Joseph Azumah

• Azumah, Joseph; Smistad, Gro & Hiorth, Marianne (2022). Preparation of stable polymer-liposome complexes by a novel approach employing a one-pot method. Colloids and Surfaces A: Physicochemical and Engineering Aspects. ISSN 0927-7757. 653. doi: 10.1016/j.colsurfa.2022.129924. Vis sammendrag

  The purpose of this study was to prepare stable polymer-liposome complexes using a new, improved one-pot method. Complexes prepared by the conventional method were used as reference. The one-pot method combines the vesicle formation and complexation with the polymer in a single step allowing for fewer steps compared to the conventional thin-film method followed by coating. This has the possibility of complexing the polymer on the surface and within the aqueous core of the liposomes. Soya phosphatidylcholine (SoyPC) in combination with different amounts of either dioleoyl trimethylammoniumpropane (DOTAP, positively charged) or egg phosphatidylglycerol (Egg PG, negatively charged) were complexed with alginate or chitosan, respectively. All the alginate-liposome complexes were larger compared to the naked liposomes and the zeta potential changed from positive to negative after complexation with the polymer. Polydispersity index (PDI) analysis showed narrow size distributions implying homogenous populations. The best stability was obtained by employing 20 mol% DOTAP in the membrane. This formulation was stable during the whole four months period when the stability test was performed. The chitosan-liposome complexes were generally difficult to extrude and were larger than the alginate-liposome complexes due to the need for a larger pore size in the membrane during extrusion. Based on these results, the one-pot method can be used for preparing stable alginate-liposome complexes. For the chitosan-liposome complexes alternative methods for size reduction should be investigated.

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• Azumah, Joseph; Smistad, Gro; Martinsen, Ørjan Grøttem & Hiorth, Marianne (2019). Development of alginate coated liposomes with potential of being used in treatment of dry mouth.
• Azumah, Joseph; Hiorth, Marianne; Smistad, Gro & Martinsen, Ørjan Grøttem (2019). Development of alginate and chitosan coated liposomes intended to use in the treatment of xerostomia.
• Azumah, Joseph; Hiorth, Marianne; Smistad, Gro & Martinsen, Ørjan Grøttem (2019). Alginate and chitosan coated liposomes intended for treatment of dry mouth.
• Hiorth, Marianne; Azumah, Joseph & Smistad, Gro (2019). The potential of polymer-coated liposomes for dental care .

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