Jo Klaveness

• Johnsen, Hennie Marie; Hiorth, Marianne & Klaveness, Jo (2023). Molecular Hydrogen Therapy—A Review on Clinical Studies and Outcomes. Molecules. ISSN 1431-5157. 28(23). doi: 10.3390/molecules28237785. Fulltekst i vitenarkiv
• Lien, Vegard Torp; Hauge, Emily; Nuruddin, Syed Mohammad; Klaveness, Jo & Olberg, Dag Erlend (2023). Synthesis and preclinical evaluation of a selective MET kinase positron emission tomography tracer. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 66(14), s. 452–460. doi: 10.1002/jlcr.4066.
• Johnsen, Hennie Marie; Filtvedt, Werner Olav; Hiorth, Marianne & Klaveness, Jo (2022). Silicon nanoparticles for oral administration of molecular hydrogen. International Journal of Pharmaceutics. ISSN 0378-5173. 629. doi: 10.1016/j.ijpharm.2022.122371. Fulltekst i vitenarkiv
• Lien, Vegard Torp; Celen, Sofie; Nuruddin, Syed; Attili, Bala; Doumont, Gilles & Van Simaeys, Gaetan [Vis alle 9 forfattere av denne artikkelen] (2021). Preclinical evaluation of [18F]cabozantinib as a PET imaging agent in a prostate cancer mouse model. Nuclear Medicine and Biology. ISSN 0969-8051. 93, s. 74–80. doi: 10.1016/j.nucmedbio.2020.12.002.
• Lien, Vegard Torp; Kristiansen, Margrethe Konstanse; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend & Waaler, Jo [Vis alle 7 forfattere av denne artikkelen] (2019). Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation. RSC Advances. ISSN 2046-2069. 9(63), s. 37092–37100. doi: 10.1039/c9ra08954c.
• Lien, Vegard Torp; Olberg, Dag Erlend; Hagelin, Gunnar & Klaveness, Jo (2019). Synthesis and antiproliferative evaluation of novel N‑arylquinolones. Monatshefte für Chemie. ISSN 0026-9247. 150(11), s. 1947–1957. doi: 10.1007/s00706-019-02504-5.
• Lien, Vegard Torp; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend; Mælandsmo, Gunhild Mari & Klaveness, Jo (2019). Design, synthesis and biological evaluation of 6‐substituted quinolines derived from cabozantinib as c‐Met inhibitors. Archiv der Pharmazie. ISSN 0365-6233. 352(9). doi: 10.1002/ardp.201900101. Fulltekst i vitenarkiv
• Klaveness, Jo (2018). Biologiske legemidler og biotilsvarende legemidler. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 126(1), s. 2–29.
• Lien, Vegard Torp; Grønås, Kari; Olberg, Dag Erlend & Klaveness, Jo (2018). Onkologiske legemidler: Utviklingen fra konvensjonelle cytostatika til nib-er, mab-er og andre nyvinninger. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 8, s. 24–29.
• Tukun, Feng-Ling; Olberg, Dag Erlend; Riss, Patrick; Haraldsen, Ira Hebold; Kåss, Anita Anjali Suri & Klaveness, Jo (2017). Recent development of non-peptide GnRH antagonists. Molecules. ISSN 1431-5157. 22:2188(12), s. 1–25. doi: 10.3390/molecules22122188. Fulltekst i vitenarkiv
• Lien, Vegard Torp; Klaveness, Jo & Olberg, Dag Erlend (2017). One-step synthesis of [18F]cabozantinib for use in positron emission tomography imaging of c-Met. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 61(1), s. 11–17. doi: 10.1002/jlcr.3564.
• Vestland, Tina Lien; Petersen, Lizette Balle; Myrset, Astrid Hilde & Klaveness, Jo (2017). Oxidative stability of omega-3 tablets. European Journal of Lipid Science and Technology. ISSN 1438-7697. 119(2). doi: 10.1002/ejlt.201500322.
• Lien, Vegard Torp; Olberg, Dag Erlend; Klaveness, Jo & Görbitz, Carl Henrik (2017). Crystal structure of 6,7-dimeth­­oxy-1-(4-nitro­phen­yl)quinolin-4(1H)-one: a mol­ecular scaffold for potential tubulin polymerization inhibitors. Acta Crystallographica Section E: Crystallographic Communications. ISSN 2056-9890. 73, s. 441–444. doi: 10.1107/S2056989017002948.
• Olberg, Dag Erlend; Bauer, Nadine; Andressen, Kjetil Wessel; Hjornevik, Trine; Cumming, Paul & Levy, Finn Olav [Vis alle 9 forfattere av denne artikkelen] (2016). Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats. Nuclear Medicine and Biology. ISSN 0969-8051. 43(8), s. 478–489. doi: 10.1016/j.nucmedbio.2016.05.003.
• Vestland, Tina Lien; Jacobsen, Øyvind; Sande, Sverre Arne; Myrset, Astrid Hilde & Klaveness, Jo (2016). Characterization of omega-3 tablets. Food Chemistry. ISSN 0308-8146. 197, s. 496–502. doi: 10.1016/j.foodchem.2015.10.142.
• Vestland, Tina Lien; Jacobsen, Øyvind; Sande, Sverre Arne; Myrset, Astrid Hilde & Klaveness, Jo (2015). Compactible powders of omega-3 and β-cyclodextrin. Food Chemistry. ISSN 0308-8146. 185, s. 151–158. doi: 10.1016/j.foodchem.2015.03.132.
• Olberg, Dag Erlend; Hausner, Sven H.; Bauer, Nadine; Klaveness, Jo; Indrevoll, Bård & Andressen, Kjetil Wessel [Vis alle 10 forfattere av denne artikkelen] (2015). Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats. MedChemComm. ISSN 2040-2503. 6, s. 708–714. doi: 10.1039/c4md00486h.
• Brudeli, Bjarne; Navaratnarajah, Mirusha; Andressen, Kjetil Wessel; Manfra, Ornella; Moltzau, Lise Roman & Nilsen, Nils Olav [Vis alle 8 forfattere av denne artikkelen] (2014). Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(18), s. 4598–4602. doi: 10.1016/j.bmcl.2014.06.083.
• Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2014). Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(7), s. 1846–1850. doi: 10.1016/j.bmcl.2014.02.002.
• Petter Arnt, Hals; Sontum, Per-Christian; Holtz, Eckardt; Klaveness, Jo & Rongved, Pål (2013). In Vivo Cleavage Rate of a Dextran-Bound Magnetic Resonance Imaging Contrast Agent: Preparation and Intravascular Pharmacokinetic Characteristics in the Rabbit. Current Drug Delivery. ISSN 1567-2018. 10(1), s. 134–143. doi: 10.2174/1567201811310010019.
• Brudeli, Bjarne; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Andressen, Kjetil Wessel; Nilsen, Nils Olav & Levy, Finn Olav [Vis alle 7 forfattere av denne artikkelen] (2013). Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European Journal of Medicinal Chemistry. ISSN 0223-5234. 64, s. 629–637. doi: 10.1016/j.ejmech.2013.03.060.
• Brudeli, Bjarne; Andressen, Kjetil Wessel; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 21(22), s. 7134–7145. doi: 10.1016/j.bmc.2013.09.004.
• Borhaug, Hilde; Kristensen, Mette; Brudeli, Bjarne; Sontum, Per Chrisian; Klaveness, Jo & Rongved, Pål (2011). Water-soluble omega-3: A concept for purification of fish oil and nutraceuticals? European Journal of Lipid Science and Technology. ISSN 1438-7697. 113(10), s. 1235–1242. doi: 10.1002/ejlt.201000502.
• Andrei, Mioara; Bakkebø, Tina; Klaveness, Jo; Tasken, Kjetil & Undheim, Kjell (2011). Stereoselective synthesis of (R-P)-8-substituted-N-6-acylated and N-6-alkylated adenosine-3 ',5 '-cyclic phosphorothioic acids as cAMP antagonists. European Journal of Medicinal Chemistry. ISSN 0223-5234. 46(12), s. 5935–5940. doi: 10.1016/j.ejmech.2011.10.003.
• Jacobsen, Øyvind; Gebreslasie, Hadgu G; Klaveness, Jo; Rongved, Pål & Gorbitz, Carl Henrik (2011). N-(tert-Butoxycarbonyl)-L-valyl-L-valine methyl ester: a twisted parallel beta-sheet in the crystal structure of a protected dipeptide. Acta Crystallographica Section C: Crystal Structure Communications. ISSN 0108-2701. 67, s. O278–O282. doi: 10.1107/S0108270111022293.
• Jacobsen, Øyvind; Maekawa, Hiroaki; Ge, Nien-Hui; Gorbitz, Carl Henrik; Rongved, Pål & Ottersen, Ole Petter [Vis alle 8 forfattere av denne artikkelen] (2011). Stapling of a 3(10)-Helix with Click Chemistry. Journal of Organic Chemistry. ISSN 0022-3263. 76(5), s. 1228–1238. doi: 10.1021/jo101670a.
• Hoff, Lars; Foss, Per A.; Dyrstad, Knut; Klaveness, Jo & Rongved, Pål (2011). Stabilization of gas bubbles released from water-soluble carbohydrates using amphiphilic compounds: preparation of formulations and acoustic monitoring of bubble lifetime. Journal of Surfactants and Detergents (JSD). ISSN 1097-3958. 14(4), s. 585–593 . doi: 10.1007/s11743-011-1250-y. Vis sammendrag

  The ultrasound contrast agents Echovist® and Levovist® (Bayer AG, Schering AG, Germany) are based on the release of gas bubbles from milled α-D-galactose. In diagnostic ultrasound, for this class of contrast agents, there is a need for prolonged contrast duration. To investigate if new carbohydrate compositions could prolong the lifetime of the gas bubbles, α-D-galactose was mixed with other carbohydrates or amphiphiles with varying log P. Acoustic attenuation vs. time (390 s) area under the curve (A 390) and bubble half-time (t½) were used as measures of prolonged lifetime of gas bubbles. The products, to which 0.1% of a lipophilic carboxylic acid (5β-cholanic acid, behenic acid, and melissic acid) has been added, showed more than 5, 7 and 11 times enhancement of A 390, respectively, compared with the reference compound 2 (RC2) corresponding to the commercial product Levovist®. The half-time t ½ of the same compounds was prolonged more than 6 times compared with RC2. A partial least square (PLS) statistical analysis confirmed that, for additives, high log P carboxylic acids lead to the highest A 390. The present results bear a promise of products with a more persistent in vivo ultrasound contrast effect than the commercially available agents.

• Jacobsen, Øyvind; Klaveness, Jo & Rongved, Pål (2010). Structural and pharmacological effects of ring-closing metathesis in peptides. Molecules. ISSN 1431-5157. 15(9), s. 6638–6677. doi: 10.3390/molecules15096638.
• Brudeli, Bjarne; Moltzau, Lise Roman; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Klaveness, Jo & Levy, Finn Olav (2010). Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 18(24), s. 8600–8613. doi: 10.1016/j.bmc.2010.10.011.
• Jacobsen, Øyvind; Klaveness, Jo; Ottersen, Ole Petter; Amiry-Moghaddam, Mahmood Reza & Rongved, Pål (2009). Synthesis of cyclic peptide analogues of the 3(10) helical Pro138-Gly144 segment of human aquaporin-4 by olefin metathesis. Organic and biomolecular chemistry. ISSN 1477-0520. 7(8), s. 1599–1611. doi: 10.1039/b823559g.
• Høyem, Sverre; Bruheim, Skjalg; Mælandsmo, Gunhild M; Standal, Marius; Olberg, Dag Erlend & Brudeli, Bjarne [Vis alle 9 forfattere av denne artikkelen] (2009). Didanosine ester prodrugs: Synthesis, albumin binding properties and pharmacokinetic studies in rats. European Journal of Medicinal Chemistry. ISSN 0223-5234. 44(10), s. 3874–3879. doi: 10.1016/j.ejmech.2009.04.008.
• Andrei, Mioara; Bjørnstad, Vidar; Langli, Geir; Rømming, Hans Christian; Klaveness, Jo & Tasken, Kjetil [Vis alle 7 forfattere av denne artikkelen] (2007). Stereoselective preparation of (R-P)-8-hetaryladenosine-3 ',5 '-cyclic phosphorothioic acids. Organic and biomolecular chemistry. ISSN 1477-0520. 5, s. 2070–2080. doi: 10.1039/b702403g.
• Odlo, Kristin; Klaveness, Jo; Rongved, Pål & Hansen, Trond Vidar (2006). Synthesis of combretastatins A-1 and B-1. Tetrahedron Letters. ISSN 0040-4039. 47, s. 1101–1103. Vis sammendrag

  Combretastatins A-1 and B-1 have been synthesized by coupling MOM-protected p-iodomethoxycatechol with 3,4,5-trimethoxyphenylacetylene in a Sonogashira reaction.

• Charnock, Colin; Brudeli, Bjarne & Klaveness, Jo (2004). Evaluation of the antibacterial efficacy of diesters of azelaic acid. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 21(5), s. 589–596.
• Løkling, Knut-Egil; Fossheim, SL; Klaveness, Jo & Skurtveit, R (2004). Biodistribution of pH-responsive liposomes for MRI and a novel approach to improve the pH-responsiveness. Journal of Controlled Release. ISSN 0168-3659. 98, s. 87–95.
• Løkling, Knut-Egil; Skurtveit, R; Dyrstad, K; Klaveness, Jo & Fossheim, SL (2004). Tuning the MR properties of blood-stable pH-responsive paramagnetic liposomes. International Journal of Pharmaceutics. ISSN 0378-5173. 274, s. 75–83.
• Hovland, Ragnar; Gløgård, Christian; Aasen, Arne Jørgen & Klaveness, Jo (2003). Preparation and in vitro Evaluation of a novel Amphiphilic GdPCTA-[12] derivative; a Micellar MRI Contrast Agent. Organic and biomolecular chemistry. ISSN 1477-0520. 1, s. 644–647.
• Hovland, Ragnar; Gløgård, Christian; Aasen, Arne Jørgen & Klaveness, Jo (2003). Preparation and in vitro Evaluation of GdDOTA-(BOM)4; a Novel Angiographic MRI Contrast Agent. Organic and biomolecular chemistry. ISSN 1477-0520. 1, s. 1707–1710.
• Løkling, Knut-Egil; Fossheim, Sigrid Lise; Smistad, Gro; Skurtveit, Roald; Henriksen, Ingrid & Klaveness, Jo (2003). pH-sensitive paramagnetic liposomes for MRI: Assessment of stability in blood. Magnetic Resonance Imaging. ISSN 0730-725X. 21, s. 531–540.
• Klaveness, Jo (2002). Liposomes as carriers of amphiphilic gadolinium chelates: the effect of membrane composition on incorporation efficacy and in vitro relaxivity. International Journal of Pharmaceutics. ISSN 0378-5173. 233, s. 131–140.
• Bergan, Tom; Klaveness, Jo & Aasen, Arne Jørgen (2001). Chelating Agents. Chemotherapy. ISSN 0009-3157. 47(1), s. 10–14. Vis sammendrag

  The antibacterial activity of metal ions, metal chelates, and molecules with chelating ability for polyvalent cations have been evaluated. The chelator N,N'-ethylenebis[2-(2-hydroxyphenyl)-glycine] (EHPG) exerted moderate-to-good activity against isolates of pathogenic bacteria and fungi. Other chelating agents such as ethylenediamine-tetraacetic acid (EDTA) and diethylene-triamine-pentaacetic acid (DTPA) revealed weak-to-moderate activity. Metal chelation of ligands reduced the activity of EDTA and DTPA.

• Sing, P. G.; Klaveness, Jo; Rise, Frode & Aasen, Arne Jørgen (2001). Lipophilic X-Ray Contrast Agents Diatrizoyl Double Esters with Cholesterol and Cholic Acid. Archive for Organic Chemistry (Arkivoc). 2(8). Vis sammendrag

  Potential biodegradable and organ-specific X-ray contrast agents have been prepared by linking diatrizoic acid to cholesterol and cholic acid, respectively, via a spacer group containing a carbonate double ester. In vitro experiments revealed that the cholic acid esters were enzymatically degraded in the presence of pig liver esterase, while the double esters with cholesterol appeared to be stable, possibly due to low solubility in water.

• Hovland, Ragnar; Gløgård, Christian; Aasen, Arne Jørgen & Klaveness, Jo (2001). Gadolinium DO3A derivatives mimicking phospholipids; preparation and in vitro evaluation as pH responsive MRI contrast agents. Journal of the Chemical Society. Perkin Transactions 2 (2001). ISSN 1472-779X. s. 929–933. Vis sammendrag

  A series of Gd-DO3A derivatives mimicking phospholipids have been prepared. Two of the complexes, Gd-HADB-DO3A and Gd-HADO-DO3A, have been evaluated as pH responsive MRI contrast agents in vitro. The T1-relaxivity (r1) of Gd-HADO-DO3A increased 142% on changing the pH from 6 to 8. The pH dependence is thought to arise from the formation of supramolecular structures caused by deprotonation of the amphiphilic complex at alkaline pH.

• Rise, Frode; Singh, Pushap G.; Klaveness, Jo & Aasen, Arne Jørgen (2001). Lipophilic X-Ray Contrast Agents. Diatrizoyl Double Esters with Cholesterol and Cholic Acid. Arkivoc. Free Online Journal of Organic Chemistry. Volume 2001(x), s. 7–15. Vis sammendrag

  http://www.arkat-usa.org/ark/journal/Volume2/Part3/Undheim/KU-205A/205.htm Abstract Potential biodegradable and organ-specific X-ray contrast agents have been prepared by linking diatrizoic acid to cholesterol and cholic acid, respectively, via a spacer group containing a carbonate double ester. In vitro experiments revealed that the cholic acid esters were enzymatically degraded in the presence of pig liver esterase, while the double esters with cholesterol appeared to be stable, possibly due to low solubility in water.

• Gløgård, Christian; Hovland, Ragnar; Fossheim, Sigrid Lise; Aasen, Arne Jørgen & Klaveness, Jo (2000). Synthesis and physicochemical characterisation of new amphilic gadolinium DO3A complexes as contrast agents for MRI. Journal of the Chemical Society. Perkin Transactions 2 (2001). ISSN 1472-779X. s. 1047–1052.
• Fossheim, Sigrid Lise; Kellar, Ken; Månsson, Stig; Colet, Jean M; Rongved, Pål & Fahlvik, Anne Kjersti [Vis alle 7 forfattere av denne artikkelen] (1999). Investigation of lanthanide-based starch particles as a model system for liver contrast agents. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. 9(2).
• Dahlgren, Anders; Gløgård, Christian; Gammelsæther, M.; Aasen, Arne Jørgen; Klaveness, Jo & Berdal, Bjørn Peter [Vis alle 7 forfattere av denne artikkelen] (1999). Organobismuth compounds: Activity against Helicobacter pylori. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 34(2), s. 135–137. Vis sammendrag

  Background and Methods: The antibacterial activity of originally devised and synthesized organobismuth compounds was tested against fresh clinical isolates of Helicobacter pylori and compared with clinically well-established inorganic bismuth salts currently used in triple antibacterial treatment to eradicate H. pylori. The test conditions in vitro were standard for determination of minimum inhibitory concentrations (MICs). Results: Organic compounds with covalently bound bismuth showed stronger and more consistent antibacterial activity than inorganic bismuth salts. Whereas the most active among the standard therapeutic inorganic compounds showed MICs against the test organisms of 4-8 mg/l (bismuth salicylate) and 0.5-64 mg/l, the most active neosynthesized organic substance, tris(2,6-dimethylphenyl)-bismuthine, consistently showed an MIC of 4 mg/l against all bacterial strains. Conclusions: The new line of organobismuth compounds might offer a therapeutic potential against the bacteria causing peptic ulcer disease.

• Løiten, Marianne Sveaas; Gløgård, Christian; Dalhus, Bjørn; Fjærtoft, Berit & Klaveness, Jo (1999). 2,4,6-Triiodo-1,3,5-tris(tert-butyldimethylsilyloxymethyl)-benzene. Acta Crystallographica Section C: Crystal Structure Communications. ISSN 0108-2701. C55.
• Løiten, Marianne Sveaas; Gløgård, Christian; Klaveness, Jo & Fjærtoft, Berit (1999). Synthesis and Crystal Structure of 1-(4-bromobenzyl)- 4-methyl-2,6,7-trioxabicyclo[2.2.2]octane. Journal of Chemical Crystallography. ISSN 1074-1542. 29, s. 493–496.
• Aasen, Arne Jørgen; Storesund, Hans Johan; Klaveness, Jo & Skramstad, Jan (1998). Cationic Protection Against Decomposition in Acidic Media. On the Acid-stability of an Aminoalkyl Substituted Furan. Acta Chemica Scandinavica. ISSN 0904-213X. 52, s. 964–965.
• Løiten, Marianne Sveaas; Dalhus, Bjørn; Fjærtoft, Berit & Klaveness, Jo (1998). trans-2,3-Diiodo-2-buten-1,4-diol. Acta Crystallographica Section C: Crystal Structure Communications. ISSN 0108-2701. C54, s. 555–557.
• Sigrid, Fossheim; Karen Briley, Sæbø; Anne Kjersti, Fahlvik; Rongved, Pål & Klaveness, Jo (1997). Low molecular weight lanthanide contrast agents: in vitro studies of mechanisms of action. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. 7(1).
• Hammer, Kristin; Hatlelid, Jostein; Grøtli, Morten; Arukwe, J.; Rise, Frode & Klaveness, Jo [Vis alle 7 forfattere av denne artikkelen] (1996). Ether, Carbonate and Urethane Deoxynucleoside Derivatives as Prodrugs. Acta Chemica Scandinavica. ISSN 0904-213X. 50, s. 609–622.
• Aasen, Arne Jørgen; Groth, P. A.; Carvalho, J.; Varadarajan, J. & Klaveness, Jo (1995). Synthesis and Crystal Structure of a Macrotricyclic Chelating Agent. Acta Chemica Scandinavica. ISSN 0904-213X. 49, s. 133–137.
• Gjøen, Tor; Holtz, E.; Strande, P.; Klaveness, Jo; Leander, P. & Berg, A J (1991). Particulate biodegradable contrast medium or CT of the liver. I Ferrucci, J.T. & Stark, D.D. (Red.), Liver Imaging. Current trends and new techniques. Andover Medical Publishers, Boston..
• Klaveness, Jo; Rise, Frode & Undheim, Kjell (1986). Synthesis of 1,2-Dithiolan-2-ylium and 1,3-Dithian-2-ylium Tetrafluoroborate Salts. Acta Chemica Scandinavica. ISSN 0904-213X. B40, s. 398–399.
• Klaveness, Jo; Rise, Frode & Undheim, Kjell (1986). Organotin Derivates in the Umpolung of 1,3-Dithian-2-ylides to 1,3-Dithian-2-ylium Salts. Journal of Organometallic Chemistry. ISSN 0022-328X. 303, s. 189–195.
• Klaveness, Jo; Rise, Frode & Undheim, Kjell (1986). Reactions of 1,3-Dithiolan-2-ylium and 1,3-Dithian-2-ylium Tetrafluoroborates and Ambident 2-Styryl Derivates. Acta Chemica Scandinavica. ISSN 0904-213X. B40, s. 373–380.

Se alle arbeider i Cristin

• Lien, Vegard Torp; Kristiansen, Margrethe Konstanse; Pettersen, Solveig; Haugen, Mads Haugland; Krauss, Stefan Johannes Karl & Olberg, Dag Erlend [Vis alle 8 forfattere av denne artikkelen] (2020). Erratum: Towards dual inhibitors of the MET kinase and WNT signaling pathway; Design, synthesis and biological evaluation (RSC Advances (2019) 9 (37092-37100) DOI: 10.1039/D0RA90007A). RSC Advances. ISSN 2046-2069. 10(9). doi: 10.1039/d0ra90007a.
• Kristiansen, Margrethe Konstanse; Lien, Vegard Torp & Klaveness, Jo (2019). Towards dual inhibitors of c-Met and WNT; synergistic treatment of cancerous diseases.
• Lien, Vegard Torp; Hauge, Emily; Nuruddin, Syed; Klaveness, Jo & Olberg, Dag Erlend (2019). Synthesis and preclinical evaluation of a selective c-Met PET tracer.
• Lien, Vegard Torp; Klaveness, Jo & Olberg, Dag Erlend (2017). One-step synthesis of [18F]cabozantinib for use in positron emission tomography imaging of c-Met.
• David, Arnaud; Andrei, Mioara; Klaveness, Jo; Undheim, Kjell & Tasken, Kjetil (2010). Fluorescence polarization used in HTS in order to identify new antagonists of cAMP to inhibit PKA activity. The FEBS Journal. ISSN 1742-464X. 277, s. 138–138.
• Klaveness, Jo & Rongved, Pål (2008). Smør deg inn med Omega 3. [Avis]. NRK Nordland.
• Klaveness, Jo & Rongved, Pål (2008). Har knekt omega-3-koden. [Internett]. Forskning.no.
• Jacobsen, Øyvind; Klaveness, Jo; Ottersen, Ole Petter; Mahmood reza, Amiry-Moghaddam & Rongved, Pål (2008). Synthesis of cyclic peptide analogues of the 310 helical Pro138-Gly144 segment of human aquaporin-4 by olefin metathesis.
• Odlo, Kristin; Klaveness, Jo; Rongved, Pål & Hansen, Trond Vidar (2006). Synthesis and 15-LO inhibitory activity of triazoles derived from Combretastatin A-4. Vis sammendrag

  Combretastatins belong to a class of natural products isolated from the South African tree Combretum caffrum. This class of compounds has been identified as competitive inhibitors of the colchicine binding site on β-tubulin. One of the most active compounds in this class of natural products is combretastatin A-4 (1). The non-complex structures and high affinity of combretastatins for the colchicine binding site make the combretastatins attractive lead compounds in the development of new tubulin inhibitors. Thus, novel compounds derived from the combretastatin family are of interest as anticancer agents. We want to replace the olefinic moiety with a 1,4-disubstitiuted 1,2,3- triazole. Introduction of this 5-membered heterocycle will offer the following advantages: 1) no isomerization of the double bond 2) increased biological specificity since the trans isomer might be recognized by other cellular targets 3) introduction of a heterocyclic system may have improved therapeutic potential 4) enhanced stability since phenanthrene formation is avoided Furthermore, the presence of one or several phenolic hydroxyl groups and methyl ethers in the combretastatins spurred our interest in examining their ability to scavenge radicals and inhibit lipoxygenases, since radicals are important in the development of cancer and atherosclerosis.

• Odlo, Kristin; Klaveness, Jo; Rongved, Pål & Hansen, Trond Vidar (2005). Synthesis and biological activity of combretastatin derivatives. Vis sammendrag

  Combretastatins belong to a class of natural products isolated from the South African tree Combretum caffrum. This class of compounds has been identified as competitive inhibitors of the colchicine binding site on β-tubulin. The non-complex structures and high affinity of combretastatins for the colchicine binding site make the combretastatins attractive lead compounds in the development of new tubulin inhibitors. Thus, novel compounds derived from the combretastatin family are of interest as anticancer agents. Furthermore, the presence of one or several phenolic hydroxyl groups and methyl ethers in the combretastatins spurred our interest in examining their ability to scavenge radicals and inhibit lipoxygenases, since radicals are important in the development of cancer and atherosclerosis.

• Odlo, Kristin; Klaveness, Jo; Rongved, Pål & Hansen, Trond Vidar (2005). Synthesis of Combretastatin A-1 and B-1. Vis sammendrag

  The microtubules play an important role among cellular structures necessary to maintain growth and function of normal ang malignant cells since they are essential components of cell structure, and are involved in many important cellular processes including mitosis, morphogenesis, intracellular transport and secretion. Tubulin, the basic subunit of microtubules, is composed of an α,β-heterodimer. The polymerization of this heterodimer complex leads to microtubule formation. The binding of small molecules and other proteins to tubulin can result in the stabilization or destabilization of microtubule formation. Compounds such as taxoids and vinca alkaloids, which interact with the α-domains on tubulin, have been synthesized and evaluated as tubulin inhibitors. However, their complex structures and demanding syntheses have limited Structural Activity Studies (SAR). Furthermore, these structurally complex natural products exhibit limited bioavailability. Combretastatins belong to a class of natural products isolated from the South African tree Combretum caffrum. This class of compounds has been identified as competitive inhibitors of the colchicine binding site on β-tubulin. We wish to report an efficient synthesis of Combretastatin A-1 and B-1.

• Løiten, Marianne Sveaas; Fjærtoft, Berit & Klaveness, Jo (2001). Structure of a Series of Aromatic DTPA - Bisamides. Vis sammendrag

  A series of twelve diethylene triamine pentaacetic acid (DTPA)-bisamide chelates containing aromatic side chains have been synthesized. We have managed to crystallize six of them in order to study the packing patterns and compare similarities and differences due to changes in the substitution on the aromatic ring in the molecules.In order to design potential MRI contrast agents, corresponding gadolinium complexes of all synthesized chelates will be made and tested for relaxometric properties. (Formulae of the compoundds are given.)

• Gløgård, Christian; Hovland, Ragnar; Fossheim, Sigrid Lise; Aasen, Arne Jørgen & Klaveness, Jo (1999). Liposomal MR-Contrast Agents: -New Amphiphilic Gd-DO3A-derivatives.
• Gløgård, Christian; Stensrud, Gry; Hovland, Ragnar; Fossheim, Sigrid Lise & Klaveness, Jo (1999). Liposomal formulations of amphiphilic Gd-DO3A-derivatives.
• Hovland, Ragnar; Gløgård, Christian; Aasen, Arne Jørgen & Klaveness, Jo (1999). Amphiphilic Paramagnetic Chelates - MR-contrast agents for liposome membrane incorporation.
• Gløgård, Christian; Hovland, Ragnar; Fossheim, Sigrid Lise; Aasen, Arne Jørgen & Klaveness, Jo (1998). Preparation of lipophilic DO3A derivatives.
• Solberg, Jan; Redford, Keith; Rongved, Pål & Klaveness, Jo (1994). Polymere, biodegraderbare ved enzymkatalyse, for medisinske anvendelser. Kjemi. ISSN 0023-1983. 54(8), s. 26–27.
• Hauge, Emily; Olberg, Dag Erlend; Lien, Vegard Torp & Klaveness, Jo (2018). New 18F-labelled Selective c-Met Inhibitor; Synthesis, 18F-radiolabelling and Binding Affinity Studies of a New Selective c-Met Inhibitor for use in Positron Emission Tomography . 7Letras.
• Rise, Frode; Efskind, Jon; Falch-Pedersen, Mette Lene; Klaveness, Jo & Gunnes, Sølvi (2001). Kjell Undheim Symposium in Organic Chemistry 1-2 November 2001 University of Oslo, ISBN 82-996093-0-5. 7Letras. ISSN 82-996093-0-5.

Se alle arbeider i Cristin