Siste publikasjoner

• Wang, You-Ren (2022). Disentangling effects of natural and anthropogenic drivers on forest net ecosystem production. Science of the Total Environment. ISSN 0048-9697. 839. doi: 10.1016/j.scitotenv.2022.156326.
• Czysch, Christian; Medina-Montano, Carolina; Dal, Nils-Jørgen Knudsen; Dinh, Thi; Fröder, Yannick & Winterwerber, Pia [Vis alle 15 forfattere av denne artikkelen] (2022). End group dye-labeled polycarbonate block copolymers for micellar (immuno-)drug delivery. Macromolecular rapid communications. ISSN 1022-1336. 00:2200095, s. 1–10. doi: 10.1002/marc.202200095.
• Bastard, Paul; Hsiao, Kuang-Chih; Zhang, Qian; Choin, Jeremy; Best, Emma & Chen, Jie [Vis alle 64 forfattere av denne artikkelen] (2022). A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 219:e20220028(6), s. 1–22. doi: 10.1084/jem.20220028.
• Yaragina, Natalia A.; Stige, Leif Christian & Langangen, Øystein Ole Gahr (2022). Bycatch data from ichthyoplankton surveys reveal long-term trends in gelatinous zooplankton in the Norwegian and Barents Seas. ICES Journal of Marine Science. ISSN 1054-3139. 79(3), s. 868–881. doi: 10.1093/icesjms/fsab225.
• Ohlberger, Jan; Langangen, Øystein Ole Gahr & Stige, Leif Christian (2022). Age structure affects population productivity in an exploited fish species. Ecological Applications. ISSN 1051-0761. doi: 10.1002/eap.2614.
• Verhellen, Jonas (2022). Graph-Based Molecular Pareto Optimisation . Chemical Science. ISSN 2041-6520.
• Chiou, Kenneth L.; Janiak, Mareike C.; Schneider-Crease, India A.; Sen, Sharmi; Ayele, Ferehiwot & Chuma, Idrissa S. [Vis alle 29 forfattere av denne artikkelen] (2022). Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas. Nature Ecology and Evolution. ISSN 2397-334X. 6(5), s. 630–643. doi: 10.1038/s41559-022-01703-4.
• Wang, Zengmiao; Liu, Yonghong; Li, Yapin; Wang, Guangze; Lourenço, José & Kraemer, Moritz [Vis alle 18 forfattere av denne artikkelen] (2022). The relationship between rising temperatures and malaria incidence in Hainan, China, from 1984 to 2010: a longitudinal cohort study. The Lancet Planetary Health. ISSN 2542-5196. 6(4), s. e350–e358. doi: 10.1016/S2542-5196%2822%2900039-0.
• Decock, Cony A.; Ryvarden, Leif & Amalfi, Mario (2022). Niveoporofomes (Basidiomycota, Fomitopsidaceae) in Tropical Africa: two additions from Afromontane forests, Niveoporofomes oboensis sp. nov. and N. widdringtoniae comb. nov. and N. globosporus comb. nov. from the Neotropics. Mycological Progress. ISSN 1617-416X. 21(2). doi: 10.1007/s11557-022-01787-z.
• Schwartz, Lawrence M. & Gundersen, Kristian (2022). Cross Talk opposing view: Myonuclei do not undergo apoptosis during skeletal muscle atrophy. Journal of Physiology. ISSN 0022-3751. 600(9), s. 2081–2084. doi: 10.1113/JP282381.
• Nipen, Maja; Jørgensen, Susanne Jøntvedt; Bohlin-Nizzetto, Pernilla; Borgå, Katrine; Breivik, Knut & Mmochi, Aviti J [Vis alle 11 forfattere av denne artikkelen] (2022). Mercury in air and soil on an urban-rural transect in East Africa. Environmental Science: Processes & Impacts. ISSN 2050-7887. doi: 10.1039/D2EM00040G. Fulltekst i vitenarkiv Vis sammendrag

  There are large knowledge gaps concerning concentrations, sources, emissions, and spatial trends of mercury (Hg) in the atmosphere in developing regions of the Southern Hemisphere, particularly in urban areas. Filling these gaps is a prerequisite for assessing the effectiveness of international regulation and for enabling a better understanding of the global transport of Hg in the environment. Here we use a passive sampling technique to study the spatial distribution of gaseous elemental Hg (Hg(0), GEM) and assess emission sources in and around Dar es Salaam, Tanzania's largest city. Included in the study were the city's main municipal waste dumpsite and an e-waste processing facility as potential sources of GEM. To complement the GEM data and for a better overview of the Hg contamination status of Dar es Salaam, soil samples were collected from the same locations where passive air samplers were deployed and analysed for total Hg. Overall, GEM concentrations ranged between <0.86 and 5.34 ng m−3, indicating significant local sources within the urban area. The municipal waste dumpsite and e-waste site had GEM concentrations elevated above the background, at 2.41 and 1.77 ng m−3, respectively. Hg concentrations in soil in the region (range 0.0067 to 0.098 mg kg−1) were low compared to those of other urban areas and were not correlated with atmospheric GEM concentrations. This study demonstrates that GEM is a significant environmental issue in the urban region of Dar es Salaam. Further studies from urban areas in the Global South are needed to better identify sources of GEM.

• Schuch, Esther & Richter, Andries Peter (2022). Tracing intuitive judgement of experts in fish stock assessment data. Fish and Fisheries. ISSN 1467-2960. 23(3), s. 758–767. doi: 10.1111/faf.12646.
• Coggan, Kimberly A.; Higgs, Matthew G.; Brutinel, Evan D.; Marden, Jeremiah N.; Intile, Peter J. & Winther-Larsen, Hanne Cecilie [Vis alle 9 forfattere av denne artikkelen] (2022). Global Regulatory Pathways Converge To Control Expression of Pseudomonas aeruginosa Type IV Pili. mBio. ISSN 2161-2129. 13(1). doi: 10.1128/MBIO.03696-21.
• Fiore-Donno, Anna Maria; Human, Zander R.; Štursová, Martina; Mundra, Sunil; Morgado, Luis & Kauserud, Håvard [Vis alle 8 forfattere av denne artikkelen] (2022). Soil compartments (bulk soil, litter, root and rhizosphere) as main drivers of soil protistan communities distribution in forests with different nitrogen deposition. Soil Biology and Biochemistry. ISSN 0038-0717. 168. doi: 10.1016/j.soilbio.2022.108628.
• Malecki, Jedrzej Mieczyslaw; Davydova, Erna & Falnes, Pål (2022). Protein methylation in mitochondria. Journal of Biological Chemistry. ISSN 0021-9258. 298(4). doi: 10.1016/j.jbc.2022.101791.
• Holme, Jørn Andreas; Valen, Håkon; Brinchmann, Bendik Christian; Vist, Gunn Elisabeth; Grimsrud, Tom Kristian & Becher, Rune [Vis alle 9 forfattere av denne artikkelen] (2022). Polycyclic aromatic hydrocarbons (PAHs) may explain the paradoxical effects of cigarette use on preeclampsia (PE). Toxicology. ISSN 0300-483X. 473. doi: 10.1016/j.tox.2022.153206.
• Motes-Rodrigo, Alba; McPherron, Shannon P.; Archer, Will; Hernandez-Aguilar, Raquel Adriana & Tennie, Claudio (2022). Experimental investigation of orangutans' lithic percussive and sharp stone tool behaviours. PLOS ONE. ISSN 1932-6203. 17(2). doi: 10.1371/journal.pone.0263343.
• Geng, Xiaojun; Fu, Yongshuo H.; Piao, Shilong; Hao, Fanghua; De Boeck, Hans J. & Zhang, Xuan [Vis alle 13 forfattere av denne artikkelen] (2022). Higher temperature sensitivity of flowering than leaf-out alters the time between phenophases across temperate tree species. Global Ecology and Biogeography. ISSN 1466-822X. 31(5), s. 901–911. doi: 10.1111/geb.13463.
• Matschiner, Michael; Barth, Julia Maria Isis; Tørresen, Ole K.; Star, Bastiaan; Baalsrud, Helle Tessand & Brieuc, Marine Servane Ono [Vis alle 10 forfattere av denne artikkelen] (2022). Supergene origin and maintenance in Atlantic cod. Nature Ecology and Evolution. ISSN 2397-334X. 6(4), s. 469–481. doi: 10.1038/s41559-022-01661-x.
• Geml, József; Arnold, Anne Elizabeth; Semenova-Nelsen, Tatiana A.; Nouhra, Eduardo R.; Drechsler-Santos, Elisandro R. & Góes-Neto, Aristóteles [Vis alle 13 forfattere av denne artikkelen] (2022). Community dynamics of soil-borne fungal communities along elevation gradients in neotropical and palaeotropical forests. Molecular Ecology. ISSN 0962-1083. 31(7), s. 2044–2060. doi: 10.1111/mec.16368.
• Parker, Jamie; Guslund, Naomi Croft; Jentoft, Sissel & Roth, Olivia (2022). Characterization of Pipefish Immune Cell Populations Through Single-Cell Transcriptomics. Frontiers in Immunology. ISSN 1664-3224. 13. doi: 10.3389/fimmu.2022.820152.
• Kajiya Endo, Clarissa Akemi; Stige, Leif Christian; Skogen, Morten D.; Ciannelli, Lorenzo & Vikebø, Frode Bendiksen (2022). Two decades of match-mismatch in Northeast Arctic cod – Feeding conditions and survival. Frontiers in Marine Science. ISSN 2296-7745. 9:767290, s. 1–14. doi: 10.3389/fmars.2022.767290. Fulltekst i vitenarkiv
• Dal, Nils-Jørgen Knudsen; Speth, Martin Tobias; Johann, Kerstin; Barz, Matthias; Beauvineau, Claire & Wohlmann, Jens [Vis alle 10 forfattere av denne artikkelen] (2022). The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds. Disease Models and Mechanisms. ISSN 1754-8403. 15(1). doi: 10.1242/dmm.049147.
• Lunde, Lisa Fagerli; Birkemoe, Tone; Kauserud, Håvard; Boddy, Lynne; Jacobsen, Rannveig Margrete & Morgado, Luis [Vis alle 8 forfattere av denne artikkelen] (2022). DNA metabarcoding reveals host-specific communities of arthropods residing in fungal fruit bodies. Proceedings of the Royal Society of London. Biological Sciences. ISSN 0962-8452. 289(1968). doi: 10.1098/rspb.2021.2622.
• Bustad, Helene J.; Flydal, Marte Innselset; Knævelsrud, Helene; Langaker, Ann Helen; Boye, Erik & Kristensen, Tom (2022). Slik utvikler vi norske fagtermer i celle-og molekylærbiologi. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(2). doi: 10.4045/tidsskr.21.0465.
• Oomen, Rebekah Alice; Knutsen, Halvor; Moland, Even; Olsen, Esben Moland; Knutsen, Jan Atle & Bernatchez, Louis [Vis alle 8 forfattere av denne artikkelen] (2022). Nothing so boundless, nothing so patient: Obituary for Professor Jeffrey Alexander Hutchings (1958–2022). Fish and Fisheries. ISSN 1467-2960. 23(3), s. 519–521. doi: 10.1111/faf.12661.
• Dao, Thanh-Son; Nguyen, Van-Tai; Baduel, Christine; Bui, Manh-Ha; Tran, Viet Tuan & Pham, Thanh-Luu [Vis alle 8 forfattere av denne artikkelen] (2022). Toxicity of di-2-ethylhexyl phthalate and tris (2-butoxyethyl) phosphate to a tropical micro-crustacean (Ceriodaphnia cornuta) is higher in Mekong River water than in standard laboratory medium. Environmental science and pollution research international. ISSN 0944-1344. doi: 10.1007/s11356-022-18993-7.
• Knutsen, Halvor; de Oliveira Catarino, Diana Sofia; Rogers, Lauren; Sodeland, Marte; Mattingsdal, Morten & jahnke, marlene [Vis alle 15 forfattere av denne artikkelen] (2022). Combining population genomics with demographic analyses highlights habitat patchiness and larval dispersal as determinants of connectivity in coastal fish species. Molecular Ecology. ISSN 0962-1083. 31(9), s. 2562–2577. doi: 10.1111/mec.16415.
• Geng, Xiaojun; Zhang, Yaru; Fu, Yongshuo H.; Hao, Fanghua; Janssens, Ivan A. & Peñuelas, Josep [Vis alle 12 forfattere av denne artikkelen] (2022). Contrasting phenology responses to climate warming across the northern extra-tropics. Fundamental Research. ISSN 2667-3258. doi: 10.1016/j.fmre.2021.11.035.
• Hynne, Håvard; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Thiede, Bernd; Palm, Øyvind & Amdal, Cecilie Delphin [Vis alle 10 forfattere av denne artikkelen] (2022). Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren’s Syndrome Patients. International Journal of Molecular Sciences. ISSN 1661-6596. 23(7). doi: 10.3390/ijms23073714.
• Grevys, Algirdas; Frick, Rahel; Mester, Simone; Flem-Karlsen, Karine; Nilsen, Jeannette & Foss, Stian [Vis alle 13 forfattere av denne artikkelen] (2022). Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life. iScience. ISSN 2589-0042. 25(2). doi: 10.1016/j.isci.2022.103746.
• Andrew, Carrie; Mueller, Gregory M. & Avis, Peter G. (2022). Do local-scale context dependencies shape how ectomycorrhizal fungal diversity structures with reduced or sustained experimental N addition? Pedobiologia. ISSN 0031-4056. 90. doi: 10.1016/j.pedobi.2022.150791.
• Broekman, Maarten J. E.; Hilbers, Jelle P.; Huijbregts, Mark A. J.; Mueller, Thomas; Ali, Abdullah H. & Andrén, Henrik [Vis alle 56 forfattere av denne artikkelen] (2022). Evaluating expert-based habitat suitability information of terrestrial mammals with GPS-tracking data. Global Ecology and Biogeography. ISSN 1466-822X. doi: 10.1111/geb.13523. Fulltekst i vitenarkiv
• Wang, Gan; Zhang, Min; Meng, Ping; Long, Chengbo; Luo, Xiaodong & Yang, Xingwei [Vis alle 22 forfattere av denne artikkelen] (2022). Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis. Acta Pharmaceutica Sinica B (APSB). ISSN 2211-3835. doi: 10.1016/j.apsb.2021.12.024.
• Mcgovern, Maeve; Warner, Nicholas Alexander; Borgå, Katrine; Evenset, Anita; Carlsson, Pernilla Marianne & Skogsberg, Stina Linnea Emelie [Vis alle 10 forfattere av denne artikkelen] (2022). Is Glacial Meltwater a Secondary Source of Legacy Contaminants to Arctic Coastal Food Webs? Environmental Science and Technology. ISSN 0013-936X. doi: 10.1021/acs.est.1c07062.
• Skogsberg, Emelie; Mcgovern, Maeve; Poste, Amanda; Jonsson, Sofi; Arts, Michael T. & Varpe, Øystein [Vis alle 7 forfattere av denne artikkelen] (2022). Seasonal pollutant levels in littoral high-Arctic amphipods in relation to food sources and terrestrial run-off. Environmental Pollution (1987). ISSN 0269-7491. 306. doi: 10.1016/j.envpol.2022.119361.
• Piot, Niels; Schweiger, Oliver; Meeus, Ivan; Yañez, Orlando; Straub, Lars & Villamar-Bouza, Laura [Vis alle 26 forfattere av denne artikkelen] (2022). Honey bees and climate explain viral prevalence in wild bee communities on a continental scale. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-05603-2.
• Su, Zhangli; Monshaugen, Ida; Wilson, Briana; Wang, Fengbin; Klungland, Arne & Ougland, Rune [Vis alle 7 forfattere av denne artikkelen] (2022). TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. Nature Communications. ISSN 2041-1723. 13(1). doi: 10.1038/s41467-022-29790-8.
• MacKenzie, Kirsteen M.; Lydersen, Christian; Haug, Tore; Routti, Heli Anna Irmeli; Aars, Jon & Andvik, Clare Margaret [Vis alle 13 forfattere av denne artikkelen] (2022). Niches of marine mammals in the European Arctic. Ecological Indicators. ISSN 1470-160X. 136. doi: 10.1016/j.ecolind.2022.108661. Fulltekst i vitenarkiv
• Kausrud, Kyrre Linné; Vandvik, Vigdis; Flø, Daniel; Geange, Sonya Rita; Hegland, Stein Joar & Hermansen, Jo Skeie [Vis alle 24 forfattere av denne artikkelen] (2022). Impacts of climate change on the forest ecosystem. VKM Report. ISSN 2535-4019.
• Lewin, Harris A.; Richards, Stephen; Aiden, Erez Lieberman; Allende, Miguel L.; Archibald, John M. & Bálint, Miklós [Vis alle 85 forfattere av denne artikkelen] (2022). The Earth BioGenome Project 2020: Starting the clock. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 119(4). doi: 10.1073/pnas.2115635118.
• Schultze, Sabrina; Andersen, Tom; Hessen, Dag Olav; Ruus, Anders; Borgå, Katrine & Poste, Amanda (2022). Land-cover, climate and fjord morphology drive differences in organic matter and nutrient dynamics in two contrasting northern river-fjord systems. Estuarine, Coastal and Shelf Science. ISSN 0272-7714. 270. doi: 10.1016/j.ecss.2022.107831.
• Cowan, Andrew J.; Moody, Suzy Clare & Skrede, Inger (2022). Cytochrome P450 Complement May Contribute to Niche Adaptation in Serpula Wood-Decay Fungi. Journal of fungi (JoF). ISSN 2309-608X. 8(3). doi: 10.3390/jof8030283. Fulltekst i vitenarkiv
• Lemma, Roza Berhanu; Fleischer, Thomas; Martinsen, Emily; Ledsaak, Marit; Kristensen, Vessela N. & Eskeland, Ragnhild [Vis alle 8 forfattere av denne artikkelen] (2022). Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers. Epigenetics & Chromatin. ISSN 1756-8935. 15. doi: 10.1186/s13072-022-00444-9.
• An, Dongchen; Pinheiro-Junior, Ernesto Lopes; Béress, László; Gladkikh, Irina; Leychenko, Elena & Undheim, Eivind Andreas Baste [Vis alle 8 forfattere av denne artikkelen] (2022). AsKC11, a Kunitz Peptide from Anemonia sulcata, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels. Marine Drugs. ISSN 1660-3397. 20(2). doi: 10.3390/md20020140.
• Lunde, Lisa Fagerli; Jacobsen, Rannveig Margrete; Kauserud, Håvard; Boddy, Lynne; Nybakken, Line & Sverdrup-Thygeson, Anne [Vis alle 7 forfattere av denne artikkelen] (2022). Legacies of invertebrate exclusion and tree secondary metabolites control fungal communities in dead wood. Molecular Ecology. ISSN 0962-1083. 31(11), s. 3241–3253. doi: 10.1111/mec.16448.
• Ramos Alonso, Lucia; Garcia Llorente, Ignacio; Enserink, Jorrit & Chymkowitch, Pierre (2022). Analysis of the pheromone signaling pathway by RT-qPCR in the budding yeast Saccharomyces cerevisiae. STAR Protocols. ISSN 2666-1667. 3(1). doi: 10.1016/j.xpro.2022.101210.
• Eagles, David A.; Saez, Natalie J.; Krishnarjuna, Bankala; Bradford, Julia J.; Chin, Yanni K.-Y. & Starobova, Hana [Vis alle 14 forfattere av denne artikkelen] (2022). A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 119(7). doi: 10.1073/pnas.2112630119.
• Alfaro Garcia, Laura Andrea; Descamps, Sebastien; Herzke, Dorte; Chastel, Olivier; Carravieri, Alice & Cherel, Yves [Vis alle 14 forfattere av denne artikkelen] (2022). Bioaccumulation of Per and Polyfluoroalkyl Substances in Antarctic Breeding South Polar Skuas (Catharacta maccormicki) and Their Prey. Frontiers in Marine Science. ISSN 2296-7745. 9. doi: 10.3389/fmars.2022.819525. Fulltekst i vitenarkiv Vis sammendrag

  Per and polyfluoroalkyl substances (PFASs) are found in Antarctic wildlife, with high levels in the avian top predator south polar skua (Catharacta maccormicki). As increasing PFAS concentrations were found in the south polar skua during the breeding season in Antarctica, we hypothesised that available prey during the breeding period contributes significantly to the PFAS contamination in skuas. To test this, we compared PFAS in south polar skuas and their main prey from two breeding sites on opposite sides of the Antarctic continent: Antarctic petrel (Thalassoica antarctica) stomach content, eggs, chicks, and adults from Svarthamaren in Dronning Maud Land and Adélie penguin chicks (Pygoscelis adeliae) from Dumont d’Urville in Adélie Land. Of the 22 PFAS analysed, seven were present in the majority of samples, except petrel stomach content [only perfluoroundecanoate (PFUnA) present] and Adélie penguins (only four compounds present), with increasing concentrations from the prey to the skuas. The biomagnification factors (BMFs) were higher at Dumont d’Urville than Svarthamaren. When adjusted to reflect one trophic level difference, the BMFs at Svarthamaren remained the same, whereas the ones at Dumont d’Urville doubled. At both the colonies, the skua PFAS pattern was dominated by perfluorooctanesulfonic acid (PFOS), followed by PFUnA, but differed with the presence of branched PFOS and perfluorotetradecanoate (PFTeA) and lack of perfluorononanoate (PFNA) and perfluorodecanoate (PFDA) at Dumont d’Urville. At Svarthamaren, the pattern in the prey was comparable to the skuas, but with a higher relative contribution of PFTeA in prey. At Dumont d’Urville, the pattern in the prey differed from the skuas, with the domination of PFUnA and the general lack of PFOS in prey. Even though the PFAS levels are low in Antarctic year-round resident prey, the three lines of evidence (pattern, BMF difference, and BMF adjusted to one trophic level) suggest that the Antarctic petrel are the significant source of PFAS in the Svarthamaren skuas, whereas the skuas in Dumont d’Urville have other important sources to PFAS than Adélie penguin, either in the continent or external on the inter-breeding foraging grounds far from Antarctica.

• Olsen, Luka Natassja; Brandrud, Marie Kristine; Mandáková, Terezie; Lysak, Martin A; Bjorå, Charlotte Sletten & Cires, Eduardo [Vis alle 8 forfattere av denne artikkelen] (2022). Genetic structure and evolution of diploid Cochlearia in Iceland. Botanical journal of the Linnean Society. ISSN 0024-4074. doi: 10.1093/botlinnean/boac018. Fulltekst i vitenarkiv
• Eldegard, Katrine; Flø, Daniel; Kirkendall, Lawrence Richard; Malmstrøm, Martin; Nielsen, Anders & Rasmussen, Claus [Vis alle 13 forfattere av denne artikkelen] (2022). Assessment of the risks to honey bees and biodiversity in Norway posed by the predatory wasp species Vespa velutina and V. mandarinia - Scientific Opinion of the Panel on Alien Organisms and Trade in Endangered species of the Norwegian Scientific Committee for Food and Enviroment . VKM Report. ISSN 2535-4019. Fulltekst i vitenarkiv
• Rasmussen, Jeppe Have; Moyano, Marta; Fuiman, Lee A. & Oomen, Rebekah Alice (2022). FishSizer: Software solution for efficiently measuring larval fish size. Ecology and Evolution. ISSN 2045-7758. 12(3), s. 1–10. doi: 10.1002/ece3.8672.
• Loughland, Isabella; Lau, Gigi Yik Chee; Jolly, Jordan & Seebacher, Frank (2022). Rates of warming impact oxidative stress in zebrafish (Danio rerio). Journal of Experimental Biology. ISSN 0022-0949. 225(6). doi: 10.1242/jeb.243740.
• Finol-Urdaneta, Rocio K.; Ziegman, Rebekah; Dekan, Zoltan; McArthur, Jeffrey R.; Heitmann, Stewart & Luna-Ramirez, Karen [Vis alle 20 forfattere av denne artikkelen] (2022). Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 119(5). doi: 10.1073/pnas.2110932119.
• Pedersen, Åshild Ønvik; Convey, P.; Newsham, Kevin K.; Mosbacher, Jesper Bruun; Fuglei, Eva & Ravolainen, Virve [Vis alle 47 forfattere av denne artikkelen] (2022). Five decades of terrestrial and freshwater research at Ny-Ålesund, Svalbard. Polar Research. ISSN 0800-0395. 41. doi: 10.33265/polar.v41.6310. Fulltekst i vitenarkiv
• Kallas, Pawel; Valen, Håkon; Hulander, Mats; Gadegaard, Nikolaj; Stormonth-Darling, John & O'Reilly, Padraic [Vis alle 9 forfattere av denne artikkelen] (2022). Protein-coated nanostructured surfaces affect the adhesion of Escherichia coli. Nanoscale. ISSN 2040-3364. doi: 10.1039/D2NR00976E. Fulltekst i vitenarkiv
• Hernandez, Luis Felipe Martell; Selsø, Katrine; Titelman, Josefin & Hosia, Aino Laila Johanna (2022). Setting the baseline for the dynamics of siphonophores and hydromedusae in Oslofjorden. Marine Ecology Progress Series. ISSN 0171-8630. 686, s. 71–89. doi: 10.3354/meps13991. Fulltekst i vitenarkiv
• Forsyth, David M.; Comte, Sebastien; Davis, Naomi E.; Bengsen, Andrew J.; Côté, Steeve D. & Hewitt, David G. [Vis alle 8 forfattere av denne artikkelen] (2022). Methodology matters when estimating deer abundance: a global systematic review and recommendations for improvements. Journal of Wildlife Management. ISSN 0022-541X. doi: 10.1002/jwmg.22207.
• Estensmo, Eva Lena Fjeld; Botnen, Synnøve Smebye; Maurice, Sundy; Martin Sanchez, Pedro Maria; Morgado, Luis & Engh, Ingeborg Bjorvand [Vis alle 9 forfattere av denne artikkelen] (2022). The Indoor Mycobiomes of Daycare Centers Are Affected by Occupancy and Climate. Applied and Environmental Microbiology. ISSN 0099-2240. 88(6). doi: 10.1128/aem.02113-21.
• Hanevik, Hans Ivar & Hessen, Dag Olav (2022). IVF and human evolution. Human Reproduction Update. ISSN 1355-4786. doi: 10.1093/humupd/dmac014. Vis sammendrag

  Humans are shaped by evolution through natural selection, as are all species. While evolution is central to all biological processes, the key stage for competition and selection is reproduction, which encompasses various events from courtship and mating to fertilization and pregnancy. In humans, IVF is used to aid the intrinsically inefficient reproduction by coitus, and in several countries, the proportion of children born after IVF is increasing. While IVF is an enabling technology for infertile patients, it also circumvents reproductive barriers and changes selection pressures. This grand theme review describes the systematic differences between IVF and coitus in selection pressures on reproducing cells, individuals and populations. At the cellular unit of selection, for example, IVF favours different traits in spermatozoa (fast swimmers over short distances) than coitus does (forward mobility over longer distances). Similarly, a male with low sperm quality and a female who decides to delay her first birth to an advanced age, can both increase their reproductive fitness by IVF compared to if reproduction by coitus is their only option. In as much as delayed reproduction is a cultural trait, IVF thus enables cultural practices that may in their turn affect human evolution. A main point in this review is to discuss the interactive effects of biological and cultural traits in the context of IVF, and how they act in concert as drivers towards increased demand for IVF. It is not the aim of this review to argue against IVF, which no doubt is a major medical advancement, but rather to examine IVF and human evolution from a broad perspective, including potential longer-term impacts. Since IVF is a young technology, the empirical data indicative of evolutionary effects of IVF in humans are sparse. In general, we argue that IVF facilitates the redirection of resources away from reproduction in humans, since reproduction by IVF bypasses some of the resource-demanding processes that reproduction by coitus entails. Hence, IVF sets the evolutionary stage for a human species increasingly reliant on, and adapted to, technological means of reproduction.

• Zhao, Xu; Hendriks, Ivo A; Le Gras, Stephanie; Ye, Tao; Ramos Alonso, Lucia & Nguéa P, Aurélie [Vis alle 13 forfattere av denne artikkelen] (2022). Waves of sumoylation support transcription dynamics during adipocyte differentiation. Nucleic Acids Research (NAR). ISSN 0305-1048. 50(3), s. 1351–1369. doi: 10.1093/nar/gkac027.
• Meuskens, Ina; Leva-Bueno, Juan; Millner, Paul; Schütz, Monika; Peyman, Sally & Linke, Dirk (2022). The Trimeric Autotransporter Adhesin YadA of Yersinia enterocolitica Serotype O:9 Binds Glycan Moieties. Frontiers in Microbiology. ISSN 1664-302X. doi: 10.3389/fmicb.2021.738818.
• Eliassen, June Edvarda; Bøe, Maria Vetleseter; Nederbragt, Lex; Berg, Marthe Mjøen & Gregers, Tone Fredsvik (2022). Motivasjon for beregningsorientert biologi og sammenhengen med matematikk R2 fra videregående opplæring. Nordic Journal of STEM Education. ISSN 2535-4574. 4(2), s. 58–70. doi: 10.5324/njsteme.v4i2.4026. Fulltekst i vitenarkiv
• Michalik, Marcin; Djahanshiri, Bardya; Leo, Jack C. & Linke, Dirk (2022). An Update on "Reverse Vaccinology": The Pathway from Genomes and Epitope Predictions to Tailored, Recombinant Vaccines. Methods in molecular biology. ISSN 1064-3745. 2412, s. 45–71. doi: 10.1007/978-1-0716-1892-9_4. Fulltekst i vitenarkiv
• Falk, Stefanie; Vollsnes, Ane Victoria; Eriksen, Aud Else Berglen; Emberson, Lisa D.; O’Neill, Connie & Stordal, Frode [Vis alle 7 forfattere av denne artikkelen] (2022). Parameterization of the responses of subarctic European vegetation to key environmental variables for ozone risk assessment. Biogeosciences. ISSN 1726-4170.
• Beal, J.; Saragliadis, Athanasios & Linke, Dirk (2021). Comparative analysis of three studies measuring fluorescence from engineered bacterial genetic constructs. PLOS ONE. ISSN 1932-6203. 16(6). doi: 10.1371/journal.pone.0252263. Fulltekst i vitenarkiv
• Fulde, Marcus; van Vorst, Kira; Zhang, Kaiyi; Westermann, Alexander J.; Busche, Tobias & Huei, Yong Chiun [Vis alle 18 forfattere av denne artikkelen] (2021). SPI2 T3SS effectors facilitate enterocyte apical to basolateral transmigration of Salmonella-containing vacuoles in vivo. Gut microbes. ISSN 1949-0976. 13(1). doi: 10.1080/19490976.2021.1973836. Fulltekst i vitenarkiv
• Figuerola, Blanca; Valiente Parra, Nicolas; Barbosa, Andres; Brasier, Madeline J.; Colominas-Ciuró, Roger & Convey, Peter [Vis alle 16 forfattere av denne artikkelen] (2021). Shifting Perspectives in Polar Research: Global Lessons on the Barriers and Drivers for Securing Academic Careers in Natural Sciences. Frontiers in Ecology and Evolution. ISSN 2296-701X. 9, s. 1–10. doi: 10.3389/fevo.2021.777009. Fulltekst i vitenarkiv
• González-Barrio, David; Köster, Pamela C.; Habela, Miguel A.; Martín-Pérez, Manuel; Fernández-García, Jose L. & Balseiro, Ana [Vis alle 14 forfattere av denne artikkelen] (2021). Molecular survey of Besnoitia spp. (Apicomplexa) in faeces from European wild mesocarnivores in Spain. Transboundary and Emerging Diseases. ISSN 1865-1674. 68(6), s. 3156–3166. doi: 10.1111/tbed.14206.
• Li, Ruizhen; Shi, Chunlin; Wang, Xiaoyang; Meng, Yan; Cheng, Lina & Jiang, Cai-Zhong [Vis alle 9 forfattere av denne artikkelen] (2021). Inflorescence abscission protein SlIDL6 promotes low light intensity-induced tomato flower abscission. Plant Physiology. ISSN 0032-0889. 186(2), s. 1288–1301. doi: 10.1093/PLPHYS/KIAB121.
• Osborne, Hugh; Lai, Yi Ming; Lepperød, Mikkel Elle; Sichau, David; Deutz, Lukas & de Kamps, Marc (2021). MIIND : A Model-Agnostic Simulator of Neural Populations. Frontiers in Neuroinformatics. ISSN 1662-5196. 15, s. 1–29. doi: 10.3389/fninf.2021.614881. Fulltekst i vitenarkiv
• Gregers, Tone Fredsvik & Lunde, Mai Lill Suhr (2021). Students' understanding of the cell and cellular structures. Nordic Studies in Science Education. ISSN 1504-4556. 17(2), s. 225–241. doi: 10.5617/NORDINA.7306. Fulltekst i vitenarkiv
• Kaartvedt, Stein; Røstad, Anders & Titelman, Josefin (2021). Sleep walking copepods? Calanus diapausing in hypoxic waters adjust their vertical position during winter. Journal of Plankton Research. ISSN 0142-7873. 43(2), s. 199–208. doi: 10.1093/plankt/fbab004. Fulltekst i vitenarkiv
• de Lira, Carla Rejane Sousa; Alvarenga, Renato Lúcio Mendes; Soares, A.M.S.; Ryvarden, Leif & Gibertoni, Tatiana Baptista (2021). Phylogeny of Megasporoporia s.lat. and related genera of Poyporaceae: New genera, new species and new combinations. Mycosphere. ISSN 2077-7000. 12(1), s. 1262–1289. doi: 10.5943/MYCOSPHERE/12/1/16. Fulltekst i vitenarkiv
• Kumar, Suresh; Javed, Ruheena; Mudd, Michal H.; Pallikkuth, Sandeep; Lidke, Keith A. & Jain, Ashish [Vis alle 22 forfattere av denne artikkelen] (2021). Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes. Cell. ISSN 0092-8674. 184(24), s. 5950–5969. doi: 10.1016/j.cell.2021.10.017. Vis sammendrag

  The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used cellular and in vitro membrane fusion analyses to show that autophagosomes are formed from a hitherto unappreciated hybrid membrane compartment. The autophagic precursors emerge through fusion of FIP200 vesicles, derived from the cis-Golgi, with endosomally derived ATG16L1 membranes to generate a hybrid pre-autophagosomal structure, HyPAS. A previously unrecognized apparatus defined here controls HyPAS biogenesis and mammalian autophagosomal precursor membranes. HyPAS can be modulated by pharmacological agents whereas its formation is inhibited upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or by expression of SARS-CoV-2 nsp6. These findings reveal the origin of mammalian autophagosomal membranes, which emerge via convergence of secretory and endosomal pathways, and show that this process is targeted by microbial factors such as coronaviral membrane-modulating proteins

• Halbwachs, H.; Ryvarden, Leif & Bässler, C. (2021). Larger basidiomycetes growing on poroid lignicolous fungi show rot typerelated colonization patterns. Asian Journal of Mycology. ISSN 2651-1339. 4(2), s. 19–28. doi: 10.5943/ajom/4/2/2.
• Uttgaard, Karianne Roti; Kwembeya, Ezekeil G.; Nordal, Inger; Carlsen, Tor & Bjorå, Charlotte Sletten (2021). A phylogenetic analysis of the Crinum rautanenianum complex (Crininae,Amaryllidaceae) - with a description of C. luangwense sp. nov. South African Journal of Botany. ISSN 0254-6299. 142, s. 391–402. doi: 10.1016/j.sajb.2021.07.016. Vis sammendrag

  Within genus Crinum L. there has been a lot of confusion, as to species delimitation, particularly in the Crinum rautanenianum complex comprising Crinum carolo-schmidtii, C. euchrophyllum, C. paludosum, C. rautanenianum, and also a specimen referred to as sp. A in Flora of Tropical East Africa. Maximum parsimony and Bayesian inference analyses were conducted on two datasets: nuclear DNA region (ITS) and five plastid regions (trnL-F spacer, trnL intron, rps16 intron, psbA-trnH spacer, and rps12-rpl20 spacer). Additionally, morphological characters based on herbarium specimens, pictures from the field, type specimens, and protologues were studied to establish diagnostic characters within the complex. Results from phylogeny and morphological characters provide evidence for the reinstatement of C. euchrophyllum, recognition of C. rautanenianum, C. carolo-schmidtii, C. paludosum, with a revisited description of C. rautanenianum, and the description of a new taxon: C. luangwense. A taxonomic revision of the C. rautanenianum complex is presented, including diagnostic characters, an identification key and distribution maps.

• Moe, Therese Fosholt; Hessen, Dag Olav & Demars, Benoît Olivier Laurent (2021). Juncus Bulbosus Tissue Nutrient Concentrations and Stoichiometry in Oligotrophic Ecosystems: Variability with Seasons, Growth Forms, Organs and Habitats. Plants. ISSN 2223-7747. 10(3). doi: 10.3390/plants10030441. Fulltekst i vitenarkiv Vis sammendrag

  Aquatic plant nutrient concentrations provide important information to characterise their role in nutrient retention and turnover in aquatic ecosystems. While large standing biomass of aquatic plants is typically found in nutrient-rich localities, it may also occur in oligotrophic ecosystems. Juncus bulbosus is able to form massive stands even in very nutrient-dilute waters. Here we show that this may be achieved by tissues with very high carbon-to-nutrient ratios combined with perennial (slow) growth and a poor food source for grazers inferred from plant stoichiometry and tissue nutrient thresholds. We also show that the C, N, P and C:N:P stoichiometric ratios of Juncus bulbosus vary with the time of year, habitats (lakes versus rivers) and organs (roots versus shoots). We found no differences between growth forms (notably in P, inferred as the most limiting nutrient) corresponding to small and large plant stands. The mass development of J. bulbosus requires C, N and P, whatever the ecosystem (lake or river), and not just CO2 and NH4, as suggested in previous studies. Since macrophytes inhabiting oligotrophic aquatic ecosystems are dominated by isoetids (perennial plants with a high root/shoot ratio), attention should be paid to quantifying the role of roots in aquatic plant stoichiometry, nutrient turnover and nutrient retention.

• Anderson, Thomas R.; Hessen, Dag Olav & Mayor, Daniel J. (2021). Is the growth of marine copepods limited by food quantity or quality? Limnology and Oceanography Letters. ISSN 2378-2242. 6(3), s. 127–133. doi: 10.1002/lol2.10184. Fulltekst i vitenarkiv
• Kraemer, Benjamin M.; Pilla, Rachel M.; Woolway, R Iestyn; Anneville, Orlane; Ban, Syuhei & Colom-Montero, William [Vis alle 37 forfattere av denne artikkelen] (2021). Climate change drives widespread shifts in lake thermal habitat. Nature Climate Change. ISSN 1758-678X. 11, s. 521–529. doi: 10.1038/s41558-021-01060-3. Fulltekst i vitenarkiv
• Pilla, Rachel M.; Mette, Elizabeth M.; Williamson, Craig E.; Adamovich, Boris V.; Adrian, Rita & Anneville, Orlane [Vis alle 86 forfattere av denne artikkelen] (2021). Global data set of long-term summertime vertical temperature profiles in 153 lakes. Scientific Data. ISSN 2052-4463. 8, s. 1–12. doi: 10.1038/s41597-021-00983-y. Fulltekst i vitenarkiv
• Stenberg, Johan A.; Melby, Kjetil K.; Magnusson, Christer; Nielsen, Anders; Rydning, Julie & Wendell, Micael [Vis alle 12 forfattere av denne artikkelen] (2021). Risk assessment of the biocontrol product Nemaslug 2.0 with the active organisms Phasmarhabditis californica (strain P19D) and Moraxella osloensis. VKM Report. ISSN 2535-4019. 2021(16), s. 1–37. Fulltekst i vitenarkiv Vis sammendrag

  Key words: VKM, risk assessment, Norwegian Scientific Committee for Food and Environment, Norwegian Food Safety Authority, biological control, Nematodes, Phasmarhabditis californica, Moraxella osloensis. Parasitic nematodes and associated bacteria are increasingly being used for biocontrol of molluscs. Functionally, it is the bacteria that kill and thus control the targeted pests, but the function of the bacteria is dependent on the nematodes, which should be regarded as vectors of biocontrol. Although the nematodes and the bacteria have a symbiotic relationship within such biocontrol formulations, it should be noted that they are not dependent on each other in the wild, but can establish separate populations which can be free-living or hosted by other organisms. The biocontrol product Nemaslug 2.0 contains the nematode Phasmarhabditis californica (strain P19D) and the bacterial symbiont Moraxella osloensis (unknown strain). The nematode was first described in 2016 and has never been reported in Norway. The lack of reports suggests that it is absent from Norway, but this conclusion comes with a high degree of uncertainty since there have been limited search efforts. The climatic thresholds of the nematode are not known, but its current distribution, spanning widely varying climates, suggests that it could survive and establish in Norway. Natural spread from currently known areas of establishment to natural habitats in Norway is ruled out due to the nematode’s limited dispersal capacity. However, human-assisted spread (e.g. via the use of biocontrol products) and establishment would be likely if Nemaslug 2.0 is allowed for use in open fields in Norway. Use of Nemaslug 2.0 in greenhouses and other enclosed areas is not likely to facilitate spread to natural habitats in Norway provided that residues are properly handled. However, deposition of product residues from greenhouses to outdoor areas may result in local establishment of the nematode in the vicinity of the deposition. Phasmarhabditis californica has a broad host range and may parasitize both rare/endangered and common mollusc species. However, there is no scientific evidence suggesting that the nematode can affect natural populations of molluscs in wild habitats, or otherwise have negative effects on biodiversity. The nematodes’ association with the bacteria Moraxella osloensis is most likely lost, or at least weakened, in natural habitats, suggesting that the nematode becomes less capable of killing its hosts in the wild. Phasmarhabditis californica is not capable of harming or infecting humans. The bacterial species Moraxella osloensis is already present in Norway in a few locations and at a low abundance, and it may be native to Norway. Little is known regarding its distribution in natural environments, but the literature shows that it can infect humans and other mammals. In humans with immunodeficiency or other comorbidities, M. osloensis can cause meningitis, vaginitis, sinusitis, bacteremia, endocarditis, and septic arthritis. The risk of infection in people handling Nemaslug 2.0 can probably be substantially reduced by protective clothing and appropriate handling. We are not aware of any reported health issues arising from use of the previous version of Nemaslug, which also contains M. osloensis. Different strains of M. osloensis are known to vary in their sensitivity to antibiotics, and likely in other traits too. Thus, the lack of information provided about the strain identity and specific characteristics of the strain used in Nemaslug 2.0 generates a high degree of uncertainty regarding its pathogenicity, climate tolerance, sensitivity to antibiotics etc.

• Bjerregaard-Andersen, Kaare; Abraha, Fana; Johannesen, Hedda; Oscarson, Stefan; Moreno, Ernesto & Krengel, Ute (2021). Key role of a structural water molecule for the specificity of 14F7 - An antitumor antibody targeting the NeuGc GM3 ganglioside. Glycobiology. ISSN 0959-6658. 31(11), s. 1500–1509. doi: 10.1093/glycob/cwab076. Fulltekst i vitenarkiv
• Sharma, Ankush; Akshay, Akshay; Rogne, Marie & Eskeland, Ragnhild (2021). ShinyArchR.UiO: User-friendly, integrative and open-source tool for visualisation of single-cell ATAC-seq data using ArchR. Bioinformatics. ISSN 1367-4803. 38(3), s. 834–836. doi: 10.1093/bioinformatics/btab680. Fulltekst i vitenarkiv Vis sammendrag

  Motivation: Mapping of chromatin accessibility landscapes in single-cells and the integration with gene expression enables a better understanding of gene regulatory mechanisms defining cell identities and cell-fate determination in development and disease. Generally, raw data generated from single-cell Assay for Transposase-Accessible Chromatin sequencing (scATAC-seq) are deposited in repositories that are generally inaccessible due to lack of in-depth knowledge of computational programming. Results: We have developed ShinyArchR.UiO, an R-based shiny app, that facilitates scATAC-seq data accessibility and visualisation in a user-friendly, interactive, and open-source web interface. ShinyArchR.UiO is an application that can streamline collaborative efforts for interpretation of massive chromatin accessibility datasets and allow for open access data sharing for wider audiences.

• Egge, Elianne Dunthorn; Elferink, Stephanie; Vaulot, Daniel; John, Uwe; Bratbak, Gunnar & Larsen, Aud [Vis alle 7 forfattere av denne artikkelen] (2021). An 18S V4 rDNA metabarcoding dataset of protist diversity in the Atlantic inflow to the Arctic Ocean, through the year and down to 1000 m depth. Earth System Science Data. ISSN 1866-3591. 13, s. 4913–4928. doi: 10.5194/essd-13-4913-2021.
• Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath K; Basic, Dean; Edvardsen, Rolf Brudvik & Dalen, Knut Tomas [Vis alle 41 forfattere av denne artikkelen] (2021). Genome editing in food and feed production – implications for risk assessment. Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment. VKM Report. ISSN 2535-4019. 2021(18). Fulltekst i vitenarkiv Vis sammendrag

  The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This report considers whether the risk assessment guidance on genetically modified organisms, developed by the European Food Safety Authority (EFSA), can be applied to evaluate potential risks of organisms developed by genome editing. Background Gene technology has allowed for the transfer of genes between organisms and species, and thereby to design altered genotypes with novel traits, i.e. GMOs. A new paradigm started in the early 2000s with the development of genome-editing techniques. Unlike traditional genetic modification techniques resulting in insertion of foreign DNA fragments at random locations in the genome, the new genome-editing techniques additionally open for a few single nucleotide edits or short insertions/deletions at a targeted site in an organism’s genome. These new techniques can be applied to most types of organisms, including plants, animals and microorganisms of commercial interest. An important question is how the novel, genome-edited organisms should be evaluated with respect to risks to health and the environment. The European Court of Justice decided in 2018 to include genome-edited organisms in the GMO definition and hence in the regulatory system already in place. This implies that all products developed by genome-editing techniques must be risk-assessed within the existing regulatory framework for GMOs. The European and Norwegian regulatory frameworks regulate the production, import and placing on the market of food and feed containing, consisting of or produced from GMOs, as well as the release of GMOs into the environment. The assessment draws on guidance documents originally developed by EFSA for risk assessment of GMOs, which were drawn up mainly to address risks regarding insertion of transgenes. The new genome-editing techniques, however, provide a new continuum of organisms ranging from those only containing a minor genetic alteration to organisms containing insertion or deletion of larger genomic regions. Risk assessment of organisms developed by genome editing The present discourse on how new genome-editing techniques should be regulated lacks an analysis of whether risk assessment methodologies for GMOs are adequate for risk assessment of organisms developed through the use of the new genome-editing techniques. Therefore, this report describes the use of genome-editing techniques in food and feed production and discusses challenges in risk assessment with the regulatory framework. Specifically, this report poses the question as to whether the EFSA guidance documents are sufficient for evaluating risks to health and environment posed by genome-edited plants, animals and microorganisms. To address these questions, the report makes use of case examples relevant for Norway. These examples, intended for food and feed, include oilseed rape with a modified fatty acid profile, herbicide-tolerant and pest-resistant crops, sterile salmon, virus-resistant pigs and hornless cattle. The report considers all aspects of the stepwise approach as described in the EFSA guidance documents. Conclusions The inherent flexibility of the EFSA guidance makes it suitable to cover health and environmental risk assessments of a wide range of organisms with various traits and intended uses. Combined with the embedded case-by-case approach the guidance is applicable to genome-edited organisms. The evaluation of the guidance demonstrates that the parts of the health and environmental risk assessment concerned with novel traits (i.e. the phenotype of the organism) may be fully applied to all categories of genome-edited organisms. ............

• Fragoso-Bargas, Nicolas; Opsahl, Julia Onsrud; Kiryushchenko, Nadezhda; Böttcher, Yvonne; Lee-Ødegård, Sindre & Qvigstad, Elisabeth [Vis alle 15 forfattere av denne artikkelen] (2021). Cohort profile: Epigenetics in Pregnancy (EPIPREG) – Population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes. PLOS ONE. ISSN 1932-6203. 16(8), s. 1–15. doi: 10.1371/journal.pone.0256158. Fulltekst i vitenarkiv
• Bjørnestad, Victoria Ariel; Rydmark, Marcella Christine Orwick & Lund, Reidar (2021). Understanding the Structural Pathways for Lipid Nanodisc Formation: How Styrene Maleic Acid Copolymers Induce Membrane Fracture and Disc Formation. Langmuir. ISSN 0743-7463. 37(20), s. 6178–6188. doi: 10.1021/acs.langmuir.1c00304. Fulltekst i vitenarkiv
• Melvold, Katrine; Giliberto, Mariaserena; Karlsen, Linda; Ayuda-Duran, Maria del Pilar; Hanes, Robert & Holien, Toril [Vis alle 11 forfattere av denne artikkelen] (2021). Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies. Molecular Oncology. ISSN 1574-7891. s. 1–18. doi: 10.1002/1878-0261.13153. Fulltekst i vitenarkiv Vis sammendrag

  Most patients with chronic lymphocytic leukemia (CLL) initially respond to targeted therapies, but eventually relapse and develop resistance. Novel treatment strategies are therefore needed to improve patient outcomes. Here, we performed direct drug testing on primary CLL cells and identified synergy between eight different mitogen-activated protein kinase kinase (MEK) inhibitors and the B-cell lymphoma 2 (Bcl-2) antagonist venetoclax. Drug sensitivity was independent of immunoglobulin heavy-chain gene variable region (IGVH) and tumor protein p53 (TP53) mutational status, and CLL cells from idelalisib-resistant patients remained sensitive to the treatment. This suggests that combined MEK/Bcl-2 inhibition may be an option for high-risk CLL. To test whether sensitivity could be detected in other B-cell malignancies, we performed drug testing on cell line models of CLL (n = 4), multiple myeloma (MM; n = 8), and mantle cell lymphoma (MCL; n = 7). Like CLL, MM cells were sensitive to the MEK inhibitor trametinib, and synergy was observed with venetoclax. In contrast, MCL cells were unresponsive to MEK inhibition. To investigate the underlying mechanisms of the disease-specific drug sensitivities, we performed flow cytometry-based high-throughput profiling of 31 signaling proteins and regulators of apoptosis in the 19 cell lines. We found that high expression of the antiapoptotic proteins myeloid cell leukemia-1 (Mcl-1) or B-cell lymphoma-extra large (Bcl-xL) predicted low sensitivity to trametinib + venetoclax. The low sensitivity could be overcome by combined treatment with an Mcl-1 or Bcl-xL inhibitor. Our findings suggest that MEK/Bcl-2 inhibition has therapeutic potential in leukemia and myeloma, and demonstrate that protein expression levels can serve as predictive biomarkers for treatment sensitivities.

• Curé, Charlotte; Isojunno, Saana; Siemensma, Marije; Wensveen, Paul; Buisson, Célia & Sivle, Lise Doksæter [Vis alle 10 forfattere av denne artikkelen] (2021). Severity Scoring of Behavioral Responses of Sperm Whales (Physeter macrocephalus) to Novel Continuous versus Conven tional Pulsed Active Sonar. Journal of Marine Science and Engineering. ISSN 2077-1312. 9(444), s. 1–25. doi: 10.3390/jmse9040444. Fulltekst i vitenarkiv
• Baho, Didier Ludovic; Rizzuto, Simone; Nizzetto, Luca; Hessen, Dag Olav; Norberg, Jon & Skjelbred, Birger [Vis alle 9 forfattere av denne artikkelen] (2021). Ecological Memory of Historical Contamination Influences the Response of Phytoplankton Communities. Ecosystems. ISSN 1432-9840. 24(7), s. 1591–1607. doi: 10.1007/s10021-021-00604-0. Fulltekst i vitenarkiv Vis sammendrag

  Ecological memory (EM) recognizes the importance of previous stress encounters in promoting community tolerance and thereby enhances ecosystem stability, provided that gained tolerances are preserved during non-stress periods. Drawing from this concept, we hypothesized that the recruitment of tolerant species can be facilitated by imposing an initial sorting process (conditioning) during the early stages of community assembly, which should result in higher production (biomass development and photosynthetic efficiency) and stable community composition. To test this, phytoplankton resting stages were germinated from lake sediments originating from two catchments that differed in contamination history: one impacted by long-term herbicides and pesticides exposures (historically contaminated lake) from an agricultural catchment compared to a low-impacted one (near-pristine lake) from a forested catchment. Conditioning was achieved by adding an herbicide (Isoproturon, which was commonly used in the catchment of the historically contaminated lake) during germination. Afterward, the communities obtained from germination were exposed to an increasing gradient of Isoproturon. As hypothesized, upon conditioning, the phytoplankton assemblages from the historically contaminated lake were able to rapidly restore photosynthetic efficiency (p > 0.01) and became structurally (community composition) more resistant to Isoproturon. The communities of the near-pristine lake did not yield these positive effects regardless of conditioning, supporting that EM was a unique attribute of the historically stressed ecosystem. Moreover, assemblages that displayed higher structural resistance concurrently yielded lower biomass, indicating that benefits of EM in increasing structural stability may trade-off with production. Our results clearly indicate that EM can foster ecosystem stability to a recurring stressor.

• Siemer, Svenja; Bauer, Tobias A.; Scholz, Paul; Breder, Christina; Fenaroli, Federico & Harms, Gregory [Vis alle 16 forfattere av denne artikkelen] (2021). Targeting Cancer Chemotherapy Resistance by Precision Medicine-Driven Nanoparticle-Formulated Cisplatin. ACS Nano. ISSN 1936-0851. 15(11), s. 18541–18556. doi: 10.1021/acsnano.1c08632. Fulltekst i vitenarkiv
• Stubberud, Marlene Wæge; Nater, Chloe Rebecca; Vindenes, Yngvild; Vøllestad, Leif Asbjørn & Langangen, Øystein Ole Gahr (2021). Low impact of first-time spawners on population growth in a brown trout population. Climate Research (CR). ISSN 0936-577X. doi: 10.3354/cr01645. Fulltekst i vitenarkiv
• Pällmann, Nora; Ke, Deng; Livgård, Marte; Tesikova, Martina; Jin, Yixin & Frengen, Nicolai Sebastian [Vis alle 18 forfattere av denne artikkelen] (2021). Stress-mediated reprogramming of prostate cancer one-carbon cycle drives disease progression. Cancer Research. ISSN 0008-5472. 81(15), s. 4066–4078. doi: 10.1158/0008-5472.CAN-20-3956.
• Skjeldal, Frode Miltzow; Haugen, Linda Hofstad; Nunes De C Mateus, Duarte; Frei, Dominik Michael; Rødseth, Anna Vik & Hu, Xian [Vis alle 7 forfattere av denne artikkelen] (2021). De novo formation of early endosomes during Rab5-to-Rab7a transition. Journal of Cell Science. ISSN 0021-9533. 134(8). doi: 10.1242/jcs.254185. Fulltekst i vitenarkiv Vis sammendrag

  Rab5 and Rab7a are the main determinants of early and late endosomes and are important regulators of endosomal progression. The transport from early endosomes to late endosome seems to be regulated through an endosomal maturation switch, where Rab5 is gradually exchanged by Rab7a on the same endosome. Here, we provide new insight into the mechanism of endosomal maturation, for which we have discovered a stepwise Rab5 detachment, sequentially regulated by Rab7a. The initial detachment of Rab5 is Rab7a independent and demonstrates a diffusion-like first-phase exchange between the cytosol and the endosomal membrane, and a second phase, in which Rab5 converges into specific domains that detach as a Rab5 indigenous endosome. Consequently, we show that early endosomal maturation regulated through the Rab5-to-Rab7a switch induces the formation of new fully functional Rab5-positive early endosomes. Progression through stepwise early endosomal maturation regulates the direction of transport and, concomitantly, the homeostasis of early endosomes.

• Vestre, Katharina; Persiconi, Irene; Distefano, Marita Borg; Mensali, Nadia; Guadagno, Noemi Antonella & Bretou, Marine [Vis alle 12 forfattere av denne artikkelen] (2021). Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton. Journal of Cell Science. ISSN 0021-9533. 134(18). doi: 10.1242/jcs.259221. Fulltekst i vitenarkiv
• Falk, Stefanie; Vollsnes, Ane V.; Eriksen, Aud Else Berglen; Stordal, Frode & Berntsen, Terje Koren (2021). Technical note: Quality assessment of ozone reanalysis products and gap-filling over subarctic Europe for vegetation risk mapping. Atmospheric Chemistry and Physics (ACP). ISSN 1680-7316. 21(20), s. 15647–15661. doi: 10.5194/acp-21-15647-2021.
• Zhang, Zijian; Ryoo, David; Balusek, Curtis; Acharya, Atanu; Rydmark, Marcella Orwick & Linke, Dirk [Vis alle 7 forfattere av denne artikkelen] (2021). Inward-facing glycine residues create sharp turns in β-barrel membrane proteins. Biochimica et Biophysica Acta - Biomembranes. ISSN 0005-2736. 1863(10). doi: 10.1016/j.bbamem.2021.183662.
• Spirin, Viacheslav; Malysheva, Vera; Schoutteten, Nathan; Viner, Ilya; Miettinen, Otto & Nordén, Jenni [Vis alle 11 forfattere av denne artikkelen] (2021). Studies in the Basidiodendron caesiocinereum complex (Auriculariales, Basidiomycota). Mycological Progress. ISSN 1617-416X. 20(10), s. 1275–1296. doi: 10.1007/s11557-021-01724-6. Fulltekst i vitenarkiv Vis sammendrag

  Taxonomy of Basidiodendron caesiocinereum complex is revised based on morphological and molecular methods (with the use of nc LSU rDNA, ITS and TEF1 regions). The basidiospore ornamentation is justified as a key morphological character for the species recognition in the group. As redefined here, B. caesiocinereum is an angiosperm-dwelling species with smooth basidiospores. Bourdotia cinerella and B. cinerella var. trachyspora are proved to represent separate species with warted basidiospores; they are reintroduced as Basidiodendron cinerellum and B. trachysporum. Additionally, eight new species related to B. caesiocinereum are described based on material from Eurasia, North America and Africa, and identity of B. spinosum from Oceania is discussed.

• Ioannidis, Alexander G.; Blanco-Portillo, Javier; Sandoval, Karla; Hagelberg, Erika; Barberena-Jonas, Carmina & Hill, Adrian V. S. [Vis alle 27 forfattere av denne artikkelen] (2021). Paths and timings of the peopling of Polynesia inferred from genomic networks. Nature. ISSN 0028-0836. 597(7877), s. 522–526. doi: 10.1038/s41586-021-03902-8.
• Berntsen, Hanne Friis; Bodin, Johanna Eva; Øvrevik, Johan; Berntsen, Christopher Friis; Østby, Gunn Charlotte & Brinchmann, Bendik Christian [Vis alle 8 forfattere av denne artikkelen] (2021). A human relevant mixture of persistent organic pollutants induces reactive oxygen species formation in isolated human leucocytes: Involvement of the β2-adrenergic receptor. Environment International. ISSN 0160-4120. 158. doi: 10.1016/j.envint.2021.106900. Fulltekst i vitenarkiv Vis sammendrag

  Exposure to chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) persistent organic pollutants (POPs) is associated with immunotoxicity and other adverse effects in humans and animals. Previous studies on POPs have mainly focused on single chemicals, while studies on complex mixtures are limited. Using DCF and luminol assays we examined effects on ROS generation in isolated human neutrophils, monocytes and lymphocytes, after in vitro exposure to a total mixture and sub-mixtures of 29 persistent compounds (Cl, Br, and PFAA). The mixtures were based on compounds prominent in blood, breast milk, and/or food. All mixture combinations induced ROS production in one or several of the cell models, and in some cases even at concentrations corresponding to human blood levels (compound range 1 pM – 16 nM). Whilst some interactions were detected (assessed using a mixed linear model), halogenated subgroups mainly acted additively. Mechanistic studies in neutrophils at 500× human levels (0.5 nM – 8 µM) indicated similar mechanisms of action for the Cl, PFAA, the combined PFAA + Cl and total (PFAA + Br + Cl) mixtures, and ROS responses appeared to involve β2-adrenergic receptor (β2AR) and Ca2+ signalling, as well as activation of NADPH oxidases. In line with this, the total mixture also increased cyclic AMP at levels comparable with the non-selective βAR agonist, isoproterenol. Although the detailed mechanisms involved in these responses remain to be elucidated, our data show that POP mixtures at concentrations found in human blood, may trigger stress responses in circulating immune cells. Mixtures of POPs, further seemed to interfere with adrenergic pathways, indicating a novel role of βARs in POP-induced effects.

• Nenseth, Hatice Zeynep; Sahu, Aparna; Saatcioglu, Fahri & Osguthorpe, Steven (2021). A Nutraceutical Formula Is Effective in Raising the Circulating Vitamin and Mineral Levels in Healthy Subjects: A Randomized Trial. Frontiers in Nutrition. ISSN 2296-861X. 8. doi: 10.3389/fnut.2021.703394. Fulltekst i vitenarkiv
• Anda, Silje; Boye, Erik; Schink, Kay Oliver & Grallert, Beata (2021). Cosegregation of asymmetric features during cell division. Open Biology. ISSN 2046-2441. 11(8), s. 1–11. doi: 10.1098/rsob.210116. Fulltekst i vitenarkiv
• Pessarrodona, Albert; Filbee-Dexter, Karen; Alcoverro, Teresa; Boada, Jordi; Feehan, Colette J. & Fredriksen, Stein [Vis alle 11 forfattere av denne artikkelen] (2021). Homogenization and miniaturization of habitat structure in temperate marine forests. Global Change Biology. ISSN 1354-1013. doi: 10.1111/gcb.15759. Fulltekst i vitenarkiv
• Malecki, Jedrzej Mieczyslaw; O'Donohue, Marie-Francoise; Kim, Yeji; Jakobsson, Magnus; Gessa, Luca & Pinto, Rita [Vis alle 14 forfattere av denne artikkelen] (2021). Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function. Nucleic Acids Research (NAR). ISSN 0305-1048. 49(6), s. 3185–3203. doi: 10.1093/nar/gkab088. Fulltekst i vitenarkiv
• Geml, József; Morgado, Luis & Semenova-Nelsen, Tatiana A. (2021). Tundra Type Drives Distinct Trajectories of Functional and Taxonomic Composition of Arctic Fungal Communities in Response to Climate Change – Results From Long-Term Experimental Summer Warming and Increased Snow Depth. Frontiers in Microbiology. ISSN 1664-302X. 12, s. 1–13. doi: 10.3389/fmicb.2021.628746. Fulltekst i vitenarkiv
• Eie, Martin; Jensen, Thomas Correll; Walseng, Bjørn; Eie, Jon Arne & Hessen, Dag Olav (2021). Long-term resilience in microcrustacean communities despite environmental changes. Ecosphere. ISSN 2150-8925. 12(7), s. 1–13. doi: 10.1002/ecs2.3676. Fulltekst i vitenarkiv Vis sammendrag

  The ability of communities to withstand stress or maintain their species composition over extended periods of environmental changes is a matter of major concern. Here, we utilize a dataset where microcrustacean communities were related to water chemistry in 82 boreal-alpine lakes over a 50-yr time span (1968 and 2016), with the same person involved in sampling both times ensuring identical sites and sampling protocols. Over this time span, there has been a 1–2°C increase in mean annual temperatures and prolonged growing seasons. Also, the strong changes in SO4 deposition and acidification, peaking in the early 1980s, followed by a recovery period, have caused not only an increase in pH but also a pronounced browning (elevated DOC) and reduced levels of Ca over the past three decades. Despite this, the microcrustacean diversity and community composition have remained remarkably stable, and this holds both for the species-rich larger, boreal sites and the species-poor alpine sites. While likely there are interannual fluctuations in species abundance, and perhaps species may also be missing for certain periods, a combination of local refugia, resting egg seed-banks and a regional recolonization that may occur at the metapopulation level, aims at maintaining a strong stability in community composition.

• Bengtsen, Mads; Winje, Ivan Myhre; Eftestøl, Einar; Landskron, Johannes; Sun, Chengyi & Nygård, Kamilla Børve [Vis alle 10 forfattere av denne artikkelen] (2021). Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle. PLoS Genetics. ISSN 1553-7390. 17:e1009907(11). doi: 10.1371/journal.pgen.1009907. Fulltekst i vitenarkiv
• Eftestøl, Einar; Ochi, Eisuke; Juvkam, Inga & Gundersen, Kristian (2021). A juvenile climbing exercise establishes a muscle memory boosting the effects of exercise in adult rats. BioRxiv. ISSN 0362-4331. s. 1–18. doi: 10.1101/2021.06.02.446793.
• Lehr, Andrew; Kumar, Arvind; Tezlaff, Christian; Hafting, Torkel; Fyhn, Marianne & Stöber, Tristan Manfred (2021). CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing. Neuroscience and Biobehavioral Reviews. ISSN 0149-7634. 126, s. 398–412. doi: 10.1016/j.neubiorev.2021.03.020. Fulltekst i vitenarkiv
• Lepperød, Mikkel Elle; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Buccino, Alessio Paolo; Yu, Jai & Fyhn, Marianne [Vis alle 7 forfattere av denne artikkelen] (2021). Optogenetic pacing of medial septum parvalbumin-positive cells disrupts temporal but not spatial firing in grid cells. Science Advances. ISSN 2375-2548. 7(19). doi: 10.1126/sciadv.abd5684. Fulltekst i vitenarkiv
• Crapart, Camille Marie; Andersen, Tom; Hessen, Dag Olav; Valiente Parra, Nicolas & Vogt, Rolf David (2021). Factors Governing Biodegradability of Dissolved Natural Organic Matter in Lake Water. Water. ISSN 2073-4441. 13(16). doi: 10.3390/w13162210. Fulltekst i vitenarkiv
• Rasmussen, Marit; Tan, Susanna; Somisetty, Venkata Satheesh; Hutin, David; Olafsen, Ninni Elise & Moen, Anders [Vis alle 9 forfattere av denne artikkelen] (2021). PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor α Signaling in Human Breast Cancer Cells. Cells. ISSN 2073-4409. 10(3). doi: 10.3390/cells10030623.
• Aarønes, Malin Røyset; Paus-Knudsen, Julie Sørlie; Nielsen, Anders; Rundberget, Thomas & Borgå, Katrine (2021). Within-Body Distributions and Feeding Effects of the Neonicotinoid Insecticide Clothianidin in Bumblebees (Bombus terrestris). Environmental Toxicology and Chemistry. ISSN 0730-7268. 40(10), s. 2781–2790. doi: 10.1002/etc.5154. Fulltekst i vitenarkiv Vis sammendrag

  Bumblebees can be exposed to neonicotinoid pesticides through nectar and pollen collected from treated crops, which can cause lethal and sublethal effects in these nontarget pollinators. However, the body distribution of the compound after exposure to neonicotinoids in bumblebees is not well studied. Bumblebee colonies (Bombus terrestris, n = 20) were exposed to field-realistic concentrations of clothianidin through artificial nectar (3.6–13 µg/L) for 9 d. Comparison of the nominal with the measured exposure in nectar indicated good compliance, confirming the applicability of the method. When quantified, clothianidin showed a concentration-dependent occurrence in the head and body of workers (head: <0.2–2.17 µg/kg; body: <0.2–3.17 µg/kg), and in the body of queens (<0.2–2.49 µg/kg), although concentrations were below those measured in the nectar (bioaccumulation factor = 0.2). Exposure to clothianidin did not affect mortality nor brood production, nor did it have a statistically significant effect on nectar consumption and size of food storage. However, visual inspection suggests higher nectar consumption of nectar with low clothianidin content compared with nectar with no or high clothianidin content. Our results show that dietary clothianidin is taken up in bumblebees, but does not bioaccumulate to elevated levels compared with exposure. Still, clothianidin may elicit responses that affect feeding behavior of the pollinator B. terrestris, although our endpoints were not significantly affected.

• Liyakat Ali, Tharvesh Moideen; Brunet, Annaëlle; Collas, Philippe & Paulsen, Jonas (2021). TAD cliques predict key features of chromatin organization. BMC Genomics. ISSN 1471-2164. 22(1). doi: 10.1186/s12864-021-07815-8. Fulltekst i vitenarkiv
• Blanc-Mathieu, Romain; Dahle, Håkon; Hofgaard, Antje; Brandt, David; Ban, Hiroki & Kalinowski, Jörn [Vis alle 8 forfattere av denne artikkelen] (2021). A persistent giant algal virus, with a unique morphology, encodes an unprecedented number of genes involved in energy metabolism. Journal of Virology. ISSN 0022-538X. 95(8), s. 1–58. doi: 10.1128/JVI.02446-20.
• Bjørnestad, Maria; Kalisch, Henrik; Abid, Malek; Kharif, Christian & Brun, Mats (2021). Wave Breaking in Undular Bores with Shear Flows. Water Waves. ISSN 2523-367X. 3, s. 473–490. doi: 10.1007/s42286-020-00046-6. Fulltekst i vitenarkiv
• Kaartvedt, Stein; Ugland, Karl I.; Heuschele, Jan David & Solberg, Ingrid (2021). Coordinated gas release among the physostomous fish sprat (Sprattus sprattus). Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-92585-2. Fulltekst i vitenarkiv
• Pihlstrøm, Nicklas; Jin, Yang; Nenseth, Hatice Zeynep; Kuzu, Omer Faruk & Saatcioglu, Fahri (2021). Stamp2 expression mediated by cytokines attenuates their growth-limiting effects in prostate cancer cells. Cancers. ISSN 2072-6694. 13(7). doi: 10.3390/cancers13071579. Fulltekst i vitenarkiv
• Adusumalli, Ravi; Åsheim, Hans-Christian; Lupashin, Vladimir; blackburn, jessica b & Prydz, Kristian (2021). Proteoglycan synthesis in conserved oligomeric Golgi subunit deficient HEK293T cells is affected differently, depending on the lacking subunit. Traffic : the International Journal of Intracellular Transport. ISSN 1398-9219. doi: 10.1111/tra.12804. Fulltekst i vitenarkiv
• Sagova-Mareckova, Marketa; Boenigk, Jens; Bouchez, Agnès; Cermakova, Kristina; Chonova, Teofana & Cordier, Tristan [Vis alle 34 forfattere av denne artikkelen] (2021). Expanding ecological assessment by integrating microorganisms into routine freshwater biomonitoring. Water Research. ISSN 0043-1354. 191. doi: 10.1016/j.watres.2020.116767. Fulltekst i vitenarkiv
• Skrede, Inger; Murat, Claude; Hess, Jaqueline; Maurice, Sundy Ursula Mary Jane; Sønstebø, Jørn Henrik & Kohler, Annegret [Vis alle 11 forfattere av denne artikkelen] (2021). Contrasting demographic histories revealed in two invasive populations of the dry rot fungus Serpula lacrymans. Molecular Ecology. ISSN 0962-1083. 30(12), s. 2772–2789. doi: 10.1111/mec.15934. Fulltekst i vitenarkiv Vis sammendrag

  Globalization and international trade have impacted organisms around the world leading to a considerable number of species establishing in new geographic areas. Many organisms have taken advantage of human-made environments, including buildings. One such species is the dry rot fungus Serpula lacrymans, which is the most aggressive wood-decay fungus in indoor environments in temperate regions. Using population genomic analyses of 36 full genome sequenced isolates, we demonstrated that European and Japanese isolates are highly divergent and the populations split 3000–19,000 generations ago, probably predating human influence. Approximately 250 generations ago, the European population went through a tight bottleneck, probably corresponding to the fungus colonization of the built environment in Europe. The demographic history of these populations, probably lead to low adaptive potential. Only two loci under selection were identified using a Fst outlier approach, and selective sweep analyses identified three loci with extended haplotype homozygosity. The selective sweep analyses found signals in genes possibly related to decay of various substrates in Japan and in genes involved DNA replication and protein modification in Europe. Our results suggest that the dry rot fungus independently established in indoor environments in Europe and Japan and that invasive species can potentially establish large populations in new habitats based on a few colonizing individuals.

• Høydahl, Lene; Frigstad, Terje; Rasmussen, Ingunn B; Øynebråten, Inger; Schjetne, Karoline W & Andersen, Jan Terje [Vis alle 10 forfattere av denne artikkelen] (2021). Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses. Vaccine. ISSN 0264-410X. 39(11), s. 1583–1592. doi: 10.1016/j.vaccine.2021.02.012. Fulltekst i vitenarkiv
• Øverbye, Anders; Torgersen, Maria Lyngaas; Sønstevold, Tonje; Iversen, Tore Geir; Mørch, Ýrr Asbjørg & Skotland, Tore [Vis alle 7 forfattere av denne artikkelen] (2021). Cabazitaxel-loaded poly(alkyl cyanoacrylate) nanoparticles: Toxicity and changes in the proteome of breast, colon and prostate cancer cells. Nanotoxicology. ISSN 1743-5390. 15(7), s. 865–884. doi: 10.1080/17435390.2021.1924888. Fulltekst i vitenarkiv
• Sharma, Ankush & Colonna, Giovanni (2021). System-Wide Pollution of Biomedical Data: Consequence of the Search for Hub Genes of Hepatocellular Carcinoma Without Spatiotemporal Consideration. Molecular Diagnosis & Therapy. ISSN 1177-1062. 25(1), s. 9–27. doi: 10.1007/s40291-020-00505-3.
• Gopakumar, Anjali; Giebichenstein, Julia; Raskhozheva, Evgeniia & Borgå, Katrine (2021). Mercury in Barents Sea fish in the Arctic polar night: Species and spatial comparison. Marine Pollution Bulletin. ISSN 0025-326X. 169, s. 1–8. doi: 10.1016/j.marpolbul.2021.112501. Fulltekst i vitenarkiv
• Andresen, Ina Jungersen; Orr, Russell John Scott; Krabberød, Anders Kristian; Shalchian-Tabrizi, Kamran & Bråte, Jon (2021). Genome sequencing and de novo assembly of the giant unicellular alga Acetabularia acetabulum using droplet MDA. Scientific Reports. ISSN 2045-2322. 11. doi: 10.1038/s41598-021-92092-4. Fulltekst i vitenarkiv
• Straumfors, Anne; Mundra, Sunil; Foss, Oda Astrid Haarr; Mollerup, Steen Kristen & Kauserud, Håvard (2021). The airborne mycobiome and associations with mycotoxins and inflammatory markers in the Norwegian grain industry. Scientific Reports. ISSN 2045-2322. 11. doi: 10.1038/s41598-021-88252-1. Fulltekst i vitenarkiv Vis sammendrag

  Grain dust exposure is associated with respiratory symptoms among grain industry workers. However, the fungal assemblage that contribute to airborne grain dust has been poorly studied. We characterized the airborne fungal diversity at industrial grain- and animal feed mills, and identified differences in diversity, taxonomic compositions and community structural patterns between seasons and climatic zones. The fungal communities displayed strong variation between seasons and climatic zones, with 46% and 21% of OTUs shared between different seasons and climatic zones, respectively. The highest species richness was observed in the humid continental climate of the southeastern Norway, followed by the continental subarctic climate of the eastern inland with dryer, short summers and snowy winters, and the central coastal Norway with short growth season and lower temperature. The richness did not vary between seasons. The fungal diversity correlated with some specific mycotoxins in settled dust and with fibrinogen in the blood of exposed workers, but not with the personal exposure measurements of dust, glucans or spore counts. The study contributes to a better understanding of fungal exposures in the grain and animal feed industry. The differences in diversity suggest that the potential health effects of fungal inhalation may also be different.

• Wutkowska, Magdalena; Ehrich, Dorothee; Mundra, Sunil; Vader, Anna & Eidesen, Pernille Bronken (2021). Can root-associated fungi mediate the impact of abiotic conditions on the growth of a High Arctic herb? Soil Biology and Biochemistry. ISSN 0038-0717. 159. doi: 10.1016/j.soilbio.2021.108284. Fulltekst i vitenarkiv Vis sammendrag

  Arctic plants are affected by many stressors. Root-associated fungi are thought to influence plant performance in stressful environmental conditions. However, the relationships are not well-known; do the number of fungal partners, their ecological functions and community composition mediate the impact of environmental conditions and/or influence host plant performance? To address these questions, we used a common arctic plant as a model system: Bistorta vivipara. Whole plants (including root system) were collected from nine locations in Spitsbergen (n=214). Morphometric features were measured as a proxy for performance and combined with metabarcoding datasets of their root-associated fungi (amplicon sequence variants, ASVs), edaphic and meteorological variables. Seven biological hypotheses regarding fungal influence on plant measures were tested using structural equation modelling. The best-fitting model revealed that local temperature affected plants both directly (negatively aboveground and positively below-ground) and indirectly - mediated by fungal richness and the ratio of symbio- and saprotrophic ASVs. The influence of temperature on host plants is therefore complex and should be examined further. Fungal community composition did not impact plant measurements and plant reproductive investment was not influenced by any fungal parameters. The lack of impact of fungal community composition on plant performance suggests that the functional importance of fungi is more essential for the plant than their identity.

• Reimers, Eigil; Eftestøl, Sindre & Colman, Jonathan Edward (2021). Vigilance in reindeer (Rangifer tarandus); evolutionary history, predation and human interference. Polar Biology. ISSN 0722-4060. 44, s. 997–1007. doi: 10.1007/s00300-021-02857-w. Fulltekst i vitenarkiv
• Knudtzon, Nina C; Thorstensen, Helene; Ruus, Anders; Helberg, Morten; Bæk, Kine & Enge, Ellen Katrin [Vis alle 7 forfattere av denne artikkelen] (2021). Maternal transfer and occurrence of siloxanes, chlorinated paraffins, metals, PFAS and legacy POPs in herring gulls (Larus argentatus) of different urban influence. Environment International. ISSN 0160-4120. 152. doi: 10.1016/j.envint.2021.106478. Fulltekst i vitenarkiv Vis sammendrag

  Urban herring gulls (Larus argentatus) are exposed to contaminants from aquatic, terrestrial and anthropogenic sources. We aim to assess if differences in urbanisation affect ecological niche and contaminant concentrations in female herring gulls. Furthermore, we investigated maternal transfer from mothers to eggs for all the target compounds, including chlorinated paraffins (CPs) and cyclic volatile methyl siloxane (cVMSs), which to our knowledge have not been assessed in herring gulls previously. We compare concentrations of legacy and emerging contaminants and metals in blood and eggs between two herring gull colonies located 51 km apart, in the urban influenced Norwegian Oslofjord. While both colonies are within an urbanised area, the inner fjord is more so, as it is surrounded by Oslo, the capital and largest city in Norway Stable isotopes of carbon and nitrogen indicated a more marine ecological niche in the outer than the inner fjord colony, although with overlap. Persistent organic pollutant (POP) concentrations were similar in the inner and outer fjord colonies, while the short-chained chlorinated paraffins (SCCP), which are recently added to the Stockholm convention and contaminants of emerging concern (CECs) varied, with higher concentrations of SCCP and the cVMS decamethylcyclopentasiloxane (D5) in females and eggs of the inner fjord colony. Per- and polyfluorinated substances (PFAS) concentrations were higher in the outer fjord colony, likely linked to releases from a point-source (airport and waste management facility with open access to food waste). In blood, chlorinated paraffins contributed most the total lipophilic contaminants (inner: 78%, outer: 56%), while polychlorinated biphenyls (PCBs) were the most abundant lipophilic contaminants in eggs (inner: 62%, outer: 46%). Dechloranes and brominated flame retardants (BFRs) were detected in few samples. Maternal transfer, assessed by egg to blood ratios, of cVMSs were similar to the POPs with mean log ratio 0.39 (D5), while it was lower for SCCPs, with log ratios-0.77. Our results indicate comparable POP exposure of the herring gulls in the inner and outer Oslofjord, likely due to overlap in ecological niches between the colonies and wide distribution of POPs. The differences between the colonies in concentrations of PFAS, cVMS and CPs shows that point source exposures and urban influence may be more important than ecological niche for these compounds.

• Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Sandve, Geir Kjetil; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2021). Chromatin occupancy and target genes of the haematopoietic master transcription factor MYB. Scientific Reports. ISSN 2045-2322. 11(9008). doi: 10.1038/s41598-021-88516-w. Fulltekst i vitenarkiv Vis sammendrag

  The transcription factor MYB is a master regulator in haematopoietic progenitor cells and a pioneer factor affecting differentiation and proliferation of these cells. Leukaemic transformation may be promoted by high MYB levels. Despite much accumulated molecular knowledge of MYB, we still lack a comprehensive understanding of its target genes and its chromatin action. In the present work, we performed a ChIP-seq analysis of MYB in K562 cells accompanied by detailed bioinformatics analyses. We found that MYB occupies both promoters and enhancers. Five clusters (C1–C5) were found when we classified MYB peaks according to epigenetic profiles. C1 was enriched for promoters and C2 dominated by enhancers. C2-linked genes were connected to hematopoietic specific functions and had GATA factor motifs as second in frequency. C1 had in addition to MYB-motifs a significant frequency of ETS-related motifs. Combining ChIP-seq data with RNA-seq data allowed us to identify direct MYB target genes. We also compared ChIP-seq data with digital genomic footprinting. MYB is occupying nearly a third of the super-enhancers in K562. Finally, we concluded that MYB cooperates with a subset of the other highly expressed TFs in this cell line, as expected for a master regulator

• Stabell, Marianne; Sæther, Thomas; Kjendseth, Åsmund Røhr; Gabrielsen, Odd Stokke & Myklebost, Ola (2021). Methylation-dependent SUMOylation of the architectural transcription factor HMGA2. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 552, s. 91–97. doi: 10.1016/j.bbrc.2021.02.099. Fulltekst i vitenarkiv Vis sammendrag

  High mobility group A2 (HMGA2) is a chromatin-associated protein involved in the regulation of stem cell function, embryogenesis and cancer development. Although the protein does not contain a consensus SUMOylation site, it is shown to be SUMOylated. In this study, we demonstrate that the first lysine residue in the reported K66KAE SUMOylation motif in HMGA2 can be methylated in vitro and in vivo by the Set7/9 methyltransferase. By editing the lysine, the increased hydrophobicity of the resulting 6-N-methyl-lysine transforms the sequence into a consensus SUMO motif. This post-translational editing dramatically increases the subsequent SUMOylation of this site. Furthermore, similar putative methylation-dependent SUMO motifs are found in a number of other chromatin factors, and we confirm methylation-dependent SUMOylation of a site in one such protein, the Polyhomeotic complex 1 homolog (PHC1). Together, these results suggest that crosstalk between methylation and SUMOylation is a general mode for regulation of chromatin function.

• Barcytė, Dovilė; Eikrem, Wenche; Engesmo, Anette; Seoane, Sergio; Wohlmann, Jens & Horák, Aleš [Vis alle 8 forfattere av denne artikkelen] (2021). Olisthodiscus represents a new class of Ochrophyta . Journal of Phycology. ISSN 0022-3646. 57(4), s. 1094–1118. doi: 10.1111/jpy.13155. Fulltekst i vitenarkiv
• Rooke, Jessica; Icke, Christopher; Wells, Timothy; Rossiter, Amanda; Browning, Douglas & Morris, Faye [Vis alle 12 forfattere av denne artikkelen] (2021). BamA and BamD Are Essential for the Secretion of Trimeric Autotransporter Adhesins. Frontiers in Microbiology. ISSN 1664-302X. 12. doi: 10.3389/fmicb.2021.628879. Fulltekst i vitenarkiv
• Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Sutterud, Hallvard & Blackstad, Jan Sigurd [Vis alle 8 forfattere av denne artikkelen] (2021). Perineuronal nets stabilize the grid cell network. Nature Communications. ISSN 2041-1723. 12. doi: 10.1038/s41467-020-20241-w. Fulltekst i vitenarkiv
• Haugland, Barbro Taraldset; Armitage, Caroline S.; Kutti, Tina; Husa, Vivian; Skogen, Morten D. & Bekkby, Trine [Vis alle 11 forfattere av denne artikkelen] (2021). Large-scale salmon farming in Norway impacts the epiphytic community of Laminaria hyperborea. Aquaculture Environment Interactions. ISSN 1869-215X. 13, s. 81–100. doi: 10.3354/AEI00392. Fulltekst i vitenarkiv
• Grønlien, Heidi Kristine; Fontaine, Romain; Hodne, Kjetil; Tysseng, Linn Isabelle; Ager-Wick, Eirill & Weltzien, Finn-Arne [Vis alle 7 forfattere av denne artikkelen] (2021). Long extensions with varicosity-like structures in gonadotrope Lh cells facilitate clustering in medaka pituitary culture. PLOS ONE. ISSN 1932-6203. 16(1). doi: 10.1371/journal.pone.0245462. Fulltekst i vitenarkiv
• Põlme, Sergei; Abarenkov, Kessy; Nilsson, R. Henrik; Lindahl, Björn D.; Clemmensen, Karina E. & Kauserud, Håvard [Vis alle 74 forfattere av denne artikkelen] (2021). FungalTraits: a user‑friendly traits database of fungi and fungus‑like stramenopiles. Fungal diversity. ISSN 1560-2745. doi: 10.1007/s13225-020-00466-2. Fulltekst i vitenarkiv
• Beal, J; Saragliadis, Athanasios & Linke, Dirk (2020). Robust estimation of bacterial cell count from optical density. Communications Biology. ISSN 2399-3642. 3(1). doi: 10.1038/s42003-020-01127-5. Fulltekst i vitenarkiv
• Anderson, Thomas R.; Raubenheimer, David; Hessen, Dag Olav; Jensen, Kim; Gentleman, Wendy C. & Mayor, Daniel J. (2020). Geometric Stoichiometry: Unifying Concepts of Animal Nutrition to Understand How Protein-Rich Diets Can Be “Too Much of a Good Thing”. Frontiers in Ecology and Evolution. ISSN 2296-701X. 8, s. 1–12. doi: 10.3389/fevo.2020.00196. Fulltekst i vitenarkiv
• Buccino, Alessio Paolo; Hurwitz, Cole Lincoln; Garcia, Samuel; Magland, Jeremy; Siegle, Joshua H. & Hurwitz, Roger [Vis alle 7 forfattere av denne artikkelen] (2020). SpikeInterface, a unified framework for spike sorting. eLIFE. ISSN 2050-084X. 9, s. 1–24. doi: 10.7554/eLife.61834.
• Kumar, Suresh; Jain, Ashish; Choi, Seong Won; da Silva, Gustavo Peixoto Duarte; Allers, Lee & Mudd, Michal H. [Vis alle 11 forfattere av denne artikkelen] (2020). Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB. Autophagy. ISSN 1554-8627. 16(12), s. 2305–2306. doi: 10.1080/15548627.2020.1837423.
• Sjøberg, Mari; Gregers, Tone Fredsvik; Ødegaard, Marianne & Tsigaridas, Kristin Glørstad (2020). Biologilæreres kryssing av kulturgrenser - fra en naturvitenskapelig kultur til en skolekultur. Nordic Studies in Science Education. ISSN 1504-4556. 16(1), s. 52–66. doi: 10.5617/NORDINA.6518. Fulltekst i vitenarkiv
• Pilla, Rachel M.; Williamson, Craig E.; Adamovich, Boris V.; Adrian, Rita; Anneville, Orlane & Chandra, Sudeep [Vis alle 58 forfattere av denne artikkelen] (2020). Deeper waters are changing less consistently than surface waters in a global analysis of 102 lakes. Scientific Reports. ISSN 2045-2322. 10, s. 1–15. doi: 10.1038/s41598-020-76873-x. Fulltekst i vitenarkiv
• Ioannidis, Alexander G.; Blanco-Portillo, Javier; Sandoval, Karla; Hagelberg, Erika; Miquel-Poblete, Juan Francisco & Moreno-Mayar, J. Víctor [Vis alle 31 forfattere av denne artikkelen] (2020). Native American gene flow into Polynesia predating Easter Island settlement. Nature. ISSN 0028-0836. 583(7817), s. 572–577. doi: 10.1038/s41586-020-2487-2.
• Stöber, Tristan Manfred; Lehr, Andrew B; Hafting, Torkel; Kumar, Arvind & Fyhn, Marianne (2020). Selective neuromodulation and mutual inhibition within the CA3-CA2 system can prioritize sequences for replay. Hippocampus. ISSN 1050-9631. doi: 10.1002/hipo.23256. Fulltekst i vitenarkiv
• Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Abraha, Fana; Šakanović, Aleksandra; Grosser, Daniel & Coskun, Ünal [Vis alle 11 forfattere av denne artikkelen] (2020). Insight into glycosphingolipid crypticity: Crystal structure of the anti-1tumor antibody 14F7 and recognition of NeuGc GM3 ganglioside. BioRxiv. ISSN 0362-4331. doi: 10.1101/2020.09.18.294777.
• Reimers, Eigil; Eftestøl, Sindre; Alemu, Diress Tsegaye & Granum, Knut (2020). Villreinens bruk av vinterbeite av høy kvalitet overstyrer barriereeffekter av kraftlinjer. Rangifer. ISSN 0333-256X. 40(1), s. 27–40. doi: 10.7557/2.40.1.4968. Fulltekst i vitenarkiv
• Brett, Jamie O; Arjona, Marina; Ikeda, Mika; Quarta, Marco; de Morree, Antoine & Egner, Ingrid Marie [Vis alle 15 forfattere av denne artikkelen] (2020). Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1. Nature Metabolism. 2(4), s. 307–317. doi: 10.1038/s42255-020-0190-0.
• Sugden, Arthur; Zaremba, Jeffrey; Sugden, Lauren A; Maguire, Kelly; Lutas, Andrew & Ramesh, Rohan [Vis alle 10 forfattere av denne artikkelen] (2020). Cortical reactivations of recent sensory experiences predict bidirectional network changes during learning. Nature Neuroscience. ISSN 1097-6256. 23, s. 981–991. doi: 10.1038/s41593-020-0651-5.
• Strand, Line Tau; Fjellstad, Wendy ; Jackson-Blake, Leah Amber & de Wit, Heleen A (2020). Afforestation of a pasture in Norway did not result in higher soil carbon, 50 years after planting. Landscape and Urban Planning. ISSN 0169-2046. 207. doi: 10.1016/j.landurbplan.2020.104007. Fulltekst i vitenarkiv
• Kara, Emrah; Nielsen, Nis Valentin; Eggertsdottir, Bergrun; Thiede, Bernd; Kanse, Sandip & Løset, Geir Åge (2020). Design and characterization of a new pVII combinatorial phage display peptide library for protease substrate mining using Factor VII activating protease (FSAP) as model. ChemBioChem. ISSN 1439-4227. 21(13), s. 1875–1884. doi: 10.1002/cbic.201900705. Fulltekst i vitenarkiv
• Hovden Aaen, Kristin; Anthi, Aina Karen; Sandlie, Inger; Nilsen, Jeannette; Mester, Simone & Andersen, Jan Terje (2020). The neonatal Fc receptor in mucosal immune regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. doi: 10.1111/sji.13017.
• Claxton, James Benedict; Joudeh, Nadeem; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Sequential magnetic mapping of bacteria loaded with Pd-Fe nanoparticles , 2020 IEEE 10th International Conference on “Nanomaterials: Applications & Properties” (NAP – 2020). IEEE. ISSN 978-1-7281-8506-4. s. 01NIC01-1–01NIC01-5. doi: 10.1109/NAP51477.2020.9309619. Fulltekst i vitenarkiv
• Campaña Perilla, Ana Lucia; Joudeh, Nadeem; Høyer, Henrik; Røyne, Anja; Linke, Dirk & Mikheenko, Pavlo (2020). Probing van der Waals and magnetic forces in bacteria with magnetic nanoparticles, 2020 IEEE 10th International Conference on “Nanomaterials: Applications & Properties” (NAP – 2020). IEEE. ISSN 978-1-7281-8506-4. s. 01NSSA03-1–01NSSA03-5. doi: 10.1109/NAP51477.2020.9309722. Fulltekst i vitenarkiv
• Brauckhoff, Melanie; Wahlberg, Magnus; Haga, Jens Ådne Rekkedal; Karlsen, Hans Erik & Wilson, Maria (2020). Embracing Their Prey at That Dark Hour: Common Cuttlefish (Sepia officinalis) Can Hunt in Nighttime Light Conditions. Frontiers in Physiology. ISSN 1664-042X. 11, s. 1–9. doi: 10.3389/fphys.2020.00525. Fulltekst i vitenarkiv
• Tamrat, Misganaw; Atickem, Anagaw Meshesha; Tsegaye, Diress; Nguyen, Nga; Bekele, Afework & Evangelista, Paul [Vis alle 8 forfattere av denne artikkelen] (2020). Human-wildlife conflict and coexistence: A case study from Senkele Swayne's Hartebeest Sanctuary in Ethiopia. Wildlife Biology. ISSN 0909-6396. 2020(3). doi: 10.2981/wlb.00712. Fulltekst i vitenarkiv
• Hansson, Kenth-Arne; Eftestøl, Einar; Bruusgaard, Jo C.; Juvkam, Inga; Cramer, Alyssa W. & Malthe-Sørenssen, Anders [Vis alle 8 forfattere av denne artikkelen] (2020). Myonuclear content regulates cell size with similar scaling properties in mice and humans. Nature Communications. ISSN 2041-1723. 11(1). doi: 10.1038/s41467-020-20057-8. Fulltekst i vitenarkiv
• Hess, Jaqueline; Balasundaram, Sudhagar V.; Bakkemo, Reneè Isabel; Drula, Elodie; Henrissat, Bernard & Högberg, Nils [Vis alle 8 forfattere av denne artikkelen] (2020). Niche differentiation and evolution of the wood decay machinery in the invasive fungus Serpula lacrymans. The ISME Journal. ISSN 1751-7362. s. 1–13. doi: 10.1038/s41396-020-00799-5. Fulltekst i vitenarkiv
• Weikum, Julia; Kulakova, Alina; Tesei, Giulio; Yoshimoto, Shogo; Vejby Jægerum, Line & Schütz, Monika [Vis alle 11 forfattere av denne artikkelen] (2020). The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action. Scientific Reports. ISSN 2045-2322. 10(1). doi: 10.1038/s41598-020-77706-7. Fulltekst i vitenarkiv
• Norderhaug, Kjell Magnus; Nedreaas, Kjell Harald; Huserbråten, Mats & Moland, Even (2020). Depletion of coastal predatory fish sub-stocks coincided with the largest sea urchin grazing event observed in the NE Atlantic. Ambio. ISSN 0044-7447. 50, s. 163–173. doi: 10.1007/s13280-020-01362-4. Fulltekst i vitenarkiv
• Johnsen, Stein Ivar; Strand, David; Rusch, Johannes & Vrålstad, Trude (2020). Environmental DNA (eDNA) monitoring of noble crayfish astacus astacus in lentic environments offers reliable presence-absence surveillance – but fails to predict population density. Frontiers in Environmental Science. ISSN 2296-665X. 8, s. 1–15. doi: 10.3389/fenvs.2020.612253. Fulltekst i vitenarkiv Vis sammendrag

  Noble crayfish is the most widespread native freshwater crayfish species in Europe. It is threatened in its entire distribution range and listed on the International Union for Concervation Nature- and national red lists. Reliable monitoring data is a prerequisite for implementing conservation measures, and population trends are traditionally obtained from catch per unit effort (CPUE) data. Recently developed environmental DNA (eDNA) tools can potentially improve the effort. In the past decade, eDNA monitoring has emerged as a promising tool for species surveillance, and some studies have established that eDNA methods yield adequate presence-absence data for crayfish. There are also high expectations that eDNA concentrations in the water can predict biomass or relative density. However, eDNA studies for crayfish have not yet been able to establish a convincing relationship between eDNA concentrations and crayfish density. This study compared eDNA and CPUE data obtained the same day and with high sampling effort, and evaluated whether eDNA concentrations can predict relative density of crayfish. We also compared two analytical methods [Quantitative real-time PCR (qPCR) and digital droplet PCR (ddPCR)], and estimated the detection probability for eDNA monitoring compared to trapping using occupancy modeling. In all lakes investigated, we detected eDNA from noble crayfish, even in lakes with very low densities. The eDNA method is reliable for presence-absence monitoring of noble crayfish, and the probability of detecting noble crayfish from eDNA samples increased with increasing relative crayfish densities. However, the crayfish eDNA concentrations were consistently low and mostly below the limit of quantification, even in lakes with very high crayfish densities. The hypothesis that eDNA concentrations can predict relative crayfish density was consequently not supported. Our study underlines the importance of intensified sampling effort for successful detection of very low-density populations, and for substantiating presumed absence, inferred from negative results. Surprisingly, we found a higher likelihood of eDNA detection using qPCR compared to ddPCR. We conclude that eDNA monitoring cannot substitute CPUE data, but is a reliable supplement for rapid presence-absence overviews. Combined with eDNA analyses of alien crayfish species and diseases such as crayfish plague, this is a cost-efficient supplement offering a more holistic monitoring approach for aquatic environments and native crayfish conservation.

• Grytten, Ivar; Rand, Knut Dagestad; Nederbragt, Alexander Johan & Sandve, Geir Kjetil (2020). Assessing graph-based read mappers against a baseline approach highlights strengths and weaknesses of current methods. BMC Genomics. ISSN 1471-2164. 21. doi: 10.1186/s12864-020-6685-y. Fulltekst i vitenarkiv
• Låg, Marit; Øvrevik, Johan; Refsnes, Magne Arnold & Holme, Jørn Andreas (2020). Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases. Respiratory Research. ISSN 1465-9921. 21. doi: 10.1186/s12931-020-01563-1. Fulltekst i vitenarkiv
• Mobekk, Hilde; Hessen, Dag Olav; Fagerstrøm, Asle & Jacobsen, Hanne (2020). For your eyes only: A field experiment on nudging hygienic behavior. Frontiers in Psychology. ISSN 1664-1078. 11, s. 1–8. doi: 10.3389/fpsyg.2020.603440. Fulltekst i vitenarkiv
• Eshun-Wilson, Franceen; Wolf, Raoul; Andersen, Tom; Hessen, Dag O & Sperfeld, Erik (2020). UV radiation affects antipredatory defense traits in Daphnia pulex. Ecology and Evolution. ISSN 2045-7758. 10(24), s. 14082–14097. doi: 10.1002/ece3.6999. Fulltekst i vitenarkiv
• Tibuhwa, Donatha D.; Hussein, Juma M.; Ryvarden, Leif; Sijaona, Mark E. R. & Tibell, Sanja (2020). A phylogeny for the plant pathogen Piptoporellus baudonii using a multigene data set. Mycologia. ISSN 0027-5514. 112(5), s. 1017–1025. doi: 10.1080/00275514.2020.1801303. Fulltekst i vitenarkiv
• Buccino, Alessio Paolo; Kuchta, Miroslav; Schreiner, Jakob Emil & Mardal, Kent-Andre (2020). Improving Neural Simulations with the EMI Model. I Tveito, Aslak; Mardal, Kent-Andre & Rognes, Marie (Red.), Modeling Excitable Tissue -- The EMI Framework. Springer. ISSN 978-3-030-61156-9. s. 87–98.
• de Wit, Heleen A; Lepistö, Ahti; Marttila, Hannu; Wenng, Hannah; Bechmann, Marianne & Blicher-Mathiesen, Gitte [Vis alle 12 forfattere av denne artikkelen] (2020). Land-use dominates climate controls on nitrogen and phosphorus export from managed and natural Nordic headwater catchments. Hydrological Processes. ISSN 0885-6087. 34(25), s. 4831–4850. doi: 10.1002/hyp.13939. Fulltekst i vitenarkiv
• Hansson, Kenth-Arne; Solbrå, Andreas Våvang; Gundersen, Kristian & Bruusgaard, Jo C. (2020). Computational assessment of transport distances in living skeletal muscle fibers studied in situ. Biophysical Journal. ISSN 0006-3495. 119(11), s. 2166–2178. doi: 10.1016/j.bpj.2020.10.016.
• Van den Abeele, Jeriek Paul (2020). Illuminating elite patches of chemical space. Chemical Science. ISSN 2041-6520. 11(42), s. 11485–11491. doi: 10.1039/d0sc03544k. Vis sammendrag

  In the past few years, there has been considerable activity in both academic and industrial research to develop innovative machine learning approaches to locate novel, high-performing molecules in chemical space. Here we describe a new and fundamentally different type of approach that provides a holistic overview of how high-performing molecules are distributed throughout a search space. Based on an open-source, graph-based implementation [J. H. Jensen, Chem. Sci., 2019, 10, 3567–3572] of a traditional genetic algorithm for molecular optimisation, and influenced by state-of-the-art concepts from soft robot design [J. B. Mouret and J. Clune, Proceedings of the Artificial Life Conference, 2012, pp. 593–594], we provide an algorithm that (i) produces a large diversity of high-performing, yet qualitatively different molecules, (ii) illuminates the distribution of optimal solutions, and (iii) improves search efficiency compared to both machine learning and traditional genetic algorithm approaches.

• Lie, Marie; Winsvold, Bendik ; Gjerstad, Johannes; Matre, Dagfinn; Pedersen, Linda Margareth & Heuch, Ingrid [Vis alle 8 forfattere av denne artikkelen] (2020). The association between selected genetic variants and individual differences in experimental pain. Scandinavian Journal of Pain. ISSN 1877-8860. 21(1), s. 163–173. doi: 10.1515/sjpain-2020-0091.
• Margiotta, Azzurra; Frei, Dominik Michael; Sendstad, Ingrid Hegnes; Janssen, Lennert; Neefjes, Jacques & Bakke, Oddmund (2020). Invariant chain regulates endosomal fusion and maturation through an interaction with the SNARE Vti1b. Journal of Cell Science. ISSN 0021-9533. 133. doi: 10.1242/jcs.244624. Fulltekst i vitenarkiv
• Nilsen, Jeannette; Trabjerg, Esben; Grevys, Algirdas; Azevedo, Claudia; Brennan, Stephen O. & Stensland, Maria [Vis alle 14 forfattere av denne artikkelen] (2020). An intact C-terminal end of albumin is required for its long half-life in humans. Communications Biology. ISSN 2399-3642. 3(1). doi: 10.1038/s42003-020-0903-7. Fulltekst i vitenarkiv
• Hubbard, Jonathan J.; Pyzik, Michal; Rath, Timo; Kozicky, Lisa K.; Sand, Kine Marita Knudsen & Gandhi, Amit K. [Vis alle 17 forfattere av denne artikkelen] (2020). FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 217(10). doi: 10.1084/jem.20200359.
• Allesson, Lina; Andersen, Tom; Dörsch, Peter; Eiler, Alexander; Wei, Jing & Hessen, Dag Olav (2020). Phosphorus availability promotes bacterial DOC-mineralization, but not cumulative CO2-production. Frontiers in Microbiology. ISSN 1664-302X. 11. doi: 10.3389/fmicb.2020.569879. Fulltekst i vitenarkiv
• Barreto, A.; Dias, Ana Cláudia; Duarte, B.; Pinto, Edgar; Almeida, Agostinho & Trindade, T. [Vis alle 10 forfattere av denne artikkelen] (2020). Biological effects and bioaccumulation of gold in gilthead seabream (Sparus aurata) – Nano versus ionic form. Science of the Total Environment. ISSN 0048-9697. 716, s. 1–13. doi: 10.1016/j.scitotenv.2020.137026. Fulltekst i vitenarkiv
• Allesson, Lina; Koehler, Birgit; Thrane, Jan-Erik; Andersen, Tom & Hessen, Dag O (2020). The role of photomineralization for CO2 emissions in boreal lakes along a gradient of dissolved organic matter. Limnology and Oceanography. ISSN 0024-3590. 66(1), s. 158–170. doi: 10.1002/lno.11594. Fulltekst i vitenarkiv
• Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M & Strandabø, Rønnaug [Vis alle 10 forfattere av denne artikkelen] (2020). Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons. Toxicology. ISSN 0300-483X. 445. doi: 10.1016/j.tox.2020.152610. Fulltekst i vitenarkiv
• White, Robert G. & Reimers, Eigil (2020). Phenotypic plasticity following weaning: winter body mass trends and food intake in relation to temperature by an arctic ungulate. Polar Biology. ISSN 0722-4060. 43(3), s. 193–205. doi: 10.1007/s00300-020-02623-4.
• Næs, Guro; Storesund, Jan Ove; Udayakumar, Priyanga-Dina; Ledsaak, Marit & Gabrielsen, Odd Stokke (2020). Dissecting the transactivation domain (tAD) of the transcription factor c‐Myb to assess recent models of tAD function. FEBS Open Bio. ISSN 2211-5463. 10(11), s. 2329–2342. doi: 10.1002/2211-5463.12978. Fulltekst i vitenarkiv
• Tamrat, Misganaw; Atickem, Anagaw Meshesha; Tsegaye, Diress; Evangelista, Paul; Bekele, Afework & Stenseth, Nils Christian (2020). The effect of season and post-fire on habitat preferences of the endangered Swayne's hartebeest (Alcelaphus buselaphus swaynei) in Maze National Park, Ethiopia. BMC Ecology. ISSN 1472-6785. 20. doi: 10.1186/s12898-020-0275-3. Fulltekst i vitenarkiv
• Janion-Scheepers, Charlene; Bengtsson, Jan; Duffy, Grant A.; Deharveng, Louis; Leinaas, Hans Petter & Chown, Steven L. (2020). High spatial turnover in springtails of the Cape Floristic Region. Journal of Biogeography. ISSN 0305-0270. 47(5), s. 1007–1018. doi: 10.1111/jbi.13801. Fulltekst i vitenarkiv
• Thoen, Ella; Harder, Christoffer Bugge; Kauserud, Håvard; Botnen, Synnøve Smebye; Vik, Unni & Taylor, Andy F.S. [Vis alle 8 forfattere av denne artikkelen] (2020). In vitro evidence of root colonization suggests ecological versatility in the genus Mycena. New Phytologist. ISSN 0028-646X. 227, s. 601–612. doi: 10.1111/nph.16545. Fulltekst i vitenarkiv
• Skrede, Inger; Ballester Gonzalvo, Luis; Mathiesen, Cecilie & Schumacher, Trond (2020). The genera Helvella and Dissingia (Ascomycota: Pezizomycetes) in Europe – Notes on species from Spain. Fungal Systematics and Evolution. ISSN 2589-3831. 6(1), s. 65–93. doi: 10.3114/fuse.2020.06.05. Fulltekst i vitenarkiv
• Kvile, Kristina Øie; Altin, Dag; Thommesen, Lotte & Titelman, Emma Rebecka Josefin (2020). Predation risk alters life history strategies in an oceanic copepod. Ecology. ISSN 0012-9658. 102(1). doi: 10.1002/ecy.3214. Fulltekst i vitenarkiv
• Hu, Qiu Xiang; Klatt, Gesa; Gudmundsrud, Ruben; Ottestad-Hansen, Sigrid; Verbruggen, Lisa & Massie, Ann [Vis alle 8 forfattere av denne artikkelen] (2020). Semi-quantitative distribution of excitatory amino acid (glutamate) transporters 1-3 (EAAT1-3) and the cystine-glutamate exchanger (xCT) in the adult murine spinal cord. Neurochemistry International. ISSN 0197-0186. 140. doi: 10.1016/j.neuint.2020.104811. Fulltekst i vitenarkiv
• Lepperød, Mikkel Elle; Dragly, Svenn-Arne; Buccino, Alessio Paolo; Mobarhan, Milad; Malthe-Sørenssen, Anders & Hafting, Torkel [Vis alle 7 forfattere av denne artikkelen] (2020). Experimental Pipeline (Expipe): A Lightweight Data Management Platform to Simplify the Steps From Experiment to Data Analysis. Frontiers in Neuroinformatics. ISSN 1662-5196. 14. doi: 10.3389/fninf.2020.00030. Fulltekst i vitenarkiv
• Guadagno, Noemi Antonella; Margiotta, Azzurra; Bjørnestad, Synne Arstad; Haugen, Linda Hofstad; Kjos, Ingrid & Xiaochun, Xu [Vis alle 10 forfattere av denne artikkelen] (2020). Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum . Journal of Cell Biology. ISSN 0021-9525. 219(7), s. 1–23. doi: 10.1083/JCB.201809020. Fulltekst i vitenarkiv
• Torgersen, Maria Lyngaas; Judge, Peter J.; Bada Juarez, Juan F.; Pandya, Abhilash D.; Fusser, Markus & Davies, Charlie W. [Vis alle 12 forfattere av denne artikkelen] (2020). Physicochemical characterization, toxicity and in vivo biodistribution studies of a discoidal, lipid-based drug delivery vehicle: Lipodisq nanoparticles containing doxorubicin. Journal of Biomedical Nanotechnology. ISSN 1550-7033. 16(4), s. 419–431. doi: 10.1166/jbn.2020.2911. Fulltekst i vitenarkiv
• Bachman, Steven P.; Wilkin, Paul; Reader, Tom; Field, Richard; Weber, Odile & Nordal, Inger [Vis alle 7 forfattere av denne artikkelen] (2020). Extinction risk and conservation gaps for Aloe (Asphodelaceae) in the Horn of Africa. Biodiversity and Conservation. ISSN 0960-3115. 29(1), s. 77–98. doi: 10.1007/s10531-019-01870-0. Fulltekst i vitenarkiv
• Hatlem, Daniel; Trunk, Thomas; Linke, Dirk & Leo, Jack Christopher (2020). Catching a SPY: Using the SpyCatcher-SpyTag and Related Systems for Labeling and Localizing Bacterial Proteins. I Leitao, JH (Red.), Microbial Virulence Factors. MDPI. ISSN 978-3-03936-946-1. s. 371–400. doi: 10.3390/ijms20092129. Fulltekst i vitenarkiv
• Wróbel, Agnieszka Ewelina; Saragliadis, Athanasios; Pérez-Ortega, Jesús; Sittman, Carolin; Göttig, Stephan & Liskiewicz, Krystyna Anna [Vis alle 11 forfattere av denne artikkelen] (2020). The inverse autotransporters of Yersinia ruckeri, YrInv and YrIlm, contribute to biofilm formation and virulence. Environmental Microbiology. ISSN 1462-2912. 22(7), s. 2939–2955. doi: 10.1111/1462-2920.15051. Fulltekst i vitenarkiv
• Lundsør, Elisabeth; Stige, Leif Christian; Sørensen, Kai & Edvardsen, Bente (2020). Long-term coastal monitoring data show nutrient-driven reduction in chlorophyll. Journal of Sea Research. ISSN 1385-1101. 164. doi: 10.1016/j.seares.2020.101925. Fulltekst i vitenarkiv
• Robledo, Gerardo Lucio; Palacio, Melissa; Urcelay, Carlos; Vasco-Palacios, Aída M.; Crespo, Esteban & Popoff, Orlando [Vis alle 9 forfattere av denne artikkelen] (2020). Mystery unveiled: Diacanthodes Singer–a lineage within the core polyporoid clade. Systematics and Biodiversity. ISSN 1477-2000. 18(6), s. 538–556. doi: 10.1080/14772000.2020.1776784.
• Kocere, Agnese; Resseguier, Julien; Wohlmann, Jens; Skjeldal, Frode Miltzow; Khan, Shanawaz & Speth, Martin [Vis alle 14 forfattere av denne artikkelen] (2020). Real-time imaging of polymersome nanoparticles in zebrafish embryos engrafted with melanoma cancer cells: Localization, toxicity and treatment analysis. EBioMedicine. ISSN 2352-3964. 58, s. 1–12. doi: 10.1016/j.ebiom.2020.102902. Fulltekst i vitenarkiv
• Buccino, Alessio Paolo & Einevoll, Gaute (2020). MEArec: A fast and customizable testbench simulator for ground-truth extracellular spiking activity. Neuroinformatics. ISSN 1539-2791. 19, s. 185–204. doi: 10.1007/s12021-020-09467-7. Fulltekst i vitenarkiv
• Andvik, Clare Margaret; Jourdain, Eve; Ruus, Anders; Lyche, Jan Ludvig; Karoliussen, Richard & Borgå, Katrine (2020). Preying on seals pushes killer whales from Norway above pollution effects thresholds. Scientific Reports. ISSN 2045-2322. 10. doi: 10.1038/s41598-020-68659-y. Fulltekst i vitenarkiv
• Andersen, Tom; Hessen, Dag Olav; Håll, Johnny Peter; Khomich, Maryia; Kyle, Marcia & Lindholm, Markus [Vis alle 10 forfattere av denne artikkelen] (2020). Congruence, but no cascade—Pelagic biodiversity across three trophic levels in Nordic lakes. Ecology and Evolution. ISSN 2045-7758. 10(15), s. 8153–8165. doi: 10.1002/ece3.6514. Fulltekst i vitenarkiv
• Skjæraasen, Jon Egil; Korsbrekke, Knut; Dingsør, Gjert Endre; Langangen, Øystein; Opdal, Anders Frugård & Jørgensen, Christian (2020). Large annual variation in the amount of skipped spawning for female Northeast Arctic haddock Melanogrammus aeglefinus. Fisheries Research. ISSN 0165-7836. 230. doi: 10.1016/j.fishres.2020.105670. Fulltekst i vitenarkiv
• Samdal, Ingunn Anita; Strand, David Allan; Ballot, Andreas; Rusch, Johannes Christopher; Haande, Sigrid & Løvberg, Kjersti Liv Eriksen [Vis alle 8 forfattere av denne artikkelen] (2020). Microcystins in European Noble Crayfish Astacus astacus in Lake Steinsfjorden, a Planktothrix-Dominated Lake. Toxins. ISSN 2072-6651. 12(5). doi: 10.3390/toxins12050298. Fulltekst i vitenarkiv Vis sammendrag

  Lake Steinsfjorden, an important Norwegian location for noble crayfish (Astacus astacus), is often affected by cyanobacterial blooms caused by microcystin (MC)-producing Planktothrix spp. The impact of MCs on noble crayfish as a food source and crayfish health is largely unknown. We investigated the quantities and correlations of MCs in noble crayfish and lake water during and after a cyanobacterial bloom peaking in June–July 2015. Noble crayfish and water samples were collected monthly from June to October 2015 and in October 2016. The content of MCs was analysed by ELISA from tail muscle, intestine, stomach and hepatopancreas. PCR analysis for Planktothrix gene markers was performed on crayfish stomach content. Water samples were analysed for phytoplankton composition, biomass and MCs. PCR-positive stomach contents indicated Planktothrix to be part of the noble crayfish diet. Concentrations of MCs were highest in the hepatopancreas, stomach and intestine, peaking in August–September. Tail muscle contained low concentrations of MCs. Similar levels of MCs were found in crayfish from 2016. Except in September 2015, a normal portion of boiled noble crayfish tails was below the tolerable daily intake (TDI) for MCs for humans. Removing the intestine more than halved the content of MCs and seems a reasonable precautionary measure for noble crayfish consumers.

• Rusch, Johannes C.; Mojžišová, Michaela; Strand, David; Svobodová, Jitka; Vrålstad, Trude & Petrusek, Adam (2020). Simultaneous detection of native and invasive crayfish and Aphanomyces astaci from environmental DNA samples in a wide range of habitats in Central Europe. NeoBiota. ISSN 1619-0033. 58, s. 1–32. doi: 10.3897/neobiota.58.49358.
• Dal, Nils-Jørgen Knudsen; Kocere, Agnese; Wohlmann, Jens; Van Herck, Simon; Bauer, Tobias A & Resseguier, Julien [Vis alle 11 forfattere av denne artikkelen] (2020). Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle–Cell Interactions. Small. ISSN 1613-6810. 16(5), s. 1–12. doi: 10.1002/smll.201906719. Fulltekst i vitenarkiv
• Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie; Lucas, Christin & Vekterud, Kristin [Vis alle 15 forfattere av denne artikkelen] (2020). LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. Cells. ISSN 2073-4409. 9(5), s. 1–26. doi: 10.3390/cells9051214. Fulltekst i vitenarkiv Vis sammendrag

  The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid metabolism in the liver. More knowledge of their mechanistic interplay is needed to understand their role in pathological conditions like fatty liver disease and insulin resistance. In the current study, LXR and ChREBP co-occupancy was examined by analyzing ChIP-seq datasets from mice livers. LXR and ChREBP interaction was determined by Co-immunoprecipitation (CoIP) and their transactivity was assessed by real-time quantitative polymerase chain reaction (qPCR) of target genes and gene reporter assays. Chromatin binding capacity was determined by ChIP-qPCR assays. Our data show that LXRα and ChREBPα interact physically and show a high co-occupancy at regulatory regions in the mouse genome. LXRα co-activates ChREBPα and regulates ChREBP-specific target genes in vitro and in vivo. This co-activation is dependent on functional recognition elements for ChREBP but not for LXR, indicating that ChREBPα recruits LXRα to chromatin in trans. The two factors interact via their key activation domains; the low glucose inhibitory domain (LID) of ChREBPα and the ligand-binding domain (LBD) of LXRα. While unliganded LXRα co-activates ChREBPα, ligand-bound LXRα surprisingly represses ChREBPα activity on ChREBP-specific target genes. Mechanistically, this is due to a destabilized LXRα:ChREBPα interaction, leading to reduced ChREBP-binding to chromatin and restricted activation of glycolytic and lipogenic target genes. This ligand-driven molecular switch highlights an unappreciated role of LXRα in responding to nutritional cues that was overlooked due to LXR lipogenesis-promoting function.

• Ryoo, David; Rydmark, Marcella Orwick; Pang, Yui Tik; Lundquist, Karl P; Linke, Dirk & Gumbart, James C (2020). BamA is required for autotransporter secretion. Biochimica et Biophysica Acta - General Subjects. ISSN 0304-4165. 1864(7), s. 1–8. doi: 10.1016/j.bbagen.2020.129581. Fulltekst i vitenarkiv
• Dobrovolska, Olena; Brilkov, Maxim; Madeleine, Noëlly; Ødegaard-Fougner, Øyvind; Strømland, Øyvind & Martin, Stephen R. [Vis alle 15 forfattere av denne artikkelen] (2020). The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection. The FEBS Journal. ISSN 1742-464X. 287, s. 4458–4480. doi: 10.1111/febs.15256. Fulltekst i vitenarkiv
• Skuland, Tonje Schwach; Låg, Marit; Gutleb, Arno; Brinchmann, Bendik Christian; Serchi, Tommaso & Øvrevik, Johan [Vis alle 8 forfattere av denne artikkelen] (2020). Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model . Particle and Fibre Toxicology. ISSN 1743-8977. 17(1), s. 1–18. doi: 10.1186/s12989-020-00345-3. Fulltekst i vitenarkiv Vis sammendrag

  Background Silica nanoparticles (SiNPs) are among the most widely manufactured and used nanoparticles. Concerns about potential health effects of SiNPs have therefore risen. Using a 3D tri-culture model of the alveolar lung barrier we examined effects of exposure to SiNPs (Si10) and crystalline silica (quartz; Min-U-Sil) in the apical compartment consisting of human alveolar epithelial A549 cells and THP-1-derived macrophages, as well as in the basolateral compartment with Ea.hy926 endothelial cells. Inflammation-related responses were measured by ELISA and gene expression. Results Exposure to both Si10 and Min-U-Sil induced gene expression and release of CXCL8, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1α (IL-1α) and interleukin-1β (IL-1β) in a concentration-dependent manner. Cytokine/chemokine expression and protein levels were highest in the apical compartment. Si10 and Min-U-Sil also induced expression of adhesion molecules ICAM-1 and E-selectin in the apical compartment. In the basolateral endothelial compartment we observed marked, but postponed effects on expression of all these genes, but only at the highest particle concentrations. Geneexpressions of heme oxygenase-1 (HO-1) and the metalloproteases (MMP-1 and MMP-9) were less affected. The IL-1 receptor antagonist (IL-1RA), markedly reduced effects of Si10 and Min-U-Sil exposures on gene expression of cytokines and adhesion molecules, as well as cytokine-release in both compartments. Conclusions Si10 and Min-U-Sil induced gene expression and release of pro-inflammatory cytokines/adhesion molecules at both the epithelial/macrophage and endothelial side of a 3D tri-culture. Responses in the basolateral endothelial cells were only induced at high concentrations, and seemed to be mediated by IL-1α/β released from the apical epithelial cells and macrophages.

• Fæste, Christiane Kruse; Tartor, Haitham; Moen, Anders; Kristoffersen, Anja Bråthen; Dhanasiri, Anusha & Anonsen, Jan Haug [Vis alle 8 forfattere av denne artikkelen] (2020). Proteomic profiling of salmon skin mucus for the comparison of sampling methods. Journal of chromatography. B. ISSN 1570-0232. 1138. doi: 10.1016/j.jchromb.2019.121965.
• Davey, Marie L.; Nybakken, Line; Kauserud, Håvard & Ohlson, Mikael (2019). Fungal biomass associated with the phyllosphere of bryophytes and vascular plants. Mycological Research. ISSN 0953-7562. 113(11), s. 1254–1260. doi: 10.1016/j.mycres.2009.08.001.
• da Silva, Rejane Maria Ferreira; Soares, Adriene Mayra; de Pádua, Ana Patricia Sousa Lopes; Firmino, André Luiz; de Souza-Motta, Cristina Maria & da Silva, Gladstone Alves [Vis alle 19 forfattere av denne artikkelen] (2019). Mycological diversity description II. Acta Botanica Brasilica. ISSN 0102-3306. 33(1), s. 163–173. doi: 10.1590/0102-33062018abb0411. Fulltekst i vitenarkiv
• Spirin, Viacheslav; Malysheva, Vera; Miettinen, Otto; Vlasák, Josef; Alvarenga, Renato Lúcio Mendes & Gibertoni, Tatiana Baptista [Vis alle 8 forfattere av denne artikkelen] (2019). On Protomerulius and Heterochaetella (Auriculariales, Basidiomycota). Mycological Progress. ISSN 1617-416X. 18(9), s. 1079–1099. doi: 10.1007/s11557-019-01507-0. Fulltekst i vitenarkiv
• Medina, Lilian; Ansari, Farhan; Carosio, Federico; Salajkova, Michaela & Berglund, Lars (2019). Nanocomposites from Clay, Cellulose Nanofibrils, and Epoxy with Improved Moisture Stability for Coatings and Semistructural Applications. ACS Applied Nano Materials. ISSN 2574-0970. 2(5), s. 3117–3126. doi: 10.1021/acsanm.9b00459.
• Zheng, Xiaoqi; Lu, Yonglong; Yuan, Jingjing; Baninla, Yvette; Zhang, Yvette & Stenseth, Nils Christian [Vis alle 10 forfattere av denne artikkelen] (2019). Drivers of change in China’s energy-related CO2 emissions. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(1), s. 29–36. doi: 10.1073/pnas.1908513117. Fulltekst i vitenarkiv
• Bostad, Inga & Hessen, Dag Olav (2019). Learning and loving of nature in the Anthropocene. How to broaden science with curiosity and passion. Studier i Pædagogisk Filosofi. ISSN 2244-9140. 8(1), s. 28–42. doi: 10.7146/spf.v8i1.113924. Fulltekst i vitenarkiv
• Hansen, Karen; Schumacher, Trond; Skrede, Inger; Huhtinen, Seppo & Wang, Xianghua (2019). Pindara revisited – evolution and generic limits in Helvellaceae. Persoonia. ISSN 0031-5850. 42, s. 186–204. doi: 10.3767/persoonia.2019.42.07. Fulltekst i vitenarkiv
• Langlete, Petter; Krabberød, Anders Kristian & Winther-Larsen, Hanne Cecilie (2019). Vesicles from vibrio cholerae contain AT-rich DNA and shorter mRNAs that do not correlate with their protein products. Frontiers in Microbiology. ISSN 1664-302X. 10, s. 1–16. doi: 10.3389/fmicb.2019.02708. Fulltekst i vitenarkiv Vis sammendrag

  Extracellular vesicles secreted by Gram-negative bacteria have proven to be important in bacterial defense, communication and host-pathogen relationships. They resemble smaller versions of the bacterial mother cell, with similar contents of proteins, LPS, DNA, and RNA. Vesicles can elicit a protective immune response in a range of hosts, and as vaccine candidates, it is of interest to properly characterize their cargo. Genetic sequencing data is already available for vesicles from several bacterial strains, but it is not yet clear how the genetic makeup of vesicles differ from that of their parent cells, and which properties may characterize enriched genetic material. The present study provides evidence for DNA inside vesicles from Vibrio cholerae O395, and key characteristics of their genetic and proteomic content are compared to that of whole cells. DNA analysis reveals enrichment of fragments containing ToxR binding sites, as well as a positive correlation between AT-content and enrichment. Some mRNAs were highly enriched in the vesicle fraction, such as membrane protein genes ompV, ompK, and ompU, DNA-binding protein genes hupA, hupB, ihfB, fis, and ssb, and a negative correlation was found between mRNA enrichment and transcript length, suggesting mRNA inclusion in vesicles may be a size-dependent process. Certain non-coding and functional RNAs were found to be enriched, such as VrrA, GcvB, tmRNA, RNase P, CsrB2, and CsrB3. Mass spectrometry revealed enrichment of outer membrane proteins, known virulence factors, phage components, flagella and extracellular proteins in the vesicle fraction, and a low, negative correlation was found between transcript-, and protein enrichment. This result opposes the hypothesis that a significant degree of protein translation occurs in vesicles after budding. The abundance of viral-, and flagellar proteins in the vesicle fraction underlines the importance of purification during vesicle isolation.

• Raheel, Tayyaba Qureshi; Sørensen, Christina; Berghuis, Paul; Jensen, Vidar; Dobszay, Marton B. & Farkas, Tamás [Vis alle 14 forfattere av denne artikkelen] (2019). The glutamine transporter Slc38a1 regulates GABAergic neurotransmission and synaptic plasticity. Cerebral Cortex. ISSN 1047-3211. 29(12), s. 5166–5179. doi: 10.1093/cercor/bhz055. Fulltekst i vitenarkiv
• Hadjineophytou, Chris; Anonsen, Jan Haug; Wang, Nelson; Ma, Kevin; Viburiene, Raimonda & Vik, Åshild [Vis alle 10 forfattere av denne artikkelen] (2019). Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system. PLoS Genetics. ISSN 1553-7390. 15(12), s. 1–24. doi: 10.1371/journal.pgen.1008532. Fulltekst i vitenarkiv Vis sammendrag

  The human pathogens N. gonorrhoeae and N. meningitidis display robust intra- and interstrain glycan diversity associated with their O-linked protein glycosylation (pgl) systems. In an effort to better understand the evolution and function of protein glycosylation operating there, we aimed to determine if other human-restricted, Neisseria species similarly glycosylate proteins and if so, to assess the levels of glycoform diversity. Comparative genomics revealed the conservation of a subset of genes minimally required for O-linked protein glycosylation glycan and established those pgl genes as core genome constituents of the genus. In conjunction with mass spectrometric–based glycan phenotyping, we found that extant glycoform repertoires in N. gonorrhoeae, N. meningitidis and the closely related species N. polysaccharea and N. lactamica reflect the functional replacement of a progenitor glycan biosynthetic pathway. This replacement involved loss of pgl gene components of the primordial pathway coincident with the acquisition of two exogenous glycosyltransferase genes. Critical to this discovery was the identification of a ubiquitous but previously unrecognized glycosyltransferase gene (pglP) that has uniquely undergone parallel but independent pseudogenization in N. gonorrhoeae and N. meningitidis. We suggest that the pseudogenization events are driven by processes of compositional epistasis leading to gene decay. Additionally, we documented instances where inter-species recombination influences pgl gene status and creates discordant genetic interactions due ostensibly to the multi-locus nature of pgl gene networks. In summary, these findings provide a novel perspective on the evolution of protein glycosylation systems and identify phylogenetically informative, genetic differences associated with Neisseria species.

• Gutema, Tariku Mekonnen; Atickem, Anagaw Meshesha; Alemu, Diress Tsegaye; Bekele, Afework; Sillero-Zubiri, Claudio & Marino, Jorgelina [Vis alle 10 forfattere av denne artikkelen] (2019). Foraging ecology of African wolves (Canis lupaster) and its implications for the conservation of Ethiopian wolves (Canis simensis). Royal Society Open Science. ISSN 2054-5703. 6(9), s. 1–9. doi: 10.1098/rsos.190772. Fulltekst i vitenarkiv
• Løken, Solveig Bua; Skrede, Inger & Schumacher, Trond (2019). The Helvella corium species aggregate in Nordic countries - Phylogeny and species delimitation. Fungal Systematics and Evolution. ISSN 2589-3831. 5, s. 169–186. doi: 10.3114/fuse.2020.05.13. Fulltekst i vitenarkiv
• Nguéa P, Aurélie; Robertson, Joseph; Herrera, Maria Carmen; Chymkowitch, Pierre & Enserink, Jorrit (2019). Desumoylation of RNA polymerase III lies at the core of the Sumo stress response in yeast. Journal of Biological Chemistry. ISSN 0021-9258. 294(49), s. 18784–18795. doi: 10.1074/jbc.RA119.009721. Fulltekst i vitenarkiv
• Fredriksen, Stein; Karsten, Ulf; Bartsch, Inka; Woelfel, Jana; Koblowsky, Miriam & Schumann, Rhena [Vis alle 11 forfattere av denne artikkelen] (2019). Biodiversity of Benthic Macro- and Microalgae from Svalbard with Special Focus on Kongsfjorden. I Hop, Haakon & Wiencke, Christian (Red.), The Ecosystem of Kongsfjorden, Svalbard. Springer. ISSN 978-3-319-46423-7. s. 331–371. doi: 10.1007/978-3-319-46425-1_9.
• Borgå, Katrine & Ruus, Anders (2019). Quantifying Bioaccumulation in the Aquatic Environment. Methods in pharmacology and toxicology. ISSN 1557-2153. s. 1–18. doi: 10.1007/7653_2019_36.
• Heuschele, Jan David; Lode, Torben; Andersen, Tom; Borgå, Katrine & Titelman, Josefin (2019). An affordable and automated imaging approach to acquire highly resolved individual data—an example of copepod growth in response to multiple stressors. PeerJ. ISSN 2167-8359. 7, s. 1–22. doi: 10.7717/peerj.6776. Fulltekst i vitenarkiv
• Sahlmann, Andrea Silke; Lode, Torben; Heuschele, Jan David; Borgå, Katrine; Titelman, Josefin & Hylland, Ketil (2019). Genotoxic Response and Mortality in 3 Marine Copepods Exposed to Waterborne Copper. Environmental Toxicology and Chemistry. ISSN 0730-7268. 38(10), s. 2224–2232. doi: 10.1002/etc.4541.
• Lau, Corinna; McAdam, Martin Berner; Bergseth, Grete; Grevys, Algirdas; Bruun, Jack-Ansgar & Ludviksen, Judith K [Vis alle 11 forfattere av denne artikkelen] (2019). NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies. mAbs. ISSN 1942-0862. 12:e1686319(1), s. 1–13. doi: 10.1080/19420862.2019.1686319. Fulltekst i vitenarkiv Vis sammendrag

  The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab (Soliris®), which is used clinically to block complement factor C5, as well as anti-human CD14 (r18D11) and anti-porcine CD14 (rMIL2) produced in our laboratory. So far, no proper IgG2/4 control antibody has been available for controlled validation of IgG2/4 antibody functions. Here, we describe the design of a recombinant control antibody (NHDL), which was generated by combining the variable light (VL) and heavy (VH) chains from two unrelated specificities. NHDL was readily expressed and purified as a stable IgG2/4 antibody, and showed no detectable specificity toward any putative antigen present in human or porcine blood. The approach of artificial VL/VH combination may be adopted for the design of other recombinant control antibodies.

• Moustakas, Michael; Baycu, Gulriz; Gevrek, Nurbir; Moustaka, Julietta; Csatari, Istvan & Rognes, Sven Erik (2019). Spatiotemporal heterogeneity of photosystem II function during acclimation to zinc exposure and mineral nutrition changes in the hyperaccumulator Noccaea caerulescens. Environmental science and pollution research international. ISSN 0944-1344. 26(7), s. 6613–6624. doi: 10.1007/s11356-019-04126-0.
• Lode, Heidrun Elisabeth; Gjølberg, Torleif Tollefsrud ; Foss, Stian; Sivertsen, Magne S.; Brustugun, Jørgen & Andersson, Yvonne [Vis alle 9 forfattere av denne artikkelen] (2019). A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes. Scientific Reports. ISSN 2045-2322. 9:18021(1), s. 1–10. doi: 10.1038/s41598-019-54226-7. Fulltekst i vitenarkiv Vis sammendrag

  Intravitreal injections of antibody-based biologics targeting vascular endothelial growth factor (VEGF) are highly effective and have markedly decreased the risk of visual impairment associated with prevalent retinal diseases, such as neovascular age-related macular degeneration and diabetes macular oedema. The diseases are chronic in their nature, and most patients need long-term therapy to suppress disease activity. We previously reported a compounding method for repackaging and storage of aflibercept (Eylea), a commonly used anti-VEGF biologic, in silicone oil-coated plastic syringes without compromising drug stability or activity. In addition to improving safety and time spent per patient, compounding of anti-VEGF biologics enables single-dose vials to be split into multiple syringes, thereby considerably reducing waste and drug expenses. However, symptomatic silicone oil droplets may deposit in the eye's vitreous body after repetitive injections. To fully avoid this complication, we here report on a novel pharmaceutical compounding method using silicone oil-free syringes and a 33 G × 9 mm Low Dead Space Needle hub injection needle. We evaluate the method for three anti-VEGF biologics commonly used in ophthalmology: aflibercept, ranibizumab (Lucentis) and bevacizumab (Avastin). Our results show that compounding and storage for one week does not compromise the functional activity of the biologics and allows for safe and cost-effective compounding of anti-VEGF biologics for intravitreal injections in prefilled silicone oil-free syringes.

• Pinto, Rita; Vågbø, Cathrine Broberg; Jakobsson, Magnus; Yeji, Kim; Baltissen, Marijke P & O'Donohue, Marie-Francoise [Vis alle 16 forfattere av denne artikkelen] (2019). The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Nucleic Acids Research (NAR). ISSN 0305-1048. 48(2), s. 830–846. doi: 10.1093/nar/gkz1147. Fulltekst i vitenarkiv
• Byskov, Kristina; M. le Gall, Sylvain; Thiede, Bernd; Camerer, Eric & Kanse, Sandip (2019). Protease activated receptors (PAR)‐1 and ‐2 mediate cellular effects of factor VII activating protease (FSAP). The FASEB Journal. ISSN 0892-6638. 34, s. 1079–1090. doi: 10.1096/fj.201801986RR. Fulltekst i vitenarkiv
• Huszthy, Peter Csaba; Gopalakrishnan, Ramakrishna Prabhu; Jacobsen, Johanne Tracey; Haabeth, Ole Audun; Løset, Geir Åge & Braathen, Ranveig [Vis alle 10 forfattere av denne artikkelen] (2019). B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 116(51), s. 25850–25859. doi: 10.1073/pnas.1902836116. Fulltekst i vitenarkiv Vis sammendrag

  The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes on B cells for recognition by CD4+ T cells. It is not known if naive B cells spontaneously display pId:MHCII in vivo or if BCR ligation is required for expression, thereby enabling collaboration between Id+ B cells and Id-specific T cells. Here, using a mouse model, we show that naive B cells do not express readily detectable levels of pId:MHCII. However, BCR ligation by Ag dramatically increases physical display of pId:MHCII, leading to activation of Id-specific CD4+ T cells, extrafollicular T-B cell collaboration and some germinal center formation, and production of Id+ IgG. Besides having implications for immune regulation, the results may explain how persistent activation of self-reactive B cells induces the development of autoimmune diseases and B cell lymphomas.

• Trousil, Jiří; Syrová, Zdeňka; Dal, Nils-Jørgen Knudsen; Rak, Dmytro; Konefal, Rafal & Pavlova, Ewa [Vis alle 16 forfattere av denne artikkelen] (2019). Rifampicin Nanoformulation Enhances Treatment of Tuberculosis in Zebrafish. Biomacromolecules. ISSN 1525-7797. 20(4), s. 1798–1815. doi: 10.1021/acs.biomac.9b00214.
• Lopez, David Massa; Thelen, Melanie; Stahl, Felix; Thiel, Christian; Linhorst, Arne & Sylvester, Marc [Vis alle 11 forfattere av denne artikkelen] (2019). The lysosomal transporter mfsd1 is essential for liver homeostasis and critically depends on its accessory subunit glmp. eLIFE. ISSN 2050-084X. 8, s. 1–27. doi: 10.7554/eLife.50025. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

• Larsson, Karl-Henrik & Ryvarden, Leif (2021). Corticioid fungi of Europe. Volum 1. Acanthobasidium – Gyrodontium. Fungiflora. ISBN 978-82-90724-60-8. 1(43). 266 s.
• Sand, Olav; Sjaastad, Øystein; Haug, Egil & Bjaalie, Jan G. (2019). Anatomi og fysiologi - Menneskekroppen, 4. utgave. Gads forlag. ISBN 9788712058328. 666 s.

Se alle arbeider i Cristin

• Nipen, Maja; Vogt, Rolf David; Bohlin-Nizzetto, Pernilla; Borgå, Katrine; Mwakalapa, Eliezer & Borgen, Anders [Vis alle 10 forfattere av denne artikkelen] (2022). Increasing Trends of Legacy and Emerging Organic Contaminants in a Dated Sediment Core From East-Africa.
• Fjelde, Markus Osaland (2022). Omringet av sopp. argument. ISSN 1504-6087. 16(2), s. 28–31.
• Yadetie, Fekadu; Brun, Nadja Rebecca; Giebichenstein, Julia; Hylland, Ketil; Borgå, Katrine & Karlsen, Odd André [Vis alle 7 forfattere av denne artikkelen] (2022). Transcriptome responses in copepods Calanus finmarchicus, Calanus glacialis and Calanus hyperboreus exposed to phenanthrene and benzo[a]pyrene.
• Wu, Qingyu; Schmidt, Wolfgang; Aalen, Reidunn B.; Xu, Cao & Takahashi, Fuminori (2022). Editorial: Peptide Signaling in Plants. Frontiers in Plant Science. ISSN 1664-462X. 13. doi: 10.3389/fpls.2022.843918.
• Lind, Vibeke; Trosvik, Pål; de Muincke, Eric; Skjånes, Kari; Jørgensen, Grete Helen Meisfjord & Borgvang, Stig A. (2022). Microalgae (Chlorella vulgaris) in diet to sheep for DNA profile in rumen microbiomes.
• Rolandsen, Christer Moe; Davey, Marie Louise; Kleven, Oddmund; Ågren, Erik; Grøntvedt, Carl Andreas & Mysterud, Atle [Vis alle 8 forfattere av denne artikkelen] (2022). Kartlegging av villsvinets diett, bestandsstruktur og slektskap med genetiske metoder og individdata fra jakt og fallvilt.
• Rolandsen, Christer Moe; Andersen, Roy; Strand, Olav; Solberg, Erling Johan; Meisingset, Erling L. & Mysterud, Atle [Vis alle 9 forfattere av denne artikkelen] (2022). Hardangervidda og Setesdal. GPS merking av villrein, elg og hjort.
• Vøllestad, Leif Asbjørn (2022). Understanding local adaptation in a salmonid fish: the European grayling, Thymallus thymallus. Vis sammendrag

  Post-glacial landscapes have evolved over time following deglaciation. This has particular effects on freshwater systems, due to a diversity of geological and hydrological processes. Freshwater organisms have dispersed into Norway from various glacial refugia, a process that is still in progress. On top of natural processes, human activity has led to major changes in distribution, mainly through translocations and remodeling of waterways. Here, I describe the distribution and biology of European grayling Thymallus thymallus in a large Norwegian river system. The main focus will be on the more recent changes to the waterways, and how it has led to habitat fragmentation, but also opened the opportunity to establish new locally-adapted populations. We have studied newly established populations using a variety of approaches; population and quantitative genetics, transcriptomics, proteomics and hopefully genomics. Overall, results from the various studies show that the populations respond evolutionary to local-scale environmental differences (mainly water temperature during early development). Further, plastic responses seem to be important in the early phase of population diversification. Population genomic studies are now becoming possible following the completion of an annotated genome of high quality. Such resources may help in addressing questions about the genetic architecture of traits important for local adaptation. However, we are not there yet.

• Kausrud, Kyrre; Melteig, Elina; Olsson, Vilde & Galteland, Torborg (2022). Biopodden -Zoonoser . [Internett]. https://www.podbean.com/ew/pb-jddi3-11d3759.
• Kausrud, Kyrre; Olsson, Vilde; Melteig, Elina & Galteland, Torborg (2022). Biopodden -Skog og Klima. [Internett]. https://www.podbean.com/ew/pb-c8rck-12057a0.
• Hatlem, Daniel; Linke, Dirk Bernd Kurt & Andersen, Elisabeth K. (2022). Forskerprosjekt på antibiotika og blodforgiftning. [Internett]. Website Oslo Cancer Cluster.
• Chunlin, Shi & Xuan, Yuan Hu (2021). OsEDR1 has non-canonical scaffold function in regulating MAPK cascade in plant immunity. Molecular Plant. ISSN 1674-2052. 14. doi: 10.1016/j.molp.2021.02.001.
• Ryvarden, Leif (2021). Aphyllophorales of Africa 53, Some new combinations in Polyporaceae. Synopsis fungorum. ISSN 0802-8966. s. 36–36.
• Decock, C.; Ryvarden, Leif & Wagara, Isabel (2021). Aphyllophorales of Africa 52, Some poroid species from Kakamega Forest National Reserve in Kenya. Synopsis fungorum. ISSN 0802-8966. 44, s. 32–35.
• Gminder, Andreas & Ryvarden, Leif (2021). Aphyllophorales of Africa 51, Some new species from Ethiopia. Synopsis fungorum. ISSN 0802-8966. 44, s. 27–31.
• Decock, C. & Ryvarden, Leif (2021). Aphyllophorales of Africa 50, The genus Donkia – a synopsis. Synopsis fungorum. ISSN 0802-8966. 44, s. 24–26.
• Decock, C. & Ryvarden, Leif (2021). Aphyllophorales of Africa 49, The genus Climacodon – a synopsis. Synopsis fungorum. ISSN 0802-8966. 44, s. 19–23.
• Decock, C. & Ryvarden, Leif (2021). Aphyllophorales of Africa 48, Some poroid species from São Tomé. Synopsis fungorum. ISSN 0802-8966. 44, s. 14–18.
• Olou, Boris Armel & Ryvarden, Leif (2021). Aphyllophorales of Africa 47, Some new and interesting polypores from Benin. Synopsis fungorum. ISSN 0802-8966. 44, s. 9–13.
• Decock, C.; Yombiyeni, P. & Ryvarden, Leif (2021). Aphyllophorales of Africa 46, Some polypores from Mont de Crystal National Park in Gabon. Synopsis fungorum. ISSN 0802-8966. 44, s. 5–8.
• Sharma, Ankush & Colonna, Giovanni (2021). Correction to: System-Wide Pollution of Biomedical Data: Consequence of the Search for Hub Genes of Hepatocellular Carcinoma Without Spatiotemporal Consideration (Molecular Diagnosis & Therapy, (2021), 25, 1, (9-27), 10.1007/s40291-020-00505-3). Molecular Diagnosis & Therapy. ISSN 1177-1062. 25(3). doi: 10.1007/s40291-021-00527-5.
• Jahnsen, Frode Lars & Johansen, Finn-Eirik (2021). Legends of allergology and immunology: Per Brandtzaeg - Pillar of mucosal immunology. Allergy. European Journal of Allergy and Clinical Immunology. ISSN 0105-4538. 76(8), s. 2634–2635. doi: 10.1111/all.14824.
• Kline, Simon Hasselø (2021). Den ensomme algen.
• Kline, Simon Hasselø (2021). The lonely Algae.
• Vollsnes, Ane Victoria; Falk, Stefanie; Berglen eriksen, Aud; Emberson, Lisa D.; O’Neill, Connie & Stordal, Frode [Vis alle 7 forfattere av denne artikkelen] (2021). Model parameterisation of subarctic vegetation in climate models, an example from an ozone effect study.
• Vollsnes, Ane Victoria; Stordal, Frode; Falk, Stefanie; Eriksen, Aud Berglen; Kauserud, Håvard & Berntsen, Terje Koren (2021). Field and lab experiments, plant ecophysiology starting from The double punch.
• Linke, Dirk (2021). #FEMSmicroBlog: The balancing act between basic and applied science.
• Hessen, Dag Olav (2021). Vi trenger en hippokratisk ed for de ufødte. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(12), s. 1–5. doi: 10.4045/tidsskr.21.0593.
• Hori, Katsutoshi & Linke, Dirk (2021). the exchange program MISC - Options for internships at Nagoya University (with descriptions of current projects by students).
• Hu, Xian; Margadant, Felix Martin & Bakke, Oddmund (2021). International Patent: Microscope apparatus. WO2021160723A1. . Vis sammendrag

  A microscope apparatus (10) comprises: an imaging volume with orthogonal X, Y and Z axes; a camera (211) having a focal plane; a light source (110, 120) for illumination of the imaging volume; and a Z-stage movement system (131, 132) for relative movement of the imaging volume and the focal plane in the Z axis. Images of microscopic biological objects S are obtained using the microscope apparatus (10) via a method comprising: using the camera (211) to obtain an image in a single exposure whilst using the Z-stage movement system (131, 132) for relative movement of the imaging volume and the focal plane; wherein the Z axis movement is a step-wise movement in which there are multiple resting steps providing periods of no relative motion in between multiple periods of relative motion; and wherein during the periods of relative motion the light source is controlled to reduce the illumination of the imaging volume.

• Lehr, Andrew B. & Stöber, Tristan Manfred (2021). Differential involvement of CA2 in internally vs. externally driven hippocampal sequences. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 118(38). doi: 10.1073/pnas.2110671118.
• Gullvåg, Rebekka; Vollsnes, Ane Victoria; Bryn, Anders; Brysting, Anne Krag & Vatne, Astrid (2021). Effects of high-latitude light conditions on stomatal conductance and photosynthesis in white clover (Trifolium repens) .
• Falk, Stefanie; Vollsnes, Ane Victoria; Eriksen, Aud E Berglen; Emberson, Lisa D.; O'Neill, Connie & Stordal, Frode [Vis alle 7 forfattere av denne artikkelen] (2021). Charakterisierung der subarktischen Ökozone hinsichtlich der Modellierung von Ozonverschmutzung und Klimarisiken. Vis sammendrag

  https://www.dpg-verhandlungen.de/year/2021/conference/smuk/part/up/session/5/contribution/2?lang=en

• Falk, Stefanie; Lombardozzi, Danica; Vollsnes, Ane Victoria; Stordal, Frode; Berntsen, Terje Koren & Eriksen, Aud Else Berglen (2021). OzoneLUNA: Ozone damage in CLM revisited.
• Falk, Stefanie; Vollsnes, Ane Victoria; Emberson, Lisa D.; O'Neill, Connie; Eriksen, Aud E Berglen & Stordal, Frode [Vis alle 7 forfattere av denne artikkelen] (2021). Characterizing subarctic biomes for land surface modeling of pollution and climate risk. Vis sammendrag

  Here we assess the importance of characterization of key meteorological variables and air pollution profiles on the modeled susceptibility of subarctic vegetation to ozone. Changes in climate (e.g. temperature, water availability) will manifest in both direct and indirect effects influencing the species' sensitivity to air pollution. A likely increase in frequency of persistent heatwaves in the future, will inflict heat related stress while generating favorable conditions for the formation of ambient air ozone, e.g. due to wildfires. We have monitored ambient air ozone concentrations at the Norwegian Institute of Bioeconomy Research (NIBIO) Environment Centre Svanhovd in Northern Norway in the vegetation period 2018/19. Due to data acquisition problems, ozone concentrations for two weeks in July 2018 were missing from our record. We present a reconstruction based on probability density function with respect to the Swedish and Finnish atmospheric monitoring sites and compare with available surface ozone products for the region. Over all, ozone concentrations did not differ significantly between the two years. While temperatures and global irradiance diverged substantially from the multi annual mean precipitation varied only to some extend. We investigate the difference in uptake of ozone using the DO3SE model, for typical vegetation at the location. We find that bespoke parameterization for subarctic vegetation is essential for an accurate estimation of Phototoxic Ozone Dose (POD) and an assessment of damage risk. Accurate estimates of the start and length of growing season are also crucial. We find that temperature and its derivative vapor pressure deficit are likely the most important climate variables while the variability of ozone concentration within climatologically reasonable limits plays a minor role. The use of subarctic parameterization suggests an improvement in risk assessment as POD values are increased in 2018; corroborated by evidence of visible injury in the Svanhovd ozone garden.

• Palsdottir, Albina Hulda (2021). Ancient DNA on Viking sheep from the North Atlantic and Ethical Approaches to Destructive Sampling of Animal Bones.
• Chowdhury, Sounak; Linke, Dirk; Happonen, Lotta Johanna & Malmström, Johan (2021). Streptococcus pyogenes forms M protein specific host-environment dependent protein complexes.
• Thibau, Arno; Linke, Dirk & Kempf, Volkhard A.J. (2021). Analysing the fibronectin binding properties and genomic variation of Bartonella henselae adhesin.
• Leva-Bueno, Juan; Meuskens, Ina; Linke, Dirk; Millner, Paul & Peyman, Sally (2021). Impedimetric biosensor based on extracellular matrix protein-adhesin interaction.
• Meuskens, Ina; Leva-Bueno, Juan; Millner, Paul; Schütz, Monika; Peyman, Sally & Linke, Dirk (2021). The Trimeric Autotransporter Adhesin YadA of Yersinia binds to glycan moieties.
• Bustad, Helene J.; Flydal, Marte Innselset; Knævelsrud, Helene; Boye, Erik & Kristensen, Tom Arne (2021). Et kappløp for norsk fagspråk. Michael. ISSN 1893-9651. 18(26), s. 81–91.
• Knudtzon, Nina Cathrine; Thorstensen, Helene; Ruus, Anders; Helberg, Morten; Bæk, Kine & Enge, Ellen Katrin [Vis alle 7 forfattere av denne artikkelen] (2021). Maternal Transfer and Occurrence of Siloxanes, Chlorinated Paraffins and Legacy POPs in Herring Gulls (Larus argentatus) of Different Urban Influence.
• Nordal, Inger (2021). «Arven etter Nansen: Banebrytende forskning nord for iskanten» – spilte også kvinnelige forskere en rolle fra starten av? Internasjonal dag for kvinner og jenter innen forskning.
• Kumar, Suresh; Jain, Ashish; Choi, Seong Won; da Silva, Gustavo Peixoto Duarte; Allers, Lee & Mudd, Michal H. [Vis alle 11 forfattere av denne artikkelen] (2020). Author Correction: Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens (Nature Cell Biology, (2020), 22, 8, (973-985), 10.1038/s41556-020-0549-1). Nature Cell Biology. ISSN 1465-7392. 22(10). doi: 10.1038/s41556-020-0574-0.
• Boesch, Christophe; Kalan, Ammie K.; Mundry, Roger; Arandjelovic, Mimi; Pika, Simone & Dieguez, Paula [Vis alle 34 forfattere av denne artikkelen] (2020). Erratum: Author Correction: Chimpanzee ethnography reveals unexpected cultural diversity (Nature human behaviour (2020) 4 9 (910-916)). Nature Human Behaviour. ISSN 2397-3374. 4(9). doi: 10.1038/s41562-020-0904-z.
• Meuskens, Ina; Michalik, Marcin; Chauhan, Nandini; Linke, Dirk & Leo, Jack Christopher (2020). Corrigendum: A New Strain Collection for Improved Expression of Outer Membrane Proteins (Frontiers in Cellular and Infection Microbiology, (2017), 7, (464), 10.3389/fcimb.2017.00464). Frontiers in Cellular and Infection Microbiology. ISSN 2235-2988. 10. doi: 10.3389/fcimb.2020.00220.
• Budy, Phaedra; Sanz Ball-llosera, Nuria; Vøllestad, Leif Asbjørn & Javier Lobón-Cerviá, Javier (2020). Opening Remarks: Proceedings of the 5th advances in the population dynamics of stream salmonids. Ecology of Freshwater Fish. ISSN 0906-6691. 29(3). doi: 10.1111/eff.12555.
• Lopes dos Santos, Adriana; Pollina, Thibaut; Gourvil, Priscillia; Corre, Erwan; Marie, Dominique & Garrido, José Luis [Vis alle 10 forfattere av denne artikkelen] (2020). Author Correction: Chloropicophyceae, a new class of picophytoplanktonic prasinophytes (Scientific Reports, (2017), 7, 1, (14019), 10.1038/s41598-017-12412-5). Scientific Reports. ISSN 2045-2322. 10(1). doi: 10.1038/s41598-020-63703-3.
• Eltahir, Yasmin; Al-Araimi, Amna; Nair, Remya R.; Autio, Kaija J.; Tu, Hongmin & Leo, Jack Christopher [Vis alle 8 forfattere av denne artikkelen] (2020). Erratum: Binding of Brucella protein, Bp26, to select extracellular matrix molecules (BMC Mol and Cell Biol. (2019) 20 (55) DOI: 10.1186/s12860-019-0239-7). BMC Molecular and Cell Biology. ISSN 2661-8850. 21(1). doi: 10.1186/s12860-020-00263-4.
• Palsdottir, Albina Hulda (2020). “Kønsforskel: Vikinger foretrak han-heste i graven [Sexing: Vikings preferred male horses for burial]”. [Internett]. Videnskab.dk.
• Palsdottir, Albina Hulda (2020). “Han-heste fik skåret halsen over ved vikingernes grave [Male horses were killed at Viking burial sites]”. [Tidsskrift]. Tölt: Dansk Islandshesteforening.
• Vandvik, Vigdis; Elvevoll, Edel O.; Finne, Merethe Aasmo; Hofshagen, Merete; Nielsen, Anders & Steffensen, Inger-Lise [Vis alle 21 forfattere av denne artikkelen] (2020). Uavhengige kunnskapssynteser: grunnlag for kunnskapsbaserte beslutninger i samfunnet. Uttalelse fra hovedkomiteen i Vitenskapskomiteen for mat og miljø (VKM) . VKM Report. ISSN 2535-4019. 2020:03, s. 1–24.
• Edvardsen, Bente; Supraha, Luka; Gran-Stadniczeñko, Sandra; Eikrem, Wenche & John, Uwe (2020). An in-depth study of Chrysochromulina leadbeateri bloom in northern Norway during spring 2019. Vis sammendrag

  The toxic algal bloom of the haptophyte Chrysochromulina leadbeateri in spring 2019 was the largest bloom of this species in Norwegian waters and worldwide ever recorded. Starting in the Vestfjorden area in northern Norway during early May and expanding north to Balsfjorden and Tromsø area, the bloom caused a major mortality of farmed salmon, with over 13 000 tonns of fish reported as lost during the outbreak. The C. leadbeateri bloom in northern Norway was studied in-depth in frame of a research cruise led by Alfred Wegener Institute (Germany) and in collaboration with the University of Oslo. The cruise focused on studies of phytoplankton diversity, distribution and functional ecology in several fjord systems along the northern Norwegian coast (Lofoten-Vesterålen area, Balsfjorden, Lyngen, Porsangerfjorden, Laksefjorden, Tanafjorden). Biological and environmental data collected during the cruise allowed for detailed analyses of the blooming organism, its distribution patterns in northern Norway, and its ecology. Cultures of C. leadbeateri isolated from the bloom were used to determine the morphology, taxonomic identity, and phylogenetic placement of the organism, and to compare it with a C. leadbeateri strain isolated from the previous major bloom in 1991. Metabarcoding data, light microscopy counts and flow cytometry data were used to map the distribution and abundance of the species along the coast of northern Norway, and correlate its distribution with biotic and abiotic parameters. Preliminary results show that the blooming organism is genetically identical in marker genes to the strain from the bloom in Vestfjorden in 1991. However, both strains and C. leadbeateri in field material exhibit significant intraspecific genetic variability. Biogeographic mapping shows that the bloom was most pronounced in the Balsfjorden area, with maximum cell concentration of over 27 million cells L-1. From an ecological perspective, C. leadbeateri abundance showed positive correlation with phosphate and nitrate, negative correlation with salinity and a slightly positive correlation with temperature. The results of our work provide a unique, in-depth insight into C. leadbeateri blooms, which may help in the monitoring, modelling and predicting similar events in the future. Ongoing work in our group focus on physiological and genetic profiling of the isolated C. leadbeateri strains with the aim to improve our understanding of factors triggering toxicity and bloom formation.

• Linke, Dirk (2020). LPS-Binding Peptides: New Tools for Endotoxin Detection and Removal?
• Hammerstad, Marta; Gudim, Ingvild & Hersleth, Hans-Petter (2020). The Crystal Structures of Bacillithiol Disulfide Reductase YpdA Reveal Structural and Functional Insight into a New Type of FAD-Containing NADPH-Dependent Oxidoreductases.
• Linke, Dirk (2020). Palladium nanoparticles made by bacteria.
• Thorstensen, H. S.; Ruus, Anders; Helberg, Morten; Bæk, Kine; Enge, Ellen Katrin & Borgå, Katrine (2020). Herring gull and common eider as indicators of contaminants in an urban fjord.
• Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2020). Analysing the fibronectin binding properties of Bartonella henselae adhesin A.
• Regan, Matthew D.; Mandic, Milica; Dhillon, Rashpal S.; Lau, Gigi Yik Chee; Farrell, Anthony P. & Schulte, Patricia M. [Vis alle 10 forfattere av denne artikkelen] (2019). Don’t throw the fish out with the respirometry water. Journal of Experimental Biology. ISSN 0022-0949. 222(6). doi: 10.1242/jeb.200253.
• Hammerstad, Marta; Gudim, Ingvild; Lofstad, Marie; Kjendseth, Åsmund Røhr & Hersleth, Hans-Petter (2019). Enzyme activation by a flavoprotein redox network. Acta Crystallographica Section A: Foundations and Advances. ISSN 2053-2733. A75, s. e128–e128. doi: 10.1107/S2053273319094282.
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta; van Beek, Wouter & Hersleth, Hans-Petter (2019). New structural insight into the well known peptide flip observed in flavodoxins. Acta Crystallographica Section A: Foundations and Advances. ISSN 2053-2733. A75, s. e123–e123. doi: 10.1107/S2053273319094336.
• Thibau, Arno; Vaca, Diana; Linke, Dirk & Kempf, Volkhard A.J. (2019). Analysing the fibronectin binding domain of the Bartonella henselae adhesin A.
• Fabrice, Tsigaing; Romuald, Oba; Blondo-Pascal, Metsebing; Claude, Mossebo Dominique; Claire, Fomena T. Mélanie & Joseph, Lumanda Kasali [Vis alle 7 forfattere av denne artikkelen] (2019). Studies in Aphyllophorales of Africa 34 - Two new species from Cameroon and the Democratic Republic of Congo. Synopsis fungorum. ISSN 0802-8966. 39, s. 76–79.
• Blondo-Pascal, Metsebing; Fabrice, Tsigaing; Romuald, Oba; Claude, Mossebo Dominique & Ryvarden, Leif (2019). Studies in Aphyllophorales of Africa 33. Two new poroid species from Cameroon. Synopsis fungorum. ISSN 0802-8966. 39, s. 72–75.
• Ryvarden, Leif (2019). Studies in Aphyllophorales of Africa 32. Some new African polypores. Synopsis fungorum. ISSN 0802-8966. 39, s. 59–71.
• Ryvarden, Leif (2019). Studies in Aphyllophorales of Africa 31. The genus Tyromyces in Africa. Synopsis fungorum. ISSN 0802-8966. 39, s. 46–58.
• Ryvarden, Leif (2019). Studies in Aphyllophorales of Africa 30. Some poroid species from Uganda. Synopsis fungorum. ISSN 0802-8966. 39, s. 41–45.
• Spirin, Viacheslav & Ryvarden, Leif (2019). Studies in Aphyllophorales of Africa 29. Some corticoid species from Uganda. Synopsis fungorum. ISSN 0802-8966. 39, s. 38–40.
• Spirin, Viacheslav & Ryvarden, Leif (2019). Studies in Aphyllophorales of Africa 28. Some corticoid species from Malawi. Synopsis fungorum. ISSN 0802-8966. 39, s. 33–37.
• Ryvarden, Leif (2019). Type studies in Polyporaceae 36, species described by E. Fries. Synopsis fungorum. ISSN 0802-8966. 39, s. 12–32.
• Ryvarden, Leif (2019). Type studies in Polyporaceae 35, species described by C. Peck. Synopsis fungorum. ISSN 0802-8966. 39, s. 8–11.
• Ryvarden, Leif (2019). Type studies in Polyporaceae 34, species described by C. Torrend. Synopsis fungorum. ISSN 0802-8966. 39, s. 6–7.
• Ryvarden, Leif (2019). Type studies in Polyporaceae 33, species described by P. van der Byl. Synopsis fungorum. ISSN 0802-8966. 39, s. 3–5.
• Garcia, Laura Andrea Alfaro; Descamps, Sebastien; Herzke, Dorte; Eckbo, Norith; Chastel, O. & Carravieri, Alice [Vis alle 12 forfattere av denne artikkelen] (2019). Biomagnification of PFAS in the Antarctic breeding south polar skua.
• Kristiansen, Silje Marie; Leinaas, Hans Petter; Herzke, Dorte; Hylland, Ketil; Gabrielsen, Geir W. & Harju, Mikael [Vis alle 7 forfattere av denne artikkelen] (2019). The Arctic tundra and its soil-dwelling springtails (Collembola) reflect nitrogen and contaminants biotransported by seabirds.
• Hammerstad, Marta; Gudim, Ingvild; Lofstad, Marie; Røhr, Åsmund Kjendseth & Hersleth, Hans-Petter (2019). Enzyme Activation by a Flavoprotein Redox Network.
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta; van Beek, Wouter & Hersleth, Hans-Petter (2019). New structural insight into the well known peptide flip observed in flavodoxins.
• Hammerstad, Marta; Zaltariov, Mirela F.; Arabshahi, Homayon John; Jovanovic, Katarina; Richter, Klaus W. & Cazacu, Maria [Vis alle 14 forfattere av denne artikkelen] (2019). New thiosemicarbazone derivatives and their copper(II) complexes as potential inhibitors against mammalian ribonucleotide reductase.
• Gudim, Ingvild; Lofstad, Marie; Hammerstad, Marta; Røhr, Åsmund Kjendseth & Hersleth, Hans-Petter (2019). Activation of the Class Ib Ribonucleotide Reductase by a Flavodoxin Reductase in Bacillus cereus.
• Strand, David; Rusch, Johannes; Brand, Lisa; Haavi, Lars; Rolen, Elin & Vrålstad, Trude (2019). Can ultrasound reduce A. astaci infection load and prevent A. astaci re-infection of carrier signal crayfish?
• Strand, David; Edsman, Lennart; Rusch, Johannes; Brand, Lisa; Haavi, Lars & Rolen, Elin [Vis alle 7 forfattere av denne artikkelen] (2019). Can ultrasonic treatment prevent crayfish plague mediated mortalities in noble crayfish? .
• Strand, David; Haavi, Lars; Brand, Lisa; Rolen, Elin & Vrålstad, Trude (2019). Ultrasonic treatment and effects on the viability of A. astaci zoospores.
• Linke, Dirk (2019). The Gram-Negative Bacterial Cell Surface: How to Study Its Protein Components and How to Remove Endotoxin.
• Lyche, Jan Ludvig; Dirven, Hubert; Låg, Marit; Nilsen, Asbjørn Magne; Borgå, Katrine & Eklo, Ole Martin [Vis alle 9 forfattere av denne artikkelen] (2019). Risk Assessment of the Metabolite M44 of Bixafen, One of the Active Substancesin Aviator Xpro EC225. European Journal of Nutrition and Food Safety. ISSN 2347-5641. 9(4), s. 317–318. doi: 10.9734/EJNFS/2019/v9i430077.
• Eklo, Ole Martin; Almvik, Marit; Hole, Halvard; Nyborg, Åge Arild; Stenrød, Marianne & Borgå, Katrine [Vis alle 13 forfattere av denne artikkelen] (2019). Degradation and Mobility of Pesticides in Norwegian Soils. European Journal of Nutrition and Food Safety. ISSN 2347-5641. 9(3), s. 303–305. doi: 10.9734/EJNFS/2019/v9i330071.
• Dirven, Hubert; Lyche, Jan Ludvig; Låg, Marit; Nilsen, Asbjørn Magne; Borgå, Katrine & Eklo, Ole Martin [Vis alle 9 forfattere av denne artikkelen] (2019). Genotoxic Assessment of the Metabolite M-11 of Mepanipyrim, the Active Ingredient in the Plant Protection Product FRUPICA SC. European Journal of Nutrition and Food Safety. ISSN 2347-5641. 9(3), s. 306–307. doi: 10.9734/EJNFS/2019/v9i330072.
• Strand, David; Johnsen, Stein Ivar; Laurendz, Charlotte; Rusch, Johannes; Edsman, Lennart & Andersen, Tom [Vis alle 8 forfattere av denne artikkelen] (2019). Can eDNA quantities predict crayfish population density and/or A. astaci prevalence?
• Strand, David; Agersnap, Sune; Rusch, Johannes; Larsen, William Brenner; Knudsen, Steen Wilhelm & Rask Møller, Peter [Vis alle 9 forfattere av denne artikkelen] (2019). Developing the concept of eDNA monitoring of native and invasive freshwater crayfish.
• Källqvist, Torsten; Grung, Merete; Borgå, Katrine; Dirven, Hubert; Eklo, Ole Martin & Lyche, Jan Ludvig [Vis alle 9 forfattere av denne artikkelen] (2019). Risk Assessment of Malakite with the Active Substances Dithianon and Pyrimenthanil. European Journal of Nutrition and Food Safety. ISSN 2347-5641. 9(4). doi: 10.9734/EJNFS/2019/v9i430075.
• Eftestøl, Einar; Psilander, Niklas; Cumming, Kristoffer Toldnes; Juvkam, Inga; Ekblom, Maria M. & Sunding, Kerstin [Vis alle 12 forfattere av denne artikkelen] (2019). Muscle memory: Are myonuclei ever lost? Journal of applied physiology. ISSN 8750-7587. 128(2), s. 456–457. doi: 10.1152/japplphysiol.00761.2019.
• Palsdottir, Albina Hulda & Leifsson, Rúnar (2019). Participant in the podcast ArchaeoAnimals, A Horse, Of Course - Ep 09. [Internett]. ArchaeoAnimals podcast.
• Palsdottir, Albina Hulda & Hallsson, Jón Hallsteinn (2019). Merkilegar rannsóknir á uppruna og sögu tamda hestsins. [Internett]. Hestamennska.
• Palsdottir, Albina Hulda (2019). Hvað er hægt að gera við 340 dýrabeinagrindur? Samanburðarsafn í dýrabeinafornleifafræði við Landbúnaðarháskóla Íslands.
• Palsdottir, Albina Hulda; Nistelberger, Heidi Maria; Star, Bastiaan; Leifsson, Rúnar; Wyrozemska, Agata Teresa & Orlando, Ludovic [Vis alle 9 forfattere av denne artikkelen] (2019). Kyngreining á hrossum úr kumlum með forn-DNA Hestar lagðir í kuml á Íslandi á víkingaöld.
• Palsdottir, Albina Hulda; Star, Bastiaan; Nistelberger, Heidi Maria; Kantanen, Juha; Hallsson, Jón Hallsteinn & Boessenkool, Sanne (2019). Viking sheep of the North Atlantic: Origins & genetic heritage.
• Palsdottir, Albina Hulda; Star, Bastiaan; Nistelberger, Heidi Maria; Kantanen, Juha; Stenseth, Nils Chr. & Hallsson, Jón Hallsteinn [Vis alle 7 forfattere av denne artikkelen] (2019). The Sheep Saga: Archaeogenomics of Viking Age sheep in the North Atlantic.
• Palsdottir, Albina Hulda (2019). Hverjar eru elstu þekktu leifar um ketti á Norðurlöndum? Vísindavefurinn.
• Reiten, Ingrid & Schlegel, Ulrike (2019). HBP Researchers' Data Curation-booklet.
• Andersson, Krister Andreas; Blixhavn, Camilla Hagen; Zehl, Lyuba; Zarfarnia, Sara; Köhnen, Stefan & Hilverling, Anna [Vis alle 19 forfattere av denne artikkelen] (2019). Resources for making neuroscience data FAIR. The Human Brain Project invites researchers to share, find, and use data via the new EBRAINS infrastructure.
• Andersson, Krister Andreas; Blixhavn, Camilla Hagen; Kleven, Heidi; Zehl, Lyuba; Bjerke, Ingvild Elise & Schmid, Oliver [Vis alle 17 forfattere av denne artikkelen] (2019). Neuroinformatics platform for making neuroscience data Findable, Accessible, Interoperable, and Reuseable.
• Andersson, Krister Andreas; Blixhavn, Camilla Hagen; Kleven, Heidi; Schlegel, Ulrike; Oliver, Schmid & Puchades, Maja [Vis alle 10 forfattere av denne artikkelen] (2019). EBRAINS fair data service: A novel infrastructure for making neuroscience data findable, accessible, interoperable, and reuseable.
• Nipen, Maja; Breivik, Knut; Vogt, Rolf David; Borgå, Katrine & Schlabach, Martin (2022). Spatial and temporal trends of anthropogenic pollutants in a tropical, urban environment in east Africa. DUO.
• Rusch, Johannes; Vrålstad, Trude; Strand, David; Andersen, Tom & Hansen, Haakon (2021). Environmental DNA (eDNA) monitoring of two different freshwater host-pathogen complexes in the interface between nature and aquaculture. Universitetsforlaget. ISSN 1501-7710. 7710(2436).
• Kline, Simon Hasselø (2021). A tale of six diatoms: an insight into the taxonomy of Arctic diatoms from different sea-ice communities and their physiological response to climate change. Det matematisk-naturvitenskapelige fakultet, Universitetet i Oslo.
• Rueness, Jan & Nøkling-Eide, Katharina (2021). Bestemmelsesnøkler til norske marine makroalger 3. Grønnalger. Norsk Botanisk Forening.
• Rueness, Jan & Nøkling-Eide, Katharina (2021). Bestemmelsesnøkler til norske marine makroalger 2. Brunalger. Norsk Botanisk Forening.
• Rueness, Jan & Nøkling-Eide, Katharina (2021). Bestemmelsesnøkler til norske marine makroalger 1. Rødalger. Norsk Botanisk Forening.
• Trunk, Thomas; Leo, Jack Christopher & Linke, Dirk (2020). Characterization and comparative analyses of type Vd-secreted phospholipases expressed in pathogenic bacteria. Universitetet i Oslo.
• Grünfeld, Lars Andreas Holm; Bekkby, Trine; Gundersen, Hege; Hancke, Kasper & Fredriksen, Stein (2020). Et taredyrkingsanleggs rolle som kunstig tareskog. Sammenlikning av faunasamfunn mellom dyrket butare (Alaria esculenta) og naturlig tareskog . Universitetet i Oslo. Vis sammendrag

  Med en økende befolkning vil behovet for mat og ferskvann også øke. Det har derfor blitt mer fokus på marine ressurser for å dekke det stadig økende behovet. Produksjon av makroalger, som tang og tare, har lenge vært en ressurs i Asia, men i nyere tid har også Europa tatt del i denne industrien. Det er per i dag lite forskning på hvordan akvakulturer for makroalger vil påvirke det marine miljøet. Denne studien ønsket derfor å se på hvordan et taredyrkingsanlegg i Frøya kommune kunne stille som et habitat for tareassosiert fauna. Studien så på hvilket dyr som ble funnet i taredyrkingsanlegget til Seaweed Energy Solutions (SES), lokalisert på Frøya, og sammenlikne funnene med dyr funnet i naturlig tareskog og åpne vannmasser. SES dyrket sukkertare (Saccharina latissima) og butare (Alaria esculenta) i taredyrkingsanlegget, hvorav denne studien fokuserte på butare. Dyrene funnet fra butaren i taredyrkingsanlegget ble sammenliknet med dyr funnet i naturlig butareskog og naturlig stortareskog som omringet anlegget. Målet med denne studien var å finne ut om et taredyrkingsanlegg kunne ha en rolle som en kunstig tareskog, både i perioden det ble dyrket tare i anlegget (april, 2019) og da anlegget sto tomt for dyrket tare (september, 2019). Studien ville også finne svar på om taredyrkingsanlegget kunne spille en rolle for truede eller invaderende arter. Funnene fra innsamlingene viste at taredyrkingsanlegget fungerte som et habitat for tareassosiert fauna, men representerte et distinkt artssamfunn, sammenliknet med dyrene funnet i naturlig tareskog. Likevel liknet artssammensetningen i april mer den som ble funnet i naturlig stortareskog. I september ble det funnet store mengder av den invaderende spøkelseskrepsen Caprella mutica i taredyrkingsanlegget, men ikke i noen av de naturlige tareskogene. Fra innsamlingen i november ble C. mutica funnet på samtlige av akvakulturene og på flere av bryggene. Disse funne tydet på at taredyrkingsanlegg, og andre akvakulturer, er gunstige habitater for C. mutica og en mulig vektor for videre spredning av arten langs norskekysten. Videre studier trengs for å forstå mer om hvordan makroalgeanlegg vil påvirke det marine miljøet.

• Torstensen, Ragnhild Ryther Grimm; Bekkby, Trine; Gundersen, Hege; Hancke, Kasper & Fredriksen, Stein (2020). Miljøeffekter ved dyrking av sukkertare (Saccharina latissima) Et taredyrkingsanleggs rolle som kunstig habitat. Universitetet i Oslo. Vis sammendrag

  Befolkningsvekst og uforutsigbarhet knyttet til landbasert industri vil medføre økt fokus på marin produksjon. Makroalger kan bli en bærekraftig ressurs blant annet i matindustri, i produksjon av biodrivstoff, og i medisin- og kosmetikkindustri. Interessen for dyrking av makroalger har blitt større også i Norge, og det antas at vi innen 2050 kan produsere så mye som 20 millioner tonn makroalger i året. En så kraftig oppskalering av en marin industri vil kreve kunnskap om både positive og negative effekter som dette kan få på det marine økosystemet. Gjennom prosjektet KELPPRO vil denne studien omhandle den effekten et taredyrkingsanlegg med sukkertare (Saccharina latissima – Linnaeus) kan ha på det marine miljøet. I denne studien vil det bli gjort en vurdering av anleggets potensielle rolle som kunstig habitat, «kunstig tareskog», og hvorvidt samfunnene man finner her gjenspeiler det man finner i naturlig tareskog. I tillegg vil taredyrkingsanleggets rolle som medium for uønskede, truede og sårbare arter blir undersøkt. For å gjennomføre studien ble taredyrkingsanlegget til Seaweed Energy Solutions på Frøya utenfor Trondheim undersøkt. Det ble utført feltarbeid i tre perioder, henholdsvis april, september og november 2019. Det ble satt ut faunafeller og fiskegarn i taredyrkingsanlegget, naturlig sukkertareskog, naturlig stortareskog og i en vannmassekontroll. Dette ble gjort før og etter høstingen av tare i anlegget. I tillegg ble det hentet inn tareplanter fra anlegget og de naturlige tareskogene på våren. Vekstperioden til sukkertaren i anlegget ble undersøkt for å kunne si om den spiller inn på den økologiske funksjonen til anlegget. Resultatene viser at taredyrkingsanlegget har en økologisk funksjon som et kunstig habitat, men samfunnet likner mer på den naturlige stortareskogen som vokste rett rundt anlegget enn den naturlige sukkertareskogen, som lå et stykke unna. Det tomme anlegget hadde stor forekomst av den fremmede arten Caprella mutica (Schurin). Feltarbeidet i november hadde som mål å sammenligne forskjellige kunstige substrater man finner på blant annet lakseoppdrettsanlegg, taredyrkingsanlegg og brygger i området rundt taredyrkingsanlegget for å undersøke forekomsten av C. mutica. Resultatene viser at C. mutica har høyest forekomst i taredyrkingsanlegget, men også høy forekomst på andre akvakulturrekvisitter. Resultatene fra denne studien vil bidra til kunnskap om taredyrkingsanleggs økologiske rolle i det marine miljø. Dette vil være viktig for forvaltningen av industrien, nå, og i en framtid med en potensiell oppskalering av industrien. Dette gjelder både med tanke på hvor man skal plassere et taredyrkingsanlegg og hva slags materialer man bør bruke for å forhindre spredning av fremmede arter.

• Wrobel, Agnieszka & Linke, Dirk (2019). Structural and functional studies of the Yersinia ruckeri inverse autotransporters. Universitetet i Oslo.
• Palsdottir, Albina Hulda (2019). Tooth wear of calf mandibles from the Icelandic ZooArch reference collection. Agricultural University of Iceland. ISSN 978‐9979‐881‐92‐6. 121(121). Vis sammendrag

  This report documents the wear stages of mandibular teeth of the calf skeletons in the Icelandic ZooArch reference collection. The purpose of the data collection is to refine the aging of cattle mandibles from very young animals, as a part of Lena Strid’s PhD project on vellum production and use in Scandinavia in the medieval period. Currently, there are two complete calf (Bos taurus) skeletons in the Icelandic ZooArch reference collections from individuals with known age at death. Both calves are of the Icelandic cattle breed and come from the Agricultural University of Iceland (AUI) Dairy Farm, Hvanneyrarbúið. Full information about each specimen can be found in Table 3.The skeletons were prepared by first being de‐fleshed and then cleaned with water maceration as is the standard preparation method for the IcelandicZooArch reference collection (Pálsdóttir & Skúladóttir, 2016, 2018). Tooth wear was recorded for right and left mandibles from both individual following Grant (1982). The mandibles were also photographed from various angles with a scale

• Palsdottir, Albina Hulda & Smith, Kevin P. (2019). Zooarchaeological analysis of bones from Hallmundarhellir cave. Agricultural University of Iceland. ISSN 978-9979-881-56-8. 85(85).
• Smith, Kevin P.; Ólafsson, Guðmundur; Palsdottir, Albina Hulda & Sigurðsson, Magnús (2019). Hallmundarhellir Cave: Report of Investigations, 2017. . Haffenreffer Museum of Anthropology, Brown University. Vis sammendrag

  Hallmundarhellir is one of eight caves within western Iceland’s Hallmundarhraun lava field that are known to contain archaeological remains. The site was discovered in 1956 by its landowner, Stefán Kalmansson of Kalmanstunga, and was briefly investigated by Gísli Gestsson in 1958. On July 27, 2017 we revisited Hallmundarhellir with a film crew; mapped it; took samples for radiocarbon dating, aDNA analysis, and zooarchaeological evaluation; and re-assessed its condition, its archaeological remains, and Gestsson’s pioneering interpretations. Gestsson’s report, published in 1960, was the only archaeological documentation of this important site before our visit. In the absence of radiocarbon dates or diagnostic objects, he interpreted it as a Viking Age outlaw shelter, and perhaps the model for Hallmundur’s lair in Grettir’s Saga. As such, Hallmundarhellir not only entered the archaeological record as a Viking Age outlaw site but also entered into debates about the historicity of the Íslendingasögur and the ways saga authors framed their scenes. Our investigations documented that the site’s archaeological features and deposits remain intact, but the cave’s walls and ceiling are fragile. Sand blowing in from outwash plains below Langjökull and Eiríksjökull already covers the site’s floor and will choke its entrance soon. We determined that Gestsson’s mapping was accurate but under-estimated the number of archaeological features and the site’s complexity. Our evaluation of the site’s faunal assemblage suggests that it is unusually composed of bones from just sheep or sheep/goats. No horse teeth (mentioned in Gestsson’s report) were identified, nor were any additional artifacts seen or recovered. Five AMS dates on sheep bones from the site indicate that it was built and used during the late-12th through mid-13th century, the so-called Age of the Sturlungs. Our investigations, therefore, indicate that Hallmundarhellir remains in good shape but is endangered. Rather than being a Viking Age outlaw shelter, it represents a new type of site from the Sturlung era.

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