Espen Molden

Professor II - Farmasøytisk institutt
Bilde av Espen Molden
English version of this page
Telefon +47 22856561
Mobiltelefon +47 41129993
Rom 484 B
Brukernavn
Besøksadresse Sem Sælands vei 3 Farmasibygningen 0371 Oslo
Postadresse Postboks 1068 Blindern 0316 Oslo

Faglige interesser

Primær faglig interesse er årsaker til individuell variabilitet i effekt og bivirkninger av legemidler, inkludert implementering av kunnskap innen dette området for å bedre legemiddelbehandling i klinisk praksis.

Undervisning

Underviser på det erfaringsbaserte masterprogrammet i klinisk farmasi.

Bakgrunn

Utdannet Cand.pharm. fra UiO i 1997, Dr.scient. samme sted i 2003. I dag ansatt i 20 % stilling som professor II ved Farmasøytisk institutt, UiO. Hovedstillingen er Forskningsleder ved Senter for Psykofarmakologi, Diakonhjemmet sykehus.

Priser

Årets farmasøyt, Norsk Farmaceutisk Forening, 2006

Samarbeid

Samarbeidspartnere innen aktuelle forskningsprosjekter:

Professor Torgeir Bruun Wyller, Oslo Universitetssykehus, Avdeling Ullevål

Professor Anette Hylen Ranhoff, Diakonhjemmet sykehus

Professor Tommy B. Andersson, Astra Zeneca, Mölndal, Sverige

Professor Erik Eliasson, Karolinska institutet, Stockholm, Sverige

Emneord: Farmakologi, Farmakokinetikk, Farmakogenetikk, Legemiddelinteraksjoner, Cytokrom P450, Klinisk farmasi

Publikasjoner

  • Bråten, Line Skute; Haslemo, Tore; Jukić, Marin M.; Ivanov, Maxim; Ingelman-Sundberg, Magnus & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2021). A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 110(3), s. 786–793. doi: 10.1002/cpt.2233.
  • Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin & Chu, Yunhan [Vis alle 20 forfattere av denne artikkelen] (2021). Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness. JAMA psychiatry. ISSN 2168-6238. 78(9), s. 1020–1030. doi: 10.1001/jamapsychiatry.2021.1435. Fulltekst i vitenarkiv
  • Frederiksen, Trine; Smith, Robert L.; Wollmann, Birgit Malene Tovik; Areberg, Johan & Molden, Espen (2021). Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data. Clinical Pharmacokinetics. ISSN 0312-5963. doi: 10.1007/s40262-021-01029-7.
  • Molden, Espen & Jukić, Marin M. (2021). CYP2D6 Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry. Frontiers in Pharmacology. ISSN 1663-9812. 12. doi: 10.3389/fphar.2021.650750.
  • Hole, Kristine; Arnestad, Marianne; Molden, Espen & Haslemo, Tore (2021). Dose-Dependent Inhibition of CYP2D6 by Bupropion in Patients with Depression. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 41(3), s. 281–285. doi: 10.1097/JCP.0000000000001387.
  • Riede, Julia; Wollmann, Birgit M.; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Primary human hepatocyte spheroids as an in vitro tool for investigating drug compounds with low hepatic clearances. Drug Metabolism And Disposition. ISSN 0090-9556. 49(7). doi: 10.1124/dmd.120.000340.
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole A. & Molden, Espen (2021). Absolute and Dose-Adjusted Serum Concentrations of Clozapine in Patients Switching vs. Maintaining Treatment: An Observational Study of 1979 Patients. CNS Drugs. ISSN 1172-7047. 35, s. 999–1008. doi: 10.1007/s40263-021-00847-4. Fulltekst i vitenarkiv
  • Jukic, Marin M.; Smith, Robert Løvsletten; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 110(3), s. 750–758. doi: 10.1002/cpt.2246.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. The Lancet Psychiatry. ISSN 2215-0374. 6(5), s. 418–426. doi: 10.1016/S2215-0366%2819%2930088-4.
  • Tveito, Marit; Høiseth, Gudrun; Haslemo, Tore; Molden, Espen & Smith, Robert Løvsletten (2021). Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations—an observational study using blood samples from 1223 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77(9), s. 1201–1208. doi: 10.1007/s00228-021-03114-z.
  • Molden, Espen (2021). Therapeutic drug monitoring of clozapine in adults with schizophrenia: a review of challenges and strategies. Expert Opinion on Drug Metabolism & Toxicology. ISSN 1742-5255. doi: 10.1080/17425255.2021.1974400.
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jucik, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2020). Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 228, s. 590–596. doi: 10.1016/j.schres.2020.11.025.
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole Andreas & Molden, Espen (2020). Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine. Nature NPJ Schizophrenia. ISSN 2334-265X. 6. doi: 10.1038/s41537-020-0107-7. Fulltekst i vitenarkiv
  • Romskaug, Rita; Wyller, Torgeir Bruun; Straand, Jørund; Kersten, Hege & Molden, Espen (2020). Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy. Drugs & Aging. ISSN 1170-229X. 37(6), s. 425–433. doi: 10.1007/s40266-020-00763-0. Fulltekst i vitenarkiv
  • Lao, Yvonne Elisabeth; Molden, Espen; Kringen, Marianne K.; Annexstad, Ellen Johanne; Sæverud, Håvard Andreassen & Jacobsen, Dag [Vis alle 7 forfattere av denne artikkelen] (2020). Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 127(1), s. 47–51. doi: 10.1111/bcpt.13389. Fulltekst i vitenarkiv
  • Milosavljević, Filip; Bukvić, Nikola; Pavlović, Zorana; Miljević, Čedo; Pešić, Vesna & Molden, Espen [Vis alle 9 forfattere av denne artikkelen] (2020). Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status with Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2020.3643.
  • Lea, Marianne; Mowe, Morten; Molden, Espen; Kvernrød, Kristin; Skovlund, Eva & Mathiesen, Liv (2020). Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial. BMJ Open. ISSN 2044-6055. 10. doi: 10.1136/bmjopen-2020-041558. Fulltekst i vitenarkiv
  • Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman Ul-Haq; Muriq, Hysen & Fosshaug, Linn Elisabeth Lillerud [Vis alle 8 forfattere av denne artikkelen] (2020). Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study. European Journal of Clinical Pharmacology. ISSN 0031-6970. 76, s. 673–683. doi: 10.1007/s00228-020-02832-0. Fulltekst i vitenarkiv
  • Kringen, Marianne K.; Bråten, Line Skute; Haslemo, Tore & Molden, Espen (2020). The Influence of Combined CYP2D6 and CYP2C19 Genotypes on Venlafaxine and O -Desmethylvenlafaxine Concentrations in a Large Patient Cohort. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 40(2), s. 137–144. doi: 10.1097/JCP.0000000000001174.
  • Thorén, Linda; Lindh, Jonatan D.; Ackehed, Gerd; Kringen, Marianne K.; Hall, Per & Bergh, Jonas [Vis alle 9 forfattere av denne artikkelen] (2020). Impairment of endoxifen formation in tamoxifen‐treated premenopausal breast cancer patients carrying reduced‐function CYP2D6 alleles. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.14500.
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole A [Vis alle 7 forfattere av denne artikkelen] (2020). Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients. European Neuropsychopharmacology. ISSN 0924-977X. 37, s. 64–69. doi: 10.1016/j.euroneuro.2020.06.007.
  • Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland; Nilsen, Roy Miodini; Wallerstedt, Susanna M. & Molden, Espen (2020). Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels. Drugs & Aging. ISSN 1170-229X. 37, s. 691–701. doi: 10.1007/s40266-020-00784-9. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; O`Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2020). Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits. Translational Psychiatry. ISSN 2158-3188. 10(1), s. 1–10. doi: 10.1038/s41398-020-00888-1. Fulltekst i vitenarkiv
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen & Høiseth, Gudrun (2020). Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77, s. 215–221. doi: 10.1007/s00228-020-03002-y. Fulltekst i vitenarkiv
  • Wollmann, Birgit Malene Tovik; Lunde, Hilde; Støten, Lene; Lunder, Niclas & Molden, Espen (2019). Substantial Differences in Serum Concentrations of Psychoactive Drugs Measured in Samples Stored for 2 Days or More on Standard Serum Tubes Versus Serum Tubes Containing Gel Separators. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(3), s. 396–400. doi: 10.1097/FTD.0000000000000592.
  • Tveito, Marit; Smith, Robert Løvsletten; Høiseth, Gudrun & Molden, Espen (2019). The Effect of Valproic Acid on Olanzapine Serum Concentration: A Study Including 2791 Patients Treated With Olanzapine Tablets or Long-Acting Injections. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 39(6), s. 561–566. doi: 10.1097/JCP.0000000000001126.
  • Smith, Robert Løvsletten; Kyllesø, Lennart; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2019). Reduction in N-desmethylclozapine level is determined by daily dose but not serum concentration of valproic acid-indications of a presystemic interaction mechanism. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(4), s. 503–508. doi: 10.1097/FTD.0000000000000619.
  • Romskaug, Rita; Skovlund, Eva; Straand, Jørund; Molden, Espen; Kersten, Hege & Pitkala, Kaisu H [Vis alle 8 forfattere av denne artikkelen] (2019). Effect of clinical geriatric assessments and collaborative medication reviews by geriatrician and family physician for improving health-related quality of life in home-dwelling older patients receiving polypharmacy: a cluster randomized clinical trial. JAMA Internal Medicine. ISSN 2168-6106. doi: 10.1001/jamainternmed.2019.5096. Fulltekst i vitenarkiv
  • Bråten, Line Skute; Haslemo, Tore; Jukic, Marin M.; Ingelman-Sundberg, Magnus; Molden, Espen & Kringen, Marianne K. (2019). Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients. Neuropsychopharmacology. ISSN 0893-133X. 45, s. 570–576. doi: 10.1038/s41386-019-0554-x.
  • Tveito, Marit; Molden, Espen; Høiseth, Gudrun; Correll, Christoph U. & Smith, Robert Løvsletten (2019). Impact of age and CYP2D6 genetics on exposure of aripiprazole and dehydroaripiprazole in patients using long-acting injectable versus oral formulation: relevance of poor and intermediate metabolizer status. European Journal of Clinical Pharmacology. ISSN 0031-6970. 76, s. 41–49. doi: 10.1007/s00228-019-02768-0.
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Vis alle 11 forfattere av denne artikkelen] (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology. ISSN 0306-4530. 103, s. 87–95. doi: 10.1016/j.psyneuen.2019.01.001. Fulltekst i vitenarkiv
  • Gjestad, Caroline; Hole, Kristine; Haslemo, Tore; Diczfalusy, Ulf & Molden, Espen (2019). Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol—an Interaction Study in Healthy Volunteers. AAPS Journal. ISSN 1550-7416. 21(58). doi: 10.1208/s12248-019-0330-1.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2019). Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. The Lancet Psychiatry. ISSN 2215-0374. 6(5), s. 418–426. doi: 10.1016/S2215-0366%2819%2930088-4.
  • Lea, Marianne; Mowe, Morten; Mathiesen, Liv; Kvernrød, Kristin; Skovlund, Eva & Molden, Espen (2019). Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward. PLOS ONE. ISSN 1932-6203. 14(7). doi: 10.1371/journal.pone.0220071. Fulltekst i vitenarkiv
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Vis alle 11 forfattere av denne artikkelen] (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research. ISSN 0022-3956. 106, s. 74–81. doi: 10.1016/j.jpsychires.2018.09.014.
  • Wollmann, Birgit Malene Tovik; Syversen, Silje Watterdal; Vistnes, Maria; Lie, Elisabeth; Mehus, Lise Larsen & Molden, Espen (2018). Associations between cytokine levels and CYP3A4 phenotype in patients with rheumatoid arthritis. Drug Metabolism And Disposition. ISSN 0090-9556. 46(10), s. 1384–1389. doi: 10.1124/dmd.118.082065.
  • Pardiñas, Antonio F.; Holmans, Peter; Pocklington, Andrew J.; Escott-Price, Valentina; Ripke, Stephan & Carrera, Noa [Vis alle 73 forfattere av denne artikkelen] (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics. ISSN 1061-4036. 50(3), s. 381–389. doi: 10.1038/s41588-018-0059-2.
  • Haslemo, Tore; Eliasson, Erik; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Molden, Espen (2018). Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.13788.
  • Hole, Kristine; Wollmann, Birgit Malene Tovik; Nguyen, Camilla; Haslemo, Tore & Molden, Espen (2018). Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(4), s. 463–468. doi: 10.1097/FTD.0000000000000518.
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Haslemo, Tore; Refsum, Helge & Hartberg, Cecilie Bhandari [Vis alle 8 forfattere av denne artikkelen] (2018). Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 38(6), s. 570–576. doi: 10.1097/JCP.0000000000000961.
  • Viktil, Kirsten Kilvik; Lehre, Ina; Ranhoff, Anette Hylen & Molden, Espen (2018). Serum concentrations and elimination rates of direct-acting oral anticoagulants (DOACs) in older hip fracture patients hospitalized for surgery: a pilot study. Drugs & Aging. ISSN 1170-229X. 36(1), s. 65–71. doi: 10.1007/s40266-018-0609-4.
  • Hole, Kristine; Heiberg, Petra Lybæk; Gjestad, Caroline; Mehus, Lise Larsen; Rø, Øyvind & Molden, Espen (2018). Elevated 4β‐hydroxycholesterol/cholesterol ratio in anorexianervosa patients. Pharmacology Research & Perspectives. ISSN 2052-1707. 6(5), s. 1–5. doi: 10.1002/prp2.430. Fulltekst i vitenarkiv
  • Jukic, Marin M.; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2018). Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients. American Journal of Psychiatry. ISSN 0002-953X. 175(5), s. 463–470. doi: 10.1176/appi.ajp.2017.17050550.
  • Smith, Robert Løvsletten; Haslemo, Tore; Chan, Hilde Fauskrud; Refsum, Helge & Molden, Espen (2018). Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration Is Restricted to Postmenopausal Women—A Study Matching Therapeutic Drug Monitoring and Genotype Data From 534 Patients. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(5), s. 567–571. doi: 10.1097/FTD.0000000000000540.
  • Baftiu, Arton; Feet, Silje Andrea; Larsson, Pål Gunnar; Burns, Margrete Larsen; Henning, Oliver Johannes & Sætre, Erik [Vis alle 10 forfattere av denne artikkelen] (2018). Utilisation and polypharmacy aspects of antiepileptic drugs in elderly versus younger patients with epilepsy: A pharmacoepidemiological study of CNS-active drugs in Norway, 2004-2015. Epilepsy Research. ISSN 0920-1211. 139, s. 35–42. doi: 10.1016/j.eplepsyres.2017.11.001.
  • Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene & Gardsjord, Erlend Strand [Vis alle 11 forfattere av denne artikkelen] (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 82, s. 263–271. doi: 10.1016/j.pnpbp.2017.11.004.
  • Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2017). 4β-Hydroxycholesterol level significantly correlates with steady-state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(11), s. 2398–2405. doi: 10.1111/bcp.13341.
  • Solhaug, Vigdis & Molden, Espen (2017). Individual variability in clinical effect and tolerability of opioid analgesics ? Importance of drug interactions and pharmacogenetics. Scandinavian Journal of Pain. ISSN 1877-8860. 17, s. 193–200. doi: 10.1016/j.sjpain.2017.09.009.
  • Kringen, Marianne K.; Chalabianloo, Fatemeh; Bernard, Jean-Paul Anthony; Bramness, Jørgen Gustav; Molden, Espen & Høiseth, Gudrun (2017). Combined Effect of CYP2B6 Genotype and Other Candidate Genes on a Steady-State Serum Concentration of Methadone in Opioid Maintenance Treatment. Therapeutic Drug Monitoring. ISSN 0163-4356. 39(5), s. 550–555. doi: 10.1097/FTD.0000000000000437.
  • Hole, Kristine; Størset, Elisabet; Olastuen, Ane; Haslemo, Tore; Kro, Grete Birkeland & Midtvedt, Karsten [Vis alle 8 forfattere av denne artikkelen] (2017). Recovery of CYP3A Phenotype after Kidney Transplantation. Drug Metabolism And Disposition. ISSN 0090-9556. 45(12), s. 1260–1265. doi: 10.1124/dmd.117.078030.
  • Svendsen, Torleiv; Brodtkorb, Eylert; Reimers, Arne; Molden, Espen; Sætre, Erik & Johannessen, Svein Ivar [Vis alle 7 forfattere av denne artikkelen] (2017). Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate – A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome. Epilepsy Research. ISSN 0920-1211. 129, s. 125–131. doi: 10.1016/j.eplepsyres.2016.12.001.
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen & Åsberg, Anders (2017). The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(7), s. 1457–1465. doi: 10.1111/bcp.13248. Fulltekst i vitenarkiv
  • Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik & Spigset, Olav (2017). Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition. PLOS ONE. ISSN 1932-6203. 12(7). doi: 10.1371/journal.pone.0181082. Fulltekst i vitenarkiv
  • Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Castberg, Ingrid Mehli & Spigset, Olav (2017). Treatment with antipsychotics in pregnancy: changes in drug disposition. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 103(3), s. 477–484. doi: 10.1002/cpt.770. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Haslemo, Tore; Andreassen, Ole Andreas; Eliasson, Erik; Dahl, Marja-Liisa & Spigset, Olav [Vis alle 7 forfattere av denne artikkelen] (2017). Correlation between serum concentrations of N-desmethylclozapine and granulocyte levels in patients with schizophrenia: a retrospective observational study. CNS Drugs. ISSN 1172-7047. 31(11), s. 991–997. doi: 10.1007/s40263-017-0469-1.
  • Waade, Ragnhild Birkeland; Molden, Espen; Martinsen, Mette; Hermann, Monica & Ranhoff, Anette Hylen (2017). Psychotropics and weak opioid analgesics in plasma samples of older hip fracture patients - detection frequencies and consistency with drug records. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(7), s. 1397–1404. doi: 10.1111/bcp.13244.
  • Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Aadal, Marianne & Spigset, Olav (2017). Changes in drug disposition of lithium during pregnancy: A retrospective observational study of patient data from two routine therapeutic drug monitoring services in Norway. BMJ Open. ISSN 2044-6055. 7(3). doi: 10.1136/bmjopen-2016-015738. Fulltekst i vitenarkiv
  • Hole, Kristine; Gjestad, Caroline; Heitmann, Kristine; Haslemo, Tore; Molden, Espen & Bremer, Sara (2017). Impact of genetic and nongenetic factors on interindividual variability in 4β-hydroxycholesterol concentration. European Journal of Clinical Pharmacology. ISSN 0031-6970. 73(3), s. 317–324. doi: 10.1007/s00228-016-2178-y.
  • Wollmann, Birgit Malene Tovik; Syversen, Silje Watterdal; Lie, Elisabeth; Gjestad, Caroline; Mehus, Lise Larsen & Olsen, Inge Christoffer [Vis alle 7 forfattere av denne artikkelen] (2017). 4β-hydroxycholesterol level in patients with rheumatoid arthritis before vs. after initiation of bDMARDs and correlation with inflammatory state. Clinical and Translational Science (CTS). ISSN 1752-8054. 10(1), s. 42–49. doi: 10.1111/cts.12431.
  • Gjestad, Caroline; Huynh, Duy Khanh; Haslemo, Tore & Molden, Espen (2016). 4β-Hydroxycholesterol correlates with dose but not steady-state concentration of carbamazepine: indication of intestinal CYP3A in biomarker formation? British Journal of Clinical Pharmacology. ISSN 0306-5251. 81(2), s. 269–276. doi: 10.1111/bcp.12833.
  • Lea, Marianne; Barstad, Ingeborg; Mathiesen, Liv; Mowe, Morten & Molden, Espen (2016). Effect of teaching and checklist implementation on accuracy of medication history recording at hospital admission. International Journal of Clinical Pharmacy. ISSN 2210-7703. 38(1), s. 20–24. doi: 10.1007/s11096-015-0218-9.
  • Smith, Robert Løvsletten; Haslemo, Tore; Refsum, Helge & Molden, Espen (2016). Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid—a large-scale study based on naturalistic therapeutic drug monitoring data. European Journal of Clinical Pharmacology. ISSN 0031-6970. 72(9), s. 1099–1104. doi: 10.1007/s00228-016-2087-0.
  • Mannheimer, Buster; Haslemo, Tore; Lindh, Jonatan D.; Eliasson, Erik & Molden, Espen (2016). Risperidone and Venlafaxine Metabolic Ratios Strongly Predict a CYP2D6 Poor Metabolizing Genotype. Therapeutic Drug Monitoring. ISSN 0163-4356. 38(1), s. 127–134. doi: 10.1097/FTD.0000000000000251.
  • Molden, Espen; Waade, Ragnhild Birkeland; Hoff, Maren & Haslemo, Tore (2016). Impact of Ageing on Serum Concentrations of Risperidone and Its Active Metabolite in Patients with Known CYP2D6 Genotype. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 119(5), s. 470–475. doi: 10.1111/bcpt.12614.
  • Bakken, Gry Vibeke; Molden, Espen & Hermann, Monica (2015). Impact of genetic variability in CYP2D6, CYP3A5, and ABCB1 on serum concentrations of quetiapine and N-desalkylquetiapine in psychiatric patients. Therapeutic Drug Monitoring. ISSN 0163-4356. 37(2), s. 256–261. doi: 10.1097/FTD.0000000000000135.
  • Høiseth, Gudrun; Haslemo, Tore; Uthus, Linda Hårstad & Molden, Espen (2015). Effect of CYP2B6*6 on steady-state serum concentrations of bupropion and hydroxybupropion in psychiatric patients: A study based on therapeutic drug monitoring data. Therapeutic Drug Monitoring. ISSN 0163-4356. 37(5), s. 589–593. doi: 10.1097/FTD.0000000000000183.
  • Hermann, Monica; Waade, Ragnhild Birkeland & Molden, Espen (2015). Therapeutic drug monitoring of selective serotonin reuptake inhibitors in elderly patients. Therapeutic Drug Monitoring. ISSN 0163-4356. 37(4), s. 546–549. doi: 10.1097/FTD.0000000000000169.
  • Hendset, Magnhild; Molden, Espen; Knape, Magnus & Hermann, Monica (2014). Serum concentrations of risperidone and aripiprazole in subgroups encoding CYP2D6 intermediate metabolizer phenotype. Therapeutic Drug Monitoring. ISSN 0163-4356. 36(1), s. 80–85. doi: 10.1097/FTD.0000000000000018.
  • Watne, Leiv Otto; Hall, Roanna J.; Molden, Espen; Ræder, Johan; Frihagen, Frede Jon & MacLullich, Alasdair M.J. [Vis alle 10 forfattere av denne artikkelen] (2014). Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium. Journal of The American Geriatrics Society. ISSN 0002-8614. 62(1), s. 94–102. doi: 10.1111/jgs.12612.
  • Söderberg, Mao Mao; Molden, Espen & Dahl, Marja-Liisa (2014). No influence of CYP3A43 rs472660G>A on steady-state serum olanzapine concentrations in White psychiatric patients. Pharmacogenetics & Genomics. ISSN 1744-6872. 24(5), s. 272–275. doi: 10.1097/FPC.0000000000000041.
  • Kersten, Hege; Wyller, Torgeir Bruun & Molden, Espen (2014). Association between inherited CYP2D6/2C19 phenotypes and anticholinergic measures in elderly patients using anticholinergic drugs. Therapeutic Drug Monitoring. ISSN 0163-4356. 36(1), s. 125–130. doi: 10.1097/FTD.0b013e31829da990.
  • Waade, Ragnhild Birkeland; Hermann, Monica; Moe, Hanne Louise & Molden, Espen (2014). Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups. European Journal of Clinical Pharmacology. ISSN 0031-6970. 70(8), s. 933–940. doi: 10.1007/s00228-014-1696-8.
  • Robertsen, Ida; Åsberg, Anders; Granseth, Tone; Vethe, Nils Tore; Akhlaghi, Fatemeh & Ghareeb, Mwlod [Vis alle 10 forfattere av denne artikkelen] (2014). More potent lipid-lowering effect by rosuvastatin compared with fluvastatin in everolimus-treated renal transplant recipients. Transplantation. ISSN 0041-1337. 97(12), s. 1266–1272. doi: 10.1097/01.TP.0000443225.66960.7e.

Se alle arbeider i Cristin

  • Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland & Molden, Espen (2019). Dose intensity of antidepressants in older persons 2007-2017 – a study based on therapeutic drug monitoring data .
  • Olsen, Thomasch R. Risom; Rasmussen, Anders R.; Kringen, Marianne K. & Molden, Espen (2019). En jente i tidlig skolealder uten effekt av opioider ved generell anestesi. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(7). doi: 10.4045/tidsskr.18.0561.
  • Ihle-Hansen, Håkon; Hagberg, Guri; Molden, Espen & Myrstad, Marius (2018). Hvem bør få klopidogrel etter hjerneslag? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(9). doi: 10.4045/tidsskr.18.0277.
  • Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2018). Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker. British Journal of Clinical Pharmacology. ISSN 0306-5251. 84(7), s. 1624–1625. doi: 10.1111/bcp.13606.
  • Dyrkorn, Roar; Lundgaard, Halvor; Stokes, Charlotte Lorentze; Molden, Espen & Spigset, Olav (2018). Serumkonsentrasjonsmålinger av DOAK-legemidler. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(7), s. 620–621. doi: 10.4045/tidsskr.18.0237.
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Laskemoen, Jannicke F. [Vis alle 11 forfattere av denne artikkelen] (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders? Journal of Psychiatric Research. ISSN 0022-3956. doi: 10.1016/j.jpsychires.2018.11.012.
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen & Åsberg, Anders (2017). Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(6), s. 1350–1352. doi: 10.1111/bcp.13188.
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen & Åsberg, Anders (2017). Response to: ‘Response to: Bodyweightadjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance’. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(6), s. 1357–1358. doi: 10.1111/bcp.13276.
  • Romskaug, Rita; Molden, Espen; Straand, Jørund; Kersten, Hege; Skovlund, Eva & Pitkala, Kaisu H [Vis alle 7 forfattere av denne artikkelen] (2017). Cooperation between geriatricians and general practitioners for improved pharmacotherapy in home-dwelling elderly people receiving polypharmacy - the COOP Study: Study protocol for a cluster randomised controlled trial. Trials. ISSN 1745-6215. 18(1). doi: 10.1186/s13063-017-1900-0. Fulltekst i vitenarkiv
  • Solberg, Dag; Refsum, Helge & Molden, Espen (2017). Hvis du skal gjøre det, gjør det riktig! Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(12/13), s. 854–854. doi: 10.4045/tidsskr.17.0441.
  • Lea, Marianne; Mathiesen, Liv; Mowe, Morten & Molden, Espen (2017). Baseline characteristics of multimorbid patients included in an RCT.
  • Solhaug, Vigdis & Molden, Espen (2016). Genetisk betinget variasjon i bioaktivering av tamoksifen og klopidogrel :. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(5), s. 434–436. doi: 10.4045/tidsskr.15.0555.
  • Lundgaard, Halvor; Dyrkorn, Roar; Stokes, Charlotte Lorentze; Molden, Espen & Spigset, Olav (2016). Tryggere behandling med serumkonsentrasjonsmåling av de nye antikoagulasjonsmidlene? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(18), s. 1556–1560. doi: 10.4045/tidsskr.16.0255.
  • Lea, Marianne; Engnes, Anette; Mathiesen, Liv; Mowe, Morten & Molden, Espen (2016). Drug-related problems at hospital admission in multimorbid internal medical patients.
  • Waade, Ragnhild Birkeland; Hermann, Monica; Ranhoff, Anette Hylen; Martinsen, Mette & Molden, Espen (2015). Therapeutic drug monitoring of psychotropic drugs and mild opioid analgesics in elderly hip fracture patients at hospital admission.
  • Waade, Ragnhild Birkeland; Ranhoff, Anette Hylen; Hermann, Monica; Martinsen, Mette & Molden, Espen (2015). Screening of psychotropic drugs and mild opioid analgesics in older hip fracture patients at hospital admission.
  • Landmark, Cecilie Johannessen; Svendsen, Torleiv; Reimers, Arne; Brodtkorb, Eylert; Sætre, Erik & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2014). Klinisk erfaring med terapeutisk legeiddelmonitorering for eslicarbazepin acetat i Norge.
  • Landmark, Cecilie Johannessen; Svendsen, Torleiv; Reimers, Arne; Brodtkorb, Eylert; Sætre, Erik & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2014). Experience of therapeutic drug monitoring of eslicarbazepine acetate in clinical practice in Norway.
  • Hendset, Magnhild; Hermann, Monica; Moe, Hanne L & Molden, Espen (2014). Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups.
  • Efjestad, Anne; Molden, Espen & Øksengård, Anne Rita (2013). Pharmacist- initiated management of antagonistic interactions between anticholinergic drugs and acetyl cholinesterase inhibitors in individuals with dementia. Journal of The American Geriatrics Society. ISSN 0002-8614. 61(9), s. 1624–1625.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete; Pedersen, R. & Molden, Espen (2013). Frequency and Management of Drug Realted Problems in an Intensive Care Unit.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete; Pedersen, R. & Molden, Espen (2013). Frequency and Management of Drug Realted Problems in an Intensive Care Unit.
  • Grundvåg, Maris; Molden, Espen & Lundereng, Kristine (2013). LegemiddelRelaterte Problemer hos eldre pasienter innlagt på ortopedisk avdeling grunnet fallhendelser.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete; Pedersen, R. & Molden, Espen (2013). Prevalence and management of drug related problems at an intensive care unit. International Journal of Clinical Pharmacology Research. ISSN 0251-1649. 35(5), s. 927–927.
  • Waade, Ragnhild Birkeland; Moe, Hanne Louise; Hermann, Monica & Molden, Espen (2013). Aldersbetinget variasjon i serumkonsentrasjon av venlafaksin og escitalopram i relasjon til CYP-genotype.
  • Halbostad, Terje; Molden, Espen & Hagen, Håvard (2014). Implementering av et strukturert kvalitetssikringsverktøy for identifisering og håndtering av legemiddelrelaterte problemer ved geriatrisk sengepost. Universitetet i Oslo.
  • Grundvåg, Maris; Molden, Espen; Lundereng, Kristine & Strugstad, Elisabeth (2013). Legemiddelrelaterte problemer hos eldre pasienter på ortopedisk avdeling grunnet fallhendelser. Universitetet i Oslo.

Se alle arbeider i Cristin

Publisert 3. nov. 2010 15:41 - Sist endret 15. okt. 2021 06:33