Xia Sheng

• Zhang, Tingting; Zhao, Faming; Lin, Yahang; Liu, Mingsheng; Zhou, Hongqing & Cui, Fengzhen [Vis alle 9 forfattere av denne artikkelen] (2024). Integrated analysis of single-cell and bulk transcriptomics develops a robust neuroendocrine cell-intrinsic signature to predict prostate cancer progression. Theranostics. ISSN 1838-7640. 14(3), s. 1065–1080. doi: 10.7150/thno.92336.
• Xiao, Rourou; You, Lixin; Zhang, Li; Guo, Xichen; Guo, Ensong & Zhao, Faming [Vis alle 29 forfattere av denne artikkelen] (2022). Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer. Advanced Science. ISSN 2198-3844. 9(21). doi: 10.1002/advs.202105469. Fulltekst i vitenarkiv
• Wang, Gan; Zhang, Min; Meng, Ping; Long, Chengbo; Luo, Xiaodong & Yang, Xingwei [Vis alle 22 forfattere av denne artikkelen] (2022). Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis. Acta Pharmaceutica Sinica B (APSB). ISSN 2211-3835. 12(5), s. 2268–2279. doi: 10.1016/j.apsb.2021.12.024. Fulltekst i vitenarkiv
• Zhang, Tingting; Li, Ningning; Sun, Chaoyang; Jin, Yang & Sheng, Xia (2020). MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? EMBO Molecular Medicine. ISSN 1757-4676. 12(5), s. 1–12. doi: 10.15252/emmm.201911845.
• Wang, Yu; Wang, Kai; Jin, Yang & Sheng, Xia (2019). Endoplasmic reticulum proteostasis control and gastric cancer. Cancer Letters. ISSN 0304-3835. 449, s. 263–271. doi: 10.1016/j.canlet.2019.01.034.
• Sheng, Xia; Nenseth, Hatice Zeynep; Qu, Su; Kuzu, Ömer Faruk; Frahnow, Turid & Simon, Lukas [Vis alle 16 forfattere av denne artikkelen] (2019). IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nature Communications. ISSN 2041-1723. 10:323, s. 1–12. doi: 10.1038/s41467-018-08152-3. Fulltekst i vitenarkiv
• Wang, Yu; Wang, Ziyi; Yu, Wenyang; Sheng, Xia; Zhang, Haolin & Han, Yingying [Vis alle 8 forfattere av denne artikkelen] (2018). Seasonal expressions of androgen receptor, estrogen receptors and cytochrome P450 aromatase in the uteri of the wild daurian ground squirrels (Spermophilus dauricus). European journal of histochemistry. ISSN 1121-760X. 62(1), s. 75–82. doi: 10.4081/ejh.2018.2889.
• Winje, Ivan; Sheng, Xia; Hansson, Kenth-Arne; Solbrå, Andreas Våvang; Tennøe, Simen & Saatcioglu, Fahri [Vis alle 8 forfattere av denne artikkelen] (2018). Cachexia does not induce loss of myonuclei or muscle fibres during xenografted prostate cancer in mice. Acta Physiologica. ISSN 1748-1708. s. 1–9. doi: 10.1111/apha.13204.
• Zhang, Fengwei; Liu, Qian; Wang, Ziyi; Xie, Wenqian; Sheng, Xia & Zhang, Haolin [Vis alle 9 forfattere av denne artikkelen] (2017). Seasonal Expression of Oxytocin and Oxytocin Receptor in the Scented Gland of Male Muskrat (Ondatra zibethicus). Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-16973-3.
• Wang, Junjie; Wang, Ying; Zhu, Manyu; Zhang, Fengwei; Sheng, Xia & Zhang, Haolin [Vis alle 9 forfattere av denne artikkelen] (2017). Seasonal expression of luteinizing hormone receptor and follicle stimulating hormone receptor in testes of the wild ground squirrels (Citellus dauricus Brandt). Acta Histochemica. ISSN 0065-1281. 119(7), s. 727–732. doi: 10.1016/j.acthis.2017.09.004.
• Zhang, Fengwei; Wang, Yu; Han, Wentao; Wang, Junjie; Zhang, Haolin & Sheng, Xia [Vis alle 9 forfattere av denne artikkelen] (2017). Seasonal changes of androgen receptor, estrogen receptors and aromatase expression in the hippocampus of the wild male ground squirrels (Citellus dauricus Brandt). General and Comparative Endocrinology. ISSN 0016-6480. 249, s. 93–100. doi: 10.1016/j.ygcen.2017.05.009.
• Xi, Liqin; Liu, Yuning; Tang, Zeqi; Sheng, Xia; Zhang, Haolin & Weng, Qiang [Vis alle 7 forfattere av denne artikkelen] (2017). Expression of leptin receptor in the oviduct of Chinese brown frog (Rana dybowskii). American Journal of Physiology. Regulatory Integrative and Comparative Physiology. ISSN 0363-6119. 312(6), s. R912–R918. doi: 10.1152/ajpregu.00020.2017.
• Urbanucci, Alfonso; Barfeld, Stefan Jörg; Kytölä, Ville; Itkonen, Harri; Coleman, Ilsa M. & Vodák, Daniel [Vis alle 34 forfattere av denne artikkelen] (2017). Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer. Cell reports. ISSN 2211-1247. 19(10), s. 2045–2059. doi: 10.1016/j.celrep.2017.05.049. Fulltekst i vitenarkiv
• Zhou, Jiao; Li, Juan; Wang, Rong; Sheng, Xia; Zong, Shixiang & Weng, Qiang [Vis alle 7 forfattere av denne artikkelen] (2016). Ecdysteroid titers and expression of Halloween genes and ecdysteroid receptor in relation to overwintering and the long larval phase in the seabuckthorn carpenterworm, Holcocerus hippophaecolus. Entomologia Experimentalis et Applicata. ISSN 0013-8703. 160(2), s. 133–146. doi: 10.1111/eea.12472.
• Sikkeland, Jørgen; Sheng, Xia; Jin, Yang & Saatcioglu, Fahri (2016). STAMPing at the crossroads of normal physiology and disease states. Molecular and Cellular Endocrinology. ISSN 0303-7207. 425, s. 26–36. doi: 10.1016/j.mce.2016.02.013.
• Storm, Margrethe Larsdatter; Sheng, Xia; Arnoldussen, Yke Jildouw & Saatcioglu, Fahri (2016). Prostate cancer and the unfolded protein response. OncoTarget. ISSN 1949-2553. 7(33), s. 54051–54066. doi: 10.18632/oncotarget.9912. Fulltekst i vitenarkiv Vis sammendrag

  The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells. Accumulation of misfolded proteins and failure of ER adaptive capacity activates the unfolded protein response (UPR) which has been implicated in several chronic diseases, including cancer. A number of recent studies have implicated UPR in prostate cancer (PCa) and greatly expanded our understanding of this key stress signaling pathway and its regulation in PCa. Here we summarize these developments and discuss their potential therapeutic implications.

• Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe Larsdatter; Tesikova, Martina; Nenseth, Hatice Zeynep & Zhao, Sen [Vis alle 15 forfattere av denne artikkelen] (2015). Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Molecular Medicine. ISSN 1757-4676. 7(6), s. 788–801. doi: 10.15252/emmm.201404509. Fulltekst i vitenarkiv Vis sammendrag

  The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As androgens regulate secretion and development of the normal prostate and drive prostate cancer (PCa) growth, they may affect UPR pathways. Here, we show that the canonical UPR pathways are directly and divergently regulated by androgens in PCa cells, through the androgen receptor (AR), which is critical for PCa survival. AR bound to gene regulatory sites and activated the IRE1α branch, but simultaneously inhibited PERK signaling. Inhibition of the IRE1α arm profoundly reduced PCa cell growth in vitro as well as tumor formation in preclinical models of PCa in vivo. Consistently, AR and UPR gene expression were correlated in human PCa, and spliced XBP‐1 expression was significantly upregulated in cancer compared with normal prostate. These data establish a genetic switch orchestrated by AR that divergently regulates the UPR pathways and suggest that targeting IRE1α signaling may have therapeutic utility in PCa.

• Jin, Yang; Ling, Wang; Qu, Su; Sheng, Xia; Kristian, Alexandr & Mælandsmo, Gunhild [Vis alle 20 forfattere av denne artikkelen] (2015). STAMP2 increases oxidative stress and is critical for prostate cancer. EMBO Molecular Medicine. ISSN 1757-4676. 7(3), s. 315–331. doi: 10.15252/emmm.201404181. Fulltekst i vitenarkiv
• Li, Juan; Zhou, Jiao; Sun, Rongbo; Zhang, Haolin; Zong, Shixiang & Luo, Youqing [Vis alle 8 forfattere av denne artikkelen] (2013). cDNA CLONING AND SEQUENCE DETERMINATION OF THE PHEROMONE BIOSYNTHESIS ACTIVATING NEUROPEPTIDE FROM THE SEABUCKTHORN CARPENTERWORM, Holcocerus hippophaecolus (LEPIDOPTERA: COSSIDAE). Archives of Insect Biochemistry and Physiology. ISSN 0739-4462. 82(4), s. 183–195. doi: 10.1002/arch.21084.

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