fyhn, Marianne & Einevoll, Gaute (2019). Hjernen digitaliseres - hvordan moderne datateknologi brukes til å forstå biologiske mekanismer i hjernen.
Iannella, Nicolangelo Libero; Prydz, Kristian; Malthe-Sørensen, Anders; Einevoll, Gaute & Fyhn, Marianne (2019). A new framework for modelling neural-ECM signaling.
Iannella, Nicolangelo Libero; Prydz, Kristian; Malthe-Sørensen, Anders; Einevoll, Gaute & Fyhn, Marianne (2019). A new framework for modelling neural-ECM signalling and interaction.
Håberg, Asta & Fyhn, Marianne (2019). Hvor god stendsans har du? [Radio]. NRK P1.
Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2019). Stable orientation tuning in the freely moving rat: Movement-robust orientation-selective neurons in the deep layers of the primary visual cortex.
Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2019). Stable orientation tuning in the freely moving rat: Movement-robust orientation-selective neurons in the deep layers of the primary visual cortex.
Hagen, Espen; Stasik, Alexander Johannes; Billeh, Yazan N.; Siegle, Joshua H.; Dai, Kael & Rimehaug, Atle Eskeland [Vis alle 14 forfattere av denne artikkelen] (2019). Comparing spikes and the local field potential (LFP) in V1 between experimental data and a comprehensive biophysical model.
Hagen, Espen; Stasik, Alexander Johannes; Billeh, Yazan; Siegle, Joshua H.; Dai, Kael & Rimehaug, Atle Eskeland [Vis alle 14 forfattere av denne artikkelen] (2019). Comparing spikes and the local field potential (LFP) in V1 between experimental data and a comprehensive biophysical model.
Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Stöber, Tristan Manfred & Einevoll, Gaute [Vis alle 8 forfattere av denne artikkelen] (2018). Stable orientation tuning in the freely moving rat: Movement-robust orientation-selective neurons in the deep layers of the primary visual cortex.
Hazen, Jennifer; Wigestrand, Mattis B; Aasebø, Ida Elisabeth Jørgensen; Tully, Annabelle; Dinh, Tovy & Lepperød, Mikkel [Vis alle 8 forfattere av denne artikkelen] (2018). Lateral hypothalamic area projection neurons contribute to an innate freezing response.
Grødem, Sverre; Sandvik, Guro Katrine; Hazen, Jennifer; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne (2018). A CRISPR-Cas9 platform for genetic perturbations of brain extracellular matrix regulators in vivo .
Lensjø, Kristian Kinden; Rowlands, Daire; Dinh, Tovy; Thompson, Elise Holter; Andrews, Melissa & Hafting, Torkel [Vis alle 9 forfattere av denne artikkelen] (2018). Conditional knock-out of the Acan gene removes perineuronal nets in adult mice and induces life-long brian plasticity.
Dragly, Svenn-Arne; Mobarhan, Milad; Lepperød, Mikkel Elle; Tennøe, Simen; Stasik, Alexander Johannes & Fyhn, Marianne [Vis alle 8 forfattere av denne artikkelen] (2018). Exdir An alternative to HDF5 that uses Numpy files for data, YAML for metadata and simple directories to define the hierarchy.
Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2018). Stable orientation tuning in the freely moving rat: Movement-robust orientation selective neurons in the deep layers of the primary visual cortex.
Aasebø, Ida Elisabeth Jørgensen; Røe, Malin Benum; Mobarhan, Milad; Lensjø, Kristian Kinden; Stöber, Tristan Manfred & Einevoll, Gaute [Vis alle 8 forfattere av denne artikkelen] (2018). Orientation selectivity in the freely moving rat: Movement-robust orientation-selectivity (MROS) of units in the deep layers of the rat visual cortex .
Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2018). Movement-resistant orientation selectivity of cells in the deep layers of the rat visual cortex.
Christensen, Ane Charlotte; Fyhn, Marianne & Hafting, Torkel (2017). The role of perineuronal nets in spatial representations.
Fyhn, Marianne; Kristensen, Solveig; Mørken, Knut Martin; Sølna, Hanne; Tellefsen, Cathrine Wahlstrøm & Villanger, Ilan Dehli (2017). Helhetlig fokus på utdanningsutvikling.
Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Fyhn, Marianne & Hafting, Torkel (2017). The role of extracellular matrix molecules for spatial representations in medial entorhinal cortex.
Lepperød, Mikkel Elle; Lai, Yi Ming; Fyhn, Marianne; Einevoll, Gaute; Solstad, Trygve & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2017). Population density model of the entorhinal stellate-cell network with adaptation.
Mobarhan, Milad; Halnes, Geir; Martínez-Cañada, Pablo; Hafting, Torkel; Fyhn, Marianne & Einevoll, Gaute (2017). Firing-rate Based Network Modeling of the dLGN Circuit: Effects of Cortical Feedback on Spatiotemporal Response Properties of Relay Cells .
Dragly, Svenn-Arne; Mobarhan, Milad; Solbrå, Andreas Våvang; Tennøe, Simen; Hafreager, Anders & Malthe-Sørenssen, Anders [Vis alle 9 forfattere av denne artikkelen] (2017). Neuronify: An Educational Simulator for Neural Circuits. Vis sammendrag
Neurons are cells in the brain that are able to rapidly change the electric field across their cell membrane. These changes allow neurons to communicate with each other and is the basis for the complex computations in the brain. Understanding how neurons communicate and the properties of neuronal networks is essential for neuroscience students. Traditionally, students draw networks with pen and paper and qualitatively deduce features of the network by analyzing the static drawings. Here, we present Neuronify, an app that allows students to draw the same networks on a computer or mobile device and run dynamic simulations without programming. The students can test their analysis by running the network and check their predictions against the outcome. Educational software (apps) can improve science education by providing an interactive way of learning about complicated topics that are hard to explain with text and static illustrations. Such software is readily available in many areas of natural science such as physics and electrical engineering. However, few educational apps are available for simulation of neural networks. Neuronify allows the user to easily create and explore neural networks in a plug-and-play simulation environment. The user can drag and drop network elements such as neurons, electrical stimulation tools and recording devices. The components can then easily be connected to one another. Building intuition for how neurons and neural networks behave has been a top priority in designing Neuronify. We aim to provide a low entry point to simulation-based neuroscience. Most undergraduate students do not have the computational experience to create their own neural simulator. Neuronify offers them an opportunity to build and experiment with neural networks in a graphical and easy-to-understand interface. By playing around with the networks, the students can develop a good understanding of their properties. To facilitate the use of Neuronify in teaching, a set of premade common network motifs is provided, performing functions such as input summation and detection of direction of stimulus movement. Neuronify is developed in C++ and QML using the cross-platform application framework Qt. It has been downloaded more than 30,000 times since its launch and is available on smart phones (Android, iOS), tablet computers as well personal computers (Windows, Mac, Linux).
Buccino, Alessio Paolo; Ness, Torbjørn Vefferstad; Einevoll, Gaute; Cauwenberghs, Gert; Fyhn, Marianne & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2017). Classification of Neural Cell-types from Extracellular Signatures on Multi-Electrode Arrays using Deep Learning .
Aasebø, Ida E. J.; Mobarhan, Milad; Røe, Malin Benum; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2017). Movement-resistant orientation-selective units in the deep layers of the visual cortex.
Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel; Malthe-Sørenssen, Anders & Fyhn, Marianne (2017). The perineuronal nets in the lateral secondary visual cortex are essential for remote visual fear memory.
Dinh, Tovy; Lensjø, Kristian Kinden; Lanton, Rune Alexander; Dick, Gunnar; Fyhn, Marianne & Hafting, Torkel (2017). Increased ocular dominance plasticity in adult visual cortex after genetic knock out of aggrecan, an essential component of perineuronal nets.
Blackstad, Jan Sigurd; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne (2016). Involvement of perineuronal nets in spatial information transfer between the entorhinal cortex and hippocampus.
Blackstad, Jan Sigurd; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne (2016). Involvement of perineuronal nets in spatial information transfer between the entorhinal cortex and hippocampus.
Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel; Fyhn, Marianne & Malthe-Sørenssen, Anders (2016). The perineuronal nets in the lateral secondary visual cortex are essential for remote visual memory.
Wigestrand, Mattis B; Aasebø, Ida E. J.; Tully, Annabelle; Lepperød, Mikkel Elle; Hafting, Torkel & Fyhn, Marianne (2016). Lateral hypothalamic outputs control innate defensive responses. Vis sammendrag
When facing a threat, animals display defensive behaviors that are critical for survival. The hypothalamus is believed to mediate such defensive responses, but the prevailing view includes a medial/lateral separation, where medial hypothalamus is thought to influence defensive responses, while the lateral hypothalamic area (LHA) regulates feeding and arousal. Here we identify two distinct neural populations in the LHA with surprising survival functions in rats. The two neural populations, defined by their output projections to either the periaqueductal gray (PAG) or the lateral habenula (LHb) have distinct anatomical placements along the anterior-posterior axis of the LHA and express distinct biochemical markers. Optogenetic stimulation of the two LHA populations robustly induced opposite active- or passive defensive responses. Further, chemogenetic silencing of LHA and optogenetic silencing of the LHA-PAG projection disrupted innate defensive responses to a predator-like looming shadow. Using single-unit recordings in the downstream LHb and PAG, we show that the LHA-LHb projection is largely excitatory, while the LHA-PAG projection is mainly inhibitory. We are currently using a miniaturized microscope to image the calcium activity of the two LHA populations during threat processing in behaving rats. Overall, our findings identify a novel LHA circuit that is critical for appropriate defensive responses to innate visual threats. The location of the LHA defense circuits, intermingled within circuitry that governs feeding, suggests that this circuit may provide rapid cross-talk between circuits that govern foraging- and anti-predator behaviors.
Lepperød, Mikkel Elle; Wigestrand, Mattis B; Frey, Mina Martine; Lensjø, Kristian Kinden; Einevoll, Gaute & Solstad, Trygve [Vis alle 8 forfattere av denne artikkelen] (2016). On the role of input-specific perturbations of medial septal projections to the grid cell network.
Røe, Malin Benum; Aasebø, Ida E. J.; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne (2016). Orientation selective cells in layer six of the primary visual cortex are resistant to the animal's movement.
Bjerke, Line; Wigestrand, Mattis B; Aasebø, Ida E. J.; Fyhn, Marianne & Hafting, Torkel (2016). Inhibitory outputs from lateral hypothalamus to paraqueductal grey control innate defensive behavior.
Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel & Fyhn, Marianne (2016). The perineuronal nets in the lateral secondary visual cortex and their impact on remote visual fear memory.
Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2016). Removal of perineuronal nets affects information processing and plasticity in the primary visual cortex.
Lepperød, Mikkel Elle; Wigestrand, Mattis B; Lensjø, Kristian Kinden; Frey, M.M.; Dragly, Svenn-Arne & Einevoll, Gaute [Vis alle 9 forfattere av denne artikkelen] (2016). Grid cell network resilient to input-specific medial septum perturbations.
Lepperød, Mikkel Elle; Wigestrand, Mattis B; Frey, M.M.; Lensjø, Kristian Kinden; Einevoll, Gaute & Solstad, Trygve [Vis alle 8 forfattere av denne artikkelen] (2016). Role of input-specific perturbations of medial septal projections to the grid cell network.
Wigestrand, Mattis B; Aasebø, Ida E. J.; Tully, Annabelle; Dinh, Vy To; Lepperød, Mikkel Elle & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2016). Lateral hypothalamic outputs control innate defensive responses.
Hobbi Mobarhan, Milad; Einevoll, Gaute; Geir, Halnes; Vervaeke, Koen Gerard Alois & Fyhn, Marianne (2015). Roles of cortical feedback in lateral geniculate nucleus.
Lepperød, Mikkel Elle; Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute (2015). Building an entorhinal cortex network.
Aasebø, Ida E. J.; Hafting, Torkel; Stavrinou, Maria; Sandra, Nøkkevangen; Lepperød, Bjørn Mikkel Elle & Fyhn, Marianne (2015). Temporal processing in the visual cortex in the awake and anesthetized rat.
Lensjø, Kristian Kinden; Lepperød, Bjørn Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2015). Removal of perineuronal nets in the visual cortex leads to a reduced inhibition and mimics critical period plasticity .
Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Bjørn Mikkel Elle; Fyhn, Marianne & Hafting, Torkel (2015). The role of extracellular matrix molecules for spatial representations and plasticity in entorhinal cortex.
Fyhn, Marianne (2014). PNNs in the cortex, hippocampus and medial entorhinal cortex .
Hafting, Torkel; Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Dick, Gunnar & Fyhn, Marianne (2014). Perineuronal nets, plasticity and information-processing in visual cortex, medial entorhinal cortex and hippocampus.
Hagen, Espen; Ness, Torbjørn Bækø; Khosrowshahi, Amir; Sørensen, Christina; Fyhn, Marianne & Hafting, Torkel [Vis alle 8 forfattere av denne artikkelen] (2013). Modeling of extracellular spike signatures.
Aasebø, Ida E. J.; Norheim, Eivind Skjønsberg; Lensjø, Kristian Kinden; Fyhn, Marianne & Fyhn, Torkel Hafting (2013). The effect of anesthesia on activity and modulation of visually responsive neurons in cortical and subcortical areas.
Lensjø, Kristian Kinden; Dick, Gunnar; Fyhn, Torkel Hafting & Fyhn, Marianne (2013). Cortical processing in awake, behaving rats after removal of perineuronal nets.
Bonnevie, Tora; Dunn, Benjamin Adric; Fyhn, Marianne; Hafting, Torkel; Derdikman, Dori Moshe & Kubie, J. L. [Vis alle 9 forfattere av denne artikkelen] (2012). 702.12/DDD28 - Entorhinal grid cells require excitatory drive from the hippocampus. SFN Abstract Viewer/Itinerary Planner.
Bonnevie, Tora; Fyhn, Marianne; Hafting, Torkel; Derdikman, Dori Moshe; Moser, Edvard Ingjald & Moser, May-Britt (2011). Preserved spatial correlation structure in grid cells after hippocampal inactivation.
Fyhn, Marianne; Hafting, Torkel & Stryker, MP (2011). Long-term in vivo imaging of dendritic spines in layer II/III of visual cortex during the critical period. Vis sammendrag
Acta Physiologica 2011; Volume 202, Supplement 685 :8.1.46
Bonnevie, Tora; Fyhn, Marianne; Hafting, Torkel; Derdikman, Dori Moshe; Moser, Edvard Ingjald & Moser, May-Britt (2010). Hippocampal contribution to maintenance of entorhinal grid fields.
Banono, Nancy Saana; Esguerra, Camila; Fyhn, Marianne & Andreassen, Ole (2021). Functional analysis of psychiatric risk genes in zebrafish (Danio rerio): a focus on the L-type voltage-gated calcium channel subtypes CaV1.2 and CaV1.3. Universitetet i Oslo.
Aasebø, Ida Elisabeth Jørgensen; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute (2018). Behavioural state and neuronal activity: how the freely moving paradigm can uncover novel response characteristics. Universitetet i Oslo.
Johansen, Finn-Eirik; Brautaset, Trygve; Aune, Marie Hjelmseth; Patriksson, Alexandra; Falkenberg, Liv Eggset & Kleppe, Rune [Vis alle 19 forfattere av denne artikkelen] (2018). Centre for Digital Life Norway - Annual report 2017. Senter for Digialt Liv Norge. Fulltekst i vitenarkiv

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