Hedvig Marie Egeland Nordeng

Professor - Section for Pharmaceutics and Social Pharmacy

Norwegian version of this page

Email h.m.e.nordeng@farmasi.uio.no

Phone +47 22856604

Mobile phone 45033984

Room 471

Username

Visiting address Gydas vei 8

Postal address Postboks 1068 Blindern 0316 Oslo

Press photo Download business card

Academic Interests

Professional interests include perinatal pharmacoepidemiology and pharmacotherapy, with special focus on medication use and safety in pregnancy and lactation.

Professor Nordeng is the holder of ERC STG Grant “DrugInPregnancy” (http://cordis.europa.eu/project/rcn/198436_en.html).

Her expertise is in perinatal pharmacoepidemiology and pharmacotherapy in pregnancy and lactation. She has studied risks of prenatal exposure to medication on immediate pregnancy outcome (e.g. birth weight, malformations) and long term outcomes such as neurodevelopmental disorders and childhood cancer.

Dr. Nordeng is head of the PharmaTox Strategic Research Initiative at the Faculty of Mathematics and Natural Sciences, University of Oslo, Norway uniting over 30 researchers within Life Sciences at the MN Faculty, and the head of the National Research School in Pharmacy, uniting more than 100 PhD students in pharmaceutical sciences in Norway.

She has hosted guest scientists from USA, Austria, Sweden, The Netherlands and UK and supervised student exchanges through the Erasmus program.

She has a PhD in pharmacoepidemiology and pharmacotherapy on drug use during pregnancy, Faculty of Medicine, University of Oslo in 2005. MSc Pharm in 1997. Dr. Nordeng became a full professor at the Faculty of Mathematics and Natural Sciences in 2011.

She is currently responsible for recommendation about medication safety in pregnancy and breast feeding in Norwegian National Formulary (http://legemiddelhandboka.no/).

As of 2018 she is an independent expert in the Pharmacovigilance Risk Assessment Committee (PRAC) which is the European Medicines Agency's (EMA) committee responsible for assessing and monitoring the safety of human medicines.

Dr. Nordeng has authored over 160 scientific articles, book chapters and national guidelines on drug use in pregnancy and lactation.

In 2016 she was awarded Pharmacist of the Year in Norway and in 2017 she was awarded the Titan prize for excellence in science dissemination by the UiO.

Teaching

Higher education and employment history

Professor, Department of pharmacy, University of Oslo, Norway, 2011 – present
Associate professor, Department of pharmacy, University of Oslo, Norway, 2007 – 2011
Researcher, The Norwegian Institute of Public Health (NIPH), Division of Mental Health, 20% position, 2005 – present
Department of Pharmacotherapeutics, Medical faculty, University of Oslo, Norway. Post doctoral position conducting research on drug safety on pregnancy, 2005 – 2007
Regional Drug Information centre. Part time position as advisor in pharmacovigilance work and counselling healthcare personnel in pharmacotherapeutical issues. 2005.
Doctorial work (dr. philos). Department of Pharmacotherapeutics, Medical faculty, University of Oslo, Norway. 1999 – 2004. Thesis on “Drug use in pregnancy and after delivery” with special focus on factors predicting drug use illness during pregnancy.
MSc in Pharmacy, School of Pharmacy, University of Oslo, Norway, 1997. Masters in analytical chemistry.

Appointments

Head of PharmaSafe Research Group at the School of Pharmacy
Head of PharmaTox Strategic Research Enviroment at MatNat from 2015
Head of Norwegian PhD School in Pharmacy 2015 - 2021
Member of Scientific Board Norwegian Pharmaceutical Journal, 2008 - 2018
Member of the Editorial board: Journal of Population Therapeutics and Clinical Pharmacology, 2012 - 2018
Board member, National Council for ranking journals in Pharmacology, Toxicology, Pharmacy, 2010 - present
Mentor, Career Development Program for female post doc fellows at UiO, 2013

Cooperation

Division of Child Health and Development, National Institute of Public Health
Genetics Dpt., Biosciences Institute, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
Center for Better Beginnings, School of Medicine, University of California, San Diego
Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Center, Nijmegen

Tags: Pharmacoepidemiology, Registry-based research, Pharmacovigilance, Pregnancy, Lactation, ERC, Neurotoxicity, Life Science

Orangzeb, Saima; Desalegn, Anteneh Assefa; Trinh, Nhung; Zhao, Jing; Nordeng, Hedvig Marie Egeland & Lupattelli, Angela (2024). COVID-19 vaccine uptake among children and adolescents in Norway: A comprehensive registry-based cohort study of over 800,000 individuals. Vaccine. ISSN 0264-410X. doi: 10.1016/j.vaccine.2024.04.039.
Moreno-Martos, David; Zhao, Jing; Li, Huiqi; Nyberg, Fredrik; Bjørndal, Ludvig Daae & Hajiebrahimi, Mohammadhossein [Show all 13 contributors for this article] (2024). Impact of the early COVID-19 pandemic on adult mental health-related dispensed medications, hospitalizations and specialist outpatient visits in Norway and Sweden: Interrupted time series analysis. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.16044.
Mercadé-Besora, Núria; Li, Xintong; Kolde, Raivo; Trinh, Nhung T.H.; Sanchez-Santos, Maria T. & Man, Wai Yi [Show all 16 contributors for this article] (2024). The role of COVID-19 vaccines in preventing post-COVID-19 thromboembolic and cardiovascular complications. Heart. ISSN 1355-6037. 110(9). doi: 10.1136/heartjnl-2023-323483.
Hurley, Eimir; Geisler, Benjamin Peter; Lupattelli, Angela; Poblador-Plou, Beatriz; Lassalle, Régis & Jové, Jérémy [Show all 30 contributors for this article] (2024). COVID-19 and pregnancy: A European study on pre- and post-infection medication use. European Journal of Clinical Pharmacology. ISSN 0031-6970. doi: 10.1007/s00228-024-03639-z.
Català, Martí; Mercadé-Besora, Núria; Kolde, Raivo; Trinh, Nhung T H; Roel, Elena & Burn, Edward [Show all 15 contributors for this article] (2024). The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia. The Lancet Respiratory Medicine. ISSN 2213-2600. doi: 10.1016/S2213-2600(23)00414-9.
Pedersen, Elisabeth; Tripodi, Elena; Aakjær, Mia; Li, Huiqi; Cantarutti, Anna & Nyberg, Fredrik [Show all 9 contributors for this article] (2024). Drug utilisation in children and adolescents before and after the start of the COVID-19 pandemic: Interrupted time-series analyses in three European countries. Paediatric and Perinatal Epidemiology. ISSN 0269-5022. doi: 10.1111/ppe.13046.
Ukah, Ugochinyere Vivian; Platt, Robert William & Nordeng, Hedvig Marie Egeland (2024). Impact of COVID-19 Pandemic on Dispensing of Cardiovascular Drugs in Norway: An Interrupted Time Series Study. American Journal of Preventive Medicine. ISSN 0749-3797. p. 1–9. doi: 10.1016/j.amepre.2023.11.008. Full text in Research Archive
Shakibfar, Saeed; Zhao, Jing; Li, Huiqi; Nordeng, Hedvig Marie Egeland; Lupattelli, Angela & Pavlović, Milena [Show all 12 contributors for this article] (2023). Machine learning-driven development of a disease risk score for COVID-19 hospitalization and mortality: a Swedish and Norwegian register-based study. Frontiers in Public Health. ISSN 2296-2565. 11. doi: 10.3389/fpubh.2023.1258840. Full text in Research Archive
Nordeng, Hedvig Marie Egeland; Wegler, Christine; Lindqvist, Annika; Melander, Erik; Magnusson, Mikaela & Gandia, Peggy [Show all 9 contributors for this article] (2023). Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 134(1), p. 153–164. doi: 10.1111/bcpt.13948. Full text in Research Archive
Spildrejorde, Mari; Samara, Athina; Sharma, Ankush; Leithaug, Magnus; Falck, Martin Bengt Alfred & Modafferi, Stefania [Show all 12 contributors for this article] (2023). Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol. iScience. ISSN 2589-0042. 26:107755(10), p. 1–29. doi: 10.1016/j.isci.2023.107755. Full text in Research Archive
Shakibfar, Saeed; Nyberg, Fredrik; Li, Huiqi; Zhao, Jing; Nordeng, Hedvig Marie Egeland & Sandve, Geir Kjetil Ferkingstad [Show all 10 contributors for this article] (2023). Artificial intelligence-driven prediction of COVID-19-related hospitalization and death: a systematic review. Frontiers in Public Health. ISSN 2296-2565. 11. doi: 10.3389/fpubh.2023.1183725. Full text in Research Archive
Maisonneuve, Emeline; de Bruin, Odette; Favre, Guillaume; Goncé, Anna; Donati, Serena & Engjom, Hilde Marie [Show all 14 contributors for this article] (2023). Evolution of National Guidelines on Medicines Used to Treat COVID-19 in Pregnancy in 2020–2022: A Scoping Review. Journal of Clinical Medicine. ISSN 2077-0383. 12(13). doi: 10.3390/jcm12134519. Full text in Research Archive
Olstad, Emilie Willoch; Nordeng, Hedvig Marie Egeland; Lyle, Robert & Gervin, Kristina (2023). No impact of prenatal paracetamol and folic acid exposure on cord blood DNA methylation in children with attention-deficit/hyperactivity disorder. Frontiers in Genetics. ISSN 1664-8021. 14, p. 1–6. doi: 10.3389/fgene.2023.1204879. Full text in Research Archive
Bromley, Rebecca; Graz, Myriam Bickle; Bluett-Duncan, Matthew; Chambers, C.; Damkier, P. & Dietrich, K. [Show all 26 contributors for this article] (2023). Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies. Frontiers in Pharmacology. ISSN 1663-9812. 14. doi: 10.3389/fphar.2023.1094698. Full text in Research Archive
Cardoso, Evelina; Guidi, Monia; Nauwelaerts, Nina; Nordeng, Hedvig Marie Egeland; Teil, Marie & Allegaert, Karel [Show all 12 contributors for this article] (2023). Safety of medicines during breastfeeding–from case report to modeling: a contribution from the ConcePTION project. Expert Opinion on Drug Metabolism & Toxicology. ISSN 1742-5255. 19(5), p. 269–283. doi: 10.1080/17425255.2023.2221847.
Monfort, Anaëlle; Cardoso, Evelina; Eap, Chin B.; Fischer Fumeaux, Céline J.; Graz, Myriam Bickle & Morisod Harari, Mathilde [Show all 17 contributors for this article] (2023). Infant exposure to Fluvoxamine through placenta and human milk: a case series - A contribution from the ConcePTION project. Frontiers in Psychiatry. ISSN 1664-0640. 14, p. 1–6. doi: 10.3389/fpsyt.2023.1167870. Full text in Research Archive
Maisonneuve, Emeline; Gerbier, Eva; Tauqeer, Fatima; Pomar, Léo; Favre, Guillaume & Winterfeld, Ursula [Show all 12 contributors for this article] (2023). Determinants of Vaccination and Willingness to Vaccinate against COVID-19 among Pregnant and Postpartum Women during the Third Wave of the Pandemic: A European Multinational Cross-Sectional Survey. Viruses. ISSN 1999-4915. 15(5). doi: 10.3390/v15051090. Full text in Research Archive
Lupattelli, Angela; Trinh, Nhung & Nordeng, Hedvig Marie Egeland (2023). Association of maternal personality traits with medication use during pregnancy to appraise unmeasured confounding in long-term pharmacoepidemiological safety studies. Frontiers in Pharmacology. ISSN 1663-9812. 14. doi: 10.3389/fphar.2023.1160168. Full text in Research Archive
Trinh, Nhung; Munk-Olsen, Trine; Wray, Naomi R.; Bergink, Veerle; Nordeng, Hedvig Marie Egeland & Lupattelli, Angela [Show all 7 contributors for this article] (2023). Timing of Antidepressant Discontinuation During Pregnancy and Postpartum Psychiatric Outcomes in Denmark and Norway. JAMA psychiatry. ISSN 2168-6238. 80(5), p. 441–450. doi: 10.1001/jamapsychiatry.2023.0041.
Olstad, Emilie Willoch; Nordeng, Hedvig Marie Egeland; Sandve, Geir Kjetil Ferkingstad; Lyle, Robert & Gervin, Kristina (2023). Effects of prenatal exposure to (es)citalopram and maternal depression during pregnancy on DNA methylation and child neurodevelopment. Translational Psychiatry. ISSN 2158-3188. 13(1). doi: 10.1038/s41398-023-02441-2. Full text in Research Archive
Ngo, Elin Thuy Phuong; Truong, Maria Bich-Thuy & Nordeng, Hedvig Marie Egeland (2023). Impact of a primary care pharmacist consultations on pregnant women’s medication use: the SafeStart intervention study linked to a national prescription database. International Journal of Clinical Pharmacy. ISSN 2210-7703. 45, p. 893–902. doi: 10.1007/s11096-023-01577-x. Full text in Research Archive
Tauqeer, Fatima; Ceulemans, Michael; Gerbier, Eva; Passier, Anneke; Oliver, Alison & Foulon, Veerle [Show all 9 contributors for this article] (2023). Mental health of pregnant and postpartum women during the third wave of the COVID-19 pandemic: a European cross-sectional study. BMJ Open. ISSN 2044-6055. 13(1). doi: 10.1136/bmjopen-2022-063391. Full text in Research Archive Show summary
Objective: To describe the mental health of perinatal women in five European countries during the third pandemic wave and identify risk factors related to depressive and anxiety symptoms. Design: A cross-sectional, online survey-based study. Setting: Belgium, Norway, Switzerland, the Netherlands and the UK, 10 June 2021-22 August 2021. Participants: Pregnant and up to 3 months postpartum women, older than 18 years of age. Primary outcome measure: The Edinburgh Depression Scale (EDS) and the Generalised Anxiety Disorder scale (GAD-7) were used to assess mental health status. Univariate and multivariate generalised linear models were performed to identify factors associated with poor mental health. Results: 5210 women participated (including 3411 pregnant and 1799 postpartum women). The prevalence of major depressive symptoms (EDS ≥13) was 16.1% in the pregnancy group and 17.0% in the postpartum . Moderate to severe generalised anxiety symptoms (GAD ≥10) were found among 17.3% of the pregnant and 17.7% of the postpartum women. Risk factors associated with poor mental health included having a pre-existing mental illness, a chronic somatic illness, having had COVID-19 or its symptoms, smoking, unplanned pregnancy and country of residence. Among COVID-19 restrictive measures specific to perinatal care, pregnant and postpartum women were most anxious about not having their partner present at the time of delivery, that their partner had to leave the hospital early and to be separated from their newborn after the delivery. Conclusion: Approximately one in six pregnant or postpartum women reported major depression or anxiety symptoms during the third wave of the pandemic. These findings suggest a continued need to monitor depression and anxiety in pregnancy and postpartum populations throughout and in the wake of the pandemic. Tailored support and counseling are essential to reduce the burden of the pandemic on perinatal and infant mental health.
Araya, Robin Aasegg; Tauqeer, Fatima; Ceulemans, Michael; Gerbier, Eva; Maisonneuve, Emeline & Passier, Anneke [Show all 10 contributors for this article] (2023). Pregnancy- and Birth-Related Experiences among Postpartum Women during the Third Wave of the COVID-19 Pandemic—A Multinational European Study. Pharmacoepidemiology. ISSN 2813-0618. 2(1), p. 54–67. doi: 10.3390/pharma2010006. Full text in Research Archive Show summary
The objective of this study was to describe pregnancy- and birth-related experiences of postpartum women during the third wave of the COVID-19 pandemic and their association with mental health outcomes. An online questionnaire was distributed in five European countries (Belgium, The Netherlands, Norway, Switzerland, UK) between June and August 2021. Participants were recruited though socialmedia platforms including pregnancy- and motherhood-related websites, pregnancy fora, and apps. Postpartum women were asked eleven specific questions about pregnancyand birth-related changes and the presence of support during delivery. The Edinburgh Depression Scale was used to assess depressive and anxiety symptoms. Covariates included sociodemographics, health and reproductive characteristics, and COVID-19 status. Associations were estimated with logistic regression. The study included 1730 postpartum women. Frequent changes included the exclusion of the partner from pregnancy care appointments (83.2%), changed prenatal care settings (64.4%), and cancellation of hospital information visits (42.7%). Few women, however, were without support apart from medical staff during delivery (1.4%). The number of pregnancy- and birth-related changes was associated with each woman’s mental health status, as well as the type of change. Experiencing changes related to delivery and cancellation or reduction of prenatal examination was associated with a doubling in the odds of symptoms of major depression and anxiety postpartum. These findings highlight the importance of ensuring adequate maternity care for women’s mental health postpartum, as well as during a pandemic.
Cardoso, Evelina; Monfort, Anaëlle; Ferreira, Ema; Nordeng, Hedvig Marie Egeland; Winterfeld, Ursula & Allegaert, Karel [Show all 9 contributors for this article] (2023). Maternal drugs and breastfeeding: Risk assessment from pharmacokinetics to safety evidence - A contribution from the ConcePTION project. The´rapie (Paris). ISSN 0040-5957. 78(2), p. 149–156. doi: 10.1016/j.therap.2023.01.008. Full text in Research Archive
Noh, Yunha; Jeong, Han Eol; Choi, Ahhyung; Choi, Eun-Young; Pasternak, Björn & Nordeng, Hedvig Marie Egeland [Show all 11 contributors for this article] (2023). Prenatal and Infant Exposure to Acid-Suppressive Medications and Risk of Allergic Diseases in Children. JAMA pediatrics. ISSN 2168-6203. 177(3), p. 267–277. doi: 10.1001/jamapediatrics.2022.5193. Full text in Research Archive
Trinh, Nhung; Nordeng, Hedvig Marie Egeland; Bandoli, Gretchen; Palmsten, Kristin; Eberhard-Gran, Malin & Lupattelli, Angela (2022). Antidepressant Fill and Dose Trajectories in Pregnant Women with Depression and/or Anxiety: A Norwegian Registry Linkage Study. Clinical Epidemiology. ISSN 1179-1349. 14, p. 1439–1451. doi: 10.2147/CLEP.S379370. Full text in Research Archive
Christensen, Jacob Juel; Bogsrud, Martin Prøven; Holven, Kirsten Bjørklund; Retterstøl, Kjetil; Veierød, Marit Bragelien & Nordeng, Hedvig Marie Egeland (2022). Use of statins and other lipid-modifying agents across pregnancy – a nationwide drug utilization study of 822 071 pregnancies in Norway in 2005-2018. medRxiv. doi: 10.1101/2022.06.28.22276237. Full text in Research Archive
Christensen, Jacob Juel; Bogsrud, Martin Prøven; Holven, Kirsten Bjørklund; Retterstøl, Kjetil; Veierød, Marit Bragelien & Nordeng, Hedvig Marie Egeland (2022). Use of statins and other lipid-modifying agents across pregnancy: A nationwide drug utilization study in Norway in 2005–2018. Atherosclerosis. ISSN 0021-9150. p. 1–10. doi: 10.1016/j.atherosclerosis.2022.11.022. Full text in Research Archive Show summary
Background and aims Statins are becoming more widely used among women of reproductive age; however, nationwide data on statin use across pregnancy is scarce. We therefore aimed to describe the drug utilization patterns for statins and other lipid-modifying agents (LMAs) before, during, and after pregnancy, for all pregnancies in Norway from 2005 to 2018. Methods We linked individual-level data from four nationwide electronic health care registries in Norway and characterized the prescription fills of statins and other LMAs across pregnancy. We also examined trends in pregnancy-related LMA use, and characterized women using statins and other LMAs on parameters of health status and co-morbidity. Results In total, 822,071 pregnancies for 503,723 women were included. The number of statin prescription fills decreased rapidly during the first trimester and returned to pre-pregnancy levels about one year postpartum. Pregnancy-related statin use increased from 2005 (approx. 0.11% of all pregnancies) to 2018 (approx. 0.29% of all pregnancies); however, in total, few statin prescriptions were filled within any trimester of pregnancy (n = 331, 0.04% of all pregnancies). Statin use was more common in women with higher age, higher weight, smoking, and comorbidities such as hypertension and diabetes mellitus; also, statin users often had co-medication pertinent to these conditions. Conclusions Although statins and other LMAs were increasingly being used around the time of pregnancy among women in Norway, drug use was mostly discontinued during the first trimester. Our results suggest that pregnancy-related statin use should be monitored, and that drug safety analyses for maternal and offspring health outcomes are needed.
Favre, Guillaume; Gerbier, Eva; Maisonneuve, Emeline; Pomar, Léo; Winterfeld, Ursula & Lepigeon, Karine [Show all 14 contributors for this article] (2022). COVID-19-related medicine utilization study in pregnancy: The COVI-PREG cohort. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.15611.
Sundbakk, Lene Maria; Gran, Jon Michael; Wood, Mollie; Handal, Marte; Skurtveit, Svetlana Ondrasova & Nordeng, Hedvig Marie Egeland (2022). Association of Prenatal Exposure to Benzodiazepines and Z-Hypnotics With Risk of Attention-Deficit/Hyperactivity Disorder in Childhood. JAMA Network Open. ISSN 2574-3805. 5(12), p. 1–15. doi: 10.1001/jamanetworkopen.2022.46889. Full text in Research Archive
Trinh, Nhung; Nordeng, Hedvig Marie Egeland; Bandoli, Gretchen; Eberhard-Gran, Malin Marie Cecilia & Lupattelli, Angela (2022). Antidepressant and mental health care utilization in pregnant women with depression and/or anxiety: An interrupted time-series analysis. Journal of Affective Disorders. ISSN 0165-0327. 308, p. 458–465. doi: 10.1016/j.jad.2022.04.101. Full text in Research Archive
Wegler, Christine; Saleh, Aljona; Lindqvist, Annika; Nordeng, Hedvig Marie Egeland; Smeraglia, John & Baranczewski, Pawel (2022). Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS. Journal of chromatography. B. ISSN 1570-0232. 1205. doi: 10.1016/j.jchromb.2022.123340.
Ngo, Elin Thuy Phuong; Truong, Maria Bich-Thuy; Wright, David John & Nordeng, Hedvig Marie Egeland (2022). Impact of a Mobile Application for Tracking Nausea and Vomiting During Pregnancy (NVP) on NVP Symptoms, Quality of Life, and Decisional Conflict Regarding NVP Treatments: MinSafeStart Randomized Controlled Trial. JMIR mhealth and uhealth. ISSN 2291-5222. 10(7). doi: 10.2196/36226. Full text in Research Archive
Andersen, Sarah Hjorth; Pottegård, Anton; Broe, Anne; Hemmingsen, Caroline H.; Leinonen, Maarit & Hargreave, Marie [Show all 8 contributors for this article] (2022). Prenatal exposure to nitrofurantoin and risk of childhood leukaemia: A registry-based cohort study in four Nordic countries. International Journal of Epidemiology. ISSN 0300-5771. 51(3), p. 778–788. doi: 10.1093/ije/dyab219. Full text in Research Archive
Slattery, Jim; Quinten, Chantal; Candore, Gianmario; Pinheiro, Luis; Flynn, Robert & Kurz, Xavier [Show all 7 contributors for this article] (2022). Ondansetron use in nausea and vomiting during pregnancy: A descriptive analysis of prescription patterns and patient characteristics in UK general practice. British Journal of Clinical Pharmacology. ISSN 0306-5251. 88(10), p. 4526–4539. doi: 10.1111/bcp.15370. Full text in Research Archive
Harris, Gerd Marie Eskerud; Wood, Mollie; Ystrøm, Eivind & Nordeng, Hedvig Marie Egeland (2022). Association of Maternal Use of Triptans during Pregnancy with Risk of Attention-Deficit/Hyperactivity Disorder in Offspring. JAMA Network Open. ISSN 2574-3805. 5(6). doi: 10.1001/jamanetworkopen.2022.15333. Full text in Research Archive
Olstad, Emilie Willoch; Nordeng, Hedvig Marie Egeland; Sandve, Geir Kjetil Ferkingstad; Lyle, Robert & Gervin, Kristina (2022). Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures. Clinical Epigenetics. ISSN 1868-7075. 14(1). doi: 10.1186/s13148-022-01299-3. Full text in Research Archive Show summary
Background: There is an increasing interest in the role of epigenetics in epidemiology, but the emerging research feld faces several critical biological and technical challenges. In particular, recent studies have shown poor correlation of measured DNA methylation (DNAm) levels within and across Illumina Infnium platforms in various tissues. In this study, we have investigated concordance between 450 k and EPIC Infnium platforms in cord blood. We could not replicate our previous fndings on the association of prenatal paracetamol exposure with cord blood DNAm, which prompted an investigation of cross-platform DNAm diferences. Results: This study is based on two DNAm data sets from cord blood samples selected from the Norwegian Mother, Father and Child Cohort Study (MoBa). DNAm of one data set was measured using the 450 k platform and the other data set was measured using the EPIC platform. Initial analyses of the EPIC data could not replicate any of our previous signifcant fndings in the 450 k data on associations between prenatal paracetamol exposure and cord blood DNAm. A subset of the samples (n=17) was included in both data sets, which enabled analyses of technical sources potentially contributing to the negative replication. Analyses of these 17 samples with repeated measurements revealed high per-sample correlations (−R ≈0.99), but low per-CpG correlations (−R≈0.24) between the platforms. 1.7% of the CpGs exhibited a mean DNAm diference across platforms >0.1. Furthermore, only 26.7% of the CpGs exhibited a moderate or better cross-platform reliability (intra-class correlation coefcient ≥0.5). Conclusion: The observations of low cross-platform probe correlation and reliability corroborate previous reports in other tissues. Our study cannot determine the origin of the diferences between platforms. Nevertheless, it emulates the setting in studies using data from multiple Infnium platforms, often analysed several years apart. Therefore, the fndings may have important implications for future epigenome-wide association studies (EWASs), in replication, meta-analyses and longitudinal studies. Cognisance and transparency of the challenges related to cross-platform studies may enhance the interpretation, replicability and validity of EWAS results both in cord blood and other tissues, ultimately improving the clinical relevance of epigenetic epidemiology.
Trønnes, Johanne Naper; Lupattelli, Angela; Ystrøm, Eivind & Nordeng, Hedvig Marie Egeland (2022). Analysis of Prenatal Exposure to Opioid Analgesics and Scholastic Skills in Children in Fifth Grade in Norway. JAMA Network Open. ISSN 2574-3805. 5(7). doi: 10.1001/jamanetworkopen.2022.22425. Full text in Research Archive
Gerbier, Eva; Favre, Guillaume; Tauqeer, Fatima; Winterfeld, Ursula; Stojanov, Milos & Oliver, Alison [Show all 13 contributors for this article] (2022). Self-Reported Medication Use among Pregnant and Postpartum Women during the Third Wave of the COVID-19 Pandemic: A European Multinational Cross-Sectional Study. International Journal of Environmental Research and Public Health (IJERPH). ISSN 1661-7827. 19(9), p. 1–16. doi: 10.3390/ijerph19095335. Full text in Research Archive
Grzeskowiak, Luke E.; Saha, Moni R.; Nordeng, Hedvig Marie Egeland; Ystrøm, Eivind & Amir, Lisa H. (2022). Perinatal antidepressant use and breastfeeding outcomes: Findings from the Norwegian Mother, Father and Child Cohort Study. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 101(3), p. 344–354. doi: 10.1111/aogs.14324. Full text in Research Archive
Thurin, Nicolas H.; Pajouheshnia, Romin; Roberto, Giuseppe; Dodd, Caitlin; Hyeraci, Giulia & Bartolini, Claudia [Show all 42 contributors for this article] (2022). From Inception to ConcePTION: Genesis of a Network to Support Better Monitoring and Communication of Medication Safety During Pregnancy and Breastfeeding. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 111(1), p. 321–331. doi: 10.1002/cpt.2476.
Ceulemans, Michael; Foulon, Veerle; Panchaud, Alice; Winterfeld, Ursula; Pomar, Léo & Lambelet, Valentine [Show all 11 contributors for this article] (2022). Self-Reported Medication Use among Pregnant and Breastfeeding Women during the COVID-19 Pandemic: A Cross-Sectional Study in Five European Countries. International Journal of Environmental Research and Public Health (IJERPH). ISSN 1661-7827. 19(3). doi: 10.3390/ijerph19031389. Full text in Research Archive
Ahmed, Seid Mussa; Sundby, Johanne Sommerschild; Aragaw, Yesuf Ahmed & Nordeng, Hedvig Marie Egeland (2021). Medicinal plants used among pregnant women in a tertiary teaching hospital in Jimma, Ethiopia: A cross-sectional study. BMJ Open. ISSN 2044-6055. 11(8). doi: 10.1136/bmjopen-2020-046495.
Trinh, Thi Hong Nhung; Andersen, Sarah Hjorth & Nordeng, Hedvig Marie Egeland (2021). Use of interrupted time-series analysis to characterise antibiotic prescription fills across pregnancy: A Norwegian nationwide cohort study. BMJ Open. ISSN 2044-6055. 11(12). doi: 10.1136/bmjopen-2021-050569. Full text in Research Archive
Lupattelli, Angela; Barone-Adesi, Francesco & Nordeng, Hedvig Marie Egeland (2021). Association between antidepressant use in pregnancy and gestational diabetes mellitus: Results from the Norwegian Mother, Father and Child Cohort Study. Pharmacoepidemiology and Drug Safety. ISSN 1053-8569. 31(2), p. 247–256. doi: 10.1002/pds.5388. Full text in Research Archive
Grzeskowiak, Luke E.; Saha, Moni R.; Ingman, Wendy V.; Nordeng, Hedvig Marie Egeland; Ystrøm, Eivind & Amir, Lisa H. (2021). Incidence, antibiotic treatment and outcomes of lactational mastitis: Findings from The Norwegian Mother, Father and Child Cohort Study (MoBa). Paediatric and Perinatal Epidemiology. ISSN 0269-5022. 36(2), p. 254–263. doi: 10.1111/ppe.12824. Full text in Research Archive
Ngo, Elin Thuy Phuong; Spigset, Olav; Lupattelli, Angela; Panchaud, Alice; Annaert, Pieter & Allegaert, Karel [Show all 7 contributors for this article] (2021). Antihistamine use during breastfeeding with focus on breast milk transfer and safety in humans: A systematic literature review. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. doi: 10.1111/bcpt.13663. Full text in Research Archive Show summary
Current data on use of antihistamines during breastfeeding and risks to the breastfed infant are insufficient. The aim of this systematic review was to provide an overview of studies measuring the levels of antihistamines in human breast milk, estimating the exposure for breastfed infants and/or reporting possible adverse effects on the breastfed infant. An additional aim was to review the antihistamine product labels available in the European Union (EU) and the United States. We searched seven online databases and identified seven human lactation studies that included 25 mother–infant pairs covering cetirizine, clemastine, ebastine, epinastine, loratadine, terfenadine and triprolidine. In addition, one study investigated the impact of chlorpheniramine or promethazine on prolactin levels among 17 women, and one study investigated possible adverse drug reactions in 85 breastfed infants exposed to various antihistamines. The relative infant dose was below 5% for all antihistamines, ranging from 0.3% for terfenadine to 4.5% for clemastine. Most product labels of the 10 antihistamines with available information in both the EU and the United States reported lack of evidence and recommended to avoid use during breastfeeding. The knowledge gap on antihistamines and lactation is extensive, and further human studies are warranted to ensure optimal treatment of breastfeeding women with allergy.
Wood, Mollie; Lupattelli, Angela; Palmsten, Kristin; Bandoli, Gretchen; Hurault-Delarue, Caroline & Damase-Michel, Christine [Show all 9 contributors for this article] (2021). Longitudinal Methods for Modeling Exposures in Pharmacoepidemiologic Studies in Pregnancy. Epidemiologic Reviews. ISSN 0193-936X. 43(1), p. 130–146. doi: 10.1093/epirev/mxab002. Full text in Research Archive
Andersen, Sarah Hjorth; Hemmingsen, Caroline H.; Bénévent, Justine; Broe, Anne; Pottegaard, Anton & Mørch, Lina S. [Show all 10 contributors for this article] (2021). Maternal Medication Use and Childhood Cancer in Offspring-Systematic Review and Considerations for Researchers. American Journal of Epidemiology. ISSN 0002-9262. 190(11), p. 2487–2499. doi: 10.1093/aje/kwab154. Full text in Research Archive
Gomes, Julia do Amaral; Olstad, Emilie Willoch; Kowalski, Thayne Woycinck; Gervin, Kristina; Vianna, Fernanda Sales Luiz & Schüler-Faccini, Lavínia [Show all 7 contributors for this article] (2021). Genetic Susceptibility to Drug Teratogenicity: A Systematic Literature Review. Frontiers in Genetics. ISSN 1664-8021. 12. doi: 10.3389/fgene.2021.645555. Full text in Research Archive
Ceulemans, Michael; Foulon, Veerle; Panchaud, Alice; Winterfeld, Ursula; Pomar, Léo & Lambelet, Valentine [Show all 12 contributors for this article] (2021). Vaccine Willingness and Impact of the COVID-19 Pandemic on Women’s Perinatal Experiences and Practices—A Multinational, Cross-Sectional Study Covering the First Wave of the Pandemic. International Journal of Environmental Research and Public Health (IJERPH). ISSN 1661-7827. 18(7). doi: 10.3390/ijerph18073367. Full text in Research Archive
Morales, Daniel R.; Fonkwen, Lionel & Nordeng, Hedvig Marie Egeland (2021). Antithyroid drug use during pregnancy and the risk of birth defects in offspring: systematic review and meta-analysis of observational studies with methodological considerations. British Journal of Clinical Pharmacology. ISSN 0306-5251. 87(10), p. 3890–3900. doi: 10.1111/bcp.14805. Full text in Research Archive
Lambelet, Valentine; Ceulemans, Michael; Nordeng, Hedvig Marie Egeland; Favre, Guillaume; Horsch, Antje & Stojanov, Milos [Show all 10 contributors for this article] (2021). Impact of the covid-19 pandemic on swiss pregnant and breastfeeding women - a cross-sectional study covering the first pandemic wave. Swiss Medical Weekly. ISSN 1424-7860. 151(37). doi: 10.4414/SMW.2021.w30009. Full text in Research Archive
Lupattelli, Angela; Mahic, Milada; Handal, Marte; Ystrøm, Eivind; Reichborn-Kjennerud, Ted & Nordeng, Hedvig Marie Egeland (2021). Attention-Deficit/Hyperactivity Disorder in Children Following Prenatal Exposure to Antidepressants: results from the Norwegian Mother, Father and Child Cohort Study. BJOG: An International Journal of Obstetrics and Gynaecology. ISSN 1470-0328. 128(21), p. 1917–1927. doi: 10.1111/1471-0528.16743. Full text in Research Archive
Trønnes, Johanne Naper; Lupattelli, Angela; Handal, Marte; Skurtveit, Svetlana Ondrasova; Ystrom, Eivind & Nordeng, Hedvig Marie Egeland (2021). Association of Timing and Duration of Prenatal Analgesic Opioid Exposure with Attention-Deficit/Hyperactivity Disorder in Children. JAMA Network Open. ISSN 2574-3805. 4(9), p. 1–14. doi: 10.1001/jamanetworkopen.2021.24324. Full text in Research Archive
Andersen, Sarah Hjorth; Lupattelli, Angela; Handal, Marte; Spigset, Olav; Ystrøm, Eivind & Nordeng, Hedvig Marie Egeland (2021). Prenatal Exposure to Non-Steroidal Anti-Inflammatory Drugs and Risk of Attention-Deficit/Hyperactivity Disorder - a Follow-Up Study in the Norwegian Mother, Father and Child Cohort. Pharmacoepidemiology and Drug Safety. ISSN 1053-8569. 30(10), p. 1380–1390. doi: 10.1002/pds.5250. Full text in Research Archive
Gustavson, Kristin; Ystrøm, Eivind; Ask, Helga; Torvik, Fartein Ask; Hornig, Mady & Susser, Ezra [Show all 16 contributors for this article] (2021). Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder - a longitudinal sibling control study. JCPP Advances. ISSN 2692-9384. 1(2). doi: 10.1002/jcv2.12020. Full text in Research Archive
Stuckelberger, Sarah; Favre, Guillaume; Ceulemans, Michael; Nordeng, Hedvig Marie Egeland; Gerbier, Eva & Lambelet, Valentine [Show all 11 contributors for this article] (2021). Sars-cov-2 vaccine willingness among pregnant and breastfeeding women during the first pandemic wave: A cross-sectional study in Switzerland. Viruses. ISSN 1999-4915. 13(8). doi: 10.3390/v13071199. Full text in Research Archive
Tauqeer, Fatima; Wood, Mollie; Andersen, Sarah Hjorth; Lupattelli, Angela & Nordeng, Hedvig (2021). Perinatal use of triptans and other drugs for migraine - A nationwide drug utilization study. PLOS ONE. ISSN 1932-6203. 16(8). doi: 10.1371/journal.pone.0256214. Full text in Research Archive Show summary
Objective To characterize nationwide utilization patterns of migraine pharmacotherapy before, during, and after pregnancy in women with triptan use. Methods Population-based data were obtained by linking the Medical Birth Registry of Norway and the Norwegian Prescription Database from 2006 to 2017. We included 22,940 pregnancies among 19,669 women with at least one filled triptan prescription, a proxy for migraine, in the year before pregnancy or during pregnancy. The population was classified into four groups: i) continuers; ii) discontinuers; iii) initiators, and vi) post-partum re-initiators. Participant characteristics and prescription fills for other drugs such as analgesics, antinauseants, and preventive drugs among the groups were examined, along with an array of triptan utilization parameters. Results In total, 20.0% of the women were classified as triptan continuers, 54.1% as discontinuers, 8.0% as initiators, and 17.6% as re-initiators. Extended use of triptans (�15 daily drug doses/month) occurred among 6.9% of the continuers in the first trimester. The top 10% of triptan continuers and initiators accounted for 41% (95% CI: 39.2% - 42.5%) and 33% (95% CI: 30.3% - 35.8%) of the triptan volume, respectively. Triptan continuers and initiators had similar patterns of acute co-medication during pregnancy, but use of preventive drugs was more common among the continuers before, during, and after pregnancy. Conclusion Among women using triptans before and during pregnancy, one in four continued triptan treatment during pregnancy, and extended triptan use was relatively low. Triptan discontinuation during and in the year after pregnancy was common. Use of other acute migraine treatments was higher among both continuers and initiators of triptans. Women using preventive migraine treatment were most commonly triptan continuers and re-initiators after pregnancy. Prescribing to and counseling of women with migraine should be tailored to the condition severity and their information needs to promote optimal migraine management in pregnancy. Introduction
Khalil, Nebghouha El; Lupattelli, Angela & Nordeng, Hedvig Marie Egeland (2021). Antithyroid drug treatment and pregnancy outcomes among women with hyperthyroidism in pregnancy: A Norwegian population-based registry-linkage study. Norsk Epidemiologi. ISSN 0803-2491. 29(1-2), p. 71–84. doi: 10.5324/nje.v29i1-2.4048. Full text in Research Archive Show summary
Aims:The aim of this study was two-fold: i) to describe factors associated with antithyroid drug (ATD) treat-ment during gestation among women with hyperthyroidism in pregnancy,ii) to investigate the impact of ATD treatment during gestation on pregnancy outcomes.Methods:Women with hyperthyroidism in pregnancy and ATD treatments were identified through linkage of three national registries (2008-2018): The Medical Birth Registry of Norway, the Norwegian Prescription Registry and the Norwegian Patient Registry. Pregnancies were categorized as ATD treated or untreated based on filled prescriptions indicating ATD exposure during pregnancy. ATD treatment was examined by trimester (T1, T2/T3) and by substance carbimazole (CMZ), propylthiouracil (PTU) and by both CMZ/PTU. Generalized estimatingequations analysis with a robust variance estimator wasused to estimate adjusted odds ratio(aOR)and adjusted standardized mean difference(aSMD)with 95% confidence interval (CI).Results:We identified 1699 pregnancies with hyperthyroidism during gestation. Hyperthyroidism was treated with ATD in 44.4% of the pregnancies, while 55.6% were untreated. Pregnant women treated with ATD had more often asthma compared to untreated women. Prenatalexposure to CMZ was associated with increased risk of preterm birth (aOR 1.8, 95% CI 1.1-2.8) whereas PTU exposure in the first trimester was associated with an increased risk of cardiac malformations (aOR 9.0, 95% CI 1.8-44.7). There was no association between ATD treatment in pregnancy and maternal preeclampsia (aOR 0.8, 95% CI 0.4-1.3) and gestational hypertension (aOR 0.9, 95% CI 0.5-1.8).Conclusion:This nationwide registry study found an association between treatment with carbimazole and in-creased risk of preterm birth. Exposure to propylthiouracil in the first trimester was associated with an increased risk of cardiac malformations. These findings should be interpreted in light of international findings on the risk of untreated hyperthyroidism and the potential risk of ATD treatment for the mother and child.
Ilic, Miljana; Nordeng, Hedvig Marie Egeland & Lupattelli, Angela (2021). Medical care contact for infertility and related medication use during pregnancy – a European, cross-sectional web-based study. Norsk Epidemiologi. ISSN 0803-2491. 29(1-2), p. 97–106. doi: 10.5324/nje.v29i1-2.4051. Full text in Research Archive
van Gelder, Marleen M.H.J. & Nordeng, Hedvig Marie Egeland (2021). Antiemetic prescription fills in pregnancy: A drug utilization study among 762,437 pregnancies in Norway. Clinical Epidemiology. ISSN 1179-1349. 13, p. 161–174. doi: 10.2147/CLEP.S287892. Full text in Research Archive
Olstad, Emilie Willoch; Nordeng, Hedvig Marie Egeland & Gervin, Kristina (2021). Prenatal medication exposure and epigenetic outcomes: a systematic literature review and recommendations for prenatal pharmacoepigenetic studies. Epigenetics. ISSN 1559-2294. doi: 10.1080/15592294.2021.1903376. Full text in Research Archive
Amundsen, Siri; Nordeng, Hedvig Marie Egeland; Fuskevåg, Ole Martin; Nordmo, Elisabet N; Sager, Georg & Spigset, Olav (2021). Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 128(6), p. 795–804. doi: 10.1111/bcpt.13579. Full text in Research Archive Show summary
Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following intake of a single dose, each participant collected seven breast milk samples at predefined intervals up to 24 hours after dose. Triptan concentrations in milk were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Infant drug exposure was estimated by calculating the relative infant dose (RID). Twenty-two breast milk sample sets were obtained for sumatriptan (n = 8), rizatriptan (n = 5), zolmitriptan (n = 4), eletriptan (n = 3), almotriptan (n = 1) and naratriptan (n = 1). Based on the average concentration in milk throughout the day, estimated mean RIDs (with range in parenthesis) were as follows: eletriptan 0.6% (0.3%-0.8%), sumatriptan 0.7% (0.2%-1.8%), rizatriptan 0.9% (0.3%-1.4%), almotriptan 1.8% (-), zolmitriptan 2.1% (0.7%-5.3%) and naratriptan 5.0% (-). Infant drug exposure through breastfeeding appears to be low and indicates that use of the triptans in this study is compatible with breastfeeding. Naratriptan may not be first choice in breastfeeding mothers initiating triptans during the neonatal period.
Bjørk, Marte-Helene; Kristoffersen, Espen Saxhaug; Tronvik, Erling Andreas & Nordeng, Hedvig Marie Egeland (2021). Management of cluster headache and other trigeminal autonomic cephalalgias in pregnancy and breastfeeding. European Journal of Neurology. ISSN 1351-5101. 28(7), p. 2443–2455. doi: 10.1111/ene.14864. Full text in Research Archive Show summary
Many clinicians lack experience in managing trigeminal autonomic cephalalgias (TACs) in pregnancy and lactation. In addition to cluster headache, TACs include hemicrania continua, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache with conjunctival injection and tearing/autonomic symptoms (SUNCT/SUNA). Treating these rare, severe headache conditions often requires off-label drugs that have uncertain teratogenic potential. In the last few years, several new treatment options and safety documentation have emerged, but clinical guidelines are lacking. This narrative review aimed to provide an updated clinical guide and good clinical practice recommendations for the management of these debilitating headache disorders in pregnancy and lactation.
Nauwelaerts, Nina; Deferm, Neel; Smits, Anne; Bernardini, Chiara; Lammens, Bart & Gandia, Peggy [Show all 17 contributors for this article] (2021). A comprehensive review on non-clinical methods to study transfer of medication into breast milk – A contribution from the ConcePTION project. Biomedicine & Pharmacotherapy. ISSN 0753-3322. 136. doi: 10.1016/j.biopha.2020.111038.
Ceulemans, Michael; Foulon, Veerle; Ngo, Elin Thuy Phuong; Panchaud, Alice; Winterfeld, Ursula & Pomar, Léo [Show all 13 contributors for this article] (2021). Mental health status of pregnant and breastfeeding women during the COVID-19 pandemic—A multinational cross-sectional study. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 100(7), p. 1219–1229. doi: 10.1111/aogs.14092. Full text in Research Archive
Vallee, Jennifer; Wong, Yih; Mannino, Eline; Nordeng, Hedvig Marie Egeland & Lupattelli, Angela (2020). Association between Antidepressant Treatment during Pregnancy and Postpartum Self-Harm Ideation in Women with Psychiatric Disorders: A Cross-Sectional, Multinational Study. International Journal of Environmental Research and Public Health (IJERPH). ISSN 1661-7827. 18(1), p. 1–15. doi: 10.3390/ijerph18010046. Full text in Research Archive

View all works in Cristin

van Gelder, Marleen; Lupattelli, Angela & Nordeng, Hedvig Marie Egeland (2023). Risk of spontaneous abortion after periconceptional medication use: Time to tackle the methodological challenges. Paediatric and Perinatal Epidemiology. ISSN 0269-5022. doi: 10.1111/ppe.12967. Full text in Research Archive
Nordeng, Hedvig Marie Egeland; Falck, Mari; Brænd, Anja Maria; Havnen, Gro Cecilie & Midtsund, Astrid Durdei (2022). GODE RÅD når barnet ditt har barnemark. Fordypningsstoff.
Nordeng, Hedvig Marie Egeland; Falck, Mari; Brænd, Anja Maria; Havnen, Gro Cecilie & Midtsund, Astrid Durdei (2022). GODE RÅD når barnet ditt har barnemark.
Falck, Mari; Nordeng, Hedvig Marie Egeland; Havnen, Gro Cecilie; Midtsund, Astrid Durdei & Brænd, Anja Maria (2022). GODE RÅD når barnet ditt har utslett. Fordypningsstoff.
Falck, Mari; Nordeng, Hedvig Marie Egeland; Havnen, Gro Cecilie; Midtsund, Astrid Durdei & Brænd, Anja Maria (2022). GODE RÅD når barnet ditt har utslett.
Midtsund, Astrid Durdei; Nordeng, Hedvig Marie Egeland; Falck, Mari; Brænd, Anja Maria & Havnen, Gro Cecilie (2022). GODE RÅD om barn og søvn. Fordypningsstoff.
Midtsund, Astrid Durdei; Nordeng, Hedvig Marie Egeland; Falck, Mari; Brænd, Anja Maria & Havnen, Gro Cecilie (2022). GODE RÅD om barn og søvn.
Falck, Mari; Midtsund, Astrid Durdei; Nordeng, Hedvig Marie Egeland; Brænd, Anja Maria & Havnen, Gro Cecilie (2022). GODE RÅD når barnet ditt har puss i øyet. Fordypningssstoff.
Falck, Mari; Midtsund, Astrid Durdei; Nordeng, Hedvig Marie Egeland; Brænd, Anja Maria & Havnen, Gro Cecilie (2022). GODE RÅD når barnet ditt har puss i øyet.
Nordeng, Hedvig Marie Egeland; Havnen, Gro Cecilie; Midtsund, Astrid Durdei; Falck, Mari & Brænd, Anja Maria (2022). GODE RÅD jern og gravide. Fordypningsstoff.
Nordeng, Hedvig Marie Egeland; Havnen, Gro Cecilie; Midtsund, Astrid Durdei; Falck, Mari & Brænd, Anja Maria (2022). GODE RÅD jern og gravide .
Nordeng, Hedvig Marie Egeland; Falck, Mari; Brænd, Anja Maria; Midtsund, Astrid Durdei & Havnen, Gro Cecilie (2022). GODE RÅD mot sure oppstøt og halsbrann hos gravide og ammende. Fordypningsstoff.
Nordeng, Hedvig Marie Egeland; Falck, Mari; Brænd, Anja Maria; Midtsund, Astrid Durdei & Havnen, Gro Cecilie (2022). GODE RÅD mot sure oppstøt og halsbrann hos gravide og ammende.
Brænd, Anja Maria; Nordeng, Hedvig Marie Egeland; Havnen, Gro Cecilie; Midtsund, Astrid Durdei & Falck, Mari (2022). GODE RÅD når barnet ditt har forstoppelse. Fordypningsstoff.
Brænd, Anja Maria; Nordeng, Hedvig Marie Egeland; Havnen, Gro Cecilie; Midtsund, Astrid Durdei & Falck, Mari (2022). GODE RÅD når barnet ditt har forstoppelse.
Nordeng, Hedvig Marie Egeland; Pedersen, Elisabeth; Hurley, Eimir; Zhao, Jing; Trinh, Nhung & Lupattelli, Angela (2022). EU-COVID-19 - a multinational registry-based study with focus on risk and protective factors, clinical outcomes and mental health.
Pedersen, Elisabeth; Lupattelli, Angela & Nordeng, Hedvig Marie Egeland (2022). Primary care diagnoses in patients developing Post COVID-19 Condition.
Lupattelli, Angela & Nordeng, Hedvig Marie Egeland (2022). Does Intrapartum Epidural Analgesia Increase the Risk of Autism Spectrum Disorder in Offspring? Most Likely Not. JAMA Network Open. ISSN 2574-3805. doi: 10.1001/jamanetworkopen.2022.14279.
Ngo, Elin Thuy Phuong; Truong, Maria Bich-Thuy; Wright, David John & Nordeng, Hedvig Marie Egeland (2022). Erratum: Authorship Correction: Impact of a Mobile Application for Tracking Nausea and Vomiting During Pregnancy (NVP) on NVP Symptoms, Quality of Life, and Decisional Conflict Regarding NVP Treatments: MinSafeStart Randomized Controlled Trial (JMIR mHealth and uHealth (2022) 10 7 (e36226)). JMIR mhealth and uhealth. ISSN 2291-5222. 10(9). doi: 10.2196/41927.
Ceulemans, Michael; Sillis, Laure; Foulon, Veerle; Panchaud, Alice; Winterfeld, Ursula & Pomar, Léo [Show all 11 contributors for this article] (2022). Comment to “Pregnancy and COVID-19, focus on vaccine and pharmacological treatment”. Journal of Reproductive Immunology. ISSN 0165-0378. 152. doi: 10.1016/j.jri.2022.103639.
Harris, Gerd Marie Eskerud; Wood, Mollie; Eberhard-Gran, Malin Marie Cecilia; Lundqvist, Christofer & Nordeng, Hedvig Marie Egeland (2022). Correction to: Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine (BMC Pregnancy and Childbirth, (2017), 17, 1, (224), 10.1186/s12884-017-1399-0). BMC Pregnancy and Childbirth. ISSN 1471-2393. 22. doi: 10.1186/s12884-022-04525-1.
Morales, Daniel R. & Nordeng, Hedvig Marie Egeland (2021). Commentary: Obstetric oxytocin exposure and risk of attention-deficit hyperactivity disorder and autism spectrum disorder in offspring-case closed. International Journal of Epidemiology. ISSN 0300-5771. 50(2), p. 457–458. doi: 10.1093/ije/dyab025.
Lupattelli, Angela & Nordeng, Hedvig Marie Egeland (2021). Does antidepressant use in pregnancy increase the risk of ADHD in children? BestPractice nordic.
Christensen, Jacob Juel; Bogsrud, Martin Prøven; Holven, Kirsten Bjørklund; Retterstøl, Kjetil; Veierød, Marit Bragelien & Nordeng, Hedvig Marie Egeland (2021). Maternal use of statins in pregnancy: a population based registry study.
Christensen, Jacob Juel; Bogsrud, Martin P.; Holven, Kirsten B.; Retterstøl, Kjetil; Veierød, Marit B. & Nordeng, Hedvig Marie Egeland (2021). Maternal use of statins in pregnancy: a population-based registry study.
Midtsund, Astrid; Brænd, Anja Maria; Nordeng, Hedvig Marie Egeland; Falck, Mari & Havnen, Gro Cecilie (2021). Kosttilskudd til spedbarn. Fordypningsstoff til helsepersonell.
Midtsund, Astrid; Nordeng, Hedvig Marie Egeland; Falck, Mari; Brænd, Anja Maria & Havnen, Gro Cecilie (2021). Gode råd om kosttilskudd.
Nordeng, Hedvig Marie Egeland; Falck, Mari; Brænd, Anja Maria; Midtsund, Astrid & Havnen, Gro Cecilie (2021). Gode råd ved treg mage og forstoppelse hos gravide. Fordypningsstoff for helsepersonell.
Nordeng, Hedvig Marie Egeland; Falck, Mari; Brænd, Anja Maria; Midtsund, Astrid & Havnen, Gro Cecilie (2021). Gode råd ved treg mage og forstoppelse hos gravide.
Falck, Mari; Nordeng, Hedvig Marie Egeland; Brænd, Anja Maria; Midtsund, Astrid & Havnen, Gro Cecilie (2021). Gode råd når barnet ditt har bleieutslett. Fordypningsstoff for helsepersonell.
Falck, Mari; Nordeng, Hedvig Marie Egeland; Brænd, Anja Maria; Midtsund, Astrid & Havnen, Gro Cecilie (2021). Gode råd når barnet ditt har bleieutslett.
Nordeng, Hedvig Marie Egeland & Ystrøm, Eivind (2021). Forskere: – Har kostet mange gravide og barselkvinner dyrt. VG : Verdens gang. ISSN 0805-5203.