Due to the success of messenger RNA (mRNA) based COVID-19 vaccines, mRNA as a therapeutic molecule and lipid nanoparticles (LNPs) as delivery systems have gained great attention in the community.
The first department seminar of 2023
The seminar will be held by Heinrich Haas, Vice President RNA Formulation & Drug Delivery at BioNTech RNA Pharmaceuticals. Their vision is to harness the power of the immune system to develop novel therapies against cancer and infectious diseases.
For all and served with coffee and cake
All department seminar are open for all. The seminars are particularly interesting for student and academic staff.
All seminars starts in the cantina with coffee and cakes before the presentation.
Abstract of today's seminar
Due to the success of messenger RNA (mRNA) based COVID-19 vaccines, mRNA as a therapeutic molecule and lipid nanoparticles (LNPs) as delivery systems have gained great attention in the community.
mRNA is of interest also for several other applications, including, but not limited to, tumor therapy or protein replacement. Several products, many of them in the field of cancer therapeutics, are currently in clinical development. For all applications, tailored delivery systems are required, which may be based on lipids, polymers, peptides or inorganic nanoparticles.
Current RNA delivery systems typically consist of lipid nanoparticle formulations as obtained by self-assembly processes between the negatively charged RNA and lipid mixtures comprising positively charged (ionizable) lipids. Thorough investigation of structural and functional coherencies inside these systems can provide a valuable basis for rational development towards clinical products.
In this presentation, key characteristics of selected RNA nanoparticle formats are described. Taking lipid based nanoparticles as an example, steps for translating RNA nanomedicines from basic research into clinical trials are outlined.
Book a meeting with Heinrich Haas
Heinrich Haas will spend the whole day at Department of Chemistry. To book a meeting, please contact Reidar Lund at Department of Chemistry.