Research interests

My group uses X-ray crystallography in combination with other structural biology techniques to determine the molecular structures of proteins to atomic resolution. The main focus of my research is on proteins of medical interest and in particular on enzymes and protein-carbohydrate interactions.

While DNA and RNA are the universal intra-cellular information carriers, protein-carbohydrate interactions are the language of choice for inter-cellular communication. Recognition of complex carbohydrates lies at the heart of many important biological processes such as protein targeting to cellular compartments, immune response, and host-pathogen interactions. However, our understanding of this glycocode is finally beginning to unfold.

My work involves the close collaboration with research groups of different specializations (e.g., biochemists, molecular modelers, bioinformaticiens, and experts in NMR spectroscopy, cryo-EM and mass spectrometry), thus warranting that the structural characterization of the chosen research targets are pursued in a broader context. This work has the potential to lead to the development of new treatments against severe human diseases, including infectious diseases and cancer.

Ongoing projects


Bacterial toxins

Anti-tumor Antibodies

Chorismate mutase

Published Dec. 28, 2010 12:07 PM - Last modified Mar. 22, 2022 9:48 AM