Emilie Willoch Olstad

• Gomes, Julia do Amaral; Olstad, Emilie Willoch; Kowalski, Thayne Woycinck; Gervin, Kristina; Vianna, Fernanda Sales Luiz & Schüler-Faccini, Lavínia [Vis alle 7 forfattere av denne artikkelen] (2021). Genetic Susceptibility to Drug Teratogenicity: A Systematic Literature Review. Frontiers in Genetics. ISSN 1664-8021. 12. doi: 10.3389/fgene.2021.645555. Fulltekst i vitenarkiv
• Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen & Hansen, Jan Niklas [Vis alle 23 forfattere av denne artikkelen] (2021). Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell reports. ISSN 2211-1247. 37(1). doi: 10.1016/j.celrep.2021.109775. Fulltekst i vitenarkiv
• Olstad, Emilie Willoch; Nordeng, Hedvig Marie Egeland & Gervin, Kristina (2021). Prenatal medication exposure and epigenetic outcomes: a systematic literature review and recommendations for prenatal pharmacoepigenetic studies. Epigenetics. ISSN 1559-2294. doi: 10.1080/15592294.2021.1903376. Fulltekst i vitenarkiv
• Ringers, Christa; Olstad, Emile Willoch & Jurisch-Yaksi, Nathalie (2019). The role of motile cilia in the development and physiology of the nervous system. Philosophical Transactions of the Royal Society of London. Biological Sciences. ISSN 0962-8436. 375:20190156, s. 1–10. doi: 10.1098/rstb.2019.0156. Fulltekst i vitenarkiv
• Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan Niklas; Wens, Adinda; Brandt, Cecilia & Wachten, Dagmar [Vis alle 8 forfattere av denne artikkelen] (2019). Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. Current Biology. ISSN 0960-9822. 29(2), s. 229–241.e6. doi: 10.1016/j.cub.2018.11.059. Vis sammendrag

  Motile cilia are miniature, propeller-like extensions, emanating from many cell types across the body. Their coordinated beating generates a directional fluid flow, which is essential for various biological processes, from respiration to reproduction. In the nervous system, ependymal cells extend their motile cilia into the brain ventricles and contribute to cerebrospinal fluid (CSF) flow. Although motile cilia are not the only contributors to CSF flow, their functioning is crucial, as patients with motile cilia defects develop clinical features, like hydrocephalus and scoliosis. CSF flow was suggested to primarily deliver nutrients and remove waste, but recent studies emphasized its role in brain development and function. Nevertheless, it remains poorly understood how ciliary beating generates and organizes CSF flow to fulfill these roles. Here, we study motile cilia and CSF flow in the brain ventricles of larval zebrafish. We identified that different populations of motile ciliated cells are spatially organized and generate a directional CSF flow powered by ciliary beating. Our investigations revealed that CSF flow is confined within individual ventricular cavities, with little exchange of fluid between ventricles, despite a pulsatile CSF displacement caused by the heartbeat. Interestingly, our results showed that the ventricular boundaries supporting this compartmentalized CSF flow are abolished during bodily movement, highlighting that multiple physiological processes regulate the hydrodynamics of CSF flow. Finally, we showed that perturbing cilia reduces hydrodynamic coupling between the brain ventricles and disrupts ventricular development. We propose that motile-cilia-generated flow is crucial in regulating the distribution of CSF within and across brain ventricles.

Se alle arbeider i Cristin

• Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Brandt, Cecilia & Wachten, Dagmar [Vis alle 8 forfattere av denne artikkelen] (2018). Spatially organized ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development.
• Olstad, Emilie Willoch; Ringers, Christa; Wens, Adinda; Hansen, Jan; Brandt, Cecilia & Yaksi, Emre [Vis alle 7 forfattere av denne artikkelen] (2018). Spatially organized ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development.
• Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Yaksi, Emre & Jurisch-Yaksi, Nathalie (2018). Cilia-driven flow in the zebrafish brain ventricles.
• Olstad, Emilie Willoch; Ringers, Christa; Yaksi, Emre & Jurisch-Yaksi, Nathalie (2018). The function of motile-cilia driven flow in the nervous system.
• Olstad, Emilie Willoch; Ringers, Christa; Hansen, Jan; Wens, Adinda; Brandt, Cecilia & Wachten, Dagmar [Vis alle 8 forfattere av denne artikkelen] (2018). The function of motile-cilia driven flow in the nervous system.

Se alle arbeider i Cristin