Siste publikasjoner

• Rognan, Stine; Kälvemark Sporrong, Sofia; Bengtsson, Kajsa; Lie, Helene Berg; Andersson, Yvonne; Mowe, Morten & Mathiesen, Liv (2021). Discharge processes and medicines communication from the patient perspective: A qualitative study at an internal medicines ward in Norway. Health Expectations.  ISSN 1369-6513. . doi: 10.1111/hex.13232 Fulltekst i vitenarkiv.
• Zou, Yuan-Feng; Zhang, Yan-Yun; Zhu, Zhong-Kai; Fu, Yu-Ping; Paulsen, Berit Smestad; Huang, Chao; Feng, Bin; Li, Li-Xia; Chen, Xing-Fu; Jia, Ren-Yong; Song, Xu; He, Chang-Liang; Yin, Li-Zi; Ye, Gang; Lv, Cheng & Yin, Zhong-Qiong (2021). Characterization of inulin-type fructans from two species of Radix Codonopsis and their oxidative defense activation and prebiotic activities. Journal of the Science of Food and Agriculture.  ISSN 0022-5142.  101(6), s 2491- 2499 . doi: 10.1002/jsfa.10875
• Bergan, Stein; Brunet, Mercé; Hesselink, Dennis A.; Johnson-Davis, Kamisha L; Kunicki, Pawel K; Lemaitre, Florian; Marquet, Pierre; Molinaro, Mariadelfina; Noceti, Ofelia; Pattanaik, T; Pawinski, Tomasz; Seger, Christoph; Shipkova, Maria; Swen, JJ; van Gelder, Teun; Venkataramanan, Raman; Wieland, Eberhard; Woillard, Jean-Baptiste; Zwart, TC; Barten, MJ; Budde, Klemens; Dieterlen, Maja-Theresa; Elens, Laure; Haufroid, Vincent; Masuda, S.; Millan, Olga; Mizuno, T.; Moes, Dirk Jan A.R.; Oellerich, Michael; Picard, N.; Salzmann, L; Tönshoff, Burkhard; Van schaik, Ron H.N.; Vethe, Nils Tore; Vinks, Alexander A; Wallemacq, Pierre; Åsberg, Anders & Langman, Loralie (2021). Mycophenolate Personalized Therapy: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic Drug Monitoring.  ISSN 0163-4356.  43(2), s 150- 200 . doi: 10.1097/FTD.0000000000000871
• Rajula, Hema Sekhar Reddy; Manchia, Mirko; Agarwal, Kratika; Akingbuwa, Wonuola A.; Allegrini, Andrea G.; Diemer, Elizabeth; Doering, Sabrina; Haan, Elis; Jami, Eshim S.; Karhunen, Ville; Leone, Marica; Schellhas, Laura; Thompson, Ashley; Van den Berg, Stéphanie M.; Bergen, Sarah E.; Kuja-Halkola, Ralf; Hammerschlag, Anke R.; Järvelin, Marjo-Riitta; Leval, Amy; Lichtenstein, Paul; Lundstrom, Sebastian; Mauri, Matteo; Munafò, Marcus R.; Myers, David; Plomin, Robert; Rimfeld, Kaili; Tiemeier, Henning; Ystrøm, Eivind; Fanos, Vassilios; Bartels, Meike & Middeldorp, Christel M. (2021). Overview of CAPICE-Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe-an EU Marie Skłodowska-Curie International Training Network. European Child and Adolescent Psychiatry.  ISSN 1018-8827.  s 1- 11 . doi: 10.1007/s00787-020-01713-2 Fulltekst i vitenarkiv.
• Jøsendal, Anette Vik & Bergmo, Trine Strand (2021). From Paper to E-Prescribing of Multidose Drug Dispensing: A Qualitative Study of Workflow in a Community Care Setting. Pharmacy.  ISSN 2226-4787.  9(1), s 1- 12 . doi: 10.3390/pharmacy9010041
• Tveito, Marit; Høiseth, Gudrun; Haslemo, Tore; Molden, Espen & Smith, Robert Løvsletten (2021). Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations—an observational study using blood samples from 1223 patients. European Journal of Clinical Pharmacology.  ISSN 0031-6970. . doi: 10.1007/s00228-021-03114-z Vis sammendrag

  Purpose Paliperidone palmitate is an antipsychotic medication available as long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age and gender on paliperidone exposure after administration of LAI formulations. Methods Data on serum concentrations of paliperidone from patients using LAI during were included retrospectively from a therapeutic drug monitoring (TDM) service. Information about dose was obtained from the requisition forms. As a measure of exposure, daily dose-adjusted serum concentration (C/D ratio) was used. Based on initial analysis of C/D ratios versus age, a breaking point close to 50 years was observed, thus deciding the grouping of patients as older (≥50 years) or younger (15–49 years). Linear mixed model analyses, allowing multiple measurements per patients, were used. Results In total, 1223 patients were included, whereof 1158 patients used paliperidone LAI in once-monthly intervals. In these patients (27.9% older), older patients had significantly higher paliperidone C/D ratio than younger patients (+20%, p<0.001). Compared to males, females had higher C/D ratio (+14%; p<0.001). Subsequently, older female users of once-monthly LAI intervals had 41% higher paliperidone C/D ratios compared to younger males (15.0 vs. 21.2 nM/mg; p<0.001). Compared to females aged 21–30 years, females with high age (≥70 years) had at least 105% higher paliperidone C/D ratio (p<0.001). Conclusion The present study shows that older age and female gender are associated with higher paliperidone exposure than younger age and males, respectively. Particularly, older female patients (>50 years) are likely exposed to high concentration and cautious dosing in this subgroup is required.

• Zou, Yuan-Feng; Chen, Mengsi; Fu, Yu-Ping; Zhu, Zhong-Kai; Zhang, Yan-Yun; Paulsen, Berit Smestad; Rise, Frode; Chen, Yu-Long; Yang, Yong-Zhi; Li, Li-Xia; Song, Xu; Tang, Hua-Qiao; Feng, Bin; Lv, Cheng; Ye, Gang; Wu, Ding-Tao; Yin, Zhong-Qiong & Huang, Chao (2021). Characterization of an antioxidant pectic polysaccharide from Platycodon grandiflorus. International Journal of Biological Macromolecules.  ISSN 0141-8130.  175, s 473- 480 . doi: 10.1016/j.ijbiomac.2021.02.041
• Blix, Hege Salvesen & Høye, Sigurd (2021). Bruk av antibiotika under covid-19-pandemien. Tidsskrift for Den norske legeforening.  ISSN 0029-2001. . doi: 10.4045/tidsskr.20.1003 Fulltekst i vitenarkiv.
• Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Fjeld, Katrine Gahre; Hove, Lene Hystad; Malterud, Karl Egil; Saghaug, Elisabeth; Slaaen, Joran; Sundal, Tone; Tollisen, Anita & Lerdal, Anners (2021). A mouth rinse based on a tea solution of Salvia officinalis for oral discomfort in palliative cancer care: A randomized controlled trial. Supportive Care in Cancer.  ISSN 0941-4355. . doi: 10.1007/s00520-021-06021-2 Fulltekst i vitenarkiv. Vis sammendrag

  Background: Few clinical studies evaluate interventions to reduce oral discomfort among patients in palliative care. Aim: This study examines the efficacy of a Salvia officinalis (SO) based herbal mouth rinse compared to conventional normal saline (NS) in order to improve oral health. Design: A block-randomized controlled trial. Data were collected before and after a 4-day intervention with either SO (n=44) or NS (n=44). Numerical rating scales (NRS, 0-10) and 12 items from the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Oral Health 17 (EORTC QLQ-OH17) measured patient-reported oral symptoms. An oral examination was performed before and after the intervention. Setting/participants: This study included adult patients with late-stage cancer in an inpatient hospice unit. Results: Of the 88 patients included (mean age=63.9 years, SD=10.6), 73 (83%) completed the study. At baseline, 78% reported dry mouth on the EORTC QLQ-OH17, and 80% rated dry mouth ≥4 on the NRS. Total oral health scores based on the 12 EORTC QLQ-OH17 items improved similarly in both groups (p

• Santhosh Kumar, JU; Ramakrishan, Mani; Gopalakrishnan Saroja, Seethapathy; Krishna, V; Shaanker, R.U. & Ravikanth, G (2020). DNA barcoding of Momordica species and assessment of adulteration in Momordica herbal products, an anti-diabetic drug. Plant Gene.  22 . doi: 10.1016/j.plgene.2020.100227
• Jerjes, Waseem; Theodossiou, Theodossis; Hirschberg, Henry; Høgset, Anders; Weyergang, Anette; Selbo, Pål Kristian; Hamdoon, Zaid; Hopper, Colin & Berg, Kristian (2020). Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research. Journal of Clinical Medicine.  ISSN 2077-0383.  9(2) . doi: 10.3390/jcm9020528
• Vallee, Jennifer; Wong, Yih; Mannino, Eline; Nordeng, Hedvig Marie Egeland & Lupattelli, Angela (2020). Association between Antidepressant Treatment during Pregnancy and Postpartum Self-Harm Ideation in Women with Psychiatric Disorders: A Cross-Sectional, Multinational Study. International Journal of Environmental Research and Public Health (IJERPH).  ISSN 1661-7827.  18(1), s 1- 15 . doi: 10.3390/ijerph18010046 Fulltekst i vitenarkiv.
• Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman Ul-Haq; Muriq, Hysen; Fosshaug, Linn Elisabeth Lillerud; Spigset, Olav & Øie, Erik (2020). Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  76, s 673- 683 . doi: 10.1007/s00228-020-02832-0 Fulltekst i vitenarkiv. Vis sammendrag

  Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the impact of CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction (MI). Methods We included 136 patients with MI discharged on treatment with metoprolol with a recommendation to the general practitioner (GP) to increase the metoprolol dose up to 200 mg/day within 2 months if possible. At follow-up, metoprolol dosage after up-titration, metoprolol steady-state trough plasma concentrations, hemodynamic parameters, potential metoprolol-induced adverse drug reactions and number of visits to the GP were measured. CYP2D6 genotyping including the reduced-function variant alleles CYP2D6*9, CYP2D6*10 and CYP2D6*41 was performed after end of follow-up. Results According to the genotype-defined CYP2D6 phenotypes, 30% of the patients were metoprolol extensive metabolizers (EMs), 55% intermediate metabolizers (IMs) and 13% poor metabolizers (PMs; carriers of non-coding and reduced-function variant included). Dose-adjusted metoprolol trough concentrations were significantly higher in IM (2-fold) and PM (6.2-fold) groups vs. the EM group (p < 0.001). Only 35% of patients in the PM group achieved the primary end point, i.e. reaching at least 85% of the expected maximum heart rate (HR) during exercise, compared with 78% in the EM group (p < 0.01), and maximum observed HR at exercise was significantly lower in the PM group vs. the EM group (129 ± 5 vs. 142 ± 2 bpm, p < 0.007). In contrast, metoprolol maintenance dose, blood pressure, exercise capacity, number of visits at the GP and frequency and severity of self-reported potential metoprolol-related adverse drug reactions were not significantly different between the groups. Conclusion Using a comprehensive CYP2D6 genotyping panel, the present study demonstrates a > 6-fold increase of dose-adjusted plasma metoprolol trough concentration in CYP2D6 PMs vs. EMs with a parallel lower increase in achieved maximum HR during exercise but without association between genotype and frequency or severity of self-reported adverse drug effects. This may indicate that CYP2D6 PMs potentially could benefit of the increased plasma concentration per dose in a naturalistic setting.

• Lea, Marianne; Mowe, Morten; Molden, Espen; Kvernrød, Kristin; Skovlund, Eva & Mathiesen, Liv (2020). Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial. BMJ Open.  ISSN 2044-6055.  10 . doi: 10.1136/bmjopen-2020-041558 Fulltekst i vitenarkiv.
• Eig, Ruth Davey; Harbin, Nicolay Jonassen; Gjelstad, Svein; Høye, Sigurd; Jensen, Siri; Lindbæk, Morten & Blix, Hege Salvesen (2020). RASK – Promoting appropriate use of antibiotics in municipal healthcare institutions, In Gunnar Skov Simonsen; Hege Salvesen Blix; Kari Grave & Anne Margrete Urdahl (ed.),  NORM/NORM-vet 2019. Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway.  NORM/NORM-VET.  Kapittel.  s 42 - 43
• Harbin, Nicolay Jonassen; Eig, Ruth Davey; Høye, Sigurd; Gjelstad, Svein; Jensen, Siri; Lindbæk, Morten & Blix, Hege Salvesen (2020). Antibiotic use in nursing homes, In Gunnar Skov Simonsen; Hege Salvesen Blix; Kari Grave & Anne Margrete Urdahl (ed.),  NORM/NORM-vet 2019. Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway.  NORM/NORM-VET.  Kapittel.  s 42 - 42
• Høye, Sigurd; Lindbæk, Morten & Blix, Hege Salvesen (2020). RAK – Promoting appropriate use of antibiotics among general practitioners, In Gunnar Skov Simonsen; Hege Salvesen Blix; Kari Grave & Anne Margrete Urdahl (ed.),  NORM/NORM-vet 2019. Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway.  NORM/NORM-VET.  Kapittel.  s 40 - 41

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• Balaban, Gabriel; Grytten, Ivar; Rand, Knut Dagestad; Scheffer, Lonneke & Sandve, Geir Kjetil (2021). Ten simple rules for quick and dirty scientific programming. PLoS Computational Biology.  ISSN 1553-734X.  17:e1008549(3), s 1- 15 . doi: 10.1371/journal.pcbi.1008549
• Hurum, Jørn Harald & Helleve, Torstein (2020). Livsfarlig leksikon - andre foredrag.
• Hurum, Jørn Harald & Helleve, Torstein (2020). Livsfarlig leksikon - første foredrag.

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