Lucie Claire Lola Gerber
I am part of the convergence environment at the University of Oslo with the aim to increase availability and function of donated organs for transplantation. I study how the crucian carp, one of the champions of anoxia tolerance, reduced its metabolism to prevent anoxic and oxidative damages. My goal is to identify key signalling pathways that can then be targeted to reduce ischemia-reperfusion injuries and inflammation for organ donation.
My research interests centre on how ectotherms cope physiologically with abiotic challenges they face in their environment. I mainly study fishes and insects but I am interested in all species. I have expertise in mitochondrial physiology and nitric oxide signalling and focus on the regulation of central physiological processes (osmoregulation, cardiac function, metabolism and respiration) and how they shape a species’ environmental tolerances/limits. I combine a broad array of tools in molecular and cellular biology (qPCR and Western blotting), physiology (Ussing chamber and everted gut sac), microscopy-based techniques (immunohistochemistry), and respirometry (OROBOROS) to integrate observations at different levels of biological organization. I am also beginning to delve into ‘omics, adding a discovery-driven approach to my repertoire to identify novel physiological targets.
Higher Education and Employment History
- 2020-present: Postdoctoral Researcher, Dept. of Biosciences, Univ. of Oslo, Norway.
- 2018-2020: Postdoctoral Researcher, Dept. of Ocean Sciences, Memorial Univ. of Newfoundland, Canada.
- 2017-2018: Postdoctoral Researcher, Dept. of Zoophysiology, Aarhus Univ., Denmark.
- 2015 (3 months): Visiting Ph.D. Fellow, Dept. of Biology, St. Francis Xavier Univ., Canada
- 2013-2016: Ph.D. Fellow, Dept. of Biology, Univ. of Southern Denmark, Denmark.
- 2011-2013: M.Sc., Biodiversity and Evolution, University of Montpellier II, France.
- 2008-2011: B.Sc., Biology of Organisms, University of Antilles, Guadeloupe.
List of Publications
16. Gerber L, MacSween CE, Staples JF and Gamperl AK. (2022). Cold-Induced Metabolic Depression in Cunner (Tautogolabrus adspersus): A Multifaceted Cellular Event. PLOS ONE 17(8) e0271086. https://doi.org/10.1371/journal.pone.0271086
15. Gerber L, Clow KA, Driedzic RW and Gamperl AK. (2021). The Relationship between Myoglobin, Aerobic Capacity, Nitric Oxide Synthase Activity and Mitochondrial Function in Fish Hearts. Antioxidants 10(7) 1072. https://doi.org/10.3390/antiox10071072
14. Overgaard J, Gerber L and Andersen MK. (2021). Osmoregulatory Capacity at Low Temperature is Critical for Insect Cold Tolerance. Review in Current Opinion in Insect Science 47: 38-45. https://doi.org/10.1016/j.cois.2021.02.015
13. Gerber L, Clow KA, and Gamperl AK. (2021). Acclimation to Warm Temperatures Has Important Implications for Mitochondrial Function in Atlantic Salmon (Salmo salar). J Exp Biol. jeb.236257. https://doi.org/10.1242/jeb.236257
12. Gerber L, Clow KA, Mark FC, and Gamperl AK. (2020). Improved Mitochondrial Function in Salmon (Salmo salar) Following High Temperatures Acclimation Suggest that there are Cracks in the Proverbial 'Ceiling'. Scientific Reports 10:21636. https://doi.org/10.1038/s41598-020-78519-4
11. Gerber L, Kresse JC, Simek P, Berková P and Overgaard J. (2020). Cold Acclimation Preserves Hindgut Reabsorption Capacity at Low Temperature in a Chill-Susceptible Insect, Locusta migratoria. J Comp Biochem Physiol Part A 252, 110850. https://doi.org/10.1016/j.cbpa.2020.110850
10. Gerber L, Clow KA, Katan T, Emam M, Leeuwis RHJ, Parrish CC and Gamperl AK (2019). Cardiac Mitochondrial Function, Nitric Oxide Sensitivity and Lipid Composition Following Hypoxia Acclimation in Sablefish. J Exp Biol. jeb.208074. https://doi.org/10.1242/jeb.208074
9. Ravn MV, Campbell JB, Gerber L, Harrison JF and Overgaard J (2019). Effects of Anoxia on ATP, Water, Ion and pH Balance in an insect (Locusta migratoria). J Exp Biol. jeb.190850 https://doi.org/10.1242/jeb.190850
8. Gerber L and Overgaard J (2018). Cold Tolerance is Linked to Osmoregulatory Function of the Hindgut in Locusta migratoria. J Exp Biol. jeb.173930. https://doi.org/10.1242/jeb.173930
7. Gerber L, Jensen FB and Madsen SS (2018). Dynamic Changes in Nitric Oxide Synthases Expression are Involved in Seawater-Acclimation of Rainbow Trout, Oncorhynchus mykiss. Am J Physiol Regul Integr Comp Physiol 314: R552–R562. https://doi.org/10.1152/ajpregu.00519.2016
6. Gerber L, Madsen SS and Jensen FB (2017). Cortisol Regulates Nitric Oxide Synthase in Freshwater and Seawater-Acclimated Rainbow Trout, Oncorhynchus mykiss. Comp Physiol Biochem Part A 204: 1-8. https://doi.org/10.1016/j.cbpa.2016.11.002
5. Tait JC, Mercer EW, Gerber L, Robertson GN and Marshall WS (2017). Osmotic versus Adrenergic Control of Ion Transport by Ionocytes of Fundulus heteroclitus in the Cold. Comp Physiol Biochem Part A 203: 255-261. https://doi.org/10.1016/j.cbpa.2016.10.003
4. Gerber L, Jensen FB, Madsen SS and Marshall WS (2016). Nitric Oxide Inhibition of NaCl Secretion in the Opercular Epithelium of Seawater-Acclimated Killifish, Fundulus heteroclitus. J Exp Biol. 219, 3455-3464. https://doi.org/10.1242/jeb.145045
3. Gerber L, Lee CE, Grousset E, Blondeau‐Bidet E, Boucheker NB, Lorin‐Nebel C, Charmantier‐Daures M, Charmantier G (2016). The Legs Have It: In Situ Expression of Ion Transporters V‐Type H+‐ATPase and Na+/K+‐ATPase in the Osmoregulatory Leg Organs of the Invading Copepod Eurytemora affinis. Physiol Biochem Zool 89: 233 –250. https://doi.org/10.1086/686323
2. Hansen MN, Gerber L, Jensen FB (2016). Nitric Oxide Availability in Deeply Hypoxic Crucian Carp: Acute and Chronic Changes and Utilization of Ambient Nitrite Reservoirs. Am J Physiol Regul Integr Comp Physiol 310: 532–540. https://doi.org/10.1152/ajpregu.00515.2015
1. Jensen FB, Gerber L, Hansen MN, Madsen SS (2015). Metabolic Fates and Effects of Nitrite in Brown Trout under Normoxic and Hypoxic Conditions: Blood and Tissue Nitrite Metabolism and Interactions with Branchial NOS, Na+/K+-ATPase and hsp70 Expression. J Exp Biol 218: 2015–2022. https://doi.org/10.1242/jeb.120394
Fant ingen resultater i Cristin