Siste publikasjoner

• Rognan, Stine Eidhammer; Lie, Helene Berg; Sporrong, Sofia Kälvemark; Bengtsson, Kajsa Rebecka; Andersson, Yvonne & Mathiesen, Liv (2026). What Do Patients with Long-Term Conditions Disclose About Medication Adherence During and After Hospital Discharge? A Qualitative Study at an Internal Medicines Ward in Norway. Patient Preference and Adherence. 20. doi: 10.2147/PPA.S615812. Fulltekst i vitenarkiv
• Weldemichael, Tsigereda; Khan, Md. Abdul Hye; Adams, Yahaya; Mishra, Abhishek; Goorani, Samaneh & Vik, Anders [Vis alle 8 forfattere av denne artikkelen] (2026). 8,9-EET analogs protect glomerular cells from doxorubicin-induced toxicity. Frontiers in Pharmacology. 17. doi: 10.3389/fphar.2026.1913312. Fulltekst i vitenarkiv Vis sammendrag

  Introduction Doxorubicin (DOX) is an anthracycline chemotherapeutic whose clinical utility is limited by dose-dependent nephrotoxicity that contributes to acute and chronic kidney injury. Podocytes are essential components of the glomerular filtration barrier and are particularly vulnerable to DOX-induced oxidative stress, cytoskeletal disruption, loss of adhesion, and apoptosis. Therapeutic strategies that protect podocytes without compromising anticancer efficacy therefore represent an important unmet need. This study investigated the protective mechanisms and translational potential of 8,9-epoxyeicosatrienoic acid (8,9-EET) analogs against DOX-induced podocyte injury. Methods Nineteen 8,9-EET analogs were screened in cultured podocytes exposed to DOX. Protective effects were evaluated by assessing cell viability, caspase-3/7 activation, reactive oxygen species (ROS) generation, and focal adhesion integrity using confocal immunofluorescence analysis of vinculin. Selected analogs were also evaluated in DU145 prostate cancer and HCC1806 breast cancer cells to determine whether podocyte protection altered the anticancer activity of DOX. Results and Discussion Several 8,9-EET analogs significantly improved podocyte viability and attenuated DOX-induced apoptosis, as demonstrated by reduced caspase-3/7 activation. DOX markedly disrupted focal adhesion complexes, decreasing vinculin number and area, whereas co-treatment with selected analogs preserved vinculin-associated focal adhesion integrity. Effective analogs also significantly reduced DOX-induced ROS generation, consistent with attenuation of oxidative stress. Importantly, selected analogs protected podocytes without compromising DOX anticancer activity in either DU145 or HCC1806 cells, supporting separation of renoprotective effects from the desired cytotoxic action of DOX. These findings identify selected 8,9-EET analogs as promising podocyte-protective agents against DOX-induced injury. Their protective effects were associated with reduced oxidative stress and apoptosis and preservation of focal adhesion architecture, suggesting coordinated maintenance of podocyte structural integrity and survival. Preservation of DOX anticancer activity in prostate and breast cancer cells further supports the translational potential of these compounds as adjunctive therapies during anthracycline chemotherapy. Collectively, targeting epoxy lipid signaling with 8,9-EET analogs may provide a strategy to limit chemotherapy-associated podocyte injury and preserve renal function without diminishing antitumor efficacy. These results support preclinical evaluation of lead analogs, including their pharmacological properties, renal protective efficacy, and therapeutic compatibility with DOX in relevant models. These findings warrant defining efficacy, safety, dosing, and translational feasibility in vivo .

• Gram, Erika B.; Lund, Lars Christian; Jensen, Peter Bjødstrup; Hallas, Jesper; Bliddal, Mette & Lambourne, Anne Broe [Vis alle 11 forfattere av denne artikkelen] (2026). Prescription Use of Paracetamol During Pregnancy and Risk of Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in Early Childhood. Journal of the American Academy of Child and Adolescent Psychiatry. ISSN 0890-8567. doi: 10.1016/j.jaac.2026.08.012.
• Alcalde-Herraiz, Marta; Delmestri, Antonella; Omulo, Hezekiah; Bräuner, Elvira; Bruun, Susanne & Norris, Raeleesha [Vis alle 26 forfattere av denne artikkelen] (2026). Characterizing clinically recognized hypertrophic cardiomyopathy in six European countries using real-world data. ESC Heart Failure. 13(5). doi: 10.1093/eschf/xvag218. Fulltekst i vitenarkiv
• Ievglevskyi, Oleksandr; Zosen, Denis; Osete, Jordi Requena; Glover, Joel Clinton; Paulsen, Ragnhild Elisabeth Heimtun & Djurovic, Srdjan [Vis alle 7 forfattere av denne artikkelen] (2026). Human iPSC-Derived Spinal Cord Organoids – The First Electrophysiological Assessment of Neuronal Maturation. ACS Chemical Neuroscience. 17(16), s. 3048–3057. doi: 10.1021/acschemneuro.5c00823. Fulltekst i vitenarkiv Vis sammendrag

  Abstract The spinal cord exhibits a complex cytoarchitecture and neuronal circuitry organization that challenges in vitro replication of its functional integrity. Here we employed a previously published protocol to generate spinal cord organoids (SCOs) from human-induced pluripotent stem cells (hiPSCs). We characterized phenotypic changes in functional neuronal properties in SCO neurons at early developmental stages (15–32 days in culture) using a quantitative electrophysiological approach. Using the whole-cell patch-clamp technique to evaluate electrophysiological properties, we found that SCO neurons exhibited progressive maturation, as evidenced by hyperpolarized resting membrane potentials, increased inward current amplitude, refined action potential kinetics, and the early emergence of mature-type firing patterns. In particular, we show that the spike frequency adaptation phenomenon, which prevails in motor neurons, appears at early stages of SCO neuron development. Immunohistochemical assessment confirmed the expression of key transcription factors in motor neurons (ISLET1 and HB9) and immature spinal interneurons (LHX1/5 and PAX2). Collectively, our findings demonstrate that neurons in hiPSC-derived SCOs exhibit physiological differentiation, which is important for using SCOs to investigate human spinal cord development and advance translational research in CNS disorders and cell replacement therapies.

• Nguyen, Anna Thu Hoai; Petersen, Nickolaj J.; Wilson, Steven Ray Haakon; Skottvoll, Frøydis Sved; Hansen, Frederik Andre & Pedersen-Bjergaard, Stig [Vis alle 7 forfattere av denne artikkelen] (2026). Electromembrane extraction of basic pharmaceuticals from biological matrices using a micro-pillar stabilized liquid membrane. Advances in Sample Preparation. 20. doi: 10.1016/j.sampre.2026.100251. Fulltekst i vitenarkiv Vis sammendrag

  In this work, a reusable microfluidic device for electromembrane extraction (EME) was fabricated from stoichiometric thiol-ene and evaluated for the extraction of a large set of pharmaceuticals across a broad polarity range and from urine and saliva samples. The device featured micro-pillar arrays for stabilization and straightforward renewal of the liquid membrane, enabling repeated use of the same microchip. The thiol-ene material provided a suitable balance of hydrophobic and hydrophilic properties, allowing controlled handling of both aqueous solutions and organic liquid membranes. Extractions were performed at sample and acceptor flow rates of 2.0 µL/min, an extraction potential of 2.0 V, and an extraction time of 10 minutes, using liquid membranes of different polarity. In total, the system was evaluated for the extraction of 61 basic pharmaceuticals covering log P values from -0.5 to 5.0 in water, urine, and saliva. Depending on membrane and matrix composition, typical recoveries were around 40%, while stable operation was observed with all three matrices. The method showed favorable greenness, with low power consumption and minimal waste generation. The thiol-ene microchip has a mass of 16 g and was reused for multiple extractions, while only 0.1 µL of liquid membrane was discarded per extraction, corresponding to more than 99.9% material reuse. Overall, this system provided a sustainable, reusable, and versatile microfluidic platform for EME of pharmaceuticals from biological fluids.

• Ludvigsen, Lene Ugilt Pagter; Thomsen, Marianne Kragh; Kro, Grete Anette Birkeland; Pedersen, Rune Micha; Gramkow, Ann Maria & Åsberg, Anders [Vis alle 16 forfattere av denne artikkelen] (2026). Epstein-Barr virus infection monitoring in kidney transplant recipients (EVITA study)—investigating the clinical significance of EBV-DNAemia and the risk of early-onset PTLD. American Journal of Transplantation. ISSN 1600-6135. s. 1–15. doi: 10.1016/j.ajt.2026.07.012. Fulltekst i vitenarkiv
• Cordero, Christian; Brenne, Hanne Britt; Ytteborg, Elisabeth; Hansen, Miroslava; Johansen, Lill-Heidi & Vanrompay, Daisy [Vis alle 8 forfattere av denne artikkelen] (2026). Immune responses in the olfactory organ and brain of Atlantic cod (Gadus morhua) following nasal vaccination against Francisella noatunensis. Fish and Shellfish Immunology. ISSN 1050-4648. 179, s. 1–14. doi: 10.1016/j.fsi.2026.111767. Fulltekst i vitenarkiv Vis sammendrag

  Bacterial infections caused by the intracellular bacterium Francisella noatunensis pose a major health challenge in Atlantic cod (Gadus morhua), largely due to the lack of effective prophylactic and therapeutic measures. Here we evaluated the immune and physiological responses of cod to two candidate live attenuated vaccines (i.e. clpB and iglC) against F. noatunensis delivered intranasally. These experimental vaccines were constructed by a single knockout mutation of a virulence gene in F. noatunensis. Cod was vaccinated intranasally and reared for 45 days until infection with the wild-type strain Francisella noatunenesis subp. noatunensis and further reared for 47 days until termination. Given the chosen delivery route, our analyses were focused on the olfactory organ and brain of cod. Infected cod presented classic gross pathologies of francisellosis, including multi-organ nodulations, splenomegaly, and hepatomegaly. Among the vaccine candidates, the clpB-vaccinated group demonstrated upregulated expression of immune response genes in both the olfactory organ and brain, exhibited the lowest nodulation score, and showed minimal histological alterations in the olfactory organ. To further explore the physiological consequences of the clpB mutant, shotgun proteomics was performed in selected olfactory organ and brain of vaccinated cod. We identified 404 differentially expressed proteins (DEPs) in the brain and 241 in the olfactory organ with 17 DEPs common to both organs. These DEPs were mostly involved in cellular signalling, transmembrane internalisation, enzymatic processes, and important immune response pathways, such as immune recruitment and activation, the respiratory burst reaction, and apoptosis. These findings suggest that the clpB-attenuated vaccine holds promise as a candidate vaccine against F. noatunensis and provides valuable insights into the mechanisms of immune modulation.

• Johnson, Hannah; Dolk, Helen; Loane, Maria; Damase-Michel, Christine; Given, Joanne & Nordeng, Hedvig Marie Egeland [Vis alle 23 forfattere av denne artikkelen] (2026). Case-malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy. British Journal of Clinical Pharmacology. ISSN 0306-5251. 92(10), s. 3586–3597. doi: 10.1002/bcp.70645. Fulltekst i vitenarkiv
• Alcalde-Herraiz, Marta; Du, Mike; Sanchez-Parada, Aina; Duarte-Salles, Talita; Palomar-Cros, Anna & Giuliodori, Agustina [Vis alle 13 forfattere av denne artikkelen] (2026). The effectiveness of HPV vaccination against invasive cervical cancer and related precancerous lesions: a multinational target trial emulation study. The Lancet Primary Care. 2(3). doi: 10.1016/j.lanprc.2026.100114. Fulltekst i vitenarkiv Vis sammendrag

  Background Human Papillomavirus (HPV) vaccines prevent HPV infection and related disease. 15 years after the first HPV vaccination programmes were launched in Europe, their long-term effectiveness can now start to be assessed. We designed a target trial emulation study to estimate the effectiveness of HPV vaccination in preventing invasive cervical cancer and high-grade precancerous lesions using three primary care databases. Methods In this target trial emulation study, we analysed primary care records from the UK (Clinical Practice Research Datalink; data from Sept 9, 1987 to Dec 15, 2023), primary care records linked to hospital records from Catalonia, Spain (Sistema d’Informació per al Desenvolupament de la Investigació en Atenció Primària; Jan 1, 2006 to June 30, 2023), and nationwide linked health registry (including primary care, secondary care, and other health data) in Norway (Norwegian Linked Health Registry; Jan 1, 2018 to Dec 31, 2023), all standardised to the Observational Medical Outcomes Partnership common data model. We included women aged 15 years or younger in 2008, coinciding with the start of public vaccination programmes. Exposure was defined as receiving one or more HPV vaccine doses by age 15 years. The main outcomes included high-grade cervical intraepithelial neoplasia (CIN2+), invasive cervical cancer, and conisation (as a proxy for CIN2+ diagnosis). Vaccinated and unvaccinated cohorts were sequentially matched on an annual basis by year of birth, location, and propensity scores, with up to five vaccinated people matched to an unvaccinated individual. Vaccine effectiveness, based on incidence rate ratios after 15 years of follow-up, were calculated using Poisson regression. Results across databases were meta-analysed using fixed-effects. The specified primary analysis in the original protocol was designed to assess exposure by HPV brand versus unvaccinated populations; however, due to the low number of events by brand, the study was underpowered and the primary analysis was amended to assess HPV vaccination exposure overall (any brand) versus unvaccinated. Findings After two-step matching, our analysis included 81 863 vaccinated and 46 357 unvaccinated women from the UK; 148 214 vaccinated and 39 952 unvaccinated from Spain; and 14 885 vaccinated and 4073 unvaccinated from Norway. Fewer than five cervical cancers were observed per cohort, precluding vaccine effectiveness estimation for this outcome. Meta-analytic vaccine effectiveness at 15 years was 42% (95% CI 6–64) against CIN2+ and 58% (6–82) against conisation. Interpretation Our estimates of vaccine effectiveness against CIN2+ and conisation in Europe align with estimates from previous systematic reviews of randomised controlled trials. We also observed an increased health-seeking behaviour among vaccinated individuals, suggesting that our study might have underestimated vaccine effectiveness. Further studies with longer follow-up are needed to estimate vaccine effectiveness against cervical cancer.

• Avershina, Ekaterina; Birkeland, Einar Elvbakken; Johannessen, Cecilie Bucher - & Rounge, Trine Ballestad (2026). CRISPR-Cas immune repertoires as an ecological record of bacterial interactions with mobile genetic elements in the human gut. Gut microbes. ISSN 1949-0976. 18(1). doi: 10.1080/19490976.2026.2734649. Fulltekst i vitenarkiv
• Mjønes, Harald Stranger; Havik, Mona; Seferi, Gezime & Morland, Cecilie (2026). High-intensity interval exercise affects neurogenesis and angiogenesis differently in diabetic and non-diabetic mice. Frontiers in Neuroscience. ISSN 1662-4548. 20, s. 1–12. doi: 10.3389/fnins.2026.1927709. Fulltekst i vitenarkiv
• Bøyum, Ingvild Reinseth; Grønlien, Krister Gjestvang; Oftedal, Thomas; Kjos, Morten; Carlsen, Harald & Tønnesen, Hanne Hjorth (2026). The bacteriocin enterocin EJ97s retains its antibacterial effect upon interaction with human serum albumin. Journal of Applied Microbiology. ISSN 1364-5072. 137(8). doi: 10.1093/jambio/lxag193. Fulltekst i vitenarkiv
• Carson, Alexis Christine; Zidan, Mahmoud; Olstad, Emilie Willoch; Gervin, Kristina; Galesloot, Tessel E. & Scholte, Iris [Vis alle 9 forfattere av denne artikkelen] (2026). Genetically Informed Research Designs in Perinatal Pharmacoepidemiology: A Methodological Overview. Drug Safety. ISSN 0114-5916. 49(7), s. 761–773. doi: 10.1007/s40264-026-01647-9. Fulltekst i vitenarkiv Vis sammendrag

  Despite the widespread use of medications during pregnancy, ethical and methodological barriers to clinical trials make observational studies necessary for evaluating medication safety in this population. Observational studies are prone to biases that often limit their validity due to the lack of randomization; integrating genetic information through discordant sibling designs, polygenic scores, and Mendelian randomization can address several confounding issues. However, application of these three approaches in perinatal pharmacoepidemiology has been limited. Complementing traditional designs with these genetically informed research designs can tackle common biases and strengthen causal inference. This paper focuses on applying genetically informed research designs to child outcomes in perinatal pharmacoepidemiology by reviewing various methods, discussing their strengths and limitations, and examining their application to date, as well as considerations for implementing them in future research. Such considerations include the availability of genetic data, the complexity of integrating genetic data with existing epidemiological data, and selection of appropriate genetic instruments for analyses. Incorporating causal inference in perinatal pharmacoepidemiology can ultimately contribute to enhancing safe medication use during pregnancy.

• Cuk, Ana; Vingen, Hans Vangsnes; Sande, Sverre Arne & Hiorth, Marianne (2026). Development of an injectable, in situ formed hydrogel for controlled delivery of local anesthetics by exploiting synergism between thermoresponsive block copolymers and alginate, chitosan, or hyaluronate. Carbohydrate Polymer Technologies and Applications. 14. doi: 10.1016/j.carpta.2026.101158. Fulltekst i vitenarkiv
• Mrsa, Ago; Larsen, Bjarke Strøm; Halvorsen, Trine Grønhaug & Reubsaet, Leon (2026). Dual Functionality in Whole Blood Microsampling: Combining Plasma Separation and Immunoaffinity Cleanup for LC-MS Based Targeted Protein Analysis. Journal of Proteome Research. ISSN 1535-3893. 25(9), s. 4665–4675. doi: 10.1021/acs.jproteome.6c00092. Fulltekst i vitenarkiv
• Shahmohammadi, Niayesh; Khan, Falguni; Jang, Haneol; Kim, Il-Hwan; Lee, Donghee & Wallen, Joseph [Vis alle 10 forfattere av denne artikkelen] (2026). EpOME functionally antagonises prostaglandin signalling in Spodoptera exigua via a specific GPCR conserved across metazoans. Nature Communications. doi: 10.1038/s41467-026-77858-6. Fulltekst i vitenarkiv

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• Tveito, Marit & Stensæth, Karette (2026). Musikkterapi (om temaet i podkasten Psykiateren). [Radio]. Podkasten Psykiateren. doi: https:/podcasts.apple.com/no/podcast/psykiateren/id1707376672?l=nb&i=1000797553566. Fulltekst i vitenarkiv Vis sammendrag

  Karette Annie Stensæth er professor i musikkterapi og leder for Senter for forskning i musikk og helse. De siste årene har hun drevet mange prosjekter innen musikk og demens, og hun har mer enn 20 års erfaring med musikkterapi for barn og unge i sårbare livssituasjoner. I denne episoden får du høre om hva musikk kan bety for den psykiske helsen. See omnystudio.com/listener for privacy information.

• Granås, Anne Gerd; Kadir, Lavin; Bjørknes, Marthe Rambøl; Nilsen, Marianne Kollerøs; Foss, Camilla & Heimdal, Mia Catharina Nikolaisen [Vis alle 9 forfattere av denne artikkelen] (2026). Pharmacy Stories - Using Historical Narratives to Shape Future Pharmacy Education in a Digital Era. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Background: Pharmacy practice is undergoing rapid transformation driven by digital technologies, new models of care, and evolving professional roles. Preparing students for these changes requires educational approaches that connect professional development over time with emerging competence needs. This study explores how pharmacists’ professional stories can be used to link past developments with future-oriented competencies in pharmacy education. Methods: A total of 49 pharmacists were interviewed across Norway. Undergraduate students conducted semi-structured interviews with 16 pharmacists, while an academic team conducted 33 additional video and audio interviews. Data were transcribed and analyzed thematically by both students and academics. Selected material was integrated into a digital learning platform used in pharmacy education in Norway. Results: Interviewees described major developments in pharmaceutical production, digitalization of logistics and dispensing, early adoption of automation, IT systems for safe medicine distribution, the emergence of clinical pharmacy, and strengthened emergency preparedness. The stories highlighted increasing competence needs in digital tools, decision support, and interdisciplinary collaboration. Students involved reported increased engagement and a deeper understanding of professional roles, career pathways, and future competence needs. The narratives also supported reflection on the societal and humanistic dimensions of pharmacy. Conclusions: Integrating professional stories into pharmacy education represents an innovative and transferable approach to linking past developments with future competencies. This method supports curriculum design by embedding authentic professional experiences and promoting competencies in digital literacy, clinical practice, and professional judgment. The approach is adaptable across educational contexts and may contribute to developing a future-oriented and resilient pharmacy workforce.

• Gutema, Girma Belachew (2026). Trends and Challenges in Antibiotic Consumption: Findings Focused on Clinical and Community Cases from Ethiopia Call for Public Health Policy Actions. Universitetet i Oslo. Fulltekst i vitenarkiv Vis sammendrag

  Antibiotics hold a unique place in the history of modern medicine. This is so not only because they lose effectiveness with their increasing use as a result of bacterial resistance, but also due to the fact that they constitute “societal drugs” for their irrational use can harm patients anywhere and everywhere in the world. No other class of drugs extended human life expectancy at birth by over four decades like antibiotics did in the history of modern medicine. This posits the rational use of antibiotics to be a COMMON GOOD for all—making a globally coordinated approach to control the judicial use of antibiotics both at the clinical and community settings very imperative. This PhD dissertation shades light on some of the challenges associated with antibiotic consumption both at clinical and community settings, with particular emphasis on cases from Ethiopia. It also draws on the analyses of trend data on antibiotic consumption as part of an attempt to identify gaps for further public health policy actions. Moreover, a model we constructed on how COVID19 might have had impacted the evolution of Antimicrobial Resistance (AMR) in African settings, based on a synthesis of the earliest available evidence, predicted that the former might have fuelled the later almost unhindered—not least during the period that constituted the peak of the pandemic. Generally, the findings in our studies underscore the need to: 1) design and implement effective Antimicrobial Stewardship programs in the Ethiopian healthcare systems, 2) institute nationally and regionally tailored stewardship strategies to effectively control the use of antibiotics to contain the challenges associated with antibiotic overuse (over consumption) and hence antibiotic resistance, 3) COVID-19 has potentially been fuelling the evolution of AMR in African settings where healthcare systems are underdeveloped, underfunded and the prevailing dynamic conditions with regard to AMR were already dire. The cumulative of all these findings call for concerted public health policy actions, especially in Ethiopia.

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