Siste publikasjoner

• Nistelberger, Heidi Maria; Palsdottir, Albina Hulda; Star, Bastiaan; Leifsson, Rúnar; Gondek, Agata Teresa; Orlando, Ludovic; Barrett, James H.; Hallsson, Jón Hallsteinn & Boessenkool, Sanne (2019). Sexing Viking Age horses from burial and non-burial sites in Iceland using ancient DNA. Journal of Archaeological Science.  ISSN 0305-4403.  101, s 115- 122 . doi: https://doi.org/10.1016/j.jas.2018.11.007 Vis sammendrag

  Horses are the most common grave goods found in Icelandic Viking Age graves. Horse skeletons have previously been sexed based on pelvis shape and the presence of canine teeth in male horses over 4–5 years of age. Morphological data has shown that all horses from Icelandic burials that were amenable to sexing were male. Yet the use of morphological methods to determine sex is problematic since they rely on finding a well-preserved pelvis and/or robust canine teeth. Furthermore, quantitative data underlying the features of the horse pelvis used for sexing is lacking and canine teeth have been reported to occur in mares. In this study we build upon and extend recently developed methodologies to make use of shotgun sequencing of ancient DNA (aDNA) for molecular sexing of Viking Age horse remains. With minimal sequencing effort we identified the sex of the largest collection (n = 22) of Viking Age Icelandic horses studied to date, sourced from both burial (n = 19) and non-burial (n = 3) sites. Our results revealed a male to female sex bias ratio of 18:1 in burial sites, versus 0:3 in non-burial sites. These findings support the significant over-representation of male horses in Viking Age graves in Iceland, yet show that –albeit rare– mares could also be selected for ritual burial in Viking Age Iceland. This cost-effective method provides statistical confidence to allow for sexing of highly fragmented archaeological specimens with low endogenous DNA content.

• Gutema, Tariku Mekonnen; Atickem, Anagaw Meshesha; Bekele, Afework; Sillero-Zubiri, Claudio; Kasso, Mohammed; Alemu, Diress Tsegaye; Venkataraman, Vivek V.; Fashing, Peter; Zinner, Dietmar & Stenseth, Nils Christian (2018). Competition between sympatric wolf taxa: An example involving African and Ethiopian wolves. Royal Society Open Science.  ISSN 2054-5703.  5:172207(5), s 1- 9 . doi: 10.1098/rsos.172207
• Liu, Yingxin; Agthe, Michael; Salajkova, Michaela; Gordeyeva, Korneliya; Guccini, Valentina; Fall, Andreas; Salazar-Alvarez, German; Schutz, Christina & Bergström, Lennart (2018). Assembly of cellulose nanocrystals in a levitating drop probed by time-resolved small angle X-ray scattering. Nanoscale.  ISSN 2040-3364.  10(38), s 18113- 18118 . doi: 10.1039/c8nr05598j
• Angelini, Jindriska; Vosolsobe, Stanislav; Skupa, Petr; Ho, Angela Yeuan Yen; Bellinvia, Erica; Valentova, Olga & Marc, Jan (2018). Phospholipase Dδ assists to cortical microtubule recovery after salt stress. Protoplasma.  ISSN 0033-183X.  255(4), s 1195- 1204 . doi: 10.1007/s00709-018-1204-6
• Wang, Yu; Wang, Ziyi; Yu, Wenyang; Sheng, Xia; Zhang, Haolin; Han, Yingying; Yuan, Zhengrong & Weng, Qiang (2018). Seasonal expressions of androgen receptor, estrogen receptors and cytochrome P450 aromatase in the uteri of the wild daurian ground squirrels (Spermophilus dauricus). European journal of histochemistry.  ISSN 1121-760X.  62(1), s 75- 82 . doi: 10.4081/ejh.2018.2889
• Gomez, Alvin; Bindesbøll, Christian; Somisetty, Venkata Satheesh; Grimaldi, Giulia; Hutin, David; MacPherson, Laura; Ahmed, Shaimaa; Tamblyn, Laura; Cho, Tiffany; Nebb, Hilde Irene; Moen, Anders; Anonsen, Jan Haug; Grant, Denis M & Matthews, Jason (2018). Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity. Biochemical Journal.  ISSN 0264-6021.  475(23), s 3827- 3846 . doi: 10.1042/BCJ20180347 Vis sammendrag

  Here we report the biochemical characterization of the mono-ADP-ribosyltransferase 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) poly-ADP-ribose-polymerase (TIPARP/ARTD14/PARP7), which is known to repress aryl hydrocarbon receptor (AHR)-dependent transcription. We found that the nuclear localization of TIPARP was dependent on a short N-terminal sequence and its zinc finger domain. Deletion and in vitro ADP-ribosylation studies identified amino acids 400- 657 as the minimum catalytically active region, which retained its ability to mono-ADPribosylate AHR. However, the ability of TIPARP to ADP-ribosylate and repress AHR in cells was dependent on both its catalytic activity and zinc-finger domain. The catalytic activity of TIPARP was resistant to meta-iodobenzylguanidine but sensitive to iodoacetamide and hydroxylamine, implicating cysteines and acidic side chains as ADP-ribosylated target residues. Mass spectrometry identified multiple ADP-ribosylated peptides in TIPARP and AHR. Electron transfer dissociation analysis of the TIPARP peptide 33ITPLKTCFK41 revealed cysteine 39 as a site for mono-ADP-ribosylation. Mutation of cysteine 39 to alanine resulted in a small, but significant, reduction in TIPARP auto-ribosylation activity, suggesting that additional amino acid residues are modified, but loss of cysteine 39 did not prevent its ability to repress AHR. Our findings characterize the subcellular localization and mono-ADP-ribosyltransferase activity of TIPARP, identify cysteine as a mono-ADP-ribosylated residue targeted by this enzyme, and confirm the TIPARP-dependent mono-ADP-ribosylation of other protein targets, such as AHR

• Ryvarden, Leif & Spirin, Slava (2018). : Studies in Aphyllophorales of Africa 21: Some corticoid species from Ethiopia .. Synopsis fungorum.  ISSN 0802-8966.  38, s 5- 8
• Ryvarden, Leif (2018). Studies in Aphyllophorales of Africa 26: The genus Tyromyceas. Synopsis fungorum.  ISSN 0802-8966.  38, s 33- 40
• Ryvarden, Leif (2018). Studies in Aphyllophorales of Africa 25: New poroid species from East and Central Africa. Synopsis fungorum.  ISSN 0802-8966.  38, s 26- 32
• Ryvarden, Leif (2018). Studies in Aphyllophorales of Africa 24 A first checklist of Polypores from Mozambique. Synopsis fungorum.  ISSN 0802-8966.  38, s 21- 25
• Ryvarden, Leif (2018). Studies in Aphyllophorales of Africa 23: Some new species of Ceriporiopsis and Diplomitoporus. Synopsis fungorum.  ISSN 0802-8966.  38, s 12- 19
• Ryvarden, Leif (2018). Studies in Aphyllophorales of Africa 22: A first checklist of polypores from Malawi. Synopsis Fung. 38:9-11. Synopsis fungorum.  ISSN 0802-8966.  38, s 9- 11
• Skre, Oddvar; Karlsen, Stein Rune; Riseth, Jan Åge & Wielgolaski, Frans Emil (2018). Consequences of Future Expansion at the Arctic Treeline in Northernmost Norway.. Journal of Agricultural Science and Technology: B.  ISSN 2161-6264.  8(3), s 195- 202 . doi: 10.17265/2161-6264/2018.03.006
• Dobrovolska, Olena; Brilkov, Maxim; Ødegård‑Fougner, Øyvind; Aasland, Rein & Halskau, Øyvind (2018). 1H, 13C, and 15N resonance assignments of CW domain of the N-methyltransferase ASHH2 free and bound to the mono-, di- and tri-methylated histone H3 tail peptides. Biomolecular NMR Assignments.  ISSN 1874-2718.  12(1), s 215- 220 . doi: 10.1007/s12104-018-9811-x
• Van Driessche, Alexandra; Kocere, Agnese; Everaert, Hannelien; Nuhn, Lutz; Van Herck, Simon; Griffiths, Gareth Wyn; Fenaroli, Federico & De Geest, Bruno G. (2018). PH-Sensitive Hydrazone-Linked Doxorubicin Nanogels via Polymeric-Activated Ester Scaffolds: Synthesis, Assembly, and in Vitro and in Vivo Evaluation in Tumor-Bearing Zebrafish. Chemistry of Materials.  ISSN 0897-4756. . doi: 10.1021/acs.chemmater.8b03702
• Crous, P.W.; Brandrud, Tor Erik; Dima, Bálint; Bendiksen, Egil; Ryvarden, Leif; Luangsa-ard, J.J.; Wingfield, M.J.; Carnegie, A.J. & Blair, J.E. (2018). Fungal Planet description sheets: 785– 867. Persoonia.  ISSN 0031-5850.  41 . doi: 10.3767/persoonia.2018.41.12 Fulltekst i vitenarkiv. Vis sammendrag

  Novel species of fungi described in this study include those from various countries as follows: Angola, Gnomoniopsis angolensis and Pseudopithomyces angolensis on unknown host plants. Australia, Dothiora corymbiae on Corymbia citriodora, Neoeucasphaeria eucalypti (incl. Neoeucasphaeria gen. nov.) on Eucalyptus sp., Fumagopsis stellae on Eucalyptus sp., Fusculina eucalyptorum (incl. Fusculinaceae fam. nov.) on Eucalyptus socialis, Harknessia corymbiicola on Corymbia maculata, Neocelosporium eucalypti (incl. Neocelosporium gen. nov., Neocelosporiaceae fam. nov. and Neocelosporiales ord. nov.) on Eucalyptus cyanophylla, Neophaeomoniella corymbiae on Corymbia citriodora, Neophaeomoniella eucalyptigena on Eucalyptus pilularis, Pseudoplagiostoma corymbiicola on Corymbia citriodora, Teratosphaeria gracilis on Eucalyptus gracilis, Zasmidium corymbiae on Corymbia citriodora. Brazil, Calonectria hemileiae on pustules of Hemileia vastatrix formed on leaves of Coffea arabica, Calvatia caatinguensis on soil, Cercospora solani-betacei on Solanum betaceum, Clathrus natalensis on soil, Diaporthe poincianellae on Poincianella pyramidalis, Geastrum piquiriunense on soil, Geosmithia carolliae on wing of Carollia perspicillata, Henningsia resupinata on wood, Penicillium guaibinense from soil, Periconia caespitosa from leaf litter, Pseudocercospora styracina on Styrax sp., Simplicillium filiforme as endophyte from Citrullus lanatus, Thozetella pindobacuensis on leaf litter, Xenosonderhenia coussapoae on Coussapoa floccosa. Canary Islands (Spain), Orbilia amarilla on Euphorbia canariensis. Cape Verde Islands, Xylodon jacobaeus on Eucalyptus camaldulensis. Chile, Colletotrichum arboricola on Fuchsia magellanica. Costa Rica, Lasiosphaeria miniovina on tree branch. Ecuador, Ganoderma chocoense on tree trunk. France, Neofitzroyomyces nerii (incl. Neofitzroyomyces gen. nov.) on Nerium oleander. Ghana, Castanediella tereticornis on Eucalyptus tereticornis, Falcocladium africanum on Eucalyptus brassiana, Rachicladosporium corymbiae on Corymbia citriodora. Hungary, Entoloma silvae-frondosae in Carpinus betulus-Pinus sylvestris mixed forest. Iran, Pseudopyricularia persiana on Cyperus sp. Italy, Inocybe roseascens on soil in mixed forest. Laos, Ophiocordyceps houaynhangensis on Coleoptera larva. Malaysia, Monilochaetes melastomae on Melastoma sp. Mexico, Absidia terrestris from soil. Netherlands, Acaulium pannemaniae, Conioscypha boutwelliae, Fusicolla septimanifiniscientiae, Gibellulopsis simonii, Lasionectria hilhorstii, Lectera nordwiniana, Leptodiscella rintelii, Parasarocladium debruynii and Sarocladium dejongiae (incl. Sarocladiaceae fam. nov.) from soil. New Zealand, Gnomoniopsis rosae on Rosa sp. and Neodevriesia metrosideri on Metrosideros sp. Puerto Rico, Neodevriesia coccolobae on Coccoloba uvifera, Neodevriesia tabebuiae and Alfaria tabebuiae on Tabebuia chrysantha. Russia, Amanita paludosa on bogged soil in mixed deciduous forest, Entoloma tiliae in forest of Tilia × europaea, Kwoniella endophytica on Pyrus communis. South Africa, Coniella diospyri on Diospyros mespiliformis, Neomelanconiella combreti (incl. Neomelanconiellaceae

• Kletting, Stephanie; Barthold, Sarah; Repnik, Urska; Griffiths, Gareth; Loretz, Brigitta; Schneider-Daum, Nicole; De Souza Carvalho-Wodarz, Cristiane & Lehr, Claus-Michael (2018). Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines. Altex.  ISSN 1868-596X.  35(2), s 211- 222 . doi: 10.14573/altex.1607191
• Cristofari, Robin; Liu, Xiaoming; Bonadonna, Francesco; Cherel, Yves; Pistorius, Pierre; Le Maho, Yvon; Raybaud, Virginie; Stenseth, Nils Christian; Le Bohec, Celine & Trucchi, Emiliano (2018). Climate-driven range shifts of the king penguin in a fragmented ecosystem. Nature Climate Change.  ISSN 1758-678X.  8(3), s 245- 251 . doi: 10.1038/s41558-018-0084-2
• Piredda, Roberta; Claverie, Jean-Michel; Decelle, Johan; de Vargas, Colomban; Dunthorn, Micah; Edvardsen, Bente; Eikrem, Wenche; Forster, D.; Koistra, Wiebe; Logares, Ramiro; Massana, Ramón; Montresor, Marina; Not, Fabrice; Ogata, Hiroyuki; Pawlowski, Jan M.; Romac, Sarah; Sarno, Diana; Stoeck, Thorsten & Zingone, Adriana (2018). Diatom diversity through HTS-metabarcoding in coastal European seas. Scientific Reports.  ISSN 2045-2322.  8(1), s 8:18059 . doi: 10.1038/s41598-018-36345-9 Vis sammendrag

  Diatoms constitute a diverse lineage of unicellular organisms abundant and ecologically important in aquatic ecosystems. Compared to other protists, their biology and taxonomy are well-studied, offering the opportunity to combine traditional approaches and new technologies. We examined a dataset of diatom 18S rRNA- and rDNA- (V4 region) reads from different plankton size-fractions and sediments from six European coastal marine sites, with the aim of identifying peculiarities and commonalities with respect to the whole protistan community. Almost all metabarcodes (99.6%) were assigned to known genera (121) and species (236), the most abundant of which were those already known from classic studies and coincided with those seen in light microscopy. rDNA and rRNA showed comparable patterns for the dominant taxa, but rRNA revealed a much higher diversity particularly in the sediment communities. Peculiar to diatoms is a tight bentho-pelagic coupling, with many benthic or planktonic species colonizing both water column and sediments and the dominance of planktonic species in both habitats. Overall metabarcoding results reflected the marked specificity of diatoms compared to other protistan groups in terms of morphological and ecological characteristics, at the same time confirming their great potential in the description of protist communities.

• Gutnik, Silvia; Thomas, Yann; Guo, Yanwu; Stoecklin, Janosch; Neagu, Anca; Pintard, Lionel; Merlet, Jorge & Ciosk, Rafal (2018). PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain.. Biology Open.  ISSN 2046-6390.  7(7) . doi: 10.1242/bio.034066
• Dallenga, Tobias; Linnemann, Lara; Paudyal, Bhesh; Repnik, Urska; Griffiths, Gareth Wyn & Schaible, Ulrich E. (2018). Targeting neutrophils for host-directed therapy to treat tuberculosis. International Journal of Medical Microbiology.  ISSN 1438-4221.  308(1), s 142- 147 . doi: 10.1016/j.ijmm.2017.10.001
• Zhang, Kaiyi; Griffiths, Gareth Wyn; Repnik, Urska & Hornef, Mathias (2018). Seeing is understanding: Salmonella's way to penetrate the intestinal epithelium. International Journal of Medical Microbiology.  ISSN 1438-4221.  308(1), s 97- 106 . doi: 10.1016/j.ijmm.2017.09.011
• Blaxland, Kim; Ballard, Harvey E. & Marcussen, Thomas (2018). Viola pluviae sp. nov. (Violaceae), a member of subsect. Stolonosae in the Pacific Northwest region of North America. Nordic Journal of Botany.  ISSN 0107-055X.  36(9) . doi: 10.1111/njb.01931
• Lode, Torben; Heuschele, Jan David; Andersen, Tom; Titelman, Josefin; Hylland, Ketil & Borgå, Katrine (2018). Predation Risk Potentiates Toxicity of a Common Metal Contaminant in a Coastal Copepod. Environmental Science and Technology.  ISSN 0013-936X.  52(22), s 13535- 13542 . doi: 10.1021/acs.est.8b03685
• Müller, Elisabeth; Speth, Martin; Christopoulos, Panagiotis; Lunde, Anna; Avdagic, Ajna; Øynebråten, Inger & Corthay, Alexandre (2018). Both type I and type II interferons can activate antitumor M1 macrophages when combined with TLR stimulation. Frontiers in Immunology.  ISSN 1664-3224.  9, s 1- 16 . doi: 10.3389/fimmu.2018.02520
• Tran, Trung; Bollineni, Ravi Chand; Koehler, Christian & Thiede, Bernd (2018). Absolute two-point quantification of proteins using dimethylated proteotypic peptides. The Analyst.  ISSN 0003-2654.  143(18), s 4359- 4365 . doi: 10.1039/c8an01081a
• Brydegaard, Mikkel; Jansson, Samuel; Schulz, Marcus & Runemark, Anna (2018). Can the narrow red bands of dragonflies be used to perceive wing interference patterns?. Ecology and Evolution.  ISSN 2045-7758.  8(11), s 5369- 5384 . doi: 10.1002/ece3.4054
• Markworth, James F.; D'Souza, Randall F.; Aasen, Kirsten M.M.; Mitchell, Sarah M.; Durainayagam, Brenan R.; Sinclair, Andrew J.; Peake, Jonathan M.; Egner, Ingrid Marie; Raastad, Truls; Cameron-Smith, David & Mitchell, Cameron J. (2018). Arachidonic acid supplementation transiently augments the acute inflammatory response to resistance exercise in trained men. Journal of applied physiology.  ISSN 8750-7587.  125(2), s 271- 286 . doi: 10.1152/japplphysiol.00169.2018 Vis sammendrag

  Strenuous exercise can result in skeletal muscle damage, leading to the systemic mobilization, activation, and intramuscular accumulation of blood leukocytes. Eicosanoid metabolites of arachidonic acid (ARA) are potent inflammatory mediators, but whether changes in dietary ARA intake influence exercise-induced inflammation is not known. This study investigated the effect of 4 wk of dietary supplementation with 1.5 g/day ARA (n = 9, 24 ± 1.5 yr) or corn-soy oil placebo (n = 10, 26 ± 1.3 yr) on systemic and intramuscular inflammatory responses to an acute bout of resistance exercise (8 sets each of leg press and extension at 80% one-repetition maximum) in previously trained men. Whole EDTA blood, serum, peripheral blood mononuclear cells (PMBCs), and skeletal muscle biopsies were collected before exercise, immediately postexercise, and at 2, 4, and 48 h of recovery. ARA supplementation resulted in higher exercise-stimulated serum creatine kinase activity [incremental area under the curve (iAUC) P = 0.046] and blood leukocyte counts (iAUC for total white cells, P < 0.001; neutrophils: P = 0.007; monocytes: P = 0.015). The exercise-induced fold change in peripheral blood mononuclear cell mRNA expression of interleukin-1β (IL1B), CD11b (ITGAM), and neutrophil elastase (ELANE), as well as muscle mRNA expression of the chemokines interleukin-8 (CXCL8) and monocyte chemoattractant protein 1 (CCL2) was also greater in the ARA group than placebo. Despite this, ARA supplementation did not influence the histological presence of leukocytes within muscle, perceived muscle soreness, or the extent and duration of muscle force loss. These data show that ARA supplementation transiently increased the inflammatory response to acute resistance exercise but did not impair recovery.

• Hozumi, Aya; Hong, Pei-Ying; Kaartvedt, Stein; Røstad, Anders & Jones, Burton H. (2018). Water quality, seasonality, and trajectory of an aquaculture-wastewater plume in the Red Sea. Aquaculture Environment Interactions.  ISSN 1869-215X.  10, s 61- 77 . doi: 10.3354/AEI00254
• Stange, Madlen; Sanchez-Villagra, Marcelo R; Salzburger, Walter & Matschiner, Michael (2018). Bayesian divergence-time estimation with genome-wide single-nucleotide polymorphism data of sea catfishes (Ariidae) supports miocene closure of the Panamanian Isthmus. Systematic Biology.  ISSN 1063-5157.  67(4), s 681- 699 . doi: 10.1093/sysbio/syy006
• Atickem, Anagaw Meshesha; Stenseth, Nils Christian; Drouilly, Marine; Bock, Steffen; Roos, Christian & Zinner, Dietmar (2018). Deep divergence among mitochondrial lineages in African jackals. Zoologica Scripta.  ISSN 0300-3256.  47(1), s 1- 8 . doi: 10.1111/zsc.12257
• Wilson, Maria; Haga, Jens Ådne Rekkedal & Karlsen, Hans Erik (2018). Behavioural responses to infrasonic particle acceleration in cuttlefish. Journal of Experimental Biology.  ISSN 0022-0949.  221, s 1- 10 . doi: 10.1242/jeb.166074
• Agostini, Antonio; Brunetti, Marta; Davidson, Ben; Tropé, Claes Gøran; Heim, Sverre; Panagopoulos, Ioannis & Micci, Francesca (2018). Identification of novel cyclin gene fusion transcripts in endometrioid ovarian carcinomas. International Journal of Cancer.  ISSN 0020-7136.  143(6), s 1379- 1387 . doi: 10.1002/ijc.31418 Fulltekst i vitenarkiv.
• Nilsen, Jeannette; Bern, Malin C.; Sand, Kine Marita Knudsen; Grevys, Algirdas; Dalhus, Bjørn; Sandlie, Inger & Andersen, Jan Terje (2018). Human and mouse albumin bind their respective neonatal Fc receptors differently. Scientific Reports.  ISSN 2045-2322.  8:14648, s 1- 12 . doi: 10.1038/s41598-018-32817-0 Fulltekst i vitenarkiv.
• Gundersen, Kristian; Bruusgaard, Jo C.; Egner, Ingrid Marie; Eftestøl, Einar & Bengtsen, Mads (2018). Muscle memory: virtues of your youth?. Journal of Physiology.  ISSN 0022-3751.  596(18), s 4289- 4290 . doi: 10.1113/JP276354
• Grabowski, Mark Walter; Hatala, Kevin G. & Jungers, William L. (2018). Body mass estimates of the earliest possible hominins and implications for the last common ancestor. Journal of Human Evolution.  ISSN 0047-2484.  122, s 84- 92 . doi: 10.1016/j.jhevol.2018.05.001
• Calleja, Maria Ll; Ansari, Mohd I; Røstad, Anders; Silva, Luis; Kaartvedt, Stein; Irigoien, Xabier & Moran, Xose Anxelu G (2018). The mesopelagic scattering layer: A hotspot for heterotrophic prokaryotes in the Red Sea twilight zone. Frontiers in Marine Science.  ISSN 2296-7745.  5 . doi: 10.3389/fmars.2018.00259
• Winje, Ivan; Sheng, Xia; Hansson, Kenth-Arne; Solbrå, Andreas Våvang; Tennøe, Simen; Saatcioglu, Fahri; Bruusgaard, Jo C. & Gundersen, Kristian (2018). Cachexia does not induce loss of myonuclei or muscle fibres during xenografted prostate cancer in mice. Acta Physiologica.  ISSN 1748-1708.  s 1- 9 . doi: 10.1111/apha.13204
• Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher & Linke, Dirk (2018). pYR4 From a Norwegian Isolate of Yersinia ruckeri Is a Putative Virulence Plasmid Encoding Both a Type IV Pilus and a Type IV Secretion System. Frontiers in Cellular and Infection Microbiology.  ISSN 2235-2988.  8, s 1- 14 . doi: 10.3389/fcimb.2018.00373 Vis sammendrag

  Enteric redmouth disease caused by the pathogen Yersinia ruckeri is a significant problem for fish farming around the world. Despite its importance, only a few virulence factors of Y. ruckeri have been identified and studied in detail. Here, we report and analyze the complete DNA sequence of pYR4, a plasmid from a highly pathogenic Norwegian Y. ruckeri isolate, sequenced using PacBio SMRT technology. Like the well-known pYV plasmid of human pathogenic Yersiniae, pYR4 is a member of the IncFII family. Thirty-one percent of the pYR4 sequence is unique compared to other Y. ruckeri plasmids. The unique regions contain, among others genes, a large number of mobile genetic elements and two partitioning systems. The G+C content of pYR4 is higher than that of the Y. ruckeri NVH_3758 genome, indicating its relatively recent horizontal acquisition. pYR4, as well as the related plasmid pYR3, comprises operons that encode for type IV pili and for a conjugation system (tra). In contrast to other Yersinia plasmids, pYR4 cannot be cured at elevated temperatures. Our study highlights the power of PacBio sequencing technology for identifying mis-assembled segments of genomic sequences. Comparative analysis of pYR4 and other Y. ruckeri plasmids and genomes, which were sequenced by second and the third generation sequencing technologies, showed errors in second generation sequencing assemblies. Specifically, in the Y. ruckeri 150 and Y. ruckeri ATCC29473 genome assemblies, we mapped the entire pYR3 plasmid sequence. Placing plasmid sequences on the chromosome can result in erroneous biological conclusions. Thus, PacBio sequencing or similar long-read methods should always be preferred for de novo genome sequencing. As the tra operons of pYR3, although misplaced on the chromosome during the genome assembly process, were demonstrated to have an effect on virulence, and type IV pili are virulence factors in many bacteria, we suggest that pYR4 directly contributes to Y. ruckeri virulence.

• Buccino, Alessio Paolo; Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Häfliger, Philipp; Fyhn, Marianne & Hafting, Torkel (2018). Open source modules for tracking animal behavior and closed-loop stimulation based on Open Ephys and Bonsai. Journal of Neural Engineering.  ISSN 1741-2560.  15, s 1- 12 . doi: 10.1088/1741-2552/aacf45 Fulltekst i vitenarkiv.
• Nørstrud, Karoline Sletbak; Vindas, Marco; Nilsson, Göran Erik & Johansen, Ida Beitnes (2018). Short-term cortisol exposure alters cardiac hypertrophic and non-hypertrophic signalling in a time-dependent manner in rainbow trout. Biology Open.  ISSN 2046-6390.  7, s 1- 9 . doi: 10.1242/bio.037853 Fulltekst i vitenarkiv. Vis sammendrag

  Cardiac disease is a growing concern in farmed animals, and stress has been implicated as a factor for myocardial dysfunction and mortality in commercial fish rearing. We recently showed that the stress hormone cortisol induces pathological cardiac remodelling in rainbow trout. Wild and farmed salmonids are exposed to fluctuations and sometimes prolonged episodes of increased cortisol levels. Thus, studying the timeframe of cortisol-induced cardiac remodelling is necessary to understand its role in the pathogenesis of cardiovascular disease in salmonids. We here establish that 3 weeks of cortisol exposure is sufficient to increase relative ventricular mass (RVM) by 20% in rainbow trout. Moreover, increased RVMs are associated with altered expression of hypertrophic and non-hypertrophic remodelling markers. Further, we characterised the time course of cortisol-induced cardiac remodelling by feeding rainbow trout cortisol-containing feed for 2, 7 and 21 days. We show that the effect of cortisol on expression of hypertrophic and non-hypertrophic remodelling markers is time-dependent and in some cases acute. Our data indicate that short-term stressors and life cycle transitions associated with elevated cortisol levels can potentially influence hypertrophic and non-hypertrophic remodelling of the trout heart.

• Buccino, Alessio Paolo; Kordovan, Michael; Ness, Torbjørn V; Merkt, Benjamin; Häfliger, Philipp; Fyhn, Marianne; Cauwenberghs, Gert; Rotter, Stefan & Einevoll, Gaute (2018). Combining biophysical modeling and deep learning for multielectrode array neuron localization and classification. Journal of Neurophysiology.  ISSN 0022-3077.  120(3), s 1212- 1232 . doi: 10.1152/jn.00210.2018 Fulltekst i vitenarkiv.
• Khezri, Abdolrahman; Jusdado, Juan German Herranz; Ropstad, Erik & Fraser, Thomas (2018). Mycotoxins induce developmental toxicity and behavioural aberrations in zebrafish larvae. Environmental Pollution.  ISSN 0269-7491.  242, s 500- 506 . doi: 10.1016/j.envpol.2018.07.010 Vis sammendrag

  Mycotoxins are secondary metabolites produced by varieties of fungi that contaminate food and feed resources and are capable of inducing a wide range of toxicity. In the current study, we investigated developmental and behavioural toxicity in zebrafish larvae after exposure to six different mycotoxins; ochratoxin A (OTA), type A trichothecenes mycotoxin (T-2 toxin), type B trichothecenes mycotoxin (deoxynivalenol - DON), and zearalenone (ZEN) and its metabolites alpha-zearalenol (α-ZOL) and beta-zearalenol (β-ZOL). Developmental defects, hatching time, and survival were monitored until 96 h post fertilisation (hpf). The EC50, LC50, and IC50 values were calculated. Subsequently, to assess behavioural toxicity, new sets of embryos were exposed to a series of non-lethal doses within the range of environmental and/or developmental concern. Results indicated that all the tested mycotoxins were toxic, they all induced developmental defects, and with the exception of OTA, all affected hatching time. Behavioural effects were only observed following exposure to OTA and ZEN and its metabolites, α ZOL and β ZOL. These results demonstrate that mycotoxins are teratogenic and can influence behaviour in a vertebrate model.

• Rowlands, Daire; Lensjø, Kristian Kinden; Dinh, Tovy; Yang, Sujeon; Andrews, Melissa; Hafting, Torkel; Fyhn, Marianne; Fawcett, James W. & Dick, Gunnar (2018). Aggrecan directs extracellular matrix mediated neuronal plasticity. Journal of Neuroscience.  ISSN 0270-6474. . doi: 10.1523/JNEUROSCI.1122-18.2018 Vis sammendrag

  In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains elusive. Here, we genetically targeted the Acan gene encoding for aggrecan utilizing a novel animal model. This allowed for conditional and targeted loss of aggrecan in vivo, which ablated the PNN structure and caused a shift in the population of parvalbumin expressing inhibitory interneurons towards a high plasticity state. Selective deletion of the Acan gene in the visual cortex of male adult mice reinstated juvenile ocular dominance plasticity, which was mechanistically identical to critical period plasticity. Brain-wide targeting improved object recognition memory.

• Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Halabelian, Levon; Nilges, Benedikt S.; Pinto, Rita; Kudithipudi, Srikanth; Munk, Stephanie; Davydova, Erna; Zuhairi, Fawsi Rahmadiyan; Arrowsmith, Cheryl H; Jeltsch, Albert; Leidel, Sebastian A.; Olsen, Jesper V. & Falnes, Pål Øystein (2018). The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nature Communications.  ISSN 2041-1723.  9:3411, s 1- 15 . doi: 10.1038/s41467-018-05646-y
• Schistad, Ellina Iordanova; Bjorland, Siri; Røe, Cecilie; Gjerstad, Johannes; Vetti, Nils; Myhre, Kjersti & Espeland, Ansgar (2018). Five-year development of lumbar disc degeneration—a prospective study. Skeletal Radiology.  ISSN 0364-2348.  s 1- 9 . doi: 10.1007/s00256-018-3062-x
• Bråte, Inger Lise N; Hurley, Rachel; Iversen, Karine; Beyer, Jonny; Thomas, Kevin V; Steindal, Calin C; Green, Norman W; Olsen, Marianne & Lusher, Amy (2018). Mytilus spp. as sentinels for monitoring microplastic pollution in Norwegian coastal waters: A qualitative and quantitative study. Environmental Pollution.  ISSN 0269-7491.  243(A), s 383- 393 . doi: 10.1016/j.envpol.2018.08.077 Fulltekst i vitenarkiv. Vis sammendrag

  Microplastic (MP) contamination is ubiquitous in the environment and many species worldwide have been shown to contain MP. The ecological impact of MP pollution is still unknown, thus there is an urgent need for more knowledge. One key task is to identify species suitable as sentinels for monitoring in key eco-compartments, such as coastal waters. In Norway, mussels (Mytilus spp.) have been monitored for hazardous contaminants through OSPAR since 1981. Norway has the longest coastline in Europe and adding MP to the Norwegian Mussel Watch is therefore important in a European and global context. The present study reports MP data in mussels (332 specimens) collected from multiple sites (n = 15) spanning the whole Norwegian coastline. MPs were detected at all locations, except at one site on the west coast. Among the most surprising findings, mussels from the Barents Sea coastline in the Finnmark region, contained significantly more MPs than mussels from most of the southern part of the country, despite the latter sites being located much closer to major urban areas. Only mussels from a site located very close to Oslo, the capital, contained levels similar to those observed in the remote site in Finnmark. In total an average of 1.5 (±2.3) particles ind−1 and 0.97 (±2.61) particles w.w. g−1 was found. The most common MPs were <1 mm in size, and fibres accounted for 83% of particles identified, although there was inter-site variability. Thirteen different polymeric groups were identified; cellulosic being the most common and black rubbery particles being the second. This study suggests Mytilus spp. are suitable for semi-quantitative and qualitatively monitoring of MPs in coastal waters. However, some uncertainties remain including mussel size as a confounding factor that may influence ingestion, the role of depuration and other fate related processes, and this call for further research.

• Gamelon, Marlène; Tufto, Jarle; Nilsson, Anna; Jerstad, Kurt; Røstad, Ole Wiggo; Stenseth, Nils Christian & Sæther, Bernt-Erik (2018). Environmental drivers of varying selective optima in a small passerine: A multivariate, multiepisodic approach. Evolution.  ISSN 0014-3820.  72(11), s 2325- 2342 . doi: 10.1111/evo.13610
• Fenaroli, Federico; Repnik, Urska; Xu, Yitian; Johann, Kerstin; Van Herck, Simon; Dey, Pradip; Skjeldal, Frode Miltzow; Frei, Dominik Michael; Fam, Shahla Bagheri; Kocere, Agnese; Haag, Rainer; De Geest, Bruno G.; Barz, Matthias; Russell, David G. & Griffiths, Gareth Wyn (2018). Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models. ACS Nano.  ISSN 1936-0851.  s 8646- 8661 . doi: 10.1021/acsnano.8b04433
• Valegård, Karin; Andralojc, P. John; Haslam, Richard P.; Pearce, F. Grant; Eriksen, Gunilla Kristina; Madgwick, Pippa J.; Kristoffersen, Anne Karin; van Lun, Michiel; Klein, Uwe; Eilertsen, Hans Christian; Parry, Martin A.J. & Andersson, Inger (2018). Structural and functional analyses of Rubisco from arctic diatom species reveal unusual posttranslational modifications. Journal of Biological Chemistry.  ISSN 0021-9258.  293(34), s 13033- 13043 . doi: 10.1074/jbc.RA118.003518
• Philipp, Marianne; Hansen, Kjersti; Monrad, Dorte; Adsersen, Henning; Bruun, Hans Henrik & Nordal, Inger (2018). Hidden biodiversity in the Arctic – a study of soil seed banks at Disko Island, Qeqertarsuaq, West Greenland. Nordic Journal of Botany.  ISSN 0107-055X.  26(7), s 1- 12 . doi: 10.1111/njb.01721
• Berntsen, Hanne Friis; Bjørklund, Cesilie Granum; Strandabø, Rønnaug; Haug, Trude; Moldes-Anaya, Angel; Fuentes-Lazaro, Judit; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Tasker, R. Andrew & Ropstad, Erik (2018). PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons. Toxicology and Applied Pharmacology.  ISSN 0041-008X.  357, s 19- 32 . doi: 10.1016/j.taap.2018.08.015
• Gudim, Ingvild; Hammerstad, Marta; Lofstad, Marie & Hersleth, Hans-Petter (2018). Characterization of different flavodoxin reductase-flavodoxin (FNR-Fld) interactions reveals an efficient FNR-Fld redox pair and identifies a novel FNR subclass. Biochemistry.  ISSN 1520-4995.  57(37), s 5427- 5436 . doi: 10.1021/acs.biochem.8b00674
• Rodriguez- Castañeda, Fernando; Lemma, Roza Berhanu; Cuervo Torre, Ignacio; Bengtsen, Mads; Moen, Lisa Marie; Ledsaak, Marit; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2018). The SUMO protease SENP1 and the chromatin remodeller CHD3 interact and jointly affect chromatin accessibility and gene expression. Journal of Biological Chemistry.  ISSN 0021-9258.  293(40), s 15439- 15454 . doi: 10.1074/jbc.RA118.002844 Vis sammendrag

  The small ubiquitin-like modifier (SUMO) post-translationally modifies lysine residues of transcription factors and co-regulators and thereby contributes to an important layer of control of the activities of these transcriptional regulators. Likewise, deSUMOylation of these factors by the sentrin-specific proteases (SENPs) also plays a role in gene regulation, but whether SENPs functionally interact with other regulatory factors that control gene expression is unclear. In the present work, we focused on SENP1, specifically, on its role in activation of gene expression investigated through analysis of the SENP1 interactome, which revealed that SENP1 physically interacts with the chromatin remodeler chromodomain helicase DNA-binding protein 3 (CHD3). Using several additional methods, including GST pull-down and co-immunoprecipitation assays, we validated and mapped this interaction, and using CRISPR-Cas9–generated CHD3- and SENP1-KO cells (in the haploid HAP1 cell line), we investigated whether these two proteins are functionally linked in regulating chromatin remodeling and gene expression. Genome-wide ATAC-Seq analysis of the CHD3- and SENP1-KO cells revealed a large degree of overlap in differential chromatin openness between these two mutant cell lines. Moreover, motif analysis and comparison with ChIP-Seq profiles in K562 cells pointed to an association of CHD3 and SENP1 with CCCTC-binding factor (CTCF) and SUMOylated chromatin–associated factors. Lastly, genome-wide RNA-Seq also indicated that these two proteins co-regulate the expression of several genes. We propose that the functional link between chromatin remodeling by CHD3 and deSUMOylation by SENP1 uncovered here provides another level of control of gene expression.

• Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Abdel-Rahman, Noha Mansour Hassan; Heggelund, Julie Elisabeth; Hoås, Helene Mykland; Abraha, Fana; Bousquet, Paula; Høydahl, Lene Støkken; Burschowsky, Daniel; Rojas, Gertrudis; Oscarson, Stefan; Løset, Geir Åge & Krengel, Ute (2018). Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour- specificity through an unusual H-chain CDR3 architecture. Scientific Reports.  ISSN 2045-2322.  8:10836, s 1- 11 . doi: 10.1038/s41598-018-28918-5 Vis sammendrag

  Targeted cancer immunotherapy offers increased efficacy concomitantly with reduced side effects. One antibody with promising clinical potential is 14F7, which specifically recognises the NeuGc GM3 ganglioside. This antigen is found in the plasma membrane of a range of tumours, but is essentially absent from healthy human cells. 14F7 can discriminate NeuGc GM3 from the very similar NeuAc GM3, a common component of cell membranes. The molecular basis for this unique specificity is poorly understood. Here we designed and expressed 14F7-derived single-chain Fvs (scFvs), which retained the specificity of the parent antibody. Detailed expression and purification protocols are described as well as the synthesis of the NeuGc GM3 trisaccharide. The most successful scFv construct, which comprises an alternative variable light chain (VLA), allowed structure determination to 2.2 Å resolution. The structure gives insights into the conformation of the important CDR H3 loop and the suspected antigen binding site. Furthermore, the presence of VLA instead of the original VL elucidates how this subdomain indirectly stabilises the CDR H3 loop. The current work may serve as a guideline for the efficient production of scFvs for structure determination.

• Olsbu, Inger Kirstine; Zoppellaro, Giorgio; Andersson, Karl Kristoffer; Boucher, Jean-Luc & Hersleth, Hans-Petter (2018). Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase. FEBS Open Bio.  ISSN 2211-5463.  8(9), s 1553- 1566 . doi: 10.1002/2211-5463.12503
• Tedersoo, Leho; Tooming-Klunderud, Ave & Anslan, Sten (2018). PacBio metabarcoding of Fungi and other eukaryotes: errors, biases and perspectives. New Phytologist.  ISSN 0028-646X.  217(3), s 1370- 1385 . doi: 10.1111/nph.14776
• Pharo, Heidi Dietrichson; Andresen, Kim; Berg, Kaja Christine Graue; Lothe, Ragnhild A; Jeanmougin, Marine & Lind, Guro Elisabeth (2018). A robust internal control for high-precision DNA methylation analyses by droplet digital PCR. Clinical Epigenetics.  ISSN 1868-7075.  10(24) . doi: 10.1186/s13148-018-0456-5 Fulltekst i vitenarkiv.
• Dukic, Aleksandra; Gerbaud, Pascal; Guibourdenche, Jean; Thiede, Bernd; Tasken, Kjetil & Pidoux, Guillaume (2018). Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion. Biochemical Journal.  ISSN 0264-6021.  475(2), s 455- 476 . doi: 10.1042/BCJ20170529
• Dragly, Svenn-Arne; Mobarhan, Milad; Lepperød, Mikkel Elle; Tennøe, Simen; Fyhn, Marianne; Hafting, Torkel & Malthe-Sørenssen, Anders (2018). Experimental directory structure (Exdir): An alternative to HDF5 without introducing a new file format. Frontiers in Neuroinformatics.  ISSN 1662-5196.  12 . doi: 10.3389/fninf.2018.00016
• Lerner, Thomas R.; Queval, Christophe J.; Fearns, Antony; Repnik, Urska; Griffiths, Gareth & Gutierrez, Maximiliano G. (2018). Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells. BMC Biology.  ISSN 1741-7007.  16(1) . doi: 10.1186/s12915-017-0471-6
• Wilkinson, Derek; Maršíková, Jana; Hlaváček, Otakar; Gilfillan, Gregor Duncan; Ježková, Eva; Aaløkken, Ragnhild; Váchová, Libuše & Palková, Zdena (2018). Transcriptome remodeling of differentiated cells during chronological ageing of yeast colonies: New insights into metabolic differentiation. Oxidative Medicine and Cellular Longevity.  ISSN 1942-0900.  2018:4932905, s 1- 17 . doi: 10.1155/2018/4932905
• Kunin, William E.; Harte, John; He, Fangliang; Hui, Cang; Jobe, R. Todd; Ostling, Annette; Polce, Chiara; Sizling, Arnost; Smith, Adam B.; Smith, Krister; Smart, Simon M; Storch, David; Tjørve, Even; Ugland, Karl Inne; Ulrich, Werner & Varma, Varun (2018). Upscaling biodiversity: estimating the species-area relationship from small samples. Ecological Monographs.  ISSN 0012-9615.  88(2), s 170- 187 . doi: 10.1002/ecm.1284
• Runemark, Anna; Fernández, Laura Piñeiro; Eroukhmanoff, Fabrice & Sætre, Glenn-Peter (2018). Genomic contingencies and the potential for local adaptation in a hybrid species. American Naturalist.  ISSN 0003-0147.  192(1), s 10- 22 . doi: 10.1086/697563
• Mobarhan, Milad; Halnes, Geir; Martínez-Cañada, Pablo; Hafting, Torkel; Fyhn, Marianne & Einevoll, Gaute (2018). Firing-rate based network modeling of the dLGN circuit: Effects of cortical feedback on spatiotemporal response properties of relay cells. PloS Computational Biology.  ISSN 1553-734X.  14(5) . doi: 10.1371/journal.pcbi.1006156 Fulltekst i vitenarkiv.
• Anglès d'Auriac, Marc B & Sirevåg, Reidun (2018). Multiplex PCR for the simultaneous detection of the Enterobacterial gene wecA, the Shiga Toxin genes (stx1 and stx2) and the Intimin gene (eae). BMC Research Notes.  ISSN 1756-0500.  11(360), s 1- 7 . doi: 10.1186/s13104-018-3457-8 Fulltekst i vitenarkiv. Vis sammendrag

  The aetiology of several human diarrhoeas has been increasingly associated with the presence of virulence factors rather than with the bacterial species hosting the virulence genes, exemplified by the sporadic emergence of new bacterial hosts. Two important virulence factors are the Shiga toxin (Stx) and the E. coli outer membrane protein (Eae) or intimin, encoded by the stx and eae genes, respectively. Although several polymerase chain reaction (PCR) protocols target these virulence genes, few aim at detecting all variants or have an internal amplification control (IAC) included in a multiplex assay. The objective of this work was to develop a simple multiplex PCR assay in order to detect all stx and eae variants, as well as to detect bacteria belonging to the Enterobacteriaceae, also used as an IAC. The wecA gene coding for the production of the Enterobacterial Common Antigen was used to develop an Enterobacteriaceae specific qPCR. Universal primers for the detection of stx and eae were developed and linked to a wecA primer pair in a robust triplex PCR. In addition, subtyping of the stx genes was achieved by subjecting the PCR products to restriction digestion and semi-nested duplex PCR, providing a simple screening assay for human diarrhoea diagnostic.

• Lindholm, Markus; Eie, Martin; Hessen, Dag Olav; Johansen, Joachim Tørum; Weiby, Kristoffer & Thaulow, Jens (2018). Effects of water browning on freshwater biodiversity: the case of the predatory phantom midge Chaoborus nyblaei. Hydrobiologia.  ISSN 0018-8158.  813(1), s 33- 40 . doi: 10.1007/s10750-017-3503-x Vis sammendrag

  Water browning, due to increased runoff of terrestrial dissolved organic carbon (DOC), has recently gained considerable attention. While it is well settled how browning affects light regime and thereby aquatic primary production, other impacts on the aquatic biota is less explored. Water browning shelters against UV radiation, and may thus benefit range expansion of UV sensitive organisms, such as midges. We mapped occurrence of Chaoborids in 148 subalpine and alpine ponds in Norway, and identified an apparent threshold for their presence around 3 mg total organic carbon (TOC) l−1. The field study was complemented with laboratory experiments on Chaoborus nyblaei (Zetterstedt, 1838), to test if this species is able to identify and select water colour (concentrations of DOC) for oviposition. Number of egg rafts on brown water tanks was significantly higher than in clear water tanks, indicating that C. nyblaei performs oviposition habitat selection. Chaoborids are effective predators in planktonic habitats, and our findings support the hypothesis that climate change may cascade through the ecosystem and promote range shifts of species due to alternated habitat frame conditions.

• Nyhagen, Fredrik Oulie; Christie, Hartvig C & Norderhaug, Kjell Magnus (2018). Will altered climate affect a discrete population of the sea urchin Strongylocentrotus droebachiensis?. Journal of Sea Research.  ISSN 1385-1101.  132, s 24- 34 . doi: 10.1016/j.seares.2017.12.001 Vis sammendrag

  The Green sea urchin Strongylocentrotus droebachiensis is a cold-water species that in the 70s and 80s was the main culprit in the major grazing of macrophytes in the Norwegian fjords and coastal areas. Recent reports have questioned a decline in the S. droebachiensis in the Oslofjord, similar to what was observed to occur in the Norwegian coastal population of S. droebachiensis after the 1990s. In surveys from 2013 we collected data on urchin density, test diameter, early urchin settlement and Gonad Index and created a framework in order to investigate if the current Inner Oslofjord populations of S. droebachiensis are different from surveys conducted in 1979 and 1992. This study found significant differences in density, diameter and settlement over time. Highest density in 1992 was at 10 and 15 m, while being at 20 m in 2013. Urchin diameter at the station with most urchins was on average 5 cm in 1992 compared to 3 cm in 2013. Settlement differed both between the number of settlers between 1992 and 2013, and season for highest settlement (summer in 1992, and autumn in 2013). The inner Oslofjord sea urchin data indicate a still healthy population, although environmental data (as temperature and salinity) have changed to less favorable conditions for this species.

• Grønnestad, Randi; Villanger, Gro Dehli; Polder, Anuschka; Kovacs, Kit M.; Lydersen, Christian; Jenssen, Bjørn Munro & Borgå, Katrine (2018). Effects of a complex contaminant mixture on thyroid hormones in breeding hooded seal mothers and their pups. Environmental Pollution.  ISSN 0269-7491.  240, s 10- 16 . doi: 10.1016/j.envpol.2018.04.052
• Grevys, Algirdas; Nilsen, Jeannette; Sand, Kine Marita Knudsen; Daba, Muluneh Bekele; Øynebråten, Inger; Bern, Malin C.; McAdam, Martin Berner; Foss, Stian; Schlothauer, Tilman; Michaelsen, Terje Einar; Christianson, Gregory J.; Roopenian, Derry C.; Blumberg, Richard S.; Sandlie, Inger & Andersen, Jan Terje (2018). A human endothelial cell-based recycling assay for screening of FcRn targeted molecules. Nature Communications.  ISSN 2041-1723.  9 . doi: 10.1038/s41467-018-03061-x Fulltekst i vitenarkiv.
• Hozumi, Aya; Kaartvedt, Stein; Røstad, Anders; Berumen, Michael L; Cochran, Jesse E.M. & Jones, Burton H. (2018). Acoustic backscatter at a Red Sea whale shark aggregation site. Regional Studies in Marine Science.  ISSN 2352-4855.  20, s 23- 33 . doi: 10.1016/j.rsma.2018.03.008
• Sivertsen, Magne S.; Jørstad, Øystein Kalsnes; Grevys, Algirdas; Foss, Stian; Moe, Morten Carsten & Andersen, Jan Terje (2018). Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties. Scientific Reports.  ISSN 2045-2322.  8(1) . doi: 10.1038/s41598-018-20525-8
• Stapleton, Nigel M.; Armstrong-Fisher, Sylvia S.; Andersen, Jan Terje; van der Schoot, C. Ellen; Porter, Charlene; Page, Kenneth R.; Falconer, Donald; de Haas, Masja; Williamson, Lorna M.; Clark, Michael R.; Vidarsson, Gestur & Armour, Kathryn L. (2018). Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport. Molecular Immunology.  ISSN 0161-5890.  95, s 1- 9 . doi: 10.1016/j.molimm.2018.01.006
• Rusch, Johannes; Hansen, Haakon; Strand, David; Markussen, Turhan; Hytterød, Sigurd & Vrålstad, Trude (2018). Catching the fish with the worm: A case study on eDNA detection of the monogenean parasite Gyrodactylus salaris and two of its hosts, Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). Parasites & Vectors.  ISSN 1756-3305.  11(333), s 1- 12 . doi: 10.1186/s13071-018-2916-3 Fulltekst i vitenarkiv.
• Pasovic, Lara; Utheim, Tor Paaske; Reppe, Sjur; Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Thiede, Bernd; Berg, Jens Petter; Messelt, Edvard Berger & Eidet, Jon Roger (2018). Improvement of storage medium for cultured human retinal pigment epithelial cells using factorial design. Scientific Reports.  ISSN 2045-2322.  8(1) . doi: 10.1038/s41598-018-24121-8 Fulltekst i vitenarkiv.
• Nilsen, Jeannette; Sandlie, Inger; Roopenian, Derry C. & Andersen, Jan Terje (2018). Animal models for evaluation of albumin-based therapeutics. Current Opinion in Chemical Engineering.  ISSN 2211-3398.  19, s 68- 76 . doi: 10.1016/j.coche.2017.11.007
• Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Neumann, Ralf Stefan; Bjerregaard-Andersen, Kaare; Nilssen, Nicolay Rustad; Sollid, Ludvig Magne; Sandlie, Inger & Løset, Geir Åge (2018). Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system. PLoS ONE.  ISSN 1932-6203.  13:e0195868(4), s 1- 15 . doi: 10.1371/journal.pone.0195868 Fulltekst i vitenarkiv. Vis sammendrag

  There is a quest for production of soluble protein of high quality for the study of T-cell receptors (TCRs), but expression often results in low yields of functional molecules. In this study, we used an E. coli chaperone-assisted periplasmic production system and compared expression of 4 different soluble TCR formats: single-chain TCR (scTCR), two different disulfide-linked TCR (dsTCR) formats, and chimeric Fab (cFab). A stabilized version of scTCR was also included. Additionally, we evaluated the influence of host (XL1-Blue or RosettaBlueTM) and the effect of IPTG induction on expression profiles. A celiac disease patient-derived TCR with specificity for gluten was used, and we achieved detectable expression for all formats and variants. We found that expression in RosettaBlueTM without IPTG induction resulted in the highest periplasmic yields. Moreover, after large-scale expression and protein purification, only the scTCR format was obtained in high yields. Importantly, stability engineering of the scTCR was a prerequisite for obtaining reliable biophysical characterization of the TCR-pMHC interaction. The scTCR format is readily compatible with high-throughput screening approaches that may enable both development of reagents allowing for defined peptide MHC (pMHC) characterization and discovery of potential novel therapeutic leads.

• Hasvik, Eivind Olay; Haugen, Anne Julsrud; Gjerstad, Johannes & Grøvle, Lars (2018). Assessing neuropathic pain in patients with low back-related leg pain: Comparing the painDETECT Questionnaire with the 2016 NeuPSIG grading system. European Journal of Pain.  ISSN 1090-3801.  22(6), s 1160- 1169 . doi: 10.1002/ejp.1204
• Winje, Ivan; Bengtsen, Mads; Eftestøl, Einar; Juvkam, Inga; Bruusgaard, Jo C. & Gundersen, Kristian (2018). Specific labelling of myonuclei by an antibody against pericentriolar material 1 on skeletal muscle tissue sections. Acta Physiologica.  ISSN 1748-1708.  223(4), s 1- 9 . doi: 10.1111/apha.13034 Fulltekst i vitenarkiv.
• Balasundaram, Sudhagar; Hess, Jaqueline; Durling, Mikael Brandström; Moody, Suzy C.; Thorbek, Birgitte Lisbeth Graae; Progida, Cinzia; LaButti, Kurt; Aerts, Andrea L.; Barry, Kerrie; Grigoriev, Igor V.; Boddy, Lynne; Högberg, Nils; Kauserud, Håvard; Eastwood, Daniel C. & Skrede, Inger (2018). The fungus that came in from the cold: dry rot’s pre-adapted ability to invade buildings. The ISME Journal.  ISSN 1751-7362.  12(3), s 791- 801 . doi: 10.1038/s41396-017-0006-8
• Martínez-Cañada, Pablo; Mobarhan, Milad; Halnes, Geir; Fyhn, Marianne; Morillas, Christian; Pelayo, Francisco & Einevoll, Gaute (2018). Biophysical network modeling of the dLGN circuit: Effects of cortical feedback on spatial response properties of relay cells. PloS Computational Biology.  ISSN 1553-734X.  14(1), s 1- 45 . doi: 10.1371/journal.pcbi.1005930 Fulltekst i vitenarkiv.
• Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Malthe-sørenssen, Anders; Hafting, Torkel & Fyhn, Marianne (2018). Removal of perineuronal nets disrupts recall of a remote fear memory. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  115(3), s 607- 612 . doi: 10.1073/pnas.1713530115 Fulltekst i vitenarkiv.
• Danielsen, Håvard Emil; Hveem, Tarjei Sveinsgjerd; Domingo, Enric; Pradhan, Manohar; Kleppe, Andreas; Syvertsen, Rolf Anders; Kostolomov, Ilya; Nesheim, John Arne; Askautrud, Hanne Arenberg; Nesbakken, Arild; Lothe, Ragnhild A; Svindland, Aud; Shephard, Neil; Novelli, Marco; Johnstone, Elaine; Tomlinson, I; Kerr, Rachel & Kerr, David (2018). Prognostic markers for colorectal cancer: Estimating ploidy and stroma. Annals of Oncology.  ISSN 0923-7534.  29(3), s 616- 623 . doi: 10.1093/annonc/mdx794
• Jacobsen, Daniel Pitz; Nielsen, Morten Birkeland; Einarsen, Ståle & Gjerstad, Johannes (2018). Negative social acts and pain. Evidence of a workplace bullying and 5-HTT genotype interaction. Scandinavian Journal of Work, Environment and Health.  ISSN 0355-3140.  44(3), s 283- 290 . doi: 10.5271/sjweh.3704
• Haarr, Ane; Hylland, Ketil; Eckbo, Norith; Gabrielsen, Geir W.; Herzke, Dorte; Bustnes, Jan Ove; Blévin, Pierre; Chastel, Olivier; Moe, Børge; Hanssen, Sveinn Are; Sagerup, Kjetil & Borgå, Katrine (2018). DNA Damage in Arctic Seabirds: Baseline, Sensitivity to a Genotoxic Stressor, and Association with Organohalogen Contaminants. Environmental Toxicology and Chemistry.  ISSN 0730-7268.  37(4), s 1084- 1091 . doi: 10.1002/etc.4035 Vis sammendrag

  Environmental contaminants are found throughout Arctic marine ecosystems, and their presence in seabirds has been associated with toxicological responses. However, there are few studies of genotoxicity in Arctic avian wildlife. The purpose of the present study was to quantify deoxyribonucleic acid (DNA) damage in lymphocytes of selected seabird species and to examine whether accumulation of organohalogen contaminants (SOHCs) affects DNA damage. Blood was sampled from common eider (Somateria mollissima), black guillemot (Cepphus grylle), black-legged kittiwake (Rissa tridactyla), glaucous gull (Larus hyperboreus), arctic skua (Stercorarius parasiticus), and great skua (Stercorarius skua) in Kongsfjorden, Svalbard (Norway). Contaminant concentrations found in the 6 species differed, presumably because of foraging ecology and biomagnification. Despite large differences in contaminant concentrations, ranging from SOHCs 3.3 ng/g wet weight in the common eider to SOHCs 895 ng/g wet weight in the great skua, there was no strong difference among the species in baseline DNA damage or sensitivity to a genotoxic stressor (hydrogen peroxide). Baseline levels of DNA damage were low, with median values ranging from 1.7% in the common eider to 8.6% in the great skua. There were no associations between DNA damage and contaminants in the investigated species, suggesting that contaminant concentrations in Kongsfjorden are too low to evoke genotoxic effects, or possibly that lymphocytes are resistant to strand breakage. Clearly, genotoxicity is a topic for future studies of Arctic seabirds Arctic; Seabirds; Genotoxicity; Comet Assay; Persistent organic pollutants; Perfluoroalkyl substances

• Wolf, Raoul; Thrane, Jan-Erik; Hessen, Dag Olav & Andersen, Tom (2018). Modelling ROS formation in boreal lakes from interactions between dissolved organic matter and absorbed solar photon flux. Water Research.  ISSN 0043-1354.  132, s 331- 339 . doi: 10.1016/j.watres.2018.01.025 Fulltekst i vitenarkiv. Vis sammendrag

  Concentrations of dissolved organic matter (DOM) are increasing in a large number of lakes across the Northern hemisphere. This browning serves a dual role for biota by protecting against harmful ultraviolet radiation, while also absorbing photosynthetically active radiation. The photochemical activation of DOM and subsequent formation of reactive oxygen species (ROS) is a potentially harmful side effect, but can be difficult to measure directly in situ. In this study, we combine a data set of physico-chemical properties from 71 Nordic lakes with in vitro ROS formation quantum yields to predict ROS formations across a representative boreal ecosystem gradient. For the upper centimeter of the water column, we calculate ROS formations in the range of 7.93–12.56 μmol L−1 h−1. In the first meter, they range between 1.69 and 6.69 μmol L−1 h−1 and in the remaining depth the range is 0.01–0.46 μmol L−1 h−1. These ROS formations are comparable with previously field-measured hydrogen peroxide formation rates and likely affect both phyto- and zooplankton, as well as lake chemistry. Interestingly, wavelengths of the visible spectrum (>400 nm) contribute more than half of the overall ROS formation in surface-near water layers. The association between DOM and ROS formation was found to be two-fold. While DOM promotes ROS formation in the first centimeters of the water column, the shading effect of light attenuation overpowers this with increasing depth. In the context of water browning, our results indicate the emergence of an underestimated oxidative stress environment for lake biota in the upper centimeters of the water column.

• Wong, Megan; Brandt, Johann Rasmus; Ahrens, Sven; Jaouen, Klervia; Bjørnstad, Gro; Naumann, Elise; Wenn, Camilla Cecilie; Kiesewetter, Henrike; Laforest, Caroline; Hagelberg, Erika; Lam, Vienna C. & Richards, Michael (2018). Pursuing pilgrims: Isotopic investigations of Roman and Byzantine mobility at Hierapolis, Turkey. Journal of Archaeological Science: Reports.  ISSN 2352-409X.  17, s 520- 528 . doi: 10.1016/j.jasrep.2017.12.005 Vis sammendrag

  Using strontium isotope analysis, we investigated the mobility of Roman (1st to 7th century AD) and Byzantine (9th–13th century AD) individuals buried at the UNESCO World Heritage site of Hierapolis, Turkey. Results from Roman and Byzantine individuals show that while the majority of the population interred at this site have local strontium isotope values, there are some individuals with values outside the local range, which we identify as migrants. This conclusion agrees in particular with the known history of pilgrimage at Hierapolis in the Byzantine period (as defined above) and with the archaeological evidence of pilgrim badges associated with human burials unearthed from recent excavations. In addition, we present the first map of bioavailable strontium in southwestern Turkey.

• Forsberg, June Thorvaldsen; Gjerstad, Johannes; Flaten, Magne & Aslaksen, Per M. (2018). Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia. Pain.  ISSN 0304-3959.  159(1), s 168- 174 . doi: 10.1097/j.pain.0000000000001081 Vis sammendrag

  Higher levels of fear have been shown to partly explain individual differences in placebo analgesic responding. The catechol-Omethyltransferase (COMT) rs4680 Val158Met polymorphism has been associated with both increased placebo analgesia and increased fear-related behavior, in what appears to be inconsistent findings in the literature. The aim of the study was therefore to investigate placebo analgesia and fear-related processes with regard to the COMT genotype, to sort out whether the Met-allele is associated with increased placebo analgesia or increased fear of pain (FOP). A 3 Group (Emla, placebo and natural history) by 5 Test (2 pretest, 3 posttests) mixed design was used (N 5 223). A contact heat-evoked stimulator was used to induce pain, and FOP was quantified with the Fear of Pain Questionnaire-III. Saliva was obtained for genotyping. As expected, we observed a significant interaction of test by group (P , 0.01), with lower pain report in the placebo group compared with the natural history group (P , 0.01). There was a main effect of the COMT genotype on fear of medical pain (P 5 0.032), and Met-allele carriers reported significantly higher fear of medical pain compared with the Val-allele (P 5 0.044). We observed no effect of the COMT genotype on mean pain-level report or placebo analgesia. Thus, we conclude that the Met-allele seems to be associated with the negative emotional process of fear, but not with placebo analgesia.

• Hyde, Kevin D.; Norphanphoun, Chada; Abreu, Vanessa P.; Bazzicalupo, Anna; Chethana, K.W. Thilini; Clericuzio, Marco; Dayarathne, Monika C.; Dissanayake, Asha J.; Ekanayaka, Anusha Hasini; He, Mao-Qiang; Hongsanan, Sinang; Huang, Shi-Ke; Jayasiri, Subashini C.; Jayawardena, Ruvishika S.; Karunarathna, Anuruddha; Konta, Sirinapa; Kušan, Ivana; Lee, Hyun; Li, Junfu; Lin, Chuan-Gen; Liu, Ning-Guo; Lu, Yong-Zhong; Luo, Zong-Long; Manawasinghe, Ishara S.; Mapook, Ausana; Perera, Rekhani H.; Phookamsak, Rungtiwa; Phukhamsakda, Chayanard; Siedlecki, Igor; Soares, Adriene Mayra; Tennakoon, Danushka S.; Tian, Qing; Tibpromma, Saowaluck; Wanasinghe, Dhanushka N.; Xiao, Yuan-Pin; Yang, Jing; Zeng, Xiang-Yu; Abdel-Aziz, Faten A.; Li, Wen-Jing; Senanayake, Indunil C.; Shang, Qiu-Ju; Daranagama, Dinushani A.; de Silva, Nimali Indeewari; Thambugala, Kasun M.; Abdel-Wahab, Mohamed A.; Bahkali, Ali H.; Berbee, Mary L.; Boonmee, Saranyaphat; Bhat, D. Jayarama; Bulgakov, Timur S.; Buyck, Bart; Camporesi, Erio; Castañeda-Ruiz, Rafael F.; Chomnunti, Putarak; Doilom, Minkwan; Dovana, Francesco; Gibertoni, Tatiana Baptista; Jadan, Margita; Jeewon, Rajesh; Jones, E.B. Gareth; Kang, Ji-Chuan; Karunarathna, Samantha C.; Lim, Young Woon; Liu, Jian-Kui; Liu, Zuo-Yi; Plautz, Helio Longoni; Lumyong, Saisamorn; Maharachchikumbura, Sajeewa S.N.; Matočec, Neven; McKenzie, Eric H.C.; Mešić, Armin; Miller, Daniel; Pawłowska, Julia; Pereira, Olinto Liparini; Promputtha, Itthayakorn; Romero, Andrea I.; Ryvarden, Leif; Su, Hong-Yan; Suetrong, Satinee; Tkalčec, Zdenko; Vizzini, Alfredo; Wen, Ting-Chi; Wisitrassameewong, Komsit; Wrzosek, Marta; Xu, Jian-Chu; Zhao, Qi; Zhao, Rui-Lin & Mortimer, Peter E. (2017). Fungal diversity notes 603-708: taxonomic and phylogenetic notes on genera and species. Fungal diversity.  ISSN 1560-2745.  87(1), s 1- 235 . doi: 10.1007/s13225-017-0391-3
• Selander, Erik; Heuschele, Jan David & Larsson, Ann I. (2017). Hydrodynamic properties and distribution of bait downstream of a zooplankton trap. Journal of Plankton Research.  ISSN 0142-7873.  39(6), s 1020- 1027 . doi: 10.1093/plankt/fbx024
• Zhang, Fengwei; Liu, Qian; Wang, Ziyi; Xie, Wenqian; Sheng, Xia; Zhang, Haolin; Yuan, Zhengrong; Han, Yingying & Weng, Qiang (2017). Seasonal Expression of Oxytocin and Oxytocin Receptor in the Scented Gland of Male Muskrat (Ondatra zibethicus). Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-16973-3
• Skatter, Hans Gaute; Charlebois, ML; Eftestøl, Sindre; Tsegaye, Diress; Colman, Jonathan Edward; Kansas, JL; Flydal, Kjetil & Balicki, B (2017). Living in a burned landscape: woodland caribou (Rangifer tarandus caribou) use of postfire residual patches for calving in a high fire - low anthropogenic Boreal Shield ecozone. Canadian Journal of Zoology.  ISSN 0008-4301.  95(12), s 975- 984 . doi: 10.1139/cjz-2016-0307
• Tsegaye, Diress; Colman, Jonathan Edward; Eftestøl, Sindre; Flydal, Kjetil; Røthe, Gunnlaug & Rapp, Kåre (2017). Reindeer spatial use before, during and after construction of a wind farm. Applied Animal Behaviour Science.  ISSN 0168-1591.  195, s 103- 111 . doi: 10.1016/j.applanim.2017.05.023 Fulltekst i vitenarkiv.
• Busserolles de, Fanny; Cortesi, Fabio; Helvik, Jon Vidar; Davies, Wayne I. L.; Templin, Rachel M.; Sullivan, Robert K. P.; Michell, Craig T.; Mountford, Jessica K.; Collin, Shaun P.; Irigoien, Xabier; Kaartvedt, Stein & Marshall, Justin (2017). Pushing the limits of photoreception in twilight conditions: The rod-like cone retina of the deep-sea pearlsides. Science Advances.  ISSN 2375-2548.  3(11), s 1- 13 . doi: 10.1126/sciadv.aao4709 Fulltekst i vitenarkiv.
• Crous, Pedro Willem; Wingfield, MJ; Burgess, TI; St J Hardy, GE; Barber, PA; Alvarado, P; Barnes, CW; Buchanan, PK; Heykoop, M; Moreno, G; Thangavel, R; Van Der Spuy, S; Barili, A; Barrett, S; Cacciola, SO; Cano-Lira, JF; Crane, C; Decock, C; Gibertoni, TB; Guarro, J; Guevara-Suarez, M; Hubka, V; Kolařík, M; Lira, CRS; Ordoñez, ME; Padamsee, M; Ryvarden, Leif; Soares, AM; Stchigel, AM; Sutton, DA; Vizzini, A; Weir, BS; Acharya, K; Aloi, F; Baseia, IG; Blanchette, RA; Bordallo, JJ; Bratek, Z; Butler, T; Cano-Canals, J; Carlavilla, JR; Chander, J; Cheewangkoon, R; Cruz, RHSF; Da Silva, M; Dutta, AK; Ercole, E; Escobio, V; Esteve-Raventós, F; Flores, JA; Gené, J; Góis, JS; Haines, L; Held, BW; Horta Jung, M; Hosaka, K; Jung, T; Jurjević, Ž; Kautman, V; Kautmanova, I; Kiyashko, AA; Kozanek, M; Kubátová, A; Lafourcade, M; La Spada, F; Latha, KPD; Madrid, H; Malysheva, EF; Manimohan, P; Manjón, JL; Martin, MP; Mata, M; Merényi, Z; Morte, A; Nagy, I; Normand, AC; Paloi, S; Pattison, N; Pawłowska, J; Pereira, OL; Petterson, ME; Picillo, B; Raj, KNA; Roberts, A; Rodríguez, A; Rodríguez-Campo, FJ; Romańsk, M; Ruszkiewicz-Michalska, M; Scanu, B; Schena, L; Semelbauer, M; Sharma, R; Shouche, YS; Silva, V; Staniaszek-Kik, M; Stielow, JB; Tapia, C; Taylor, PWJ; Toome-Heller, M; Vabeikhokhei, JMC; Van Diepeningen, AD; Van Hoa, N; Van Tri, M; Wiederhold, NP; Wrzosek, M; Zothanzama, J & Groenewald, Johannes Zacharias Ewald (2017). Fungal planet description sheets: 558-624. Persoonia.  ISSN 0031-5850.  38(JUNE), s 240- 384 . doi: 10.3767/003158517X698941
• Tibpromma, Saowaluck; Hyde, Kevin D.; Jeewon, Rajesh; Maharachchikumbura, Sajeewa S.N.; Liu, Jian-Kui; Bhat, D Jayarama; Jones, E.B. Gareth; McKenzie, Eric H.C.; Camporesi, Erio; Bulgakov, Timur S.; Doilom, Mingkwan; de Azevedo Santiago, André Luiz Cabral Monteiro; Das, Kanad; Manimohan, Patinjareveettil; Gibertoni, Tatiana B.; Lim, Young Woon; Ekanayaka, Anusha Hasini; Thongbai, Benjarong; Lee, Hyang Burm; Yang, Jun-Bo; Kirk, Paul M.; Sysouphanthong, Phongeun; Singh, Sanjay K.; Boonmee, Saranyaphat; Dong, Wei; Raj, K.N. Anil; Latha, K.P. Deepna; Phookamsak, Rungtiwa; Phukhamsakda, Chayanard; Konta, Sirinapa; Jayasiri, Subashini C.; Norphanphoun, Chada; Tennakoon, Danushka S.; Li, Junfu; Dayarathne, Monika C.; Perera, Rekhani H.; Xiao, Yuanpin; Wanasinghe, Dhanushka N.; Senanayake, Indunil C.; Goonasekara, Ishani D.; de Silva, Nimali Indeewari; Mapook, Ausana; Jayawardena, Ruvishika S.; Dissanayake, Asha J.; Manawasinghe, Ishara S.; Chethana, K.W. Thilini; Luo, Zong-Long; Hapuarachchi, Kalani Kanchana; Baghela, Abhishek; Soares, Adriene Mayra; Vizzini, Alfredo; Meiras-Ottoni, Angelina; Mešić, Armin; Dutta, Arun Kumar; de Souza, Carlos Alberto Fragoso; Richter, Christian; Lin, Chuan-Gen; Chakrabarty, Debasis; Daranagama, Dinushani A.; Lima, Diogo Xavier; Chakraborty, Dyutiparna; Ercole, Enrico; Wu, Fang; Simonini, Giampaolo; Vasquez, Gianrico; da Silva, Gladstone Alves; Plautz, Helio Longoni; Ariyawansa, Hiran A.; Lee, Hyun; Kušan, Ivana; Song, Jie; Sun, Jingzu; Karmakar, Joydeep; Hu, Kaifeng; Semwal, Kamal C.; Thambugala, Kasun M.; Voigt, Kerstin; Acharya, Krishnendu; Rajeshkumar, Kunhiraman C.; Ryvarden, Leif; Jadan, Margita; Hosen, Md Iqbal; Mikšík, Michal; Samarakoon, Milan C.; Wijayawardene, Nalin N.; Kim, Nam Kyu; Matočec, Neven; Singh, Paras Nath; Tian, Qing; Bhatt, RP; de Oliveira, Rafael José Vilela; Tulloss, Rodham E.; Aamir, Sadaf; Kaewchai, Saithong; Marathe, Sayali D.; Khan, Sehroon; Hongsanan, Sinang; Adhikari, Sinchan; Mehmood, Tahir; Bandyopadhyay, Tapas Kumar; Svetasheva, Tatyana Yu; Nguyen, Thi Thuong Thuong; Antonín, Vladimír; Li, Wen-Jing; Wang, Yong; Indoliya, Yuvraj; Tkalčec, Zdenko; Elgorban, Abdallah M.; Bahkali, Ali H.; Tang, Alvin M.C.; Su, Hong-Yan; Zhang, Huang; Promputtha, Itthayakorn; Luangsa-ard, Jennifer; Xu, Jianchu; Yan, Jiye; Ji-Chuan, Kang; Stadler, Marc; Mortimer, Peter E.; Chomnunti, Putarak; Zhao, Qi; Phillips, Alan J.L.; Nontachaiyapoom, Sureeporn; Wen, Ting-Chi & Karunarathna, Samantha C. (2017). Fungal diversity notes 491-602: taxonomic and phylogenetic contributions to fungal taxa. Fungal diversity.  ISSN 1560-2745.  83(1), s 1- 261 . doi: 10.1007/s13225-017-0378-0
• Schjerven, Hilde; Ayongaba, Etapon Fonabei; Aghajanirefah, Ali; McLaughlin, Jami; Cheng, Donghui; Geng, Huimin; Boyd, Joseph R; Eggesbø, Linn Margrethe; Lindeman, Ida; Heath, Jessica L; Park, Eugene; Witte, Owen N.; Smale, Stephen T.; Frietze, Seth & Müschen, Markus (2017). Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALL. Journal of Experimental Medicine.  ISSN 0022-1007.  214(3), s 793- 814 . doi: 10.1084/jem.20160049 Fulltekst i vitenarkiv.
• Inderberg, Else Marit; Mensali, Nadia; Oksvold, Morten Pedersen; Fallang, Lars Egil; Fåne, Anne; Skorstad, Gjertrud; Stenvik, Grethe-Elisabeth; Progida, Cinzia; Bakke, Oddmund; Kvalheim, Gunnar; Myklebust, June & Wälchli, Sébastien (2017). Human c-SRC kinase (CSK) overexpression makes T cells dummy. Cancer Immunology and Immunotherapy.  ISSN 0340-7004.  67(4), s 525- 536 . doi: 10.1007/s00262-017-2105-9
• Kurena, Baiba; Müller, Elisabeth; Christopoulos, Panagiotis; Johnsen, Ingvild Bjellmo; Stankovic, Branislava; Øynebråten, Inger; Corthay, Alexandre & Zajakina, Anna (2017). Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ. Frontiers in Immunology.  ISSN 1664-3224.  8 . doi: 10.3389/fimmu.2017.01667 Fulltekst i vitenarkiv.
• Haugen, Linda Hofstad; Skjeldal, Frode Miltzow; Bergeland, Trygve & Bakke, Oddmund (2017). Endosomal binding kinetics of Eps15 and Hrs specifically regulate the degradation of RTKs. Scientific Reports.  ISSN 2045-2322.  7:17962, s 1- 13 . doi: 10.1038/s41598-017-17320-2 Fulltekst i vitenarkiv.
• Boye, Erik; Skotland, Tore; Østerud, Bjarne & Nissen-Meyer, Jon (2017). Doping and drug testing. EMBO Reports.  ISSN 1469-221X.  18(3), s 351- 354 . doi: 10.15252/embr.201643540
• Ulanova, Lilia; Pinheiro, Marina; Vibe, Carina Beatrice; Nunes, Clàudia; Misaghian, Dorna; Wilson, Steven Ray Haakon; Zhu, Kaizheng; Fenaroli, Federico; Winther-Larsen, Hanne Cecilie; Reis, Saletta & Griffiths, Gareth (2017). Treatment of Francisella infections via PLGA-and lipid-based nanoparticle delivery of antibiotics in a zebrafish model. Diseases of Aquatic Organisms.  ISSN 0177-5103.  125(1), s 19- 29 . doi: 10.3354/dao03129
• van Velthoven, Cindy TJ; de Morree, Antoine; Egner, Ingrid Marie; Brett, Jamie O & Rando, Thomas A (2017). Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo. Cell reports.  ISSN 2211-1247.  21(7), s 1994- 2004 . doi: 10.1016/j.celrep.2017.10.037
• Carrillo, Presentación; Medina-Sánchez, Juan Manuel; Villar-Argaiz, Manuel; Bullejos Carrillo, Francisco José; Duran, C; Bastidas-Navarro, M; Souza, MS; Balseiro, EG & Modenutti, BE (2017). Vulnerability of mixotrophic algae to nutrient pulses and UVR in an oligotrophic Southern and Northern Hemisphere lake. Scientific Reports.  ISSN 2045-2322.  7(1), s 1- 11 . doi: 10.1038/s41598-017-06279-9
• Malecki, Jedrzej Mieczyslaw; Jakobsson, Magnus; Ho, Angela Yeuan Yen; Moen, Anders; Rustan, Arild & Falnes, Pål (2017). Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation. Journal of Biological Chemistry.  ISSN 0021-9258.  292(43), s 17950- 17962 . doi: 10.1074/jbc.M117.808451 Fulltekst i vitenarkiv.
• Eisenhauer, Nico; Antunes, Pedro; Bennett, Alison E; Birkhofer, Klaus; Bissett, Andrew; Bowker, Matthew A; Caruso, Tancredi; Chen, Baodong; Coleman, David C; Boer, Wietse de; Ruiter, Peter de; DeLuca, Thomas H; Frati, Francesco; Griffiths, Bryan S.; Hart, Miranda M; Hattenschwiler, Stephan; Haimi, Jari; Heethoff, Michael; Kaneko, Nobuhiro; Kelly, Laura C; Leinaas, Hans Petter; Lindo, Zoe; Macdonald, Catriona; Rillig, Matthias C; Ruess, Liliane; Scheu, Stefan; Schmidt, Olaf; Seastedt, Timothy R; Straalen, Nico M van; Tiunov, Alexei V; Zimmer, Martin & Powell, Jeff R (2017). Priorities for research in soil ecology. Pedobiologia.  ISSN 0031-4056.  63, s 1- 7 . doi: 10.1016/j.pedobi.2017.05.003
• Oliver, Cristian; Hernández, Mauricio Alejandro; Tandberg, Julia Isabel; Valenzuela, Karla Natalia; Lagos Rojas, Leidy Ximena; Haro, Ronie E.; Sánchez, Patricio; Ruiz, Pamela Andrea; Sanhueza-Oyarzun, Constanza; Cortes, Marcos Andres; Lecumberri, Maria Teresa; Artigues-Serra, Antonio; Winther-Larsen, Hanne Cecilie; Avendano-Herrera, Ruben & Yáñez, Alejandro J. (2017). The proteome of biologically active membrane vesicles from Piscirickettsia salmonis LF-89 type strain identifies plasmid-encoded putative toxins. Frontiers in Cellular and Infection Microbiology.  ISSN 2235-2988.  7:420, s 1- 15 . doi: 10.3389/fcimb.2017.00420
• Mwafongo, Elizabeth Brighton Mvula; Vollsnes, Ane Victoria; Bjorå, Charlotte Sletten; Nordal, Inger & Eriksen, Aud Else Berglen (2017). Leaf mottling/variegation and shape in the Ledebouria revoluta complex ? Development, stability and putative function. Flora: Morphologie, Geobotanik, Oekophysiologie.  ISSN 0367-2530.  236-237, s 33- 43 . doi: 10.1016/j.flora.2017.09.009 Fulltekst i vitenarkiv.
• Repnik, Urska; Distefano, Marita Borg; Speth, Martin; NG, Matthew Yoke Wui; Progida, Cinzia; Hoflack, Bernard; Gruenberg, Jean & Griffiths, Gareth (2017). L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes. Journal of Cell Science.  ISSN 0021-9533.  130(18), s 3124- 3140 . doi: 10.1242/jcs.204529
• Niazy, Naima; Temme, Sebastian; Bocuk, Derya; Giesen, Carmen; Konig, Angelika; Temme, Nadine; Ziegfeld, Angelique; Gregers, Tone Fredsvik; Bakke, Oddmund; Lang, Thorsten; Eis-Hübinger, Anna M. & Koch, Norbert (2017). Misdirection of endosomal trafficking mediated by herpes simplex virus-encoded glycoprotein B. The FASEB Journal.  ISSN 0892-6638.  31(4), s 1650- 1667 . doi: 10.1096/fj.201600521R
• Justo, Alfredo; Miettinen, Otto; Floudas, Dimitrios; Ortiz-Santana, Beatriz; Sjökvist, Elisabet; Lindner, Daniel; Nakasone, Karen; Niemelä, Tuomo; Larsson, Karl-Henrik; Ryvarden, Leif & Hibbett, David S. (2017). A revised family-level classification of the Polyporales (Basidiomycota). Fungal Biology.  ISSN 1878-6146.  121(9), s 798- 824 . doi: 10.1016/j.funbio.2017.05.010
• Barreto, A; Luis, L.G.; Soares, A. M. V. M.; Paiga, P; Santos, LHMLM; Delerue-Matos, C; Hylland, Ketil; Loureiro, Susana & Oliveira, M (2017). Genotoxicity of gemfibrozil in the gilthead seabream (Sparus aurata). Mutation research. Genetic toxicology and environmental mutagenesis.  ISSN 1383-5718.  821, s 36- 42 . doi: 10.1016/j.mrgentox.2017.05.011
• Dai, Yu-Cheng; Zhou, Li-Wei; Hattori, Tsutomu; Cao, Yun; Stalpers, Joost A.; Ryvarden, Leif; Buchanan, Peter; Oberwinkler, Franz; Hallenberg, Nils; Liu, Pei-Gui & Wu, Sheng-Hua (2017). Ganoderma lingzhi (Polyporales, Basidiomycota): the scientific binomial for the widely cultivated medicinal fungus Lingzhi. Mycological progress.  ISSN 1617-416X.  16(11-12), s 1051- 1055 . doi: 10.1007/s11557-017-1347-4
• Xi, Liqin; Liu, Yuning; Tang, Zeqi; Sheng, Xia; Zhang, Haolin; Weng, Qiang & Xu, Meiyu (2017). Expression of leptin receptor in the oviduct of Chinese brown frog (Rana dybowskii). American Journal of Physiology. Regulatory Integrative and Comparative Physiology.  ISSN 0363-6119.  312(6), s R912- R918 . doi: 10.1152/ajpregu.00020.2017
• Gelmetti, Vania; De Rosa, Priscilla; Torosantucci, Liliana; Marini, Elettra Sara; Romagnoli, Alessandra; Di Rienzo, Martina; Arena, Giuseppe; Vignone, Domenico; Fimia, Gian Maria & Valente, Enza Maria (2017). PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation. Autophagy.  ISSN 1554-8627.  13(4), s 654- 669 . doi: 10.1080/15548627.2016.1277309
• Holth, Tor Fredrik; Storset, Audun; Ribeiro, Anne Luise; Ólafsdóttir, Ásdís; Halldorsson, Halldor P. & Hylland, Ketil (2017). Environmentally realistic exposure to weathered North Sea oil: Sublethal effects in Atlantic cod (Gadus morhua) and turbot (Scophthalmus maximus). Journal of Toxicology and Environmental Health, Part A.  ISSN 1528-7394.  80(16-18), s 895- 906 . doi: 10.1080/15287394.2017.1352195
• Villar-Argaiz, Manuel; Balseiro, EG; Modenutti, BE; Souza, M; Bullejos Carrillo, Francisco José; Medina-Sánchez, Juan Manuel & Carrillo, Presentación (2017). Resource versus consumer regulation of phytoplankton: testing the role of UVR in a Southern and Northern hemisphere lake. Hydrobiologia.  ISSN 0018-8158.  s 1- 14 . doi: 10.1007/s10750-017-3251-y
• Pyzik, Michal; Rath, Timo; Kuo, Timothy T.; Win, Sanda; Baker, Kristi; Hubbard, Jonathan J.; Grenha, Rosa; Gandhi, Amit; Krämer, Thomas D.; Mezo, Adam R.; Taylo, Zachary S.; McDonnell, Kevin; Nienaber, Vicki; Andersen, Jan Terje; Mizoguchi, Atsushi; Blumberg, Laurence; Purohit, Shalaka; Jones, Susan D.; Christianson, Gregory J.; Lencer, Wayne I.; Sandlie, Inger; Kaplowitz, Neil; Roopenian, Derry C. & Blumberg, Richard S. (2017). Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  114(14), s E2862- E2871 . doi: 10.1073/pnas.1618291114 Fulltekst i vitenarkiv.
• Baycu, Gulriz; Rognes, Sven Erik; Ozden, Hakan; Goren-Saglam, Nihal; Csatari, Istvan & Szabo, Szilard Daniel (2017). Abiotic stress effects on the antioxidative response profile of Albizia julibrissin Durazz. (Fabaceae). Revista Brasileira de Botânica.  ISSN 0100-8404.  40(1), s 21- 32 . doi: 10.1007/s40415-016-0318-3
• Everaert, Gert; Ruus, Anders; Hjermann, Dag Øystein; Borgå, Katrine; Green, Norman Whitaker; Boitsov, Stepan; Jensen, Henning & Poste, Amanda (2017). Additive Models Reveal Sources of Metals and Organic Pollutants in Norwegian Marine Sediments. Environmental Science and Technology.  ISSN 0013-936X.  51(21), s 12764- 12773 . doi: 10.1021/acs.est.7b02964 Fulltekst i vitenarkiv.
• Kjos, Ingrid; Distefano, Marita Borg; Sætre, Frank Ove; Repnik, Urska; Holland, Petter; Jones, Arwyn T; Engedal, Nikolai; Simonsen, Anne; Bakke, Oddmund & Progida, Cinzia (2017). Rab7b modulates autophagic flux by interacting with Atg4B. EMBO Reports.  ISSN 1469-221X.  18(10), s 1727- 1739 . doi: 10.15252/embr.201744069 Fulltekst i vitenarkiv.
• Wielgolaski, Frans Emil (2017). Complexity in Effects of Climate Change; an Example from Treeline Areas in Northernmost Europe. JSM Environmental Science & Ecology.  ISSN 2333-7141.  5(4), s 1- 3
• Stadniczenko, Sandra Gran; Supraha, Luka; Egge, Elianne Dunthorn & Edvardsen, Bente (2017). Haptophyte Diversity and Vertical Distribution Explored by 18S and 28S Ribosomal RNA Gene Metabarcoding and Scanning Electron Microscopy. Journal of Eukaryotic Microbiology.  ISSN 1066-5234.  64(4), s 514- 532 . doi: 10.1111/jeu.12388 Vis sammendrag

  Haptophyta encompasses more than 300 species of mostly marine pico‐ and nanoplanktonic flagellates. Our aims were to investigate the Oslofjorden haptophyte diversity and vertical distribution by metabarcoding, and to improve the approach to study haptophyte community composition, richness and proportional abundance by comparing two rRNA markers and scanning electron microscopy (SEM). Samples were collected in August 2013 at the Outer Oslofjorden, Norway. Total RNA/cDNA was amplified by haptophyte‐specific primers targeting the V4 region of the 18S, and the D1‐D2 region of the 28S rRNA. Taxonomy was assigned using curated haptophyte reference databases and phylogenetic analyses. Both marker genes showed Chrysochromulinaceae and Prymnesiaceae to be the families with highest number of Operational Taxonomic Units (OTUs), as well as proportional abundance. The 18S rRNA data set also contained OTUs assigned to eight supported and defined clades consisting of environmental sequences only, possibly representing novel lineages from family to class. We also recorded new species for the area. Comparing coccolithophores by SEM with metabarcoding shows a good correspondence with the 18S rRNA gene proportional abundances. Our results contribute to link morphological and molecular data and 28S to 18S rRNA gene sequences of haptophytes without cultured representatives, and to improve metabarcoding methodology.

• Sahlmann, Andrea Silke; Wolf, Raoul; Holth, Tor Fredrik; Titelman, Josefin & Hylland, Ketil (2017). Baseline and oxidative DNA damage in marine invertebrates. Journal of Toxicology and Environmental Health, Part A.  ISSN 1528-7394.  80(16-18), s 807- 819 . doi: 10.1080/15287394.2017.1352179 Fulltekst i vitenarkiv.
• Lopes Dos Santos, Adriana; Pollina, Thibaut; Gourvil, Priscillia; Corre, Erwan; Marie, Dominique; Garrido, Jose Luis; Rodriguez, Francisco; Noel, Mary-Helene; Vaulot, Daniel & Eikrem, Wenche (2017). Chloropicophyceae, a new class of picophytoplanktonic prasinophytes. Scientific Reports.  ISSN 2045-2322.  7, s 1- 20 . doi: 10.1038/s41598-017-12412-5 Fulltekst i vitenarkiv.
• Plath, Jenny A; Entler, Brian V; Kirkerud, Nicholas Hagen; Schlegel, Ulrike; Galizia, C Giovanni & Barron, Andrew B (2017). Different roles for honey bee mushroom bodies and central complex in visual learning of colored lights in an aversive conditioning assay. Frontiers in Behavioral Neuroscience.  ISSN 1662-5153.  11 . doi: 10.3389/fnbeh.2017.00098
• Kirkerud, Nicholas Hagen; Schlegel, Ulrike & Giovanni Galizia, C. (2017). Aversive learning of colored lights in walking honeybees. Frontiers in Behavioral Neuroscience.  ISSN 1662-5153.  11 . doi: 10.3389/fnbeh.2017.00094
• Kyriazopoulos, Apostolos P.; Skre, Oddvar; Sarkki, Simo; Wielgolaski, Frans Emil; Abraham, Eleni M. & Ficko, Andrej (2017). Human−environment dynamics in European treeline ecosystems: A synthesis based on the DPSIR framework. Climate Research (CR).  ISSN 0936-577X.  73(1-2), s 17- 29 . doi: 10.3354/cr01454
• Speth, Martin; Repnik, Urska; Müller, Elisabeth; Spanier, Julia; Kalinke, Ulrich; Corthay, Alexandre & Griffiths, Gareth Wyn (2017). Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guerin (BCG) via Synergistic Activation of Innate Immune Receptors. Molecular Pharmaceutics.  ISSN 1543-8384.  14(11), s 4098- 4112 . doi: 10.1021/acs.molpharmaceut.7b00795
• Lehtinen, Sirpa; Tamminen, Timo; Ptacnik, Robert & Andersen, Tom (2017). Phytoplankton species richness, evenness, and production in relation to nutrient availability and imbalance. Limnology and Oceanography.  ISSN 0024-3590.  62(4), s 1393- 1408 . doi: 10.1002/lno.10506 Fulltekst i vitenarkiv.
• Dragly, Svenn-Arne; Mobarhan, Milad; Solbrå, Andreas Våvang; Tennøe, Simen; Hafreager, Anders; Malthe-Sørenssen, Anders; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute (2017). Neuronify: An educational simulator for neural circuits. eNeuro.  ISSN 2373-2822.  4(2:e0022-17.2017), s 1- 13 . doi: 10.1523/ENEURO.0022-17.2017 Fulltekst i vitenarkiv.
• Skre, Oddvar; Wertz, Bogdan; Wielgolaski, Frans Emil; Szydlowska, Paulina & Karlsen, Stein Rune (2017). Bioclimatic effects on different mountain birch populations in Fennoscandia. Climate Research (CR).  ISSN 0936-577X.  73(1-2), s 111- 124 . doi: 10.3354/cr01457
• Totland, Max; Bergsland, Christian Holst; Fykerud, Tone Aase; Knudsen, Lars Mørland; Rasmussen, Nikoline L.; Eide, Peter Andreas Wold; Yohannes, Zeremariam; Sørensen, Vigdis; Brech, Andreas; Lothe, Ragnhild A & Leithe, Edward (2017). The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions. Journal of Cell Science.  ISSN 0021-9533.  130(17), s 2867- 2882 . doi: 10.1242/jcs.202408
• Müller, Elisabeth; Christopoulos, Panagiotis; Halder, Sanjib; Lunde, Anna; Beraki, Kahsai; Speth, Martin; Øynebråten, Inger & Corthay, Alexandre (2017). Toll-like receptor ligands and interferon-gamma synergize for induction of antitumor M1 macrophages. Frontiers in Immunology.  ISSN 1664-3224.  8 . doi: 10.3389/fimmu.2017.01383 Fulltekst i vitenarkiv.
• Sengupta, Sagnik; Ergon, Torbjørn & Leinaas, Hans Petter (2017). Thermal plasticity in postembryonic life history traits of a widely distributed Collembola: Effects of macroclimate and microhabitat on genotypic differences. Ecology and Evolution.  ISSN 2045-7758.  7(19), s 8100- 8112 . doi: 10.1002/ece3.3333 Fulltekst i vitenarkiv.
• Bottermann, Maria; Lode, Heidrun Elisabeth; Watkinson, Ruth E.; Foss, Stian; Sandlie, Inger; Andersen, Jan Terje & James, Leo C. (2017). Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity. Scientific Reports.  ISSN 2045-2322. . doi: 10.1038/srep45418 Fulltekst i vitenarkiv.
• Ekblad, Bie; Nissen-Meyer, Jon & Kristensen, Tom (2017). Whole-genome sequencing of mutants with increased resistance against the two-peptide bacteriocin plantaricin JK reveals a putative receptor and potential docking site. PLoS ONE.  ISSN 1932-6203. . doi: 10.1371/journal.pone.0185279 Fulltekst i vitenarkiv.
• Lefevre, Sjannie; Stecyk, Jonathan Anthony William; Torp, May-Kristin; Løvold, Lisa Yuen; Sørensen, Christina; Johansen, Ida Beitnes; Stensløkken, Kåre-Olav; Couturier, Christine Stephanie; Sloman, Katherine A. & Nilsson, Göran Erik (2017). Re-oxygenation after anoxia induces brain cell death and memory loss in the anoxia-tolerant crucian carp. Journal of Experimental Biology.  ISSN 0022-0949.  220(21), s 3883- 3895 . doi: 10.1242/jeb.165118 Fulltekst i vitenarkiv.
• Ippen, Tammo; Eppler, Jochen Martin; Plesser, Hans Ekkehard & Diesmann, Markus (2017). Constructing neuronal network models in massively parallel environments. Frontiers in Neuroinformatics.  ISSN 1662-5196.  11 . doi: 10.3389/fninf.2017.00030 Fulltekst i vitenarkiv.
• Thrane, Jan-Erik; Hessen, Dag Olav & Andersen, Tom (2017). Plasticity in algal stoichiometry: Experimental evidence of a temperature-induced shift in optimal supply N:P ratio. Limnology and Oceanography.  ISSN 0024-3590.  62(4), s 1346- 1354 . doi: 10.1002/lno.10500
• Skau, Lars Fredrik; Andersen, Tom; Thrane, Jan-Erik & Hessen, Dag Olav (2017). Growth, stoichiometry and cell size; temperature and nutrient responses in haptophytes. PeerJ.  ISSN 2167-8359.  5 . doi: 10.7717/peerj.3743 Fulltekst i vitenarkiv.
• Hessen, Dag Olav; Håll, Johnny Peter; Thrane, Jan-Erik & Andersen, Tom (2017). Coupling dissolved organic carbon, CO2 and productivity in boreal lakes. Freshwater Biology.  ISSN 0046-5070.  62(5), s 945- 953 . doi: 10.1111/fwb.12914
• Beyer, Jonny; Green, Norman Whitaker; Brooks, Steven; Allan, Ian; Ruus, Anders; Gomes, Tania; Bråte, Inger Lise Nerland & Schøyen, Merete (2017). Blue mussels (Mytilus edulis spp.) as sentinel organisms in coastal pollution monitoring: A review. Marine Environmental Research.  ISSN 0141-1136.  130, s 338- 365 . doi: 10.1016/j.marenvres.2017.07.024
• Heuschele, Jan David; Ekvall, Mikael T.; Mariani, Patrizio & Lindemann, Christian (2017). On the missing link in ecology: improving communication between modellers and experimentalists. Oikos.  ISSN 0030-1299.  126(8), s 1071- 1077 . doi: 10.1111/oik.03885
• Mutinova, Petra Thea; Kulichova, Jana & Ugland, Karl Inne (2017). Temporal and Spatial Dynamics of Diatom (Bacillariophyceae) Communities in a Peatland Area. Cryptogamie. Algologie.  ISSN 0181-1568.  38(3), s 253- 266 . doi: 10.7872/crya/v38.iss3.2017.253
• Hu, Xian; Margadant, Felix Martin; Yao, Mingxi & Sheetz, Michael Patrick (2017). Molecular stretching modulates mechanosensing pathways. Protein Science.  ISSN 0961-8368.  26(7), s 1337- 1351 . doi: 10.1002/pro.3188
• von Krogh, Kristine; Bjørndal, Gunnveig Toft; Nourizadeh-Lillabadi, Rasoul; Hodne, Kjetil; Ropstad, Erik; Haug, Trude M & Weltzien, Finn-Arne (2017). Sex steroids differentially regulate fshb, lhb and gnrhr expression in Atlantic cod (Gadus morhua). Reproduction.  ISSN 1470-1626.  154(5), s 581- 594 . doi: 10.1530/REP-17-0208
• Andreassen, Cecilie Schou; Nielsen, Morten Birkeland; Pallesen, Ståle & Gjerstad, Johannes (2017). The Relationship Between Psychosocial Work Variables and Workaholism: Findings From a Nationally Representative Survey. International Journal of Stress Management.  ISSN 1072-5245.  26(1), s 1- 10 . doi: 10.1037/str0000073
• Vedeld, Hege Marie; Merok, Marianne Aarstad; Jeanmougin, Marine; Danielsen, Stine Aske; Honne, Hilde; Presthus, Gro; Svindland, Aud; Sjo, Ole Helmer; Hektoen, Merete; Eknæs, Mette; Nesbakken, Arild; Lothe, Ragnhild A & Lind, Guro Elisabeth (2017). CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers. International Journal of Cancer.  ISSN 0020-7136.  141(5), s 967- 976 . doi: 10.1002/ijc.30796
• Lorberau, Kelsey; Botnen, Synnøve Smebye; Mundra, Sunil; Aas, Anders Bjørnsgard; Rozema, Jelte; Eidesen, Pernille Bronken & Kauserud, Håvard (2017). Does warming by open-top chambers induce change in the root-associated fungal community of the arctic dwarf shrub Cassiope tetragona (Ericaceae)?. Mycorrhiza.  ISSN 0940-6360.  27(5), s 513- 524 . doi: 10.1007/s00572-017-0767-y
• Vuong, Tram Thu; Rønning, Sissel Beate; Suso, Henri-Pierre; Schmidt, Ralf; Prydz, Kristian; Lundström, Marlene; Moen, Anders & Pedersen, Mona Elisabeth (2017). The extracellular matrix of eggshell displays anti-inflammatory activities through NF-κB in LPS-triggered human immune cells. Journal of Inflammation Research.  ISSN 1178-7031.  10, s 83- 96 . doi: 10.2147/JIR.S130974 Fulltekst i vitenarkiv.
• Aynekulu, Ermias; Mekuria, Wolde; Alemu, Diress Tsegaye; Feyissa, Kenea; Angassa, Ayana; de Leeuw, Jan & Shepherd, Keith D (2017). Long-term livestock exclosure did not affect soil carbon in southern Ethiopian rangelands. Geoderma.  ISSN 0016-7061.  307, s 1- 7 . doi: 10.1016/j.geoderma.2017.07.030
• Vindas, Marco Antonio; Gorissen, Marnix; Höglund, Erik; Flik, Gert; Tronci, Valentina; Damsgård, Børge; Thörnqvist, Per-Ove; Nilsen, Tom Ole; Winberg, Svante; Øverli, Øyvind & Ebbesson, Lars O.E. (2017). How do individuals cope with stress? Behavioural, physiological and neuronal differences between proactive and reactive coping styles in fish. Journal of Experimental Biology.  ISSN 0022-0949.  220(8), s 1524- 1532 . doi: 10.1242/jeb.153213
• Vindas, Marco Antonio; Magnhagen, Carin; Brännäs, Eva; Øverli, Øyvind; Winberg, Svante; Nilsson, Jan & Backström, Tobias (2017). Brain cortisol receptor expression differs in Arctic charr displaying opposite coping styles. Physiology and Behavior.  ISSN 0031-9384.  177, s 161- 168 . doi: 10.1016/j.physbeh.2017.04.024
• Johansen, Ida Beitnes; Sandblom, Erik; Skov, Peter V.; Gräns, Albin; Ekström, Andreas; Lunde, Ida Gjervold; Vindas, Marco Antonio; Zhang, Lili; Höglund, Erik; Frisk, Michael; Sjaastad, Ivar; Nilsson, Göran Erik & Øverli, Øyvind (2017). Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids. Journal of Experimental Biology.  ISSN 0022-0949.  220(14), s 2545- 2553 . doi: 10.1242/jeb.135046 Fulltekst i vitenarkiv.
• Aileni, Vinay Kumar; Davydova, Erna; Moen, Anders & Falnes, Pål (2017). A System for Enzymatic Lysine Methylation in a Desired Sequence Context. ACS Omega.  ISSN 2470-1343.  2(2), s 462- 469 . doi: 10.1021/acsomega.6b00486 Fulltekst i vitenarkiv.
• Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Nilges, Benedikt S.; Moen, Anders; Leidel, Sebastian A. & Falnes, Pål (2017). Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. Nucleic Acids Research.  ISSN 0305-1048.  45, s 8239- 8254 . doi: 10.1093/nar/gkx432 Fulltekst i vitenarkiv.
• Vindas, Marco Antonio; Madaro, Angelico; Fraser, Thomas; Höglund, Erik; Olsen, Rolf Erik; Kristiansen, Tore S & Øverli, Øyvind (2017). Uncontrollable chronic stress reduces growth disparities in farmed Atlantic salmon. Physiology and Behavior.  ISSN 0031-9384.  179, s 246- 252 . doi: 10.1016/j.physbeh.2017.06.012
• Alfsnes, Kristian; Leinaas, Hans Petter & Hessen, Dag Olav (2017). Genome size in arthropods; different roles of phylogeny, habitat and life history in insects and crustaceans. Ecology and Evolution.  ISSN 2045-7758.  7(15), s 5939- 5947 . doi: 10.1002/ece3.3163 Fulltekst i vitenarkiv.
• Hitchcock, Daniel James; Varpe, Øystein; Andersen, Tom & Borgå, Katrine (2017). Effects of reproductive strategies on pollutant concentrations in pinnipeds: a meta-analysis. Oikos.  ISSN 0030-1299.  126(6), s 772- 781 . doi: 10.1111/oik.03955
• Abraityte, Judita Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika; Christensen, Geir Arve; Aukrust, Pål; Yndestad, Arne; Fiane, Arnt E; Andreassen, Arne K.; Aakhus, Svend; Dahl, Christen Peder; Gullestad, Lars; Broch, Kaspar & Ueland, Thor (2017). Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-03625-9 Fulltekst i vitenarkiv.
• Øverbye, Anders; Holsæter, Ann Mari; Fusser, Markus; Skalko-Basnet, Natasa; Iversen, Tore Geir; Torgersen, Maria Lyngaas; Sønstevold, Tonje; Engebråten, Olav; Flatmark, Kjersti; Mælandsmo, Gunhild; Skotland, Tore & Sandvig, Kirsten (2017). Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. OncoTarget.  ISSN 1949-2553.  8(44), s 76921- 76934 . doi: 10.18632/oncotarget.20217 Fulltekst i vitenarkiv.
• Michalik, Marcin; Rydmark, Marcella Orwick; Habeck, Michael; Alva, Vikram; Arnold, Thomas & Linke, Dirk (2017). An evolutionarily conserved glycine-tyrosine motif forms a folding core in outer membrane proteins. PLoS ONE.  ISSN 1932-6203.  12(8) . doi: 10.1371/journal.pone.0182016
• Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Tennøe, Simen; Fyhn, Marianne & Hafting, Torkel (2017). Differential Expression and Cell-Type Specificity of Perineuronal Nets in Hippocampus, Medial Entorhinal Cortex and Visual Cortex Examined in the Rat and Mouse. eNeuro.  ISSN 2373-2822.  4(3), s 1- 18 . doi: 10.1523/ENEURO.0379-16.2017 Fulltekst i vitenarkiv.
• Lai, Floriana; Fagernes, Cathrine Elisabeth; Bernier, Nicholas J; Miller, Gabrielle; Munday, Philip L; Nilsson, Göran Erik & Nilsson, Goran E (2017). Responses of neurogenesis and neuroplasticity related genes to elevated CO2 levels in the brain of three teleost species. Biology Letters.  ISSN 1744-9561.  13(8) . doi: 10.1098/rsbl.2017.0240 Vis sammendrag

  The continuous increase of anthropogenic CO2 in the atmosphere resulting in ocean acidification has been reported to affect brain function in some fishes. During adulthood, cell proliferation is fundamental for fish brain growth and for it to adapt in response to external stimuli, such as environmental changes. Here we report the first expression study of genes regulating neurogenesis and neuroplasticity in brains of three-spined stickleback (Gasterosteus aculeatus), cinnamon anemonefish (Amphiprion melanopus) and spiny damselfish (Acanthochromis polyacanthus) exposed to elevated CO2. The mRNA expression levels of the neurogenic differentiation factor (NeuroD) and doublecortin (DCX) were upregulated in three-spined stickleback exposed to high-CO2 compared with controls, while no changes were detected in the other species. The mRNA expression levels of the proliferating cell nuclear antigen (PCNA) and the brain-derived neurotrophic factor (BDNF) remained unaffected in the high-CO2 exposed groups compared to the control in all three species. These results indicate a species-specific regulation of genes involved in neurogenesis in response to elevated ambient CO2 levels. The higher expression of NeuroD and DCX mRNA transcripts in the brain of high-CO2–exposed three-spined stickleback, together with the lack of effects on mRNA levels in cinnamon anemonefish and spiny damselfish, indicate differences in coping mechanisms among fish in response to the predicted-future CO2 level.

• Aasebø, Ida E. J.; Lepperød, Mikkel Elle; Stavrinou, Maria; Nøkkevangen, Sandra; Einevoll, Gaute; Hafting, Torkel & Fyhn, Marianne (2017). Temporal processing in the visual cortex of the awake and anesthetized rat. eNeuro.  ISSN 2373-2822.  4:e0059-17.2017(4), s 1- 26 . doi: 10.1523/ENEURO.0059-17.2017 Fulltekst i vitenarkiv. Vis sammendrag

  The activity pattern and temporal dynamics within and between neuron ensembles are essential features of information processing and believed to be profoundly affected by anesthesia. Much of our general understanding of sensory information processing, including computational models aimed at mathematically simulating sensory information processing, rely on parameters derived from recordings conducted on animals under anesthesia. Due to the high variety of neuronal subtypes in the brain, population-based estimates of the impact of anesthesia may conceal unit- or ensemble-specific effects of the transition between states. Using chronically implanted tetrodes into primary visual cortex (V1) of rats, we conducted extracellular recordings of single units and followed the same cell ensembles in the awake and anesthetized states. We found that the transition from wakefulness to anesthesia involves unpredictable changes in temporal response characteristics. The latency of single-unit responses to visual stimulation was delayed in anesthesia, with large individual variations between units. Pair-wise correlations between units increased under anesthesia, indicating more synchronized activity. Further, the units within an ensemble show reproducible temporal activity patterns in response to visual stimuli that is changed between states, suggesting state-dependent sequences of activity. The current dataset, with recordings from the same neural ensembles across states, is well suited for validating and testing computational network models. This can lead to testable predictions, bring a deeper understanding of the experimental findings and improve models of neural information processing. Here, we exemplify such a workflow using a Brunel network model.

• Fuglerud, Bettina Maria; Lemma, Roza Berhanu; Wanichawan, Pimthanya; Sundaram, Arvind; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2017). A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function. Nucleic Acids Research.  ISSN 0305-1048.  45(13), s 7681- 7696 . doi: 10.1093/nar/gkx364
• Malecki, Jedrzej Mieczyslaw; Aileni, Vinay Kumar; Ho, Angela Yeuan Yen; Schwarz, Juliane; Moen, Anders; Sørensen, Vigdis; Nilges, Benedikt S.; Jakobsson, Magnus; Leidel, Sebastian A. & Falnes, Pål (2017). The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). Nucleic Acids Research.  ISSN 0305-1048.  45(8), s 4370- 4389 . doi: 10.1093/nar/gkx002
• Wielgolaski, Frans Emil; Hofgaard, Annika & Holtmeier, Friedrich-Karl (2017). Sensitivity to environmental change of the treeline ecotone and its associated biodiversity in European mountains. Climate Research (CR).  ISSN 0936-577X.  73(1-2), s 151- 166 . doi: 10.3354/cr01474 Fulltekst i vitenarkiv. Vis sammendrag

  Transition zones between mountain forests and treeless tundra, i.e. treeline ecotones, are characterized by great regional variety. In this paper, we discuss the biodiversity in various trophic levels in treeline ecotones throughout Europe, with particular focus on recent changes in land use and climate in northern and central mountains. In northernmost Europe, mountain birch prevails, while conifers (spruce, pine, larch) are the dominating species further south. While at continent-wide to global scales, the ecotone position is largely controlled by heat deficiency, it depends on a multitude of partly interacting abiotic and biotic factors other than climate at smaller scales. Climate change is a driving factor in treeline ecotone change, including physiognomic structure and biodiversity, although the effects of climate and other factors often overlap. Historical legacy plays an important role in this respect, and human impacts are particularly important. The recent decline in pastoral use of many European treeline areas often strongly influences plant diversity and re-growth of trees and other woody species. Climate change together with changing tree cover may influence snow cover, moisture regime, and nutrient conditions. Subsequently changed site conditions influence plant−plant interactions, favoring some species and disfavoring others, and plant−animal interactions. Native animals may cause widespread or local disturbances in treeline ecotone areas. Mass outbreaks of leaf-eating insects, for example, usually affect comparatively large forested areas whereas mammalian herbivores and birds have more local impact. However, high numbers of wild or domestic mammalian herbivores may challenge the carrying capacity of treeline ecotone areas at the same time as they preserve an open pasture character. This calls for cross-disciplinary study approaches, addressing the complexity of the ecotone regarding both causal background and biogeographic diversity. Treeline ecotone, ecotone change, land use change, climate change, anumal impact

• Cudlin, Pavel; Klopcic, Matija; Tognetti, Roberto; Mális, Frantisek; Alados, Concepcion L.; Bebi, Peter; Grunewald, Karsten; Zhiyanski, Miglena; Andonowski, Vlatko; La Porta, Nicola; Bratanova-Doncheva, Svetlana; Kachaunova, Eli; Edwards-Jonášová, Magda; Ninot, Josep Maria; Rigling, Andreas; Hofgaard, Annika; Hlásny, Tomáš; Skalák, Petr & Wielgolaski, Frans Emil (2017). Drivers of treeline shift in different European mountains. Climate Research (CR).  ISSN 0936-577X.  73(1-2), s 135- 150 . doi: 10.3354/cr01465 Fulltekst i vitenarkiv. Vis sammendrag

  A growing body of evidence suggests that processes of upward treeline expansion and shifts in vegetation zones may occur in response to climate change. However, such shifts can be limited by a variety of non-climatic factors, such as nutrient availability, soil conditions, landscape fragmentation and some species-specific traits. Many changes in species distributions have been observed, although no evidence of complete community replacement has been registered yet. Climatic signals are often confounded with the effects of human activity, for example, forest encroachment at the treeline owing to the coupled effect of climate change and highland pasture abandonment. Data on the treeline ecotone, barriers to the expected treeline or dominant tree species shifts due to climate and land use change, and their possible impacts on biodiversity in 11 mountain areas of interest, from Italy to Norway and from Spain to Bulgaria, are reported. We investigated the role of environmental conditions on treeline ecotone features with a focus on treeline shift. The results showed that treeline altitude and the altitudinal width of the treeline ecotone, as well as the significance of climatic and soil parameters as barriers against tree species shift, significantly decreased with increasing latitude. However, the largest part of the commonly observed variability in mountain vegetation near the treeline in Europe seems to be caused by geomorphological, geological, pedological and microclimatic variability in combination with different land use history and present socio-economic relation Vegetation zone shift · Climate change · Climate models · Treeline ecotone · European mountains · Ecosystem services

• Fagernes, Cathrine Elisabeth; Stensløkken, Kåre-Olav; Kjendseth, Åsmund Røhr; Berenbrink, Michael; Ellefsen, Stian & Nilsson, Göran Erik (2017). Extreme anoxia tolerance in crucian carp and goldfish through neofunctionalization of duplicated genes creating a new ethanol- producing pyruvate decarboxylase pathway. Scientific Reports.  ISSN 2045-2322.  (7) . doi: 10.1038/s41598-017-07385-4 Fulltekst i vitenarkiv.
• Poleo, Antonio; Scholden, Joachim; Sørensen, Jørgen & Nilsson, Göran Erik (2017). The high tolerance to aluminum in crucian crap (Carcassius carcassius) is associated with its ability to avoid hypoxia. PLoS ONE.  ISSN 1932-6203.  12(6) . doi: 10.1371/journal.pone.0179519 Fulltekst i vitenarkiv.
• Bengtsen, Mads; Sørensen, Linda Therese; Aabel, Linn Ingeborg; Ledsaak, Marit; Matre, Vilborg & Gabrielsen, Odd Stokke (2017). The adaptor protein ARA55 and the nuclear kinase HIPK1 assist c-Myb in recruiting p300 to chromatin. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms.  ISSN 1874-9399.  1860(7), s 751- 760 . doi: 10.1016/j.bbagrm.2017.05.001
• Bjorland, Siri; Røe, Cecilie; Moen, Aurora Lie; Schistad, Ellina Iordanova; Aqsa, Mahmood & Gjerstad, Johannes (2017). Genetic predictors of recovery in low back and lumbar radicular pain. Pain.  ISSN 0304-3959.  158(8), s 1456- 1460 . doi: 10.1097/j.pain.0000000000000934
• Moen, Gunn-Helen Øiseth; Moen, Aurora Lie; Schistad, Ellina Iordanova & Gjerstad, Johannes (2017). Local up-regulation of interferon-γ (IFN-γ) following disc herniation is involved in the inflammatory response underlying acute lumbar radicular pain. Cytokine.  ISSN 1043-4666.  97, s 181- 186 . doi: 10.1016/j.cyto.2017.06.005
• Brandrud, Marie Kristine; Paun, Ovidiu; Lorenzo, Maria Teresa; Nordal, Inger & Brysting, Anne Krag (2017). RADseq provides evidence for parallel ecotypic divergence in the autotetraploid Cochlearia officinalis in Northern Norway. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/s41598-017-05794-z Fulltekst i vitenarkiv.
• Kara, Emrah; Manna, Dipankar; Løset, Geir Åge; Schneider, E L; Craik, C S & Kanse, Sandip (2017). Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thrombosis and Haemostasis.  ISSN 0340-6245. . doi: 10.1160/TH17-02-0081 Fulltekst i vitenarkiv.
• Mayer, Christine & Hansen, Thomas F (2017). Evolvability and Robustness: A paradox restored. Journal of Theoretical Biology.  ISSN 0022-5193.  430, s 78- 85 . doi: 10.1016/j.jtbi.2017.07.004
• García, Marta; Barrio, Raquel; García-Lavandeira, Montserrat; Garcia-Rendueles, Angela R.; Escudero, Adela; Diaz-Rodríguez, Esther; Gorbenko Del Blanco, Darya; Fernández, Ana; De Rijke, Yolanda B.; Vallespín, Elena; Nevado, Julián; Lapunzina, Pablo; Matre, Vilborg; Hinkle, Patricia M.; Hokken-Koelega, Anita C.S.; De Miguel, María P.; Cameselle-Teijeiro, José Manuel; Nistal, Manuel; Alvarez, Clara V. & Moreno, José C. (2017). The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGF? and Activin pathways. Scientific Reports.  ISSN 2045-2322.  7:42937, s 1- 18 . doi: 10.1038/srep42937 Fulltekst i vitenarkiv.
• Grundt, Kirsten; Thiede, Bernd & Østvold, Anne Carine (2017). Identification of kinases phosphorylating 13 sites in the nuclear, DNA-binding protein NUCKS. Biochimica et Biophysica Acta - Proteins and Proteomics.  ISSN 1570-9639.  1865(3), s 359- 369 . doi: 10.1016/j.bbapap.2016.12.009
• Zadraznik, Tanja M; Jacobsen, Wolfgang Mathias; Meglic, Vladimir & Sustar-Vozlic, Jelka (2017). Proteomic analysis of common bean stem under drought stress using in-gel stable isotope labeling. Journal of plant physiology.  ISSN 0176-1617.  209, s 42- 50 . doi: 10.1016/j.jplph.2016.10.015
• Skrede, Inger; Carlsen, Tor & Schumacher, Trond (2017). A synopsis of the saddle fungi (Helvella: Ascomycota) in Europe – species delimitation, taxonomy and typification. Persoonia.  ISSN 0031-5850.  39, s 201- 253 . doi: 10.3767/persoonia.2017.39.09 Fulltekst i vitenarkiv.
• Hylland, Ketil; Skei, Bjørn Borge; Brunborg, Gunnar; Lang, Thomas; Gubbins, Matthew J.; Le Goff, Jérémie & Burgeot, Thierry (2017). DNA damage in dab (Limanda limanda) and haddock (Melanogrammus aeglefinus) from European seas. Marine Environmental Research.  ISSN 0141-1136.  124, s 54- 60 . doi: 10.1016/j.marenvres.2016.01.001 Fulltekst i vitenarkiv.
• Fraser, Thomas; Khezri, Abdolrahman; Jusdado, Juan German Herranz; Lewandowska-Sabat, Anna; Henry, Theodore & Ropstad, Erik (2017). Toxicant induced behavioural aberrations in larval zebrafish are dependent on minor methodological alterations. Toxicology Letters.  ISSN 0378-4274.  276, s 62- 68 . doi: 10.1016/j.toxlet.2017.05.021
• Klaveness, Dag (2017). Hydrurus foetidus (Chrysophyceae) - an inland macroalga with potential. Journal of Applied Phycology.  ISSN 0921-8971.  29, s 1485- 1491 . doi: 10.1007/s10811-016-1047-5
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta & Hersleth, Hans-Petter (2017). Measurement of FNR-NrdI Interaction by Microscale Thermophoresis (MST). Bio-protocol.  ISSN 2331-8325.  7(8), s e2223 . doi: 10.21769/BioProtoc.2223 Fulltekst i vitenarkiv.
• Moen, Aurora Lie; Jacobsen, Daniel; Phuyal, Santosh; Legfeldt, Anna; Haugen, Fred; Røe, Cecilie & Gjerstad, Johannes (2017). MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation. Journal of Translational Medicine.  ISSN 1479-5876.  15(89), s 1- 11 . doi: 10.1186/s12967-017-1194-8 Fulltekst i vitenarkiv.
• Simovski, Boris; Vodak, Daniel; Gundersen, Sveinung; Domanska, Diana Ewa; Azab, Abdulrahman; Holden, Lars; Holden, Marit; Grytten, Ivar; Rand, Knut Dagestad; Drabløs, Finn; Johansen, Morten; Mora Ortiz, Antonio Carlos; Lund-Andersen, Christin; Fromm, Bastian; Eskeland, Ragnhild; Gabrielsen, Odd Stokke; Ferkingstad, Egil; Nakken, Sigve; Bengtsen, Mads; Nederbragt, Alexander Johan; Thorarensen, Hildur Sif; Akse, Johannes Andreas; Glad, Ingrid Kristine; Hovig, Johannes Eivind & Sandve, Geir Kjetil (2017). GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome. GigaScience.  ISSN 2047-217X.  6(7), s 1- 12 . doi: 10.1093/gigascience/gix032 Fulltekst i vitenarkiv. Vis sammendrag

  Background: Recent large-scale undertakings such as ENCODE and Roadmap Epigenomics have generated experimental data mapped to the human reference genome (as genomic tracks) representing a variety of functional elements across a large number of cell types. Despite the high potential value of these publicly available data for a broad variety of investigations, little attention has been given to the analytical methodology necessary for their widespread utilisation. Findings: We here present a first principled treatment of the analysis of collections of genomic tracks. We have developed novel computational and statistical methodology to permit comparative and confirmatory analyses across multiple and disparate data sources. We delineate a set of generic questions that are useful across a broad range of investigations and discuss the implications of choosing different statistical measures and null models. Examples include contrasting analyses across different tissues or diseases. The methodology has been implemented in a comprehensive open-source software system, the GSuite HyperBrowser. To make the functionality accessible to biologists, and to facilitate reproducible analysis, we have also developed a web-based interface providing an expertly guided and customizable way of utilizing the methodology. With this system, many novel biological questions can flexibly be posed and rapidly answered. Conclusions: Through a combination of streamlined data acquisition, interoperable representation of dataset collections and customizable statistical analysis with guided setup and interpretation, the GSuite HyperBrowser represents a first comprehensive solution for integrative analysis of track collections across the genome and epigenome. The software is available at: https://hyperbrowser.uio.no

• Skotland, Tore; Sandvig, Kirsten & Llorente, Alicia (2017). Lipids in exosomes: Current knowledge and the way forward. Progress in lipid research.  ISSN 0163-7827.  66, s 30- 41 . doi: 10.1016/j.plipres.2017.03.001 Fulltekst i vitenarkiv.
• Zaltariov, Mirela F.; Hammerstad, Marta; Arabshahi, Homayon John; Jovanovic, Katarina; Richter, Klaus W.; Cazacu, Maria; Shova, Sergiu; Balan, Mihaela; Andersen, Niels Højmark; Radulovic, Sinisa; Reynisson, Jóhannes; Andersson, Karl Kristoffer & Arion, Vladimir B (2017). New Iminodiacetate–Thiosemicarbazone Hybrids and Their Copper(II) Complexes Are Potential Ribonucleotide Reductase R2 Inhibitors with High Antiproliferative Activity. Inorganic Chemistry.  ISSN 0020-1669.  56, s 3532- 3549 . doi: 10.1021/acs.inorgchem.6b03178 Fulltekst i vitenarkiv.
• Weitzner, Brian D.; Jeliazkov, Jeliazko R.; Lyskov, Sergey; Marze, Nicholas; Kuroda, Daisuke; Frick, Rahel; Adolf-Bryfogle, Jared; Biswas, Naireeta; Dunbrack, Roland L. & Gray, Jeffrey J. (2017). Modeling and docking of antibody structures with Rosetta. Nature Protocols.  ISSN 1754-2189.  12(2), s 401- 416 . doi: 10.1038/nprot.2016.180
• Wigestrand, Mattis B; Schiff, Hillary C.; Fyhn, Marianne; LeDoux, Joseph E & Sears, Robert M. (2017). Primary auditory cortex regulates threat memory specificity. Learning & memory (Cold Spring Harbor, N.Y.).  ISSN 1072-0502.  24(1), s 55- 58 . doi: 10.1101/lm.044362.116
• Lopez Soop, Graciela; Rønningen, Torunn; Rogala, Agnieszka; Richartz, Nina; Blomhoff, Heidi Kiil; Thiede, Bernd; Collas, Philippe & Küntziger, Thomas M. (2017). AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint. Cell Cycle.  ISSN 1538-4101.  16(10), s 947- 956 . doi: 10.1080/15384101.2017.1310350 Fulltekst i vitenarkiv.
• Andrew, Carrie Joy; Heegaard, Einar; Kirk, Paul M.; Bässler, Claus; Heilmann-Clausen, Jacob; Krisai-Greilhuber, Irmgard; Kuyper, Thomas W.; Senn-Irlet, Beatrice; Büntgen, Ulf; Diez, Jeffrey Michael; Egli, Simon; Gange, Alan C.; Halvorsen, Rune; Høiland, Klaus; Nordén, Jenni; Rustøen, Fredrik; Boddy, Lynne & Kauserud, Håvard (2017). Big data integration: Pan-European fungal species observations' assembly for addressing contemporary questions in ecology and global change biology. Fungal Biology Reviews.  ISSN 1749-4613.  31(2), s 88- 98 . doi: 10.1016/j.fbr.2017.01.001 Vis sammendrag

  Species occurrence observations are increasingly available for scientific analyses through citizen science projects and digitization of museum records, representing a largely untapped ecological resource. When combined with open-source data, there is unparalleled potential for understanding many aspects of the ecology and biogeography of organisms. Here we describe the process of assembling a pan-European mycological meta-database (ClimFun) and integrating it with open-source data to advance the fields of macroecology and biogeography against a backdrop of global change. Initially 7.3 million unique fungal species fruit body records, spanning nine countries, were processed and assembled into 6 million records of more than 10,000 species. This is an extraordinary amount of fungal data to address macro-ecological questions. We provide two examples of fungal species with different life histories, one ectomycorrhizal and one wood decaying, to demonstrate how such continental-scale meta-databases can offer unique insights into climate change effects on fungal phenology and fruiting patterns in recent decades. Keywords Biogeography; Citizen science; Fungi; Global change; Meta-database; Open-source

• Krabberød, Anders Kristian; Orr, Russell; Bråte, Jon; Kristensen, Tom; Bjørklund, Kjell Rasmus & Shalchian-Tabrizi, Kamran (2017). Single cell transcriptomics, mega-phylogeny and the genetic basis of morphological innovations in Rhizaria. Molecular biology and evolution.  ISSN 0737-4038. . doi: /10.1093/molbev/msx075 Vis sammendrag

  The innovation of the eukaryote cytoskeleton enabled phagocytosis, intracellular transport and cytokinesis, and is responsible for the diversity of eukaryotic morphologies. Still, the relationship between phenotypic innovations in the cytoskeleton and their underlying genotype is poorly understood. To explore the genetic mechanism of morphological evolution of the eukaryotic cytoskeleton we provide the first single cell transcriptomes from uncultured, free-living unicellular eukaryotes: the polycystine radiolarian Lithomelissa setosa (Nassellaria) and Sticholonche zanclea (Taxopodida). A phylogenomic approach using 255 genes finds Radiolaria and Foraminifera as separate monophyletic groups (together as Retaria), while Cercozoa is shown to be paraphyletic. Analysis of the genetic components of the cytoskeleton and mapping of the evolution of these to the revised phylogeny of Rhizaria reveal lineage-specific gene duplications and neofunctionalization of α and β tubulin in Retaria, actin in Retaria and Endomyxa, and Arp2/3 complex genes in Chlorarachniophyta. We show how genetic innovations have shaped cytoskeletal structures in Rhizaria, and how single cell transcriptomics can be applied for resolving deep phylogenies and studying gene evolution in uncultured protist species.

• Cardoso, Ines Do Rosario; Østerlund, Eva Christina; Stamnæs, Jorunn; Iversen, Rasmus; Andersen, Jan Terje; Jørgensen, Thomas J D & Sollid, Ludvig Magne (2017). Dissecting the interaction between transglutaminase 2 and fibronectin. Amino Acids.  ISSN 0939-4451.  49(3), s 489- 500 . doi: 10.1007/s00726-016-2296-y Fulltekst i vitenarkiv.
• Ailte, Ieva; Anne Berit Dyve, Lingelem; Kvalvaag, Audun Sverre Myrset; Kavaliauskiene, Simona; Brech, Andreas; Koster, Gerbrand; Dommersnes, Paul Gunnar; Bergan, Jonas; Skotland, Tore & Sandvig, Kirsten (2017). Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis. Traffic : the International Journal of Intracellular Transport.  ISSN 1398-9219.  18(3), s 176- 191 . doi: 10.1111/tra.12468
• Sarkki, Simo; Ficko, Andrej; Wielgolaski, Frans Emil; Abraham, Eleni M.; Bratanova-Doncheva, Svetla; Grunewald, Karsten; Hofgaard, Annika; Holtmeier, Friedrich-Karl; Kyriazopoulos, Apostolos P.; Broll, Gabriele; Nijnik, Maria & Sutinen, Marja-Liisa (2017). Assessing the resilient provision of ecosystem services by social-ecological systems: introduction and theory. Climate Research (CR).  ISSN 0936-577X.  73(1-2), s 7- 15 . doi: 10.3354/cr01437 Fulltekst i vitenarkiv. Vis sammendrag

  The concepts of resilience and ecosystem. servicesbroaden the opportunities for assessing sustainability of social-ecological systems (SESs). The lack of operational frameworks for assessing the resilient provision of ecosystem services by SESs impedes greater integration of resilience thinking in natural resource governance. The greatest challenge sofarhas been to understand the capacity of the SESto (re)organize itself and sustain theflow of benefitsfromnature topeopleundervarious global and local pressures and trade-offs between ecosystem services users. To assess the resilience of an SES within a singleframework, we propose anew approach whic:his a combination of: (1) the Drlver-Pres­ sure-State-Impact-Response (DPSIR)framework; (2) social-ecological indicatms; and (3) scenario build­ ing. Practicalapplication of the approach isdemonstrated with the example of European polar andalti­ turunal treeline areas.The DPSIRframework analyzes causal relationships between the components of the SES. Social-ecological indicators quantify processes in the SES and estimate trends in the DPSIR factors. Combined top-down and bottom-up scenariosenvision plausible development paths of the SES inthe future based onexpected global environmental and social changeswhich create context specific dynamics between DPsmfactors at specific localities. Theproposed approach represents the analytical framework of the European Cooperation in Science and Technology (COST) action SENSFOR (En­ hancing the resilience capacity of SENSitive mountain FORest ecosystems under environmental change) andcan be applied to promote systemicresiliencethinking inany SES. Human-environment intera.cti.on ·Eoo&ylitem services ·DPSIR framework ·Resilience · Social-ecological:indicators ·Scenarios

• Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne (2017). Removal of perineuronal nets unlocks juvenile plasticity through network mechanisms of decreased inhibition and increased gamma Activity. Journal of Neuroscience.  ISSN 0270-6474.  37(5), s 1269- 1283 . doi: 10.1523/JNEUROSCI.2504-16.2016
• Li, Jianbao; Huang, Xianjin; Yang, Hong; Chuai, Xiaowei & Wu, Changyan (2017). Convergence of carbon intensity in the Yangtze River Delta, China. Habitat International.  ISSN 0197-3975.  60, s 58- 68 . doi: 10.1016/j.habitatint.2016.12.012 Vis sammendrag

  As China's industrialization and urbanization have grown rapidly in recent years, China's CO2 emissions rose from 3405.1799 Mt to 10,249.4630 Mt from 2000 to 2013, and it has reached the highest levels in the word since 2006. Chinese government has emphasized the importance of reducing carbon emissions and set the target of reducing carbon intensity to 60e65% of 2005 levels by 2030. Investigating the convergence of carbon intensity can identify the convergence rate, which is helpful in guiding allocations of carbon intensity reduction. The Yangtze River Delta is one of the key carbon emission regions in China, with higher urbanization levels and larger carbon emissions; thus, we employed prefecture-level panel data derived from grid data between 2000 and 2010 to examine whether the convergence of carbon intensity exists across prefecture-level cities in the Yangtze River Delta. Spatial panel data models were utilized to investigate b-convergence of carbon intensity. The results indicated that carbon intensity showed divergence during 2002e2004 and s-convergence over other periods (2000e2002 and 2004 e2010). Carbon intensity exhibited stochastic convergence, indicating that the shocks to carbon intensity relative to the average level of carbon intensity are only transitory. There was a spatial spillover effect and b-convergence of carbon intensity, suggesting that prefecture-level cities with higher carbon intensity would decrease rapidly in the Yangtze River Delta. Our results highlight the importance of considering the present state of carbon intensity, spatial factors, and socioeconomic factors such as industrial structure and economic levels during allocation planning for reducing carbon intensity.

• Dukic, Aleksandra; Haugen, Linda Hofstad; Pidoux, Guillaume; Leithe, Edward; Bakke, Oddmund & Tasken, Kjetil (2017). A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells. Cellular Signalling.  ISSN 0898-6568.  32, s 1- 11 . doi: 10.1016/j.cellsig.2017.01.008
• Grønnestad, Randi; Villanger, Gro Dehli; Polder, Anuschka; Kovacs, Kit; Lydersen, Christian; Jenssen, Bjørn Munro & Borgå, Katrine (2017). Maternal transfer of perfluoralkyl substances in hooded seals. Environmental Toxicology and Chemistry.  ISSN 0730-7268.  36(3), s 763- 770 . doi: 10.1002/etc.3623 Fulltekst i vitenarkiv.
• Mühlenkamp, Melanie C.; Hallstrom, Teresia; Autenrieth, Ingo B.; Bohn, Erwin; Linke, Dirk; Rinker, Janina; Riesbeck, Kristian; Singh, Birendra; Leo, Jack Christopher; Hammerschmidt, Sven; Zipfel, Peter F. & Schütz, Monika (2017). Vitronectin binds to a specific stretch within the head region of yersinia adhesin a and thereby modulates yersinia enterocolitica host interaction. Journal of Innate Immunity.  ISSN 1662-811X.  9(1), s 33- 51 . doi: 10.1159/000449200 Fulltekst i vitenarkiv.
• Mayer, Christine; Windhager, Sonja; Schaefer, Katrin & Mitteroecker, Philipp (2017). BMI and WHR Are Reflected in Female Facial Shape and Texture: A Geometric Morphometric Image Analysis. PLoS ONE.  ISSN 1932-6203.  12(1) . doi: 10.1371/journal.pone.0169336 Fulltekst i vitenarkiv.
• Baycu, Gulriz; Gevrek-Kurum, Nurbir; Moustaka, Julietta; Csatari, Istvan; Rognes, Sven Erik & Moustakas, Michael (2017). Cadmium-zinc accumulation and photosystem II responses of Noccaea caerulescens to Cd and Zn exposure. Environmental science and pollution research international.  ISSN 0944-1344.  24(3), s 2840- 2850 . doi: 10.1007/s11356-016-8048-4
• Michaelsen, Terje Einar; Emilsen, Sidsel; Sandin, Randi Helene; Granerud, Beathe Kiland; Bratlie, Diane Lynn Bryant; Ihle, Øistein & Sandlie, Inger (2017). Human secretory IgM antibodies activate human complement and offer protection at mucosal surface. Scandinavian Journal of Immunology.  ISSN 0300-9475.  83(1), s 43- 50 . doi: 10.1111/sji.12508 Fulltekst i vitenarkiv.
• Mariussen, Espen; Heier, Lene Sørlie; Teien, Hans-Christian; Pettersen, Marit Nandrup; Holth, Tor Fredrik; Salbu, Brit & Rosseland, Bjørn Olav (2017). Accumulation of lead (Pb) in brown trout (Salmo trutta) from a lake downstream a former shooting range. Ecotoxicology and Environmental Safety.  ISSN 0147-6513.  135, s 327- 336 . doi: 10.1016/j.ecoenv.2016.10.008
• Bjorå, Charlotte Sletten; Elden, Marte; Nordal, Inger; Brysting, Anne Krag; Awas, Tesfaye; Sebsebe, Demissew & Bendiksby, Mika (2017). Speciation in the genera Anthericum and Chlorophytum (Asparagaceae) in Ethiopia — a molecular phylogenetic approach. Phytotaxa.  ISSN 1179-3155.  297(2), s 139- 156 . doi: 10.11646/phytotaxa.297.2.2 Fulltekst i vitenarkiv. Vis sammendrag

  Sister group relations of Ethiopian species of Anthericum and Chlorophytum and variation patterns in the C. gallabatense and C. comosum complexes are studied using molecular phylogenetic analyses, morphometrics, and scanning electron microscopy of seed surfaces. Our results indicate that molecular data largely support previous morphological conclusions, and that speciation has occurred in Ethiopia at least three times in Anthericum and repeatedly within different subclades of Chlorophytum. Areas particularly rich in endemic species are the lowland area around Bale Mountains in SE Ethiopia and in the Beninshangul Gumuz regional state in W Ethiopia near the border to Sudan. A new species, Chlorophytum mamillatum sp. nov., is described, and the names Chlorophytum tordense Chiov. and Chlorophytum tetraphyllum f. are re-erected.

• Edwards, Andrew & Louch, William Edward (2017). Species-dependent mechanisms of cardiac arrhythmia: A cellular focus. Clinical Medicine Insights: Cardiology.  ISSN 1179-5468.  11 . doi: 10.1177/1179546816686061
• Abdullah, Mohamed I; Fredriksen, Stein & Christie, Hartvig (2017). The impact of the kelp (Laminaria hyperborea) forest on the organic matter content in sediment of the west coast of Norway. Marine Biology Research.  ISSN 1745-1000.  13(2), s 151- 160 . doi: 10.1080/17451000.2016.1240369
• Colman, Jonathan Edward; Bergmo, Tine; Tsegaye, Diress; Flydal, Kjetil; Eftestøl, Sindre; Lilleeng, Marte Synnøve & Moe, Stein Ragnar (2017). Wildlife response to infrastructure: the problem with confounding factors. Polar Biology.  ISSN 0722-4060.  40, s 477- 482 . doi: 10.1007/s00300-016-1960-8
• Løvmo, Signe Dille; Speth, Martin; Repnik, Urska; Koppang, Erling Olaf; Griffiths, Gareth Wyn & Hildahl, Jon Paul (2017). Translocation of nanoparticles and Mycobacterium marinum across the intestinal epithelium in zebrafish and the role of the mucosal immune system. Developmental and Comparative Immunology.  ISSN 0145-305X.  67, s 508- 518 . doi: 10.1016/j.dci.2016.06.016
• Yazdani, Mazyar (2016). Technical aspects of oxygen level regulation in primary cell cultures: A review. Interdisciplinary Toxicology.  ISSN 1337-6853.  9(3-4), s 85- 89 . doi: 10.1515/intox-2016-0011
• Edvardsen, Bente; Egge, Elianne Dunthorn & Vaulot, Daniel (2016). Diversity and distribution of haptophytes revealed by environmental sequencing and metabarcoding – a review. Perspectives in Phycology.  ISSN 2364-6993.  3(2), s 77- 91 . doi: 10.1127/pip/2016/0052
• Otto, Miettinen & Ryvarden, Leif (2016). Polypore genera Antella, Austeria, Butyrea, Citripora, Metuloidea and Trulla (Steccherinaceae, Polyporales). Annales Botanici Fennici.  ISSN 0003-3847.  53(3-4), s 157- 172
• Ryvarden, Leif (2016). Neotropical polypores Part 3. Polyporaceae, Obba-Wrightoporia. Synopsis fungorum.  ISSN 0802-8966.  36, s 445- 613
• Gomes-Silva, Allyne Christina; Ryvarden, Leif & Gibertoni, Tatiana Baptista (2016). Studies in Neotropical polypores 45. Two new species (Polyporales, Agaricomycetes) from the Brazilian Amazonia. Synopsis fungorum.  ISSN 0802-8966.  35, s 55- 61
• Ryvarden, Leif (2016). Some Basidiomycetes (Aphyllophorales) from Namibia. Synopsis fungorum.  ISSN 0802-8966.  35, s 53- 54
• Ryvarden, Leif (2016). Studies in Neotropical polypores 43. Some new species from tropical America. Synopsis fungorum.  ISSN 0802-8966.  35, s 43- 47
• Ryvarden, Leif (2016). Studies in Neotropical polypores 44. A note the genus Tyromyces in tropical America. Synopsis fungorum.  ISSN 0802-8966.  35, s 48- 52
• Spirin, Viacheslav & Ryvarden, Leif (2016). Some basidiomycetes (Aphyllophorales) from Mexico. Synopsis fungorum.  ISSN 0802-8966.  35, s 34- 42
• Vlasák, Josef; Vlasák Jr., Josef & Ryvarden, Leif (2016). Studies in Neotropical polypores 42. New and noteworthy polypores from Costa Rica and two new species Elmerina phellinoides and Melanoporia condensa. Synopsis fungorum.  ISSN 0802-8966.  35, s 9- 33
• Drechsler-Santos, Elisandro R.; Salvador-Montoya, Carlos Alberto & Ryvarden, Leif (2016). Studies in Neotropical polypores 41, a new species of Amylosporus from Caatinga dry woodlands, Brazil. Synopsis fungorum.  ISSN 0802-8966.  35, s 4- 8
• Fykerud, Tone Aase; Knudsen, Lars Mørland; Totland, Max; Sørensen, Vigdis; Dahal-Koirala, Shiva; Lothe, Ragnhild A; Brech, Andreas & Leithe, Edward (2016). Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding. Cell Cycle.  ISSN 1538-4101.  15(21), s 2943- 2957 . doi: 10.1080/15384101.2016.1231280 Fulltekst i vitenarkiv.
• Kucera, Ana; Bakke, Oddmund & Progida, Cinzia (2016). The multiple roles of Rab9 in the endolysosomal system. Communicative & Integrative Biology.  ISSN 1942-0889.  9(4) . doi: 10.1080/19420889.2016.1204498
• Nordal, Inger & Bjorå, Charlotte Sletten (2016). Family delimitation in flowering plants, should we bother? – A case study of Asparagales. Symbolae Botanicae Upsalienses.  ISSN 0082-0644.  38, s 41- 48
• Progida, Cinzia & Bakke, Oddmund (2016). Bidirectional traffic between the Golgi and the endosomes - machineries and regulation.. Journal of Cell Science.  ISSN 0021-9533. . doi: 10.1242/jcs.185702
• Jacobsen, Daniel Pitz; Moen, Aurora Lie; Haugen, Fred & Gjerstad, Johannes (2016). Hyperexcitability in spinal WDR neurons following experimental disc herniation is associated with upregulation of fractalkine and its receptor in nucleus pulposus and the dorsal root ganglion. International Journal of Inflammation.  ISSN 2042-0099. . doi: 10.1155/2016/6519408

Se alle arbeider i Cristin

• Sjaastad, Øystein; Toverud, Kari C.; Sand, Olav; Bjaalie, Jan G. & Egil, Haug (2018). Arbeidsbok til Menneskekroppen - Fysiologi og anatomi, 3. utgave. Gyldendal Akademisk.  ISBN 978-82-05-51403-4.  224 s.
• Sand, Olav; Sjaastad, Øystein; Haug, Egil & Bjaalie, Jan G. (2018). Menneskekroppen - Fysiologi og anatomi, 3. utgave. Gyldendal Akademisk.  ISBN 978-82-05-50482-0.  666 s.
• Sjaastad, Øystein; Sand, Olav & Hove, Knut (2017). Fiziologija domacih zivotinja. Naklada Slap.  ISBN 978-953-191-858-9.  803 s.
• Austad, Ingvild; Hauge, Leif; Oterholm, Alf Ivar; Ryvarden, Leif & Skaarer, Nils (2017). Ville vekster for hager og grøntanlegg. Vigmostad & Bjørke.  ISBN 978-82-419-1217-7.  239 s.
• Brandt, Johann Rasmus; Hagelberg, Erika; Bjørnstad, Gro & Ahrens, Sven (ed.) (2017). Life and Death in Asia Minor in Hellenistic, Roman and Byzantine Times: Studies in Archaeology and Bioarchaeology. Oxbow Books.  ISBN 9781785703591.  432 s. Vis sammendrag

  Life and Death in Asia Minor combines contributions in both archaeology and bioarchaeology in Asia Minor in the period ca. 200 BC – AD 1300 for the first time. The archaeology topics are wide-ranging including death and territory, death and landscape perception, death and urban transformations from pagan to Christian topography, changing tomb typologies, funerary costs, family organization, funerary rights, rituals and practices among pagans, Jews, and Christians, inhumation and Early Byzantine cremations and use and reuse of tombs. The bioarchaeology chapters use DNA, isotope and osteological analyses to discuss, both among children and adults, questions such as demography and death rates, pathology and nutrition, body actions, genetics, osteobiography, and mobility patterns and diet. The areas covered in Asia Minor include the sites of Hierapolis, Laodikeia, Aphrodisias, Tlos, Ephesos, Priene, Kyme, Pergamon, Amorion, Gordion, Boğazkale, and Arslantepe. The theoretical and methodological approaches used make it highly relevant for people working in other geographical areas and time periods. Many of the articles could be used as case studies in teaching at schools and universities. An important objective of the publication has been to see how the different types of results emerging from archaeological and natural science studies respectively could be integrated with each other and pose new questions on ancient societies, which were far more complex than historical and social studies of the past often manage to transmit.

• Gunderson, Inger & Ryvarden, Leif (2016). Blomster i nord. Fungiflora.  ISBN 978-82-90724-53-0.  311 s.

Se alle arbeider i Cristin

• Palsdottir, Albina Hulda (2019, 15. februar). Reindeer Cyclones Are Real, and You Definitely Don't Want to Get Caught in One. [Internett].  LiveScience website.
• Palsdottir, Albina Hulda; Nistelberger, Heidi Maria; Star, Bastiaan; Leifsson, Rúnar; Wyrozemska, Agata Teresa; Orlando, Ludovic; Barrett, James H.; Hallsson, Jón Hallsteinn & Boessenkool, Sanne (2019). Kyngreining á hrossum úr kumlum með fornDNA. Vis sammendrag

  Hestar voru algengasta haugfé sem lagt var í kuml á Íslandi á víkingaöld. Beinagrindur hrossa er hægt að kyngreina á formi mjaðmagrindar og því hvort vígtennur eru til staðar. Vígtennur koma upp við 4-5 ára aldur í karldýrum en þó hafa rannsóknir sýnt að allt að þriðjungur hryssa getur haft vígtennur þó þær séu yfirleitt mun minni en í karldýrunum. Beinagreining hefur sýnt að öll hross sem hægt er að kyngreina úr íslenskum kumlum er úr karlkyns hestum en þar sem stór hluti þessara kumla fannst fyrir mörgum áratugum síðan við framkvæmdir eru beinagrindurnar oft of illa varðveittar til þess að hægt sé að kyngreina þær með vissu. Í þessari rannsókn notum við forn-DNA-greiningu til að kyngreina 22 hross frá víkingaöld. 19 hross voru úr kumlum en þrjú bein úr hellum og býlum voru einnig greind. Rannsóknir okkar leiddu í ljós að af 19 hrossum úr kumlum sem greind voru reyndist aðeins vera ein hryssa en öll sýnin sem komu úr helli og býli reyndust vera hryssur. Í greininni er einnig sýnt fram á að hægt er að kyngreina dýr jafnvel þó afar lítið sé varðveitt af DNA í hverju sýni og því má nota aðferðafræðina í greininni til að kyngreina fornleifafræðileg bein á mun stærri skala og fyrir minna fé en áður var talið. Fjallað verður um niðurstöður í nýútkominni grein Heidi M. Nistelberger, Albínu Huldu Pálsdóttur, Bastiaan Star, Rúnars Leifssonar, Agötu T. Gondek, Ludovic Orlando, James H. Barrett, Jóns Hallsteins Hallssonar og Sanne Boessenkool “Sexing Viking Age horses from burial and non-burial sites in Iceland using ancient DNA,” Journal of Archaeological Science 101 (2019), 115–122. https://doi.org/10.1016/j.jas.2018.11.007. Albína Hulda Pálsdóttir er dýrabeinafornleifafræðingur og starfar við Landbúnaðarháskóla Íslands. Hún er doktorsnemi við Óslóarháskóla en doktorsverkefni hennar heitir „Hestar og sauðfé víkinganna: Fornerfðafræði húsdýra í Norður-Atlantshafi“. Hún hefur greint dýrabeinasöfn frá Íslandi, Írlandi, Grænlandi og Færeyjum. Leiðbeinendur Albínu eru dr. Sanne Boessenkool við Óslóarháskóla, dr. Jón Hallsteinn Hallsson við Landbúnaðarháskóla Íslands og dr. Juha Kantanen hjá LUKE í Finnlandi. Verkefnið er styrkt af rannsóknasjóði Rannís á styrk nr. 162783051

• Orwick-Rydmark, Marcella; Chauhan, Nandini; Van Rossum, Barth-J & Linke, Dirk (2019). Towards the structure of the YadA anchor domain in the native membrane.
• Linke, Dirk & Saragliadis, Athanasios (2019). Bacterial adhesion to living and non-living surfaces.
• Palsdottir, Albina Hulda; Barrett, James H.; Boessenkool, Sanne; Hallsson, Jón Hallsteinn; Leifsson, Rúnar; Nistelberger, Heidi Maria; Orlando, Ludovic; Star, Bastiaan & Wyrozemska, Agata Teresa (2019, 02. januar). Powerful Icelandic Vikings were buried with stallions. [Internett].  phys.org.
• Leifsson, Rúnar; Palsdottir, Albina Hulda; Barrett, James H.; Boessenkool, Sanne; Hallsson, Jón Hallsteinn; Nistelberger, Heidi Maria; Orlando, Ludovic; Star, Bastiaan & Wyrozemska, Agata Teresa (2019, 05. januar). Horses buried with Icelandic Viking nobles were male, ancient DNA shows. [Internett].  CBC news.
• Palsdottir, Albina Hulda; Barrett, James H.; Boessenkool, Sanne; Hallsson, Jón Hallsteinn; Leifsson, Rúnar; Nistelberger, Heidi Maria; Orlando, Ludovic; Star, Bastiaan & Wyrozemska, Agata Teresa (2019, 10. januar). Burials Suggest Icelandic Vikings Had a Thing for Stallions. [Internett].  www.smithsonianmag.com.
• Palsdottir, Albina Hulda; Boessenkool, Sanne; Nistelberger, Heidi Maria; Hallsson, Jón Hallsteinn; Star, Bastiaan; Barrett, James H. & Leifsson, Rúnar (2019, 07. januar). Ancient Horse DNA From Burial Sites In Iceland Suggests That Viking Age Warriors Preferred Male Horses. [Internett].  www.inquisitr.com.
• Palsdottir, Albina Hulda; Barrett, James H.; Boessenkool, Sanne; Hallsson, Jón Hallsteinn; Leifsson, Rúnar; Nistelberger, Heidi Maria; Orlando, Ludovic; Star, Bastiaan & Wyrozemska, Agata Teresa (2019, 07. januar). POWERFUL MALE VIKINGS WERE BURIED WITH THEIR POWERFUL MALE HORSES. [Internett].  Newsweek.com.
• Palsdottir, Albina Hulda; Barrett, James H.; Boessenkool, Sanne; Hallsson, Jón Hallsteinn; Leifsson, Rúnar; Nistelberger, Heidi Maria; Orlando, Ludovic; Star, Bastiaan & Wyrozemska, Agata Teresa (2019, 07. januar). Ancient DNA from Viking Graves Proves the Fierce Fighters Rode Male Horses. [Internett].  https://www.livescience.com/64432-vikings-buried-with-stalli.
• Palsdottir, Albina Hulda; Barrett, James H.; Boessenkool, Sanne; Hallsson, Jón Hallsteinn; Leifsson, Rúnar; Nistelberger, Heidi Maria; Orlando, Ludovic; Star, Bastiaan & Wyrozemska, Agata Teresa (2019, 07. januar). Lítið um hryssur í kumlum víkinga.  Morgunblaðið.
• Palsdottir, Albina Hulda; Nistelberger, Heidi Maria; Star, Bastiaan; Leifsson, Rúnar; Gondek, Agata Teresa; Orlando, Ludovic; Barrett, James H. & Hallsson, Jón Hallsteinn (2019). Which horse should we sacrifice? Sex as a determining factor for the selection of horses in Viking Age burials in Iceland.
• Tietgen, M; Weidensdorfer, M; Djahanshiri, Bardya; Linke, Dirk; Kempf, Volkhard A.J. & Gottig, Stephan (2019). Virulence of Acinetobacter baumannii depends on the Acinetobacter trimeric autotransporter adhesin Ata.
• Skre, Oddvar & Wielgolaski, Frans Emil (2018). Dates of budburst in birch provenances during the period 1992-2017 as related to cllimatic variables in northern Fennoscandia. Geophysical Research Abstracts.  ISSN 1029-7006.  20(EGU2018-1861)
• Palsdottir, Albina Hulda (2018, 12. juli). Ancient ‘Iceman’ shows signs of a well-balanced last meal. [Internett].  AP news, Associated Press.
• Palsdottir, Albina Hulda (2018, 12. juli). Insides of ancient 'Iceman' shows signs of a well-balanced last meal. [Internett].  NBC Newa.
• Palsdottir, Albina Hulda; Barrett, James H.; Boessenkool, Sanne; Hallsson, Jón Hallsteinn; Leifsson, Rúnar; Nistelberger, Heidi Maria; Orlando, Ludovic; Star, Bastiaan & Wyrozemska, Agata Teresa (2018, 17. desember). Folum fórnað. [Internett].  Bændablaðið online.
• Hadjineophytou, Chris; Anonsen, Jan Haug & Koomey, Michael (2018). A genus-wide assessment of neisserial Tfp pilin subunit glycosylation: a systems level approach reveals distribution and governing co-factors.
• Linke, Dirk (2018). Structural Biology of Membrane Proteins: Expression Tricks, and to Solubilize or Not to Solubilize.
• Økstad, Ole Andreas Løchen & Linke, Dirk (2018). Hvor farlig er antibiotikaresistens?. Ingeniørenes Stemme.  Vinter 2018, s 37- 37
• Nederbragt, Alexander Johan (2018). Programmering og modellering i biovitenskapsutdanning.
• Palsdottir, Albina Hulda (2018). Sauðkindin og dýrabeinafornleifafræði (The Zooarchaeology of the Icelandic Sheep).
• Palsdottir, Albina Hulda & Joensen, Christina (ed.) (2018). Icelandic ZooArch laboratory website https://www.icelandiczooarch.is/.
• Drønen, Elena Klåpbakken; Namork, Ellen; Dirven, Hubert; Hylland, Ketil & Nygaard, Unni Cecilie (2018). Does altered gut barrier function facilitate food allergy?.
• Olsbu, Inger Kirstine; Hersleth, Hans-Petter & Sørlie, Morten (2018). Substrate recognition and redox partner identification in nitric oxide synthases. Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo.. 2047.
• Nistelberger, Heidi Maria; Palsdottir, Albina Hulda; Star, Bastiaan; Leifsson, Rúnar; Gondek, Agata Teresa; Orlando, Ludovic; Barrett, James H.; Hallsson, Jón Hallsteinn & Boessenkool, Sanne (2018). Sexing Viking Age horses from burial and non-burial sites in Iceland using ancient DNA.
• Palsdottir, Albina Hulda; Nistelberger, Heidi Maria; Weldenegodguad, Melak; Kantanen, Juha; Hallsson, Jón Hallsteinn & Boessenkool, Sanne (2018). Viking Age Sheep in the North Atlantic.
• Palsdottir, Albina Hulda; Blauer, Auli & Rannamäe, Eva (2018). Sample now or save for later? Destructive sampling of archaeological animal remains.
• Palsdottir, Albina Hulda; Nistelberger, Heidi Maria; Weldenegodguad, Melak; Kantanen, Juha; Hallsson, Jón Hallsteinn & Boessenkool, Sanne (2018). Archaeogenomics of Viking Age Sheep in the North Atlantic.
• Palsdottir, Albina Hulda (2018, 06. november). Sheep vs Goats - Ep04 https://www.archaeologypodcastnetwork.com/animals/04. [Internett].  ArchaeoAnimals podcast.
• Rusch, Johannes; Strand, David; Laurendz, Charlotte; Johnsen, Stein Ivar; Edsman, Lennart; Andersen, Tom & Vrålstad, Trude (2018). Simultaneous eDNA monitoring of the host-pathogen complex Pacifastacus leniusculus and Aphanomycis astaci under varying environmental conditions. Vis sammendrag

  In 2016 the North-American signal crayfish Pacifastacus leniusculus was included in the list of Invasive Alien Species of concern to the European Union. In Norway the species is black-listed and rated as a high-risk species and eradication has been carried out whenever feasible. This is because it is a chronic carrier of the oomycete Aphanomyces astaci, which is lethal to all European freshwater crayfish species and listed among the 100 worst invasive species. Environmental DNA (eDNA) methodology is now being used on a wide variety of target species and on many different platforms including targeted PCR and broad spectred sequencing methods. Detection and monitoring of invasive, endangered and elusive species is commonly performed using species specific quantitative real-time PCR (qPCR) or droplet digital PCR (ddPCR), and has proved useful for targeting species of specific concern. Recently eDNA monitoring of A. astaci has been implemented in the national crayfish plague surveillance in Norway. For the carrier of the crayfish plague, the signal crayfish, a qPCR assay for eDNA detection has also been published recently. In this study we present simultaneous eDNA monitoring of the host-pathogen complex P. leniusculus - A.astaci under varying environmental conditions both in aquarium and field experiments. We used the published qPCR assays for both species and redesigned them so they can be run as a duplex ddPCR assay. We compared water samples by means of qPCR and ddPCR from two lakes in Sweden and Norway with different signal crayfish population densities and A. astaci prevalence in the population. We also studied eDNA emission from the host-pathogen couple in aquarium-experiments with A. astaci positive signal crayfish held at different densities, temperatures and feeding regimes. Samples were obtained by filtering water (1 & 5 L) on-site through glass fibre filters. These were subsequently analysed using the species-specific qPCR and ddPCR assays for the respective targets. The concentrations of detectable eDNA copies of the two targets are influenced differently and by several factors, including population density of the crayfish, pathogen prevalence, temperature, and turbidity including microbiological activity in the water. They are therefore subject to significant fluctuation. Thus, there seems to be no straightforward correlation between eDNA copy-number and crayfish density and the probability of detecting one target rather than the other varies according to different conditions. Therefore, for a reliable monitoring of crayfish plague (A. astaci) and signal crayfish alone or together, the simultaneous monitoring concept for both targets is recommended.

• Sirevåg, Reidun (2018). Diktatur kan være nyttig. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Sirevåg, Reidun (2018). Et bioteknologisk eventyr med store politiske følger. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Tairova, Zhanna; Müller, Mette Helen Bjørge; Lyche, Jan Ludvig; Mayer, Ian; Berg, Vidar; Blaser, Nello; Brun, Morten; Grung, Merete; Eide, Marta; Dale, Karina; Goksøyr, Siri Øfsthus; Aranguren, Libe; Goksøyr, Anders & Ketil, Hylland (2018). Adverse health effects related to chemical exposure in Atlantic cod (Gadus morhua) from Norwegian fjords.
• Mwafongo, Elizabeth; Vollsnes, Ane Victoria; Bjorå, Charlotte Sletten; Nordal, Inger & Eriksen, Aud Berglen (2018). Anthocyaniner, pigmenter med mange roller.
• Wrobel, Agnieszka; Saragliadis, Athanasios; Leo, Jack Christopher; Ottoni, Claudio & Linke, Dirk (2018). Type Ve autotransporters in Yersinia ruckeri.
• Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - understanding adhesive function and screening for inhibitors.
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta; Røhr, Åsmund Kjendseth & Hersleth, Hans-Petter (2018). Activation of the Class Ib Ribonucleotide Reductase by a Flavodoxin Reductase in Bacillus cereus.
• Sjøberg, Espen A.; Engelsen, Eirik; Nilsson, Emma; Sanden, Selma & Wilner, Raquel (2018). Confirmation bias in psychology, art history, biology and behavior analysis.
• Linke, Dirk (2018). Trimeric Autotransporter Adhesins and routes to their inhibition.
• Bjerketvedt, Dag Kjartan; Reimers, Eigil & Borgstrøm, Reidar (2018). Villreinforvaltningen på Hardangervidda. En historisk tilbakeblikk.. Villreinen.  ISSN 0801-6321.  s 32- 37
• Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - Understanding adhesive function and screening for inhibitors.
• Joudeh, Nadeem; Leo, Jack Christopher; Torgeman, Eric & Linke, Dirk (2018). Mechanism of Palladium and Gold uptake and reduction in E. coli.
• Balusek, Curtis; Linke, Dirk & Gumbart, JC (2018). The effect of beta-barrel geometry on ion conduction through Escherichia coli OmpX.
• Khalil, Hawzeen; Øgaard, Jonas; Linke, Dirk & Leo, Jack Christopher (2018). Co-aggregation properties of trimeric autotransporter adhesins.
• Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher & Linke, Dirk (2018). The repeat structure of two paralogous genes, Yersinia ruckeri invasin (yrInv) and a “Y. ruckeri invasin-like molecule”, (yrIlm) sheds light on the evolution of adhesive capacities of a fish pathogen.
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta & Hersleth, Hans-Petter (2018). Enzyme activation by a flavoprotein redox network. NBS-nytt.  ISSN 0801-3535.  s 40- 40
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta & Hersleth, Hans-Petter (2018). Enzyme activation by a flavoprotein redox network.
• Hansson, Kenth-Arne; Gundersen, Kristian & Bruusgaard, Jo C. (2018). In vivo confocal imaging and 3D rendering of the neuromuscular end plate and its synaptic myonuclei. Acta Physiologica.  ISSN 1748-1708.
• Kaetzel, Charlotte S.; Mestecky, Jiri & Johansen, Finn-Eirik (2017). Two Cells, One Antibody: The Discovery of the Cellular Origins and Transport of Secretory IgA. Journal of Immunology.  ISSN 0022-1767.  198(5), s 1765- 1767
• Skre, Oddvar; Karlsen, Stein Rune; Riseth, Jan Åge & Wielgolaski, Frans Emil (2017). Consequences of future expansion at the arctic treeline in northernmost Norway. Vis sammendrag

  Program: http://www.agrosym.rs.ba/documents/Symposium_Programme_2017.pdf

• Rodriguez, Marta; Bajo-Santos, Cristina; Hessvik, Nina Pettersen; Lorenz, Susanne; Fromm, Bastian; Berge, Viktor; Sandvig, Kirsten; Line, Aija & Llorente, Alicia (2017). Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes. Molecular Cancer.  ISSN 1476-4598.  16:156, s 1- 6 . doi: 10.1186/s12943-017-0726-4 Vis sammendrag

  The aim of this study was to identify microRNAs in urinary exosomes that are differently expressed in prostate cancer patients and healthy donors. For this purpose, RNA was extracted from urinary exosomes from 20 prostate cancer patients and 9 healthy males and the microRNAs were analyzed by next generation sequencing. Interestingly, 5 microRNAs - miR-196a-5p, miR-34a-5p, miR-143-3p, miR-501-3p and miR-92a-1-5p - were significantly downregulated in exosomes from prostate cancer patients. Furthermore, RT-qPCR analysis of an independent cohort of 28 prostate cancer patients and 19 healthy males confirmed that miR-196a-5p and miR-501-3p were downregulated in prostate cancer samples. These results suggest that specific microRNAs in urinary exosomes might serve as non-invasive biomarkers for prostate cancer. In particular, miR-196a-5p and miR-501-3p are promising biomarkers that need to be further studied in large patient cohorts.

• Klaveness, Dag (2017). Når modner blåbæra? Om begynnende fruktmodning, alminnelig fruktmodning og modningstid hos blåbær. Biolog.  ISSN 0801-0722.  2017(2), s 33- 36
• Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Fyhn, Marianne & Hafting, Torkel (2017). The role of extracellular matrix molecules for spatial representations in medial entorhinal cortex.
• Lepperød, Mikkel Elle; Lai, Yi Ming; Fyhn, Marianne; Einevoll, Gaute; Solstad, Trygve; Hafting, Torkel & de Kamps, Marc (2017). Population density model of the entorhinal stellate-cell network with adaptation.
• Edvardsen, Bente; Egge, Elianne Dunthorn; Vaulot, Daniel; Larsen, Aud; Bratbak, Gunnar; Moreau, Hervé & John, Uwe (2017). Protist community structure in Atlantic Arctic through the year as revealed by high throughput sequencing.
• Liskiewicz, Krystyna; Wrobel, Agnieszka; Leo, Jack Christopher & Linke, Dirk (2017). Identification of potential adhesin receptors from Yersinia ruckeri.
• Wielgolaski, Frans Emil; Laine, Kari; Inkeröinen, Jouko & Skre, Oddvar (2017). Enhancing the resilience capacity of sensitive mountain forest ecosystems under environmental change (SENSFOR). Climate Research (CR).  ISSN 0936-577X.  73(1-2), s 3- 6 . doi: 10.3354/cr01482
• Linke, Dirk (2017). Do we have to purify membrane proteins? Solid-state NMR in the native membrane.
• Linke, Dirk (2017). Type Ve secretion in Gram-negative Bacteria.
• Bjorå, Charlotte Sletten (2017, 16. juni). Abels tårn. [Radio].  NRK P2.
• Buchanan, Bob B.; Sirevåg, Reidun; Fuchs, Georg; Ivanovksy, Ruslan N.; Igarashi, Yasuo; Ishii, Masaharu; Tabita, F. Robert & Berg, Ivan A. (2017). The Arnon-Buchanan cycle; a retrospective, 1966-2016. Photosynthesis Research.  ISSN 0166-8595.  134(2), s 117- 131 . doi: 10.1007/s11120-017-0429-0
• Nielsen, Anders; Hatteland, Bjørn Arild; Malmstrøm, Martin; Proschwitz, Ted von; Velle, Gaute; de Boer, Hugo; Gjershaug, Jan Ove; Kirkendall, Lawrence R.; Rueness, Eli Knispel & Vandvik, Vigdis (2017). Assessment of the risk to Norwegian biodiversity from the import and keeping of terrestrial gastropods in terraria. Opinion of the Panel on Alien Organisms and Trade in Endangered Species of the Norwegian Scientific Committee for Food and Environment. VKM report. 2017:33.
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta & Hersleth, Hans-Petter (2017). Enzyme activation by a flavoprotein redox network.
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta; Kjendseth, Åsmund Røhr & Hersleth, Hans-Petter (2017). Activation of the class Ib ribonucleotide reductase by a flavodoxin reductase in Bacillus cereus.
• Hallsson, Jón Hallsteinn & Palsdottir, Albina Hulda (2017). Viking origin of native breeds in the North Atlantic?. Vis sammendrag

  The voyages of the Vikings, starting in the late 8th century, did not only spread Viking culture and language throughout the North Atlantic but also moved animals of several domestic species - sheep, cattle, horse, goats, dogs, pigs, and chicken – around the whole of Northern Europe. In some cases, it is believed that modern breeds are direct descendants of animals brought by Vikings while in other cases it is believed that those breeds have been mixed and/or replaced by others. Although we do have a good understanding of where the Vikings travelled and settled, exactly how the Viking diaspora shaped the genetic composition and diversity in the North Atlantic domestic animals has not been fully explained. Although much has been written about individual domestic breeds a comprehensive overview is missing; here we aim to present an overview of native breeds in the region, what is known about their origin and how plausible it is that they remain relics of Viking migration rather than more modern immigrants.

• Palsdottir, Albina Hulda (2017). Sample now or save for later? Destructive analysis of domesticate bones from archaeofaunal collections. Vis sammendrag

  Destructive sampling of animal bones from archaeological excavations is becoming more common. The refinement of ancient DNA technology, the use of next-generation sequencing, and the rapidly lowering cost of whole genome sequencing has led to a rapid growth in the field of ancient DNA analysis. This has again led to increased interest in destructive sampling of animal bones from archaeological excavations. Recent advances have shown that the petrous bone of the skull best preserves DNA in ancient samples which will lead to increased sampling pressure for that element. The ethical implications of destructive sampling for aDNA are not the same for every species due factors like size differences between species and large variations in rarity. Discussions of the ethical implications of destructive sampling have been largely absent in the zooarchaeological literature. Due to the increase in destructive sampling zooarchaeologists, as specialists in ancient animal bones, need to seriously consider these issues both within their discipline as well as with the specialists outside the field that are driving most of these studies.

• Colman, Jonathan Edward; Flydal, Kjetil; Rannestad, Ole Tobias; Tsegaye, Diress; Ryvarden, Leif; Høiland, Klaus; Eftestøl, Sindre; González-León, Alejandro & Reksten, Synne Sofie (2017). Effects of the Lista wind power plant on roadside revegetation and the space use of moose, red deer and roe deer.
• Heikal, Adam; Samuelsen, Ørjan; Kristensen, Tom & Økstad, Ole Andreas Løchen (2017). Complete genome sequence of a multidrug-resistant, blaNDM-1-expressing Klebsiella pneumoniae K66-45 clinical isolate from Norway. Genome Announcements.  ISSN 2169-8287.  5:e00601(27), s 1- 2 . doi: 10.1128/genomeA.00601-17
• Nordal, Inger; Bjorå, Charlotte Sletten & Stedje, Brita (2017). Training in the North of Researchers from the South: Experiences from Nordic-African collaboration. Scientia Danica, Series B, Biologica.  ISSN 1904-5484.  6, s 187- 197
• Falnes, Pål (2017). Identification and characterisation of lysine-specific methyltransferases in humans.
• Wrobel, Agnieszka; Leo, Jack Christopher; Ottoni, Claudio; Gulla, Snorre & Linke, Dirk (2017). Comparative structure-function analysis of adhesins from different Yersinia ruckeri strains.
• Leo, Jack Christopher & Linke, Dirk (2017). Inverse autotransport: the mechanism of type Ve secretion​..
• Wrobel, Agnieszka & Linke, Dirk (2017). The repeat structure of two paralogous invasin genes from Yersinia ruckeri sheds light on the evolution of adhesive capacities of a Fish pathogen.
• Dinh, Tovy; Lensjø, Kristian Kinden; Lanton, Rune Alexander; Dick, Gunnar; Fyhn, Marianne & Hafting, Torkel (2017). Increased ocular dominance plasticity in adult visual cortex after genetic knock out of aggrecan, an essential component of perineuronal nets.
• Palsdottir, Albina Hulda (2017). The Sheep and Horses of the Vikings: Archaeogenomics of Domesticates in the North Atlantic.
• Palsdottir, Albina Hulda (2017, 12. april). THE ORIGINS OF ICELANDIC HORSES AND SHEEP WITH GRANDMA’S ICELANDIC LAMB SADDLE RECIPE. [Internett].  Cooking with Archaeologists. Vis sammendrag

  Zooarchaeologists Albina Hulda Palsdottir is a Ph.D. candidate at the University of Oslo. Her research focuses on the origins of the horses and sheep that were brought to Iceland in the 9th century. The project is called, “The Sheep and Horses of the Vikings: Archaeogenomics of Domesticates in the North Atlantic.” Anyone who has an interest in ancient DNA should have a listen to this podcast!

• Joudeh, Nadeem & Linke, Dirk (2017). Mechanism of palladium and gold uptake and transport in E. coli.
• Saragliadis, Athanasios & Linke, Dirk (2017). STRUCTURE-FUNCTION RELATIONSHIP IN BACTERIAL ADHESINS.
• Leo, Jack Christopher; Oberhettinger, Philipp; Schütz, Monika & Linke, Dirk (2017). Inverse autotransport: the mechanism of type Ve secretion.
• Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christopher & Linke, Dirk (2017). IDENTIFICATION AND CHARACTERIZATION OF INVERSE AUTOTRANSPORTERS FROM A FISH PATHOGEN, YERSINIA RUCKERI.
• Schneider, Kenneth; Haugen, Håvard Jostein & Linke, Dirk (2017). Assay Development: Adhesin Interaction with Implant Materials.
• Orwick-Rydmark, Marcella; Chauhan, Nandini; Shahid, Shakeel & Linke, Dirk (2017). Solid-state NMR studies on Yersinia YadA: from autotransport to drug screening.
• Johannesen, Hedda; Kumar, Rohit; Hersleth, Hans-Petter; Hammerstad, Marta; Logan, Derek & Andersson, Karl Kristoffer (2017). A STRUCTURAL AND FUNCTIONAL INVESTIGATION OF RIBONUCLEOTIDE REDUCTASE CLASS III IN BACILLUS CEREUS.
• Michalik, Marcin; Orwick-Rydmark, Marcella; Arnold, Thomas; Habeck, Michael & Linke, Dirk (2017). An evolutionarily conserved motif forms a folding core in Outer membrane proteins.
• Kralsen, Victoria; Hamre, Anne Grethe; Bissaro, Bastien; Sørlie, Morten & Kjendseth, Åsmund Røhr (2017). Converting Charges in the Active Site of Lytic Polysaccharide Monooxygenases - Effect on Catalysis.
• Isaksen, Ingvild; Suvamay, Jana; Payne, Christina M. & Kjendseth, Åsmund Røhr (2017). Computational study of the protonation states of the conserved HIS172 in the lytic polysaccharide monooxygenase ScLPMO10B.
• Eikrem, Wenche; Medlin, Linda K.; Henderiks, Jorijntje; Rokitta, Sebastian; Rost, Björn; Throndsen, Jahn; Edvardsen, Bente & Probert, Ian (2017). Haptophyta, In John M. Archibald; Alastair G B Simpson & Claudio H Slamovits (ed.),  Handbook of the Protists.  Springer Publishing Company.  ISBN 978-3-319-28148-3.  Kapittel.  s 1 - 61 Vis sammendrag

  Haptophyta are predominantly planktonic and phototrophic organisms that have their main distribution in marine environments worldwide. They are a major component of the microbial ecosystem, some form massive blooms and some are toxic. Haptophytes are significant players in the global carbonate cycle through photosynthesis and calcification. They are characterized by the haptonema, a third appendage used for attachment and food handling, two similar flagella, two golden-brown chloroplasts, and organic body scales that serve in species identification. Coccolithophores have calcified scales termed coccoliths. Phylogenetically Haptophyta form a well-defined group and are divided into two classes Pavlovophyceae and Coccolithophyceae (Prymnesiophyceae). Currently, about 330 species are described. Environmental DNA sequencing shows high haptophyte diversity in the marine pico- and nanoplankton, of which many likely represent novel species and lineages. Haptophyte diversity is believed to have peaked in the past and their presence is documented in the fossil record back to the Triassic, approximately 225 million years ago. Some biomolecules of haptophyte origin are extraordinarily resistant to decay and are thus used by geologists as sedimentary proxies of past climatic conditions.

• Joudeh, Nadeem; Leo, Jack Christopher; Torgeman, Eric; Mikheenko, Pavlo & Linke, Dirk (2017). Mechanism of Palladium and Gold uptake and transport in E. coli.
• Shoor, Marita; Gudim, Ingvild; Hammerstad, Marta & Hersleth, Hans-Petter (2017). Structural and functional characterization of redox proteins in an enzyme activating network involving the thioredoxin reductase in Bacillus cereus.
• Johannesen, Hedda; Hersleth, Hans-Petter; Hammerstad, Marta & Andersson, K. Kristoffer (2017). A structural and functional investigation of ribonucleotide reductase class III in Bacillus cereus.
• Olsbu, Inger Kirstine; Lombard, M; Hersleth, Hans-Petter; Boucher, Jean-Luc & Andersson, K. Kristoffer (2017). Key role of Val-567 on L-Arg analogues and heme ligands to neuronal nitric oxide syntase.
• Hammerstad, Marta; Kjendseth, Åsmund Røhr & Hersleth, Hans-Petter (2017). A research-inspired biochemistry laboratory module – Combining, expression,purification, crystallisation, structure solving and characterisation of a flavdoxin-like protein.. NBS-nytt.  ISSN 0801-3535.  s 63- 63
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta; Kjendseth, Åsmund Røhr & Hersleth, Hans-Petter (2017). Activation of the class Ib RNR by a flavodoxin reductase in B. cereus. NSB-nytt.  s 105- 105
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta; Kjendseth, Åsmund Røhr & Hersleth, Hans-Petter (2017). Activation of the class Ib ribonucleotide reductase by a flavodoxin reductase in Bacillus cereus.
• Hatlem, Daniel; Leo, Jack Christopher; Saragliadis, Athanasios; Krengel, Ute & Linke, Dirk (2017). Bacterial adhesion: Characterization of trimeric autotransporter binding.
• Zaltariov, Mirela-Fernanda; Hammerstad, Marta; Arabshahi, Homayon John; Jovanović, Katarina; Richter, Klaus W.; Cazacu, Maria; Shova, Sergiu; Balan, Mihaela; Radulović, Siniša; Andersen, Niels Højmark; Reynisson, Jóhannes; Andersson, K. Kristoffer & Arion, Vladimir B (2017). New iminodiacetate-thiosemicarbazone hybrids and their copper(II) complexes are potential mR2 RNR inhibitors with high antiproliferative activity. NBS-nytt.  ISSN 0801-3535.  s 104- 104
• Hammerstad, Marta (2017). New iminodiacetate-thiosemicarbazone hybrids and their copper(II) complexes are potential mR2 RNR inhibitors with high antiproliferative activity.
• Linke, Dirk (2017). Trimeric autotransporter adhesins (TAAs) and routes to their inhibition.
• Lofstad, Marie; Andersson, K. Kristoffer; Hersleth, Hans-Petter; Hammerstad, Marta & Kjendseth, Åsmund Røhr (2017). Activation Pathways of the Class Ib Ribonucleotide Reductase in Bacillus cereus. Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo.. 1808.
• Hammerstad, Marta; Lofstad, Marie; Böttger, Lars H.; Kjendseth, Åsmund Røhr; Hersleth, Hans-Petter; Zaltariov, Mirela-Fernanda; Arion, Vladimir B; Solomon, Edward I. & Andersson, K. Kristoffer (2017). INHIBITION OF CLASS 1A RIBONUCLEOTIDE REDUCTASE, AND A COMPARISON OF THE DIMANGANESE ACTIVE SITES OF CLASS IB RIBONUCLEOTIDE REDUCTASE AND MANGANESE CATALASE. Vis sammendrag

  INHIBITION OF CLASS 1A RIBONUCLEOTIDE REDUCTASE, AND A COMPARISON OF THE DIMANGANESE ACTIVE SITES OF CLASS IB RIBONUCLEOTIDE REDUCTASE AND MANGANESE CATALASE Marta Hammerstad1*; Marie Lofstad1*; Lars H. Böttger2*; Åsmund Kjendseth Røhr3; Hans-Petter Hersleth1; Mirela F. Zaltariov4; Vladimir B. Arion4; Edward I. Solomon2 and K. Kristoffer Andersson1 1Department of Biosciences, University of Oslo, Pb.1066 Blindern, NO-0316 Oslo, Norway 2Department of Chemistry, Stanford University, Stanford, CA 94305, USA 3Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, NO-1432 Ås, Norway 4Institute of Inorganic Chemistry, Universität Wien, AT-1090 Vienna, Austria *These three authors contributed equally Presenting Author’s e-mail address: k.k.andersson@ibv.uio.no Ribonucleotide reductases (RNRs) are enzymes that convert RNA building blocks into DNA building blocks [1]. The reductive reaction by RNRs requires a cysteine thiyl radical, which, in the case of class Ia or Ib RNRs, is initiated by an FeIII2- or MnIII2-tyrosyl radical (Y•) cofactor in the R2 subunit of RNR. During enzymatic turnover, the cofactor is activated by oxygen, and generates a Y• that is transported from the smaller R2 subunit to the large catalytic subunit R1 of RNR, where DNA building blocks are formed. The small subunit of class Ia RNRs can be inhibited by several small compounds [2], through the inhibition of the active FeIII2- Y• cofactor. We have performed interaction studies and Kd measurements of a mammalian R2 protein with several newly synthesized compounds, and studied their potential inhibitory effect on the protein with EPR, showing promising results. Manganese catalase (MnCAT) enzymes [3] contain an active site that is similar in structure to the MnIII2 form of NrdF (the R2 subunit in class Ib RNR), characterized by a carboxylate-bridged MnIII-O-MnIII cofactor. However, it catalyzes a different reaction – the degradation of hydrogen peroxide to dioxygen and water. A still unresolved question is how these enzymes containing similar active sites can catalyze different reactions. A variety of spectroscopic methods have been used to try to resolve this question. Samples containing NrdF with active MnIII-O-MnIII cofactor have been prepared and studied by circular dichroism (CD) and magnetic CD (MCD) spectroscopy. The data show both similar and distinct features as compared to MnCAT. 1. A.B. Tomter; G. Zoppelaro; N.H. Andersen; H.-P. Hersleth; M. Hammerstad; Å.K. Røhr; G.K. Sandvik; G.E. Nilsson; C.B. Bell; A.L. Barra; E. Blasco; L. Le Pape; E.I. Solomon; and K.K. Andersson. Coord. Chem. Rev. (2013), 257, 3 2. A. Popovic-Bijelic A; C.R. Kowol; M.E.S. Lind; J. Luo; F. Himo; A.E. Enyedy; V.B. Arion; and A. Gräslund. (2011) J. Inorg. Biochem. 105, 1422-1431 3. T.C. Brunold; D.R. Gamelin; T.L. Stemmler; S.K. Mandal; W.H. Armstrong; J.E. Penner-Hahn; and E. I. Solomon. J. Am. Chem. Soc. (1998), 120, 8724

• Schøyen, Merete; Øxnevad, Sigurd; Hjermann, Dag Øystein; Mund, Christian; Böhmer, Thomas; Beckmann, Karin & Powell, David E. (2016). Levels of siloxanes (D4, D5, D6) in biota and sediments from the Inner Oslofjord, Norway, 2011-2014.
• Hurem, Selma; Gomes, Tania; Brede, Dag Anders; Hansen, Elisabeth Lindbo; Lobert, Viola; Martin, Leonardo M; Mayer, Ian; Mutoloki, Stephen; Salbu, Brit; Teien, Hans-Christian; Oughton, Deborah Helen; Aleström, Peter & Lyche, Jan Ludvig (2016). Gamma radiation causes adverse reproductive and heritable effects in zebrafish.
• Palsdottir, Albina Hulda (2016). Livestock movements in the North Atlantic.
• Palsdottir, Albina Hulda (2016). Hestar og sauðfé víkinganna: Fornerfðafræði húsdýra í Norður-Atlantshafi.
• Wigestrand, Mattis B; Aasebø, Ida E. J.; Tully, Annabelle; Lepperød, Mikkel Elle; Hafting, Torkel & Fyhn, Marianne (2016). Lateral hypothalamic outputs control innate defensive responses. Vis sammendrag

  When facing a threat, animals display defensive behaviors that are critical for survival. The hypothalamus is believed to mediate such defensive responses, but the prevailing view includes a medial/lateral separation, where medial hypothalamus is thought to influence defensive responses, while the lateral hypothalamic area (LHA) regulates feeding and arousal. Here we identify two distinct neural populations in the LHA with surprising survival functions in rats. The two neural populations, defined by their output projections to either the periaqueductal gray (PAG) or the lateral habenula (LHb) have distinct anatomical placements along the anterior-posterior axis of the LHA and express distinct biochemical markers. Optogenetic stimulation of the two LHA populations robustly induced opposite active- or passive defensive responses. Further, chemogenetic silencing of LHA and optogenetic silencing of the LHA-PAG projection disrupted innate defensive responses to a predator-like looming shadow. Using single-unit recordings in the downstream LHb and PAG, we show that the LHA-LHb projection is largely excitatory, while the LHA-PAG projection is mainly inhibitory. We are currently using a miniaturized microscope to image the calcium activity of the two LHA populations during threat processing in behaving rats. Overall, our findings identify a novel LHA circuit that is critical for appropriate defensive responses to innate visual threats. The location of the LHA defense circuits, intermingled within circuitry that governs feeding, suggests that this circuit may provide rapid cross-talk between circuits that govern foraging- and anti-predator behaviors.

• Mysterud, Ivar (2016). Range extensions of some boreal owl species: comments on snow cover, ice crusts, and climate change. Arctic, Antarctic and Alpine research.  ISSN 1523-0430.  48(1), s 213- 219 . doi: 10.1657/AAAR0015-041
• Nederbragt, Alexander Johan (ed.) (2016). In between lines of code - a blog about biology, sequencing, bioinformatics and more.
• Jakobsson, Magnus; Moen, Anders; Davidson, Ben & Falnes, Pål (2016). METTL21A-catalysed lysine methylation of Hsp70 proteins.
• Aileni, Vinay Kumar; Davydova, Erna; Kernstock, Jens Stefan; Moen, Anders & Falnes, Pål (2016). VCP-KMT (METTL21D)-mediated lysine methylation of histone H3 peptide sequences grafted onto a VCP-derived scaffold.
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara Louise; Donaldson, Ian M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Kreft-spesifikke betennelsesreaksjoner kan beskytte mot kreft. BestPractice. Onkologi Hematologi.  February
• Furnes, Clemens; Mannelqvist, Monica; Sarria, Shirley Vanessa; Aasland, Rein & Szilvay, Anne Marie (2016). In vivo proteolytic activity assayed by subcellular localization switching.
• Palsdottir, Albina Hulda (2016). Livestock movements in the North Atlantic. Vis sammendrag

  Livestock movements in the North Atlantic The settlers of the Faroe Islands and Iceland brought with them domestic livestock animals, cattle, horses, sheep, goats, pigs and dogs. Little is known about the origin of these animals and how the breeds formed and adapted to the climate of the North Atlantic Islands. My research is interdisciplinary and uses traditional zooarchaeological methods and ancient DNA to study livestock origins and movement in the North Atlantic. I will also be exploring the importance of local collaboration in international research projects and the dissemination of results both to the local population and the local academic community.

• Palsdottir, Albina Hulda (2016). The Sheep and Horses of the Vikings: Archaeogenomics of Domesticates in the North Atlantic.. Vis sammendrag

  The Sheep and Horses of the Vikings: Archaeogenomics of Domesticates in the North Atlantic Albína Hulda Pálsdóttir Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Norway and Faculty of Land and Animal Resources, Agricultural University of Iceland, Reykjavík, Iceland albinap@gmail.com Viking settlers introduced a range of domestic animals to Iceland, Faroe Islands and Greenland in the 9th and 10th centuries. Many of these animals have been an important part of agriculture in this region since settlement. The primary aims of my project are to determine the origin of sheep and horses in the North Atlantic, and to understand the human selection of traits relating to the products from sheep and the religious and ritual importance of horses in the Viking Age. This project will deepen the understanding of how the rapid settlement of the North Atlantic shaped the population structure and genetic diversity of sheep and horses in the region and how they have changed in the thousand years since settlement. Furthermore, understanding the adaptation and development of modern livestock breeds is imperative to the successful management of genetic resources, since the crossing of traditional breeds with modern, high-producing commercial breeds, can lead an irreversible loss of valuable adaptive traits. Sheep are ideally suited to the landscapes and climate of the islands of the North Atlantic and mostly served a utilitarian purpose in Viking society, providing food and wool for clothing. They quickly became the most economically important domestic animal in the North Atlantic but little is known about the genomic composition of Viking Age sheep or their contributions to modern breeds. To date, ancient DNA analyses of sheep are limited and most ongoing work focuses on older time periods (e.g. the Neolithic and Bronze ages). The horse had a very different role in society since it was of central cultural and ritual importance during the Viking Age in additions to its use in transportation, agriculture and warfare. We will obtain and analyze archaeological bone material from around the North Atlantic and Scandinavia and compare these with modern breeds in the region. The project will combine zooarchaeological analyses with genomics, applying the latest advances in high throughput sequencing and ancient DNA analysis. Using this multidisciplinary approach will allow us to assemble a unique dataset in which we observe broad biogeographic patterns, functional traits as well as societal aspects such as herding techniques.

• Ferter, Keno; Kleiven, Alf Ring; Colman, Jonathan Edward; Haugen, Thrond Oddvar; Stensland, Stian; Strehlow, Harry Vincent; Weltersbach, Marc Simon & Vølstad, Jon Helge (2016). Developing a sampling scheme to evaluate Norwegian marine recreational fisheries - A case study from the Oslofjord.
• Karlsen, Hans Erik (2016). Particle motion levels in frequency-dependent responses in penned mackerel.

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