Knut Liestøl

• Pladsen, Arne Valebjørg; Nilsen, Gro; Rueda, Oscar M.; Aure, Miriam Ragle; Borgan, Ørnulf; Liestøl, Knut; Vitelli, Valeria; Frigessi Di Rattalma, Arnoldo; Langerød, Anita; Mathelier, Anthony; Engebråten, Olav; Kristensen, Vessela N.; Wedge, David C.; Van Loo, Peter; Caldas, Carlos; Børresen-Dale, Anne-Lise; Russnes, Hege Elisabeth Giercksky & Lingjærde, Ole Christian (2020). DNA copy number motifs are strong and independent predictors of survival in breast cancer. Communications Biology.  ISSN 2399-3642.  3 . doi: 10.1038/s42003-020-0884-6
• Skrede, Ole-Johan; De Raedt, Sepp; Kleppe, Andreas; Hveem, Tarjei Sveinsgjerd; Liestøl, Knut; Maddison, John; Askautrud, Hanne Arenberg; Pradhan, Manohar; Nesheim, John Arne; Albregtsen, Fritz; Farstad, Inger Nina; Domingo, Enric; Church, David N.; Nesbakken, Arild; Shepherd, Neil A; Tomlinson, Ian; Kerr, Rachel; Novelli, Marco; Kerr, David & Danielsen, Håvard Emil (2020). Deep learning for prediction of colorectal cancer outcome: a discovery and validation study. The Lancet.  ISSN 0140-6736.  395:10221, s 350- 360 . doi: 10.1016/S0140-6736(19)32998-8
• Ersvær, Elin; Kildal, Wanja; Vlatkovic, Ljiljana; Cyll, Karolina Urszula; Pradhan, Manohar; Kleppe, Andreas; Hveem, Tarjei Sveinsgjerd; Askautrud, Hanne Arenberg; Novelli, Marco; Wæhre, Haakon; Liestøl, Knut & Danielsen, Håvard Emil (2019). Prognostic value of mitotic checkpoint protein BUB3, cyclin B1, and pituitary tumor-transforming 1 expression in prostate cancer. Modern Pathology.  ISSN 0893-3952.  s 1- 11 . doi: 10.1038/s41379-019-0418-2
• Lie-Jensen, Anette; Ivanauskiene, Kristina; Malerød, Lene; Jain, Ashish; Tan, Kia Wee; Lærdahl, Jon Kristen; Liestøl, Knut; Stenmark, Harald & Haglund, Kaisa (2019). Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding. Current Biology.  ISSN 0960-9822.  29(20), s 3538- 3548.e7 . doi: 10.1016/j.cub.2019.09.025
• Mariampillai, Julian Eek; Liestøl, Knut; Kjeldsen, Sverre; Prestgaard, Erik Edvard; Engeseth, Kristian; Bodegard, Johan; Berge, Eivind; Gjesdal, Knut; Erikssen, Jan Emil; Grundvold, Irene & Skretteberg, Torger (2019). Exercise Systolic Blood Pressure at Moderate Workload Is Linearly Associated With Coronary Disease Risk in Healthy Men. Hypertension Research.  ISSN 0916-9636.  75(1), s 44- 50 . doi: 10.1161/HYPERTENSIONAHA.119.13528 Fulltekst i vitenarkiv.
• Mariampillai, Julian Eek; Prestgaard, Erik Edvard; Kjeldsen, Sverre; Liestøl, Knut; Engeseth, Kristian; Erikssen, Jan Emil; Bodegard, Johan; Berge, Eivind; Grundvold, Irene & Skretteberg, Torger (2019). SBP above 180 mmHg at moderate exercise workload increases coronary heart disease risk in healthy men during 28-year follow-up.. Journal of Hypertension.  ISSN 0263-6352.  37(5), s 949- 955 . doi: 10.1097/HJH.0000000000001959
• Mehlum, Maria Hollund; Liestøl, Knut; Wyller, Torgeir Bruun; Hua, Tsushung A.; Rostrup, Morten & Berge, Eivind (2019). Blood pressure variability in hypertensive patients with atrial fibrillation in the VALUE trial. Blood Pressure.  ISSN 0803-7051.  28(2), s 77- 83 . doi: 10.1080/08037051.2018.1524707
• Steen, Chloe Beate; Leich, Ellen; Myklebust, June Helen; Lockmer, Sandra; Wise, Jillian; Wahlin, Björn Engelbrekt; Østenstad, Bjørn; Liestøl, Knut; Kimby, Eva; Rosenwald, Andreas; Smeland, Erlend B; Holte, Harald; Lingjærde, Ole Christian & Brodtkorb, Marianne (2019). A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy. Haematologica.  ISSN 0390-6078.  104(10), s 460- 464 . doi: 10.3324/haematol.2018.209080 Fulltekst i vitenarkiv.
• Engeseth, Kristian; Prestgaard, Erik Edvard; Mariampillai, Julian Eek; Grundvold, Irene; Liestøl, Knut; Kjeldsen, Sverre; Bodegard, Johan; Erikssen, Jan Emil; Gjesdal, Knut & Skretteberg, Torger (2018). Physical fitness is a modifiable predictor of early cardiovascular death: A 35-year follow-up study of 2014 healthy middle-aged men. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873.  25(15), s 1655- 1663 . doi: 10.1177/2047487318793459
• Erikssen, Gunnar; Aboulhosn, Jamil; Lin, Jeannette; Liestøl, Knut; Estensen, Mette-Elise; Gjesdal, Ola; Skulstad, Helge; Døhlen, Gaute & Lindberg, Harald L (2018). Survival in patients with univentricular hearts: The impact of right versus left ventricular morphology. Open heart.  ISSN 2053-3624.  5:e000902(2), s 1- 9 . doi: 10.1136/openhrt-2018-000902 Fulltekst i vitenarkiv.
• Kristiansen, Stein; Sønsteby Hugaas, Mari; Goebel, Vera Hermine; Plagemann, Thomas Peter; Nikolaidis, Konstantinos & Liestøl, Knut (2018). Data Mining for Patient Friendly Apnea Detection. IEEE Access.  ISSN 2169-3536.  6, s 74598- 74615 . doi: 10.1109/ACCESS.2018.2882270 Fulltekst i vitenarkiv.
• Malerød, Lene; Le Borgne, Roland; Lie-Jensen, Anette Christensen; Eikenes, Åsmund Husabø; Brech, Andreas; Liestøl, Knut; Stenmark, Harald & Haglund, Kaisa (2018). Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics. EMBO Journal.  ISSN 0261-4189.  37(13), s 1- 21 . doi: 10.15252/embj.201797741
• Mehlum, Maria Hollund; Liestøl, Knut; Kjeldsen, Sverre; Julius, Stevo; Hua, Tsushung A.; Rothwell, Peter M.; Mancia, Giuseppe; Parati, Gianfranco; Weber, Michael A. & Berge, Eivind (2018). Blood pressure variability and risk of cardiovascular events and death in patients with hypertension and different baseline risks. European Heart Journal.  ISSN 0195-668X.  39(24), s 2243- 2251 . doi: 10.1093/eurheartj/ehx760
• Prestgaard, Erik Edvard; Mariampillai, Julian Eek; Engeseth, Kristian; Erikssen, Jan Emil; Bodegard, Johan; Liestøl, Knut; Gjesdal, Knut; Kjeldsen, Sverre; Grundvold, Irene & Berge, Eivind (2018). Change in Cardiorespiratory Fitness and Risk of Stroke and Death.. Stroke.  ISSN 0039-2499.  50, s 155- 161 . doi: 10.1161/STROKEAHA.118.021798
• Westvik, Asbjørn; Weedon-Fekjær, Harald; Mæhlen, Jan & Liestøl, Knut (2018). Evaluating different breast tumor progression models using screening data. BMC Cancer.  ISSN 1471-2407.  18(1) . doi: 10.1186/s12885-018-4130-2
• Barzenje, Dlawer Abdulla; Holte, Harald; Fosså, Alexander; Ghanima, Waleed Khalid; Liestøl, Knut; Delabie, Jan & Kolstad, Arne (2017). Long-term outcome for patients with early stage marginal zone lymphoma and mantle cell lymphoma. Leukemia and Lymphoma.  ISSN 1042-8194.  58(3), s 623- 632 . doi: 10.1080/10428194.2016.1204653
• Jørgensen, Silje; Søraas, Arne Vasli; Sundsfjord, Arnfinn; Liestøl, Knut; Leegaard, Truls Michael & Jenum, Pål (2017). Fecal carriage of extended spectrum β-lactamase producing Escherichia coli and Klebsiella pneumoniae after urinary tract infection - A three year prospective cohort study. PLOS ONE.  ISSN 1932-6203.  12:e017w|(16), s 13510- 1 . doi: 10.1371/journal.pone.0173510 Fulltekst i vitenarkiv.
• Larssen, Marte Strømsnes; Steine, Kjetil; Mykland Hilde, Janne; Skjørten, Ingunn; Hodnesdal, Christian; Liestøl, Knut & Gjesdal, Knut (2017). Mechanisms of ECG signs in chronic obstructive pulmonary disease. Open heart.  ISSN 2053-3624.  4(1) . doi: 10.1136/openhrt-2016-000552 Fulltekst i vitenarkiv.
• Mariampillai, Julian Eek; Engeseth, Kristian; Kjeldsen, Sverre Erik; Grundvold, Irene; Liestøl, Knut; Erikssen, Gunnar; Erikssen, Jan Emil; Bodegard, Johan & Skretteberg, Torger (2017). Exercise systolic blood pressure at moderate workload predicts cardiovascular disease and mortality through 35 years of follow-up in healthy, middle-aged men. Blood Pressure.  ISSN 0803-7051.  26(4), s 229- 236 . doi: 10.1080/08037051.2017.1291276
• Myklebust, June; Brody, Joshua; Kohrt, Holbrook E.; Kolstad, Arne; Czerwinski, Debra K; Waelchli, Sebastien; Green, Michael R.; Trøen, Gunhild; Liestøl, Knut; Beiske, Klaus; Houot, Roch; Delabie, Jan; Alizadeh, Ash A.; Irish, Jonathan M. & Levy, Ronald (2017). Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling. Blood.  ISSN 0006-4971.  129(6), s 759- 770 . doi: 10.1182/blood-2016-05-718494
• Prestgaard, Erik Edvard; Hodnesdal, Christian; Engeseth, Kristian; Erikssen, Jan Emil; Bodegard, Johan; Liestøl, Knut; Gjesdal, Knut; Kjeldsen, Sverre; Grundvold, Irene & Berge, Eivind (2017). Long-term predictors of stroke in healthy middle-aged men. International Journal of Stroke.  ISSN 1747-4930.  13(3), s 292- 300 . doi: 10.1177/1747493017730760
• Christ, Liliane Florence; Wenzel, Eva; Liestøl, Knut; Raiborg, Camilla; Campsteijn, Coen & Stenmark, Harald Alfred (2016). ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission. Journal of Cell Biology.  ISSN 0021-9525.  212(5), s 499- 513 . doi: 10.1083/jcb.201507009
• Engeseth, Kristian; Hodnesdal, Christian; Grundvold, Irene; Liestøl, Knut; Gjesdal, Knut; Erikssen, Gunnar; Kjeldsen, Sverre Erik; Erikssen, Jan Emil; Bodegard, Johan & Skretteberg, Torger (2016). Heart rate reserve predicts cardiovascular death among physically unfit but otherwise healthy middle-aged men: a 35-year follow-up study. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873.  23(1), s 59- 66 . doi: 10.1177/2047487314553202
• Engeseth, Kristian; Hodnesdal, Christian; Grundvold, Irene; Liestøl, Knut; Gjesdal, Knut; Kjeldsen, Sverre Erik; Erikssen, Jan Emil; Bodegard, Johan & Skretteberg, Torger (2016). Temporal reduction in chronotropic index predicts risk of cardiovascular death among healthy middle-aged men: A 28-year follow-up study. Journal of the American Heart Association.  ISSN 2047-9980.  5:e004555, s 1- 12 . doi: 10.1161/JAHA.116.004555 Vis sammendrag

  Background Chronotropic index is a standardized measure of heart rate (HR) increment during exercise that reflects the combined effects of age, resting HR, and physical fitness. Low chronotropic index has been reported to predict disease and death. We tested whether temporal change in chronotropic index over 7 years influenced risk of cardiovascular death through up to 28 years. Methods and Results Chronotropic index was calculated ([achieved maximal HR−resting HR]/[age‐predicted maximal HR−resting HR]) after a symptom‐limited bicycle ECG exercise test in 1420 healthy men at 2 examinations 7 years apart, in 1972 and 1979. Events of cardiovascular death were registered by manual scrutiny of all participants’ hospital charts and the Norwegian Cause of Death Registry. The participants were divided into quartiles of temporal change in chronotropic index, with quartile one having the most negative value. Cox proportional hazard regression models were used to estimate risks and adjusted for classical cardiovascular risk factors. Incidence of cardiovascular death was 310 (22%) during median of 21 years of follow‐up. After multivariable adjustment, and comparison with quartile four (mean +0.11), quartiles one (−0.16), two (−0.04), and three (+0.02) were associated with hazard ratios 1.50 (95% CI 1.10–2.05), 1.10 (0.79–1.53), and 1.04 (0.74–1.45) for cardiovascular death. Results remained robust also after exclusion of 31 participants with exercise ECG‐induced signs of coronary ischemia. Conclusions Temporal reduction in chronotropic index was associated with increased long‐term risk of cardiovascular death and might be a clinically important predictor when assessing risk in healthy individuals over a longer time.

• Holland, Petter; Knævelsrud, Helene; Søreng, Kristiane; Mathai, Benan John; Lystad, Alf Håkon; Pankiv, Serhiy; Bjørndal, Gunnveig Toft; Schultz, Sebastian; Lobert, Viola; Chan, Robin B; Zhou, Bowen; Liestøl, Knut; Carlsson, Sven R; Melia, Thomas J; Di Paolo, Gilbert & Simonsen, Anne (2016). HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels. Nature Communications.  ISSN 2041-1723.  7 . doi: 10.1038/ncomms13889 Fulltekst i vitenarkiv.
• Hveem, Tarjei Sveinsgjerd; Kleppe, Andreas; Vlatkovic, Ljiljana; Ersvær, Elin; Wæhre, Haakon; Nielsen, Birgitte; Kjær, Marte Avranden; Pradhan, Manohar; Syvertsen, Rolf Anders; Nesheim, John Arne; Liestøl, Knut; Albregtsen, Fritz & Danielsen, Håvard Emil (2016). Chromatin changes predict recurrence after radical prostatectomy. British Journal of Cancer.  ISSN 0007-0920.  114(11), s 1243- 1250 . doi: 10.1038/bjc.2016.96
• Hveem, Tarjei Sveinsgjerd; Njølstad, Tormund Salvesen; Nielsen, Birgitte; Syvertsen, Rolf Anders; Nesheim, John Arne; Kjæreng, Marna Lill; Kildal, Wanja; Pradhan, Manohar; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Haugland, Hans Kristian; Eraker, Runar; Oddenes, Klaus; Rokne, Jan Anders; Tjugum, Jostein; Lode, Margaret Sævik; Amant, Frédéric; Werner, Henrica Maria Johanna; Bjørge, Line; Albregtsen, Fritz; Liestøl, Knut; Salvesen, Helga; Trovik, Jone & Danielsen, Håvard Emil (2016). Changes in Chromatin Structure in Curettage Specimens Identifies High-Risk Patients in Endometrial Cancer. Cancer Epidemiology, Biomarkers and Prevention.  ISSN 1055-9965.  26(1), s 61- 67 . doi: 10.1158/1055-9965.EPI-16-0215
• Jørgensen, Magne; Dybå, Tore; Liestøl, Knut & Sjøberg, Dag (2016). Incorrect results in software engineering experiments: How to improve research practices. Journal of Systems and Software.  ISSN 0164-1212.  116, s 133- 145 . doi: 10.1016/j.jss.2015.03.065 Fulltekst i vitenarkiv. Vis sammendrag

  Context The trustworthiness of research results is a growing concern in many empirical disciplines. Aim The goals of this paper are to assess how much the trustworthiness of results reported in software engineering experiments is affected by researcher and publication bias, given typical statistical power and significance levels, and to suggest improved research practices. Method First, we conducted a small-scale survey to document the presence of researcher and publication biases in software engineering experiments. Then, we built a model that estimates the proportion of correct results for different levels of researcher and publication bias. A review of 150 randomly selected software engineering experiments published in the period 2002–2013 was conducted to provide input to the model. Results The survey indicates that researcher and publication bias is quite common. This finding is supported by the observation that the actual proportion of statistically significant results reported in the reviewed papers was about twice as high as the one expected assuming no researcher and publication bias. Our models suggest a high proportion of incorrect results even with quite conservative assumptions. Conclusion Research practices must improve to increase the trustworthiness of software engineering experiments. A key to this improvement is to avoid conducting studies with unsatisfactory low statistical power.

• Pharo, Heidi Dietrichson; Honne, Hilde; Vedeld, Hege Marie; Dahl, Christina; Andresen, Kim; Liestøl, Knut; Jeanmougin, Marine; Guldberg, Per & Lind, Guro Elisabeth (2016). Experimental factors affecting the robustness of DNA methylation analysis. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep33936
• Szymanska, Monika; Fosdahl, Anne-Marthe; Raiborg, Camilla; Dietrich, Markus; Liestøl, Knut; Stang, Espen & Bertelsen, Vibeke (2016). Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3. BBA - Molecular Cell Research.  ISSN 0167-4889.  1863(6), s 1179- 1188 . doi: 10.1016/j.bbamcr.2016.03.011
• Barzenje, Dlawer Abdulla; Småstuen, Milada C; Liestøl, Knut; Fosså, Alexander; Delabie, Jan; Kolstad, Arne & Holte, Harald (2015). Radiotherapy compared to other strategies in the treatment of stage I/II follicular lymphoma: A study of 404 patients with a median follow-up of 15 years. PLOS ONE.  ISSN 1932-6203.  10:e0131158(7) . doi: 10.1371/journal.pone.0131158
• Blaker, Yngvild Nuvin; Brodtkorb, Marianne; Maddison, John; Hveem, Tarjei Sveinsgjerd; Nesheim, John Arne; Mohn, Hans Martin; Kolstad, Arne; Geisler, Christian H.; Liestøl, Knut; Smeland, Erlend B; Holte, Harald; Delabie, Jan & Danielsen, Håvard Emil (2015). Computerized image analysis of the Ki-67 proliferation index in mantle cell lymphoma. Histopathology.  ISSN 0309-0167.  67(1), s 62- 69 . doi: 10.1111/his.12624
• Bruun, Jarle; Kolberg, Matthias; Ahlquist, Terje Cruickshank; Røyrvik, Ellen Christine; Nome, Torfinn; Leithe, Edward; Lind, Guro Elisabeth; Merok, Marianne Aarstad; Rognum, Torleiv Ole; Bjørkøy, Geir; Johansen, Terje; Lindblom, Annika; Sun, X-F.; Svindland, Aud; Liestøl, Knut; Nesbakken, Arild; Skotheim, Rolf Inge & Lothe, Ragnhild A (2015). Regulator of chromosome condensation 2 identifies high-risk patients within both major phenotypes of colorectal cancer. Clinical Cancer Research.  ISSN 1078-0432.  21(16), s 3759- 3770 . doi: 10.1158/1078-0432.CCR-14-3294
• Eikenes, Åsmund Husabø; Malerød, Lene; Christensen, Anette Lie; Steen, Chloe Beate; Mathieu, Juliette; Nezis, Ioannis P; Liestøl, Knut; Huynh, Jean-Rene; Stenmark, Harald & Haglund, Kaisa (2015). ALIX and ESCRT-III Coordinately Control Cytokinetic Abscission during Germline Stem Cell Division In Vivo. PLoS Genetics.  ISSN 1553-7390.  11(1) . doi: 10.1371/journal.pgen.1004904
• Eikenes, Åsmund Husabø; Malerød, Lene; Christensen, Anette Lie; Wegner, Catherine E Sem; Brech, Andreas; Liestøl, Knut; Stenmark, Harald Alfred & Haglund, Kaisa (2015). Src64 controls a novel actin network required for proper ring canal formation in the drosophila male germline. Development.  ISSN 0950-1991.  142(23), s 4107- 4118 . doi: 10.1242/dev.124370 Vis sammendrag

  In many organisms, germ cells develop as cysts in which cells are interconnected via ring canals (RCs) as a result of incomplete cytokinesis. However, the molecular mechanisms of incomplete cytokinesis remain poorly understood. Here, we address the role of tyrosine phosphorylation of RCs in the Drosophila male germline. We uncover a hierarchy of tyrosine phosphorylation within germline cysts that positively correlates with RC age. The kinase Src64 is responsible for mediating RC tyrosine phosphorylation, and loss of Src64 causes a reduction in RC diameter within germline cysts. Mechanistically, we show that Src64 controls an actin network around the RCs that depends on Abl and the Rac/SCAR/Arp2/3 pathway. The actin network around RCs is required for correct RC diameter in cysts of developing germ cells. We also identify that Src64 is required for proper germ cell differentiation in the Drosophila male germline independent of its role in RC regulation. In summary, we report that Src64 controls actin dynamics to mediate proper RC formation during incomplete cytokinesis during germline cyst development in vivo.

• Erikssen, Gunnar; Liestøl, Knut; Seem, Egil; Birkelance, Sigurce; Saatvedt, Kjell; Nilsen-Hoel, Tom; Døhlen, Gaute; Skulstad, Helge; Svennevig, Jan Ludvig; Thaulow, Erik & Lindberg, Harald L (2015). Achievements in congenital heart defect surgery: A prospective, 40-year study of 7038 patients. Circulation.  ISSN 0009-7322.  131, s 337- 346 . doi: 10.1161/CIRCULATIONAHA.114.012033
• Fiskvik, Idun Hege; Beiske, Klaus; Delabie, Jan; Yri, Olav Erich; Spetalen, Signe; Karjalainen-Lindsberg, Marja-Liisa; Leppä, Sirpa; Liestøl, Knut; Smeland, Erlend B & Holte, Harald (2015). Combining MYC, BCL2 and TP53 gene and protein expression alterations improves risk stratification in diffuse large B-cell lymphoma. Leukemia and Lymphoma.  ISSN 1042-8194.  56(6), s 1742- 1749 . doi: 10.3109/10428194.2014.970550
• Helmer, Caroline; Skranes, Janne Helen; Liestøl, Knut & Fugelseth, Drude (2015). Using adrenaline during neonatal resuscitation may have an impact on serum cardiac troponin-T levels. Acta Paediatrica.  ISSN 0803-5253.  104(9), s e378- e383 . doi: 10.1111/apa.13055
• Kumar, Neena Theresa; Liestøl, Knut; Løberg, Else Marit; Reims, Henrik Mikael & Mæhlen, Jan (2015). Apolipoprotein E allelotype is associated with neuropathological findings in Alzheimer's disease. Virchows Archiv.  ISSN 0945-6317.  467(2), s 225- 235 . doi: 10.1007/s00428-015-1772-1
• Thorvaldsen, Tor Espen; Pedersen, Nina Marie; Wenzel, Eva; Schultz, Sebastian; Brech, Andreas; Liestøl, Knut; Waaler, Jo; Krauss, Stefan & Stenmark, Harald Alfred (2015). Structure, dynamics, and functionality of tankyrase inhibitor-induced degradasomes. Molecular Cancer Research.  ISSN 1541-7786.  13(11), s 1487- 1501 . doi: 10.1158/1541-7786.MCR-15-0125
• Bethge, Nicole; Honne, Hilde; Andresen, Kim; Hilden, Vera Irene; Trøen, Gunhild; Liestøl, Knut; Holte, Harald; Delabie, Jan; Lind, Guro Elisabeth & Smeland, Erlend B (2014). A gene panel, including LRP12, is frequently hypermethylated in major types of B-cell lymphoma. PLOS ONE.  ISSN 1932-6203.  9(9) . doi: 10.1371/journal.pone.0104249
• Bethge, Nicole; Lothe, Ragnhild A; Honne, Hilde; Andresen, Kim; Trøen, Gunhild; Eknæs, Mette; Liestøl, Knut; Holte, Harald; Delabie, Jan; Smeland, Erlend B & Lind, Guro Elisabeth (2014). Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma. Epigenetics.  ISSN 1559-2294.  9(3), s 428- 436 . doi: 10.4161/epi.27554
• Blaker, Yngvild Nuvin; Eide, Marianne Brodtkorb; Liestøl, Knut; Lauritzsen, Grete Fossum; Kolstad, Arne; Fosså, Alexander; Smeland, Erlend B & Holte, Harald (2014). High dose chemotherapy with autologous stem cell transplant for patients with transformed B-cell non-Hodgkin lymphoma in the rituximab era. Leukemia and Lymphoma.  ISSN 1042-8194.  55(10), s 2319- 2327 . doi: 10.3109/10428194.2013.871632
• Chen, Ying; Klingen, Tor Audun; Wik, Elisabeth; Aas, Hans; Vigeland, Einar; Liestøl, Knut; Garred, Øystein; Mæhlen, Jan; Akslen, Lars A. & Lømo, Jon (2014). Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study. Diagnostic Pathology.  ISSN 1746-1596.  9 . doi: 10.1186/s13000-014-0230-8 Fulltekst i vitenarkiv.
• Eriksen, Beate Horsberg; Nestaas, Eirik; Hole, Torstein; Liestøl, Knut; Støylen, Asbjørn & Fugelseth, Drude (2014). Myocardial function in term and preterm infants. Influence of heart size, gestational age and postnatal maturation. Early Human Development.  ISSN 0378-3782.  90(7), s 359- 364 . doi: 10.1016/j.earlhumdev.2014.04.010 Vis sammendrag

  Background Sparse knowledge exists on the differences in cardiac function between term and preterm infants. This study examines the impact of heart size, gestational age and postnatal maturation on myocardial function. Aim To assess and compare serial echocardiographic indices of myocardial function in term and moderately preterm infants. Methods Longitudinal, prospective, observational echocardiographic cohort study of 45 healthy term infants examined at day three and at 12–20 weeks postnatal age and 53 moderately preterm infants (gestational age 31–35 weeks) examined at day three and at term equivalent (4–10 weeks postnatal age). Outcomes Primary: Systolic mitral and tricuspid annular plane excursions and annular peak systolic pulsed wave tissue Doppler (pwTDI) velocities. Secondary: Indices normalized for heart size. Results On day three, all indices were higher in the term than in the preterm infants whereas normalized systolic pwTDI velocities were lower in the term infants and normalized excursions showed no difference. All indices increased with advanced postnatal age. The indices in term infants on day three were lower than in preterm infants at term equivalent, with and without normalization. After postnatal maturation in both groups, all indices were higher in the term group (except left pwTDI), whereas normalized indices showed no consistent pattern. Conclusions Myocardial function indices increased with gestational age at birth and more profoundly with postnatal maturation. Serial examinations of non-normalized and normalized myocardial function indices showed no sustained differences between the preterm and the term infants. Normalization by heart size may be of value when assessing myocardial function in infants.

• Haugsten, Ellen Margrethe; Brech, Andreas; Liestøl, Knut; Norman, Jim C. & Wesche, Jørgen (2014). Photoactivation Approaches Reveal a Role for Rab11 in FGFR4 Recycling and Signalling. Traffic : the International Journal of Intracellular Transport.  ISSN 1398-9219.  15(6), s 665- 683 . doi: 10.1111/tra.12168
• Hveem, Tarjei Sveinsgjerd; Merok, Marianne Aarstad; Pretorius, Maria; Novelli, Marco; Silihagen, Mette; Sjo, Ole Helmer; Clinch, N; Liestøl, Knut; Svindland, Aud; Lothe, Ragnhild A; Nesbakken, Arild & Danielsen, Håvard Emil (2014). Prognostic impact of genomic instability in colorectal cancer. British Journal of Cancer.  ISSN 0007-0920.  110(8), s 2159- 2164 . doi: 10.1038/bjc.2014.133
• Kumar, Neena Theresa; Liestøl, Knut; Løberg, Else Marit; Reims, Henrik Mikael & Mæhlen, Jan (2014). Postmortem heart weight: relation to body size and effects of cardiovascular disease and cancer. Cardiovascular pathology.  ISSN 1054-8807.  23(1), s 5- 11 . doi: 10.1016/j.carpath.2013.09.001
• Lee, Anja; Nestaas, Eirik; Liestøl, Knut; Brunvand, Leif; Lindemann, Rolf & Fugelseth, Drude (2014). Tissue Doppler imaging in very preterm infants during the first 24 h of life: an observational study. Archives of Disease in Childhood: Fetal and Neonatal Edition.  ISSN 1359-2998.  99(1), s F64- F69 . doi: 10.1136/archdischild-2013-304197
• Søraas, Arne Vasli Lund; Sundsfjord, Arnfinn; Jørgensen, Silje Bakken; Liestøl, Knut & Jenum, Pål (2014). High rate of per oral mecillinam treatment failure in community-acquired urinary tract infections caused by ESBL-producing escherichia coli. PLOS ONE.  ISSN 1932-6203.  9(1:e85889) . doi: 10.1371/journal.pone.0085889 Fulltekst i vitenarkiv.
• Thoresen, Sigrid Bratlie; Campsteijn, Coen; Vietri, Marina; Schink, Kay Oliver; Liestøl, Knut; Andersen, Jens S.; Raiborg, Camilla & Stenmark, Harald (2014). ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4. Nature Cell Biology.  ISSN 1465-7392.  16(6), s 547- 557 . doi: 10.1038/ncb2959
• Sandve, Geir Kjetil; Gundersen, Sveinung; Johansen, Morten; Glad, Ingrid Kristine; Gunathasan, Krishanthi; Holden, Lars; Holden, Marit; Liestøl, Knut; Nygård, Ståle; Nygaard, Vegard; Paulsen, Jonas; Rydbeck, Halfdan; Trengereid, Kai; Clancy, Trevor; Drabløs, Finn; Ferkingstad, Egil; Kalaš, Matúš; Lien, Tonje Gulbrandsen; Rye, Morten Beck; Frigessi, Arnoldo & Hovig, Johannes Eivind (2013). The Genomic HyperBrowser: an analysis web server for genome-scale data. Nucleic Acids Research.  ISSN 0305-1048.  41(W1), s W133- W141 . doi: 10.1093/nar/gkt342 Fulltekst i vitenarkiv. Vis sammendrag

  The immense increase in availability of genomic scale datasets, such as those provided by the ENCODE and Roadmap Epigenomics projects, presents unprecedented opportunities for individual researchers to pose novel falsifiable biological questions. With this opportunity, however, researchers are faced with the challenge of how to best analyze and interpret their genome-scale datasets. A powerful way of representing genome-scale data is as feature-specific coordinates relative to reference genome assemblies, i.e. as genomic tracks. The Genomic HyperBrowser (http://hyperbrowser.uio.no) is an open-ended web server for the analysis of genomic track data. Through the provision of several highly customizable components for processing and statistical analysis of genomic tracks, the HyperBrowser opens for a range of genomic investigations, related to, e.g., gene regulation, disease association or epigenetic modifications of the genome.

• Aure, Miriam Ragle; Steinfeld, I; Baumbusch, Lars Oliver; Liestøl, Knut; Lipson, Doron; Nyberg, Sandra Johanna; Naume, Bjørn; Sahlberg, Kristine Kleivi; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Lingjærde, Ole Christian & Yakhini, Zohar (2013). Identifying In-Trans Process Associated Genes in Breast Cancer by Integrated Analysis of Copy Number and Expression Data. PLOS ONE.  ISSN 1932-6203.  8(1) . doi: 10.1371/journal.pone.0053014
• Baumbusch, Lars Oliver; Helland, Åslaug; Wang, Yun; Liestøl, Knut; Schaner, M.E.; Holm, Ruth; Etemadmoghadam, D; Alsop, Kathryn; Brown, Pat; Mitchell, Gillian; Fereday, Sian; deFazio, Anna; Bowtell, David D.L.; Kristensen, Gunnar S Balle; Lingjærde, Ole Christian & Børresen-Dale, Anne-Lise (2013). High Levels of Genomic Aberrations in Serous Ovarian Cancers Are Associated with Better Survival. PLOS ONE.  ISSN 1932-6203.  8(1) . doi: 10.1371/journal.pone.0054356
• Bethge, Nicole; Honne, Hilde; Hilden, Vera Irene; Trøen, Gunhild; Eknæs, Mette; Liestøl, Knut; Holte, Harald; Delabie, Jan; Smeland, Erlend B & Lind, Guro Elisabeth (2013). Identification of Highly Methylated Genes across Various Types of B-Cell Non-Hodgkin Lymphoma. PLOS ONE.  ISSN 1932-6203.  8(11) . doi: 10.1371/journal.pone.0079602
• Eriksen, Beate Horsberg; Nestaas, Eirik; Hole, Torstein; Liestøl, Knut; Støylen, Asbjørn & Fugelseth, Drude (2013). Longitudinal assessment of atrioventricular annulus excursion by grey-scale m-mode and colour tissue Doppler imaging in premature infants. Early Human Development.  ISSN 0378-3782.  89(12), s 977- 982 . doi: 10.1016/j.earlhumdev.2013.09.006
• Eriksen, Beate Horsberg; Nestaas, Eirik; Hole, Torstein; Liestøl, Knut; Støylen, Asbjørn & Fugelseth, Drude (2013). Myocardial function in premature infants: a longitudinal observational study. BMJ Open.  ISSN 2044-6055.  3(3) . doi: 10.1136/bmjopen-2012-002441 Fulltekst i vitenarkiv.
• Grundvold, Irene; Skretteberg, Torger; Liestøl, Knut; Erikssen, Gunnar; Engeseth, Kristian; Gjesdal, Knut; Kjeldsen, Sverre Erik; Arnesen, Harald; Erikssen, Jan Emil & Bodegard, Johan (2013). Low Heart Rates Predict Incident Atrial Fibrillation in Healthy Middle-Aged Men. Circulation: Arrhythmia and Electrophysiology.  ISSN 1941-3149.  6(4), s 726- 731 . doi: 10.1161/CIRCEP.113.000267
• Hodnesdal, Christian; Prestgaard, Erik Edvard; Erikssen, Gunnar; Gjesdal, Knut; Kjeldsen, Sverre Erik; Liestøl, Knut; Skretteberg, Torger; Erikssen, Jan Emil & Bodegard, Johan (2013). Rapidly upsloping ST-segment on exercise ECG: a marker of reduced coronary heart disease mortality risk. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873.  20(4), s 541- 548 . doi: 10.1177/2047487312444370
• Knævelsrud, Helene; Søreng, Kristiane; Raiborg, Camilla; Håberg, Karin; Rasmuson, Fredrik; Brech, Andreas; Liestøl, Knut; Rusten, Tor Erik; Stenmark, Harald Alfred; Neufeld, TP; Carlsson, Sven & Simonsen, Anne (2013). Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation. Journal of Cell Biology.  ISSN 0021-9525.  202(2), s 331- 349 . doi: 10.1083/jcb.201205129
• Kolberg, Matthias; Høland, Maren; Ågesen, Trude Holmeide; Brekke, Helge Roar; Liestøl, Knut; Hall, Kirsten Sundby; Mertens, Fredrik; Picci, Piero; Smeland, Sigbjørn & Lothe, Ragnhild A (2013). Survival meta-analyses for > 1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1. Neuro-Oncology.  ISSN 1522-8517.  15(2), s 135- 147 . doi: 10.1093/neuonc/nos287
• Nilsen, Gro; Borgan, Ørnulf; Liestøl, Knut & Lingjærde, Ole Christian (2013). Identifying clusters in genomics data by recursive partitioning. Statistical Applications in Genetics and Molecular Biology.  ISSN 1544-6115.  12(5), s 637- 652 . doi: 10.1515/sagmb-2013-0016
• Oppelt, Angela; Lobert, Viola Helene; Haglund, Kaisa; Mackey, Ashley M.; Rameh, Lucia E.; Liestøl, Knut; Schink, Kay Oliver; Pedersen, Nina Marie; Wenzel, Eva; Haugsten, Ellen Margrethe; Brech, Andreas; Rusten, Tor Erik; Stenmark, Harald Alfred & Wesche, Jørgen (2013). Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Reports.  ISSN 1469-221X.  14(1), s 57- 64 . doi: 10.1038/embor.2012.183
• Pust, Sascha; Klokk, Tove Irene; Musa, Nagham; Jenstad, Monica; Risberg, Bjørn Åke; Erikstein, Bjørn K; Tcatchoff, Lionel; Liestøl, Knut; Danielsen, Håvard Emil; van Deurs, Bo & Sandvig, Kirsten (2013). Flotillins as regulators of ErbB2 levels in breast cancer. Oncogene.  ISSN 0950-9232.  32(29), s 3443- 3451 . doi: 10.1038/onc.2012.357
• Skretteberg, Per Torger; Grundvold, Irene; Kjeldsen, Sverre Erik; Engeseth, Kristian; Liestøl, Knut; Erikssen, Gunnar; Erikssen, Jan Emil; Gjesdal, Knut & Bodegard, Johan (2013). Seven-Year Increase in Exercise Systolic Blood Pressure at Moderate Workload Predicts Long-Term Risk of Coronary Heart Disease and Mortality in Healthy Middle-Aged Men. Hypertension.  ISSN 0194-911X.  61(5), s 1134- 1140 . doi: 10.1161/HYPERTENSIONAHA.111.00793
• Skretteberg, Torger; Nordeide, Grytten Anette; Gjertsen, Kathrine; Grundvold, Irene; Kjeldsen, Sverre Erik; Erikssen, Jan Emil; Mellbin, Linda; Liestøl, Knut; Fraser, David A.; Erikssen, Gunnar; Pedersen, Terje Rolf & Bodegard, Johan (2013). Triglycerides-diabetes association in healthy middle-aged men: Modified by physical fitness? A long term follow-up of 1962 Norwegian men in the Oslo Ischemia Study. Diabetes Research and Clinical Practice.  ISSN 0168-8227.  101(2), s 201- 209 . doi: 10.1016/j.diabres.2013.06.001
• Vikne, Harald; Bakke, Eva; Liestøl, Knut; Engen, Stian Rugsveen & Vøllestad, Nina Køpke (2013). Muscle activity and head kinematics in unconstrained movements in subjects with chronic neck pain; cervical motor dysfunction or low exertion motor output?. BMC Musculoskeletal Disorders.  ISSN 1471-2474.  14(1), s 314 . doi: 10.1186/1471-2474-14-314 Fulltekst i vitenarkiv.
• Vikne, Harald; Bakke, Eva; Liestøl, Knut; Sandbæk, Gunnar & Vøllestad, Nina Køpke (2013). The smoothness of unconstrained head movements is velocity-dependent. Human Movement Science.  ISSN 0167-9457.  32(4), s 540- 554 . doi: 10.1016/j.humov.2012.12.013
• Yri, Olav Erich; Ekstrøm, Per Olaf; Hilden, Vera Irene; Gaudernack, Gustav; Liestøl, Knut; Smeland, Erlend B & Holte, Harald (2013). Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab. Leukemia and Lymphoma.  ISSN 1042-8194.  54(10), s 2205- 2214 . doi: 10.3109/10428194.2013.774392
• Kresse, Stine Henrichson; Rydbeck, Halfdan; Skårn, Magne; Namløs, Heidi Maria; Barragan Polania, Ana H.; Cleton-Jansen, Anne-Marie; Serra, Massimo; Liestøl, Knut; Hogendoorn, Pancras C. W.; Hovig, Eivind; Myklebost, Ola & Meza-Zepeda, Leonardo Andrés (2012). Integrative Analysis Reveals Relationships of Genetic and Epigenetic Alterations in Osteosarcoma. PLOS ONE.  ISSN 1932-6203.  7(11) . doi: 10.1371/journal.pone.0048262
• Bodegard, Johan; Skretteberg, Torger; Gjesdal, Knut; Pyöräla, Kalevi; Kjeldsen, Sverre Erik; Liestøl, Knut; Erikssen, Gunnar & Erikssen, Jan Emil (2012). Low-grade systolic murmurs in healthy middle-aged individuals: innocent or clinically significant? A 35-year follow-up study of 2014 Norwegian men. Journal of Internal Medicine.  ISSN 0954-6820.  271(6), s 581- 588 . doi: 10.1111/j.1365-2796.2011.02480.x
• Erikssen, Gunnar; Liestøl, Knut; Gullestad, Lars; Haugaa, Kristina; Bendz, Bjørn & Amlie, Jan Peder (2012). The Terminal Part of the QT Interval (T peak to T end): A Predictor of Mortality after Acute Myocardial Infarction. Annals of Noninvasive Electrocardiology.  ISSN 1082-720X.  17(2), s 85- 94 . doi: 10.1111/j.1542-474X.2012.00493.x
• Grundvold, Irene; Skretteberg, Torger; Liestøl, Knut; Erikssen, Gunnar; Kjeldsen, Sverre Erik; Arnesen, Harald; Erikssen, Jan Emil & Bodegard, Johan (2012). Upper Normal Blood Pressures Predict Incident Atrial Fibrillation in Healthy Middle-Aged Men A 35-Year Follow-Up Study. Hypertension.  ISSN 0194-911X.  59(2), s 198- 204 . doi: 10.1161/HYPERTENSIONAHA.111.179713
• Grundvold, Irene; Skretteberg, Torger; Liestøl, Knut; Gjesdal, Knut; Erikssen, Gunnar; Kjeldsen, Sverre Erik; Arnesen, Harald; Erikssen, Jan Emil & Bodegard, Johan (2012). Importance of physical fitness on the predictive effect of body mass index and weight gain on incident atrial fibrillation in healthy middle-aged men. American Journal of Cardiology.  ISSN 0002-9149.  110(3), s 425- 432 . doi: 10.1016/j.amjcard.2012.03.043
• Huse, Kanutte; Bakkebø, Maren; Waelchli, Sebastien; Oksvold, Morten Pedersen; Hilden, Vera Irene; Forfang, Lise; Bredahl, May K. Lyamouri; Liestøl, Knut; Alizadeh, Ash A.; Smeland, Erlend B & Myklebust, June (2012). Role of Smad Proteins in Resistance to BMP-Induced Growth Inhibition in B-Cell Lymphoma. PLOS ONE.  ISSN 1932-6203.  7(10) . doi: 10.1371/journal.pone.0046117 Fulltekst i vitenarkiv.
• Kumar, Neena Theresa; Liestøl, Knut; Løberg, Else Marit; Reims, Henrik Mikael; Brorson, Sverre Henning & Mæhlen, Jan (2012). The apolipoprotein E polymorphism and cardiovascular diseases-an autopsy study. Cardiovascular pathology.  ISSN 1054-8807.  21(6), s 461- 469 . doi: 10.1016/j.carpath.2012.02.005
• Meen, Øystein; Brosstad, Frank Roger; Liestøl, Knut; Kunszt, Gabor; Bendz, Bjørn; Wettergreen, Marianne; Schjelderup, NM; Andreassen, Trine & Erikssen, Gunnar (2012). Sequential ADP-stimulated light transmission and multiple electrode aggregometry in patients taking aspirin and clopidogrel after non ST-elevation myocardial infarction. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  72(4), s 318- 325 . doi: 10.3109/00365513.2012.666565
• Nilsen, Gro; Liestøl, Knut; Van Loo, P; Vollan, Hans Kristian Moen; Eide, Marianne Brodtkorb; Rueda, Oscar M.; Chin, Suet-Feung; Russel, Roslin; Baumbusch, Lars Oliver; Caldas, Carlos; Børresen-Dale, Anne-Lise & Lingjærde, Ole Christian (2012). Copynumber: Efficient algorithms for single and multi-track copy number segmentation. BMC Genomics.  ISSN 1471-2164.  13(591) . doi: 10.1186/1471-2164-13-591
• Pedersen, Nina Marie; Raiborg, Camilla; Brech, Andreas; Skarpen, Ellen; Roxrud, Ingrid; Platta, Harald W.; Liestøl, Knut & Stenmark, Harald Alfred (2012). The PtdIns3P-Binding Protein Phafin 2 Mediates Epidermal Growth Factor Receptor Degradation by Promoting Endosome Fusion. Traffic : the International Journal of Intracellular Transport.  ISSN 1398-9219.  13(11), s 1547- 1563 . doi: 10.1111/j.1600-0854.2012.01400.x
• Ruud Mathiesen, Randi Margit; Fjelldal, Renathe; Liestøl, Knut; Due, Eldri Undlien; Geigl, Jochen; Riethdorf, Sabine; Borgen, Elin; Rye, Inga Hansine; Schneider, Ida Johansson; Obenauf, Anna; Mauermann, Oliver; Nilsen, Gro; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Pantel, Klaus; Speicher, Michael R; Naume, Bjørn & Baumbusch, Lars Oliver (2012). High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer. International Journal of Cancer.  ISSN 0020-7136.  131(4), s E405- E415 . doi: 10.1002/ijc.26444
• Sveen, Anita; Ågesen, Trude Holmeide; Nesbakken, Arild; Meling, Gunn Iren; Rognum, Torleiv Ole; Liestøl, Knut; Skotheim, Rolf Inge & Lothe, Ragnhild A (2012). ColoGuidePro: A Prognostic 7-Gene Expression Signature for Stage III Colorectal Cancer Patients. Clinical Cancer Research.  ISSN 1078-0432.  18(21), s 6001- 6010 . doi: 10.1158/1078-0432.CCR-11-3302
• Vikne, Harald; Gundersen, Kristian; Liestøl, Knut; Mæhlen, Jan & Vøllestad, Nina Køpke (2012). Intermuscular relationship of human muscle fiber type proportions: Slow leg muscles predict slow neck muscles. Muscle and Nerve.  ISSN 0148-639X.  45(4), s 527- 535 . doi: 10.1002/mus.22315
• Yri, Olav Erich; Ekstrøm, Per Olaf; Hilden, Vera Irene; Gaudernack, Gustav; Liestøl, Knut; Smeland, Erlend B & Holte, Harald (2012). Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma. Leukemia and Lymphoma.  ISSN 1042-8194.  53(10), s 1934- 1944 . doi: 10.3109/10428194.2012.682307
• Sandve, Geir Kjetil; Gundersen, Sveinung; Rydbeck, Halfdan; Glad, Ingrid Kristine; Holden, Lars; Holden, Marit; Liestøl, Knut; Clancy, Trevor; Drabløs, Finn; Ferkingstad, Egil; Johansen, Morten; Nygaard, Vegard; Tøstesen, Eivind; Frigessi, Arnoldo & Hovig, Eivind (2011). The differential disease regulome. BMC Genomics.  ISSN 1471-2164.  12, s 353 . doi: 10.1186/1471-2164-12-353 Vis sammendrag

  Background Transcription factors in disease-relevant pathways represent potential drug targets, by impacting a distinct set of pathways that may be modulated through gene regulation. The influence of transcription factors is typically studied on a per disease basis, and no current resources provide a global overview of the relations between transcription factors and disease. Furthermore, existing pipelines for related large-scale analysis are tailored for particular sources of input data, and there is a need for generic methodology for integrating complementary sources of genomic information. Results We here present a large-scale analysis of multiple diseases versus multiple transcription factors, with a global map of over-and under-representation of 446 transcription factors in 1010 diseases. This map, referred to as the differential disease regulome, provides a first global statistical overview of the complex interrelationships between diseases, genes and controlling elements. The map is visualized using the Google map engine, due to its very large size, and provides a range of detailed information in a dynamic presentation format. The analysis is achieved through a novel methodology that performs a pairwise, genome-wide comparison on the cartesian product of two distinct sets of annotation tracks, e.g. all combinations of one disease and one TF. The methodology was also used to extend with maps using alternative data sets related to transcription and disease, as well as data sets related to Gene Ontology classification and histone modifications. We provide a web-based interface that allows users to generate other custom maps, which could be based on precisely specified subsets of transcription factors and diseases, or, in general, on any categorical genome annotation tracks as they are improved or become available. Conclusion We have created a first resource that provides a global overview of the complex relations between transcription factors and disease. As the accuracy of the disease regulome depends mainly on the quality of the input data, forthcoming ChIP-seq based binding data for many TFs will provide improved maps. We further believe our approach to genome analysis could allow an advance from the current typical situation of one-time integrative efforts to reproducible and upgradable integrative analysis. The differential disease regulome and its associated methodology is available at http://hyperbrowser.uio.no

• Aden, Petra; Paulsen, Ragnhild Elisabeth; Mæhlen, Jan; Løberg, Else Marit; Goverud, Ingeborg Løstegaard; Liestøl, Knut & Lømo, Jon (2011). Glucocorticoids dexamethasone and hydrocortisone inhibit proliferation and accelerate maturation of chicken cerebellar granule neurons. Brain Research.  ISSN 0006-8993.  1418, s 32- 41 . doi: 10.1016/j.brainres.2011.08.053
• Eide, Marianne Brodtkorb; Lauritzsen, Grete Fossum; Kvalheim, Gunnar; Kolstad, Arne; Fagerli, Unn-Merete; Maisenhölder, Martin; Østenstad, Bjørn; Fluge, Øystein; Delabie, Jan; Aarset, Harald; Liestøl, Knut & Holte, Harald (2011). High dose chemotherapy with autologous stem cell support for patients with histologically transformed B-cell non-Hodgkin lymphomas. A Norwegian multi centre phase II study. British Journal of Haematology.  ISSN 0007-1048.  152(5), s 600- 610 . doi: 10.1111/j.1365-2141.2010.08519.x
• Malerød, Lene; Pedersen, Nina Marie; Wegner, Catherine E Sem; Lobert, Viola Helene; Leithe, Edward; Brech, Andreas; Rivedal, Edgar; Liestøl, Knut & Stenmark, Harald (2011). Cargo-Dependent Degradation of ESCRT-I as a Feedback Mechanism to Modulate Endosomal Sorting. Traffic : the International Journal of Intracellular Transport.  ISSN 1398-9219.  12(9), s 1211- 1226 . doi: 10.1111/j.1600-0854.2011.01220.x
• Sagona, Antonia; Nezis, Jonnis P; Pedersen, Nina Marie; Liestøl, Knut; Poulton, J; Rusten, Tor Erik; Skotheim, Rolf Inge; Raiborg, Camilla & Stenmark, Harald Alfred (2010). PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nature Cell Biology.  ISSN 1465-7392.  12(4), s 362- U140 . doi: 10.1038/ncb2036

Se alle arbeider i Cristin

• Frølich, Nicoline; Mangset, Marte; Teigen, Mari; Liestøl, Knut; Enli, Gunn & Christensen, Lina (2019, 11. oktober). Endelig likestilling? Ikke ennå.. [Tidsskrift].  Forskerforum.no.
• Nikolaidis, Konstantinos; Kristiansen, Stein; Goebel, Vera Hermine; Plagemann, Thomas Peter & Liestøl, Knut (2019). Augmenting Physiological Time Series Data: A Case study for Sleep Apnea Detection.
• Mehlum, Maria Hollund; Liestøl, Knut; Kjeldsen, Sverre & Berge, Eivind (2018). Response to letters from Torp-Pedersen and colleagues and de Courson and colleagues. European Heart Journal.  ISSN 0195-668X.  39(47), s 4221- 4221 . doi: 10.1093/eurheartj/ehy605
• Holter, Øystein Gullvåg; Liestøl, Knut; Tallaksen, Lena M. & Kristensen, Solveig (2016). Universitetene er sterkt konkurransedrevet. I dette løpet taper kvinnene. Kronikk Aftenposten 7.3.2016 http://www.aftenposten.no/meninger/kronikker/Kronikk-Universitetene-er-sterk t-konkurransedrevet-I-dette-lopet-taper-kvinnene-8380246.html. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Grundvold, Irene; Skretteberg, Per Torger; Engeseth, Kristian; Gjesdal, Knut; Kjeldsen, Sverre Erik; Arnesen, Harald; Bodegard, J; Liestøl, Knut; Eriksen, G & Eriksen, Jan (2013). Response to Letter by Morris et al Regarding Article, "Low Heart Rates Predict Incident Atrial Fibrillation in Healthy Middle-Aged Men" by Grundvold et al. Circulation Arrhythm Electrophysiology.  6(6), s E102- E102 . doi: 10.1161/CIRCEP.113.001154
• Grundvold, Irene; Skretteberg, Torger; Liestøl, Knut; Erikssen, Gunnar; Engeseth, Kristian; Gjesdal, Knut; Kjeldsen, Sverre Erik; Arnesen, Harald; Erkssen, J. & Bodegard, Johan (2013). Predictors of atrial fibrillation differ in men with high vs low physical fitness. European Heart Journal.  ISSN 0195-668X.  34, s 1041- 1041
• Baumbusch, Lars Oliver; Helland, Åslaug; Wang, Yun; Liestøl, Knut; Schaner, Marci; Holm, Ruth; Etemadmoghadam, Dariush; Alsop, Kathryn; Brown, Patrick; Cancer Study Group, Australian Ovarian; Mitchell, Gillian; Fereday, Sian; DeFazio, Anna; Bowtell, David DL; Kristensen, Gunnar B.; Lingjærde, Ole Christian & Børresen-Dale, Anne-Lise (2012). High levels of genomic aberrations in serous ovarian cancers are associated with better survival.
• Engeseth, Kristian; Skretteberg, Per Torger; Grundvold, Irene; Liestøl, Knut; Erikssen, Gunnar; Erikssen, Jan Emil; Kjeldsen, Sverre Erik & Bodegard, Johan (2012). 7-year reduction of exercise max heart rate predicts new onset diabetes. European Heart Journal.  ISSN 0195-668X.  33, s 886- 887
• Holden, Marit; Glad, Ingrid Kristine; Hauge, Håvard Hildeng; Hovig, Eivind & Liestøl, Knut (2012). Image restoration and analysis of biomolecular radioactivity images II. NR-notat. SAMBA/11/12.
• Skretteberg, Per Torger; Grundvold, Irene; Kjeldsen, Sverre Erik; Gjesdal, Knut; Liestøl, Knut; Erikssen, Jan Emil; Erikssen, Gunnar & Bodegard, Johan (2012). Seven-year increase in exercise systolic blood pressure at 100w predicts long-term risk of coronary heart disease in healthy middle-aged men. Journal of the American College of Cardiology.  ISSN 0735-1097.  59(13), s E1627- E1627 . doi: 10.1016/S0735-1097(12)61628-3
• Hodnesdal, Christian; Prestgaard, Erik Edvard; Erikssen, Gunnar; Gjesdal, Knut; Kjeldsen, Sverre Erik; Liestøl, Knut; Skretteberg, Torger; Erikssen, Jan Emil & Bodegard, Johan (2011). Rapid ST-upslope on Exercise Electrocardiogram Predicts Reduced Long Term Mortality from Coronary Heart Disease. Circulation.  ISSN 0009-7322.  124(21)
• Yri, Olav Erich; Hilden, Vera Irene; Smeland, Erlend B; Gaudernack, Gustav; Liestøl, Knut; Ekstrøm, Per Olaf & Holte, Harald (2011). GENETIC POLYMORPHISMS INFLUENCE THE RISK OF HODGKIN'S LYMPHOMA. Annals of Oncology.  ISSN 0923-7534.  22, s 138- 138

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