Hege Christensen

• Egeland, Erlend Johannessen; Witczak, Bartlomiej J; Zare, Hasse Khiabani; Christensen, Hege Staaland; Åsberg, Anders & Robertsen, Ida (2020). Chronic Inhibition of CYP3A is Temporarily Reduced by Each Hemodialysis Session in Patients With End‐Stage Renal Disease. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  108(4), s 866- 873 . doi: 10.1002/cpt.1875
• Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria; Hjelmesæth, Jøran; Sandbu, Rune; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Jansson-Löfmark, Rasmus; Karlsson, Cecilia; Andersson, Shalini; Åsberg, Anders; Andersson, Tommy B. & Christensen, Hege Staaland (2020). Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes. Journal of Pharmaceutical Sciences.  ISSN 0022-3549.  110(1), s 432- 437 . doi: 10.1016/j.xphs.2020.10.027 Fulltekst i vitenarkiv.
• Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Wegler, Christine; Angeles, Philip Carlo Soriano; Hjelmesæth, Jøran; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Åsberg, Anders; Andersson, Tommy B & Christensen, Hege Staaland (2019). A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity. Drug Metabolism And Disposition.  ISSN 0090-9556.  48(1), s 8- 17 . doi: 10.1124/DMD.119.087940
• Hjelmesæth, Jøran; Åsberg, Anders; Andersson, Shalini; Sandbu, Rune; Robertsen, Ida; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Hertel, Jens Kristoffer; Skovlund, Eva; Heijer, Maria; Ek, Anna-Lena; Krogstad, Veronica; Karlsen, Tor-Ivar; Christensen, Hege Staaland; Andersson, Tommy B & Karlsson, Cecilia (2018). Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for an open, non-randomised, three-armed single centre study (COCKTAIL). BMJ Open.  ISSN 2044-6055.  8:e021878(5), s 1- 10 . doi: 10.1136/bmjopen-2018-021878 Fulltekst i vitenarkiv.
• Krogstad, Veronica; Vethe, Nils Tore; Robertsen, Ida; Hasvold, Grete; Ose, Anne-Marthe Due; Hermann, Monica; Andersen, Anders Mikal; Chan, Wai Joe; Skauby, Morten Heier; Svensson, My Hanna Sofia; Åsberg, Anders & Christensen, Hege Staaland (2018). Determination of Tacrolimus Concentration and Protein Expression of P-Glycoprotein in Single Human Renal Core Biopsies. Therapeutic Drug Monitoring.  ISSN 0163-4356.  40(3), s 292- 300 . doi: 10.1097/FTD.0000000000000510
• Hermann, Monica; Robertsen, Ida & Christensen, Hege Staaland (2015). Immunologisk aktivitet og biologiske legemidler påvirker legemiddelmetabolisme og -transport. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  123(6), s 22- 25
• Robertsen, Ida; Vethe, Nils Tore; Midtvedt, Karsten; Falck, Pål; Christensen, Hege Staaland & Åsberg, Anders (2015). Closer to the site of action: everolimus concentrations in peripheral blood mononuclear cells correlate well with whole blood concentrations. Therapeutic Drug Monitoring.  ISSN 0163-4356.  37(5), s 675- 680 . doi: 10.1097/FTD.0000000000000185
• Lunde, Ingrid; Bremer, Sara; Midtvedt, Karsten; Mohebi, Beata Urbanczyk; Husvegg, Miriam Dahl; Bergan, Stein; Åsberg, Anders & Christensen, Hege Staaland (2014). The influence of CYP3A, PPARA and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  70(6), s 685- 693 . doi: 10.1007/s00228-014-1656-3
• Bräunlich, Paula Marie; Christensen, Hege Staaland; Johannesen, Siri; Slimestad, Rune; Wangensteen, Helle; Malterud, Karl Egil & Barsett, Hilde (2013). In Vitro Inhibition of Cytochrome P450 3A4 by Aronia melanocarpa Constituents. Planta Medica.  ISSN 0032-0943.  79(2), s 137- 141 . doi: 10.1055/s-0032-1328055
• Darwich, AS; Pade, D; Rowland-Yeo, K; Jamei, M; Åsberg, Anders; Christensen, Hege Staaland; Ashcroft, DM & Rostami-Hodjegan, Amin (2013). Application of an in silico physiologically based pharmacokinetic model to simulate oral drug bioavailability of atorvastatin and cyclosporine post bariatric surgery. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  2, s E47 . doi: 10.1038/psp.2013.23
• Jakobsen, Gunn Signe; Skottheim, Ine Blankenberg; Sandbu, Rune; Christensen, Hege Staaland; Røislien, Jo; Åsberg, Anders & Hjelmesæth, Jøran (2013). Long-term effects of gastric bypass and duodenal switch on systemic exposure of atorvastatin. Surgical Endoscopy.  ISSN 0930-2794.  27(6), s 2094- 2101 . doi: 10.1007/s00464-012-2716-3
• Robertsen, Ida; Falck, Pål; Andreassen, Arne K.; Næss, Nina Kaajal; Lunder, Niclas; Christensen, Hege Staaland; Gullestad, Lars & Åsberg, Anders (2013). Endomyocardial, intralymphocyte and whole blood concentrations of ciclosporin A in heart transplant recipients. Transplantation Research.  ISSN 2047-1440.  2(5) . doi: 10.1186/2047-1440-2-5
• Ulvestad, Maria; Skottheim, Ine Blankenberg; Jakobsen, Gunn Signe; Bremer, Sara; Molden, Espen; Åsberg, Anders; Hjelmesæth, Jøran; Andersson, Tommy B; Sandbu, Rune & Christensen, Hege Staaland (2013). Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  93(3), s 275- 282 . doi: 10.1038/clpt.2012.261
• Amundsen, Rune; Åsberg, Anders; Ohm, Ingrid Kristine & Christensen, Hege Staaland (2012). Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro. Drug Metabolism And Disposition.  ISSN 0090-9556.  40(4), s 655- 661 . doi: 10.1124/dmd.111.043018
• Christensen, Hege Staaland & Hermann, Monica (2012). Immunological response as a source to variability in drug metabolism and transport. Frontiers in Pharmacology.  ISSN 1663-9812.  3(8), s 1- 10 . doi: 10.3389/fphar.2012.00008
• Christensen, Hege Staaland; Hestad, Anette Leirvik; Molden, Espen & Mathiesen, Liv (2011). CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity. Xenobiotica.  ISSN 0049-8254.  41(1), s 1- 5 . doi: 10.3109/00498254.2010.523734
• Amundsen, Rune; Christensen, Hege Staaland; Zabihyan, Behnaz & Åsberg, Anders (2010). Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin. Drug Metabolism And Disposition.  ISSN 0090-9556.  38(9), s 1499- 1504 . doi: 10.1124/dmd.110.032268
• Skottheim, IB; Jakobsen, Gunn Signe; Stormark, Kjartan; Christensen, H; Hjelmesæth, Jøran; Jenssen, Trond Geir; Åsberg, Anders & Sandbu, Rune (2010). Significant Increase in Systemic Exposure of Atorvastatin After Biliopancreatic Diversion With Duodenal Switch. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  87(6), s 699- 705 . doi: 10.1038/clpt.2010.32
• Christensen, Hege Staaland; Mathiesen, Liv; Postvoll, Lillian Wåge; Winther, Bjørn & Molden, Espen (2009). Different Enzyme Kinetics of Midazolam in Recombinant CYP3A4 Microsomes from Human and Insect Sources. Drug Metabolism and Pharmacokinetics (DMPK).  ISSN 1347-4367.  24(3), s 261- 268
• Bakken, Gry Vibeke; Rudberg, Ida; Christensen, Hege Staaland; Molden, Espen; Refsum, Helge & Hermann, Monica (2009). Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome b5. Drug Metabolism And Disposition.  ISSN 0090-9556.  37(2), s 254- 258 . doi: 10.1124/dmd.108.023291
• Skottheim, IB; Stormark, KM; Stormark, Kjartan; Christensen, H; Jakobsen, GS; Hjelmesæth, Jøran; Hjelmesæth, Jøran; Jenssen, Trond Geir; Reubsaet, JLE; Sandbu, R & Åsberg, Anders (2009). Significantly Altered Systemic Exposure to Atorvastatin Acid Following Gastric Bypass Surgery in Morbidly Obese Patients. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  86(3), s 311- 318 . doi: 10.1038/clpt.2009.82
• Waade, RB; Christensen, Hege Staaland; Rudberg, Ida; Refsum, H & Hermann, Monica (2009). Influence of Comedication on Serum Concentrations of Aripiprazole and Dehydroaripiprazole. Therapeutic Drug Monitoring.  ISSN 0163-4356.  31(2), s 233- 238
• Christensen, Hege Staaland & Åsberg, Anders (2008). Interaksjon mellom næringsmidler og legemidler. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.  (3), s 16- 21
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2006). Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data. Journal of Pharmaceutical Sciences.  ISSN 0022-3549.  95(12), s 2778- 2787
• Hermann, Monica; Kase, Eili Tranheim; Molden, Espen & Christensen, Hege Staaland (2006). Evaluation of microsomal incubation conditions on CYP3A4-mediated metabolism of cyclosporine A by a statistical experimental design. Current drug metabolism.  ISSN 1389-2002.  7, s 265- 271
• Hermann, Monica; Christensen, Hege Staaland & Reubsaet, Jan Leo (2005). Determination of atorvastatin and metabolites in human plasma with solid-phase extraction followed by LC-tandem MS. Analytical and Bioanalytical Chemistry.  ISSN 1618-2642.  382, s 1242- 1249
• Molden, Espen; Bøe, Grethe Helen; Christensen, Hege Staaland & Reubsaet, Leon (2003). High-performance liquid chromatography - mass spectrometry analysis of diltiazem and 11 of its phase I metabolites. Journal of Pharmaceutical and Biomedical Analysis.  ISSN 0731-7085.  33, s 275- 285
• Wangensteen, Helle; Molden, Espen; Christensen, Hege Staaland & Malterud, Karl Egil (2003). Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  58, s 663- 668
• Christensen, Hege Staaland; Åsberg, Anders; Holmboe, Aase-Britt & Berg, Knut Joachim. (2002). Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  58, s 515- 520
• Hermann, Monica; Åsberg, Anders; Reubsaet, Jan Leo; Berg, Knut Joachim.; Sæther, Stig & Christensen, Hege Staaland (2002). Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients. International journal of clinical pharmacology and therapeutics.  ISSN 0946-1965.  40, s 451- 456
• Molden, Espen; Johansen, Per Wiik; Bøe, Grethe Helen; Bergan, Stein; Christensen, Hege Staaland; Rugstad, Hans Erik; Rootwelt, Helge; Reubsaet, Jan Leo & Lehne, Gustav (2002). Pharmacokinetics of diltiazem and its metabolites in relation to CYP2D6 genotype. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  72, s 333- 342
• Hermann, Monica; Christensen, Hege Staaland & Reubsaet, Jan Leo (2002). Evaluation of essential parameters in the chromatographic determination of cyclosporin A and metabolites using a D-optimal design. Journal of Pharmaceutical and Biomedical Analysis.  ISSN 0731-7085.  30, s 1263- 1276
• Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (2002). Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared to CYP3A4. Drug Metabolism And Disposition.  ISSN 0090-9556.  30, s 1- 3
• Molden, Espen; Christensen, Hege Staaland & Sund, Reidar Bredo (2000). Extensive metabolism of diltiazem and P-glycoprotein-mediated efflux of desacetyl-diltiazem (M1) by rat jejunum in vitro. Drug Metabolism And Disposition.  ISSN 0090-9556.  28(2), s 107- 109
• Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (2000). CYP2D6 is involved in O-demethylation of diltiazem. An in vitro study with transfected human liver cells. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  56, s 575- 579
• Christensen, Hege Staaland; Carlsen, E; Åsberg, Anders; Schram, Lita & Berg, Knut Joachim. (1999). A simple and sensitive high-performance liquid chromatography assay of diltiazem and main metabolites in renal transplanted patients. Clinica Chimica Acta.  ISSN 0009-8981.  283(1-2), s 63- 75 Vis sammendrag

  A sensitive and specific reversed-phase high-performance liquid chromatographic method was developed for determination of the benzothiazepine calcium channel blocker diltiazem and three of its main metabolites in human plasma. A solid-phase extraction method (C18) is described for isolating diltiazem and the metabolites N-demethyl- diltiazem (M(A)), deacetyldiltiazem (M1) and N-demethyl-deacetyl- diltiazem (M2) from human plasma spiked with trans-diltiazem as internal standard. Chromatographic analysis of the eluate was accomplished using a reversed-phase column (C8) and a mobile phase consisting of acetonitrile, potassium dihydrogen phosphate-buffer (pH 2.9), triethylamine and methanol (280:598:2:90 v/v/v/v). The limit of detection was 5 ng/ml for diltiazem and 2.5 ng/ml for the metabolites (UV detection). Recoveries were > 75% for all substances. Precision analysis indicated a coefficient of variation below 5% for both diltiazem and metabolites at plasma concentrations ranging from 30 to 120 ng/ml for diltiazem and from 15 to 60 ng/ml for the metabolites. The accuracy was < 3% for diltiazem at all concentrations investigated. Metabolites showed an accuracy of < 7% at higher concentrations, however at low concentration the accuracy was < 16%. A pilot study has been performed in order to study whether the method was applicable to patients and volunteers. Plasma samples from renal transplanted patients treated with cyclosporin A and healthy volunteers did not show any interference by cyclosporin A with the determination of diltiazem and metabolites.

• Åsberg, Anders; Christensen, Hege Staaland; Hartmann, Anders; Calson, E.; Molden, Espen & Berg, Knut Joachim. (1999). Pharmacokinetic between microemulsion formulated cyklosporine A and diltiazem in renal transplant recipients. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  55, s 383- 387
• Åsberg, Anders; Christensen, Hege Staaland; Hartmann, Anders; Carlsen, E; Molden, Espen & Berg, Knut Joachim. (1999). Pharmacokinetic interactions between microemulsion formulated cyclosporine A and diltiazem in renal transplant recipients. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  55, s 383- 387
• Christensen, Hege Staaland (1999). Legemidler og næringsstoffer, I: Gunn Elin Bjørneboe & Christian A Drevon (red.),  Mat og Medisin.  Høyskoleforlaget, Oslo.  Kap.40.

Se alle arbeider i Cristin

• Ose, Anne M; Krogstad, Veronica; Hasvold, Grete; Robertsen, Ida; Egeland, Erlend Johannessen; Hermann, Monica; Skauby, Morten Heier; Åsberg, Anders & Christensen, Hege Staaland (2017). Optimalisering av metode for kvantifisering av CYP3A5 og P_glykoprotein i små nyrebiopsier.
• Vu, Martin; Krogstad, Veronica; Johnson, Line Kristin; Angeles, Philip Carlo S; Hasvold, Grete; Hermann, Monica; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B; Hjelmesæth, Jøran; Åsberg, Anders; Christensen, Hege Staaland & Robertsen, Ida (2017). Effect of low calorie diet on the absolute bioavailability of midazolam in patients with severe obesity.
• Le, Peter Huy Vo; Robertsen, Ida; Åsberg, Anders; Christensen, Hege Staaland & Hermann, Monica (2016). Utvikling av en sensitiv LC-MS/MS-metode for å kvantifisere midazolam og metabolitter i pasienter med sykelig overvekt før og etter gastrisk bypass-operasjon.
• Myhrer, Marthe; Krogstad, Veronica; Christensen, Hege Staaland; Reubsaet, Leon & Hermann, Monica (2015). Kvantifisering av P-glykoprotein i lymfocytter ved bruk av LC-MS/MS.
• Ulvmoen, Anders; Robertsen, Ida; Åsberg, Anders; Christensen, Hege Staaland & Hermann, Monica (2015). Utvikling av en sensitiv LC-MS/MS-metode for å kvantifisere midazolam og metabolitter in vitro og i sykelig overvektige pasienter.
• Ahlsen, Kathrine; Robertsen, Ida; Midtvedt, Karsten; Åsberg, Anders & Christensen, Hege Staaland (2014). Aktivitet av P-glykoprotein i mononukleære celler fra perifert blod.
• Ho, Giang Thanh Thi; Braünlich, Marie; Wangensteen, Helle; Malterud, Karl Egil; Økstad, Ole Andreas Løchen; Christensen, Hege Staaland; Johannesen, Siri; Slimestad, Rune & Barsett, Hilde (2014). Spennende helseeffekter av aroniabær.
• Lilleengen, Anniken; Lunde, Ingrid; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2014). CYP3A4-aktivitet ex vivo i individuelle humane intestinale mikrosomer.
• Barsett, Hilde; Bräunlich, Paula Marie; Wangensteen, Helle; Malterud, Karl Egil; Christensen, Hege Staaland; Johannesen, Siri; Ho, Giang Thanh Thi; Vo, L.V. & Slimestad, Rune (2013). Bioactive compounds in Aronia melanocarpa berries.
• Bjøringsøy, Stine Karen; Barsett, Hilde & Christensen, Hege Staaland (2013). Ekstrakter av hageblåbær, skogsblåbær, tranebær og tyttebær hemmer CYP3A4 in vitro.
• Bräunlich, Paula Marie; Christensen, Hege Staaland; Johannesen, Siri; Ho, Giang Thanh Thi; Wangensteen, Helle & Barsett, Hilde (2013). Complement fixing Activity and in vitro inhibition of cytochrome P450 3A4 by Aronia melanocarpa constituents.
• Dahl, Miriam; Lunde, Ingrid; Mohebi, Beata Urbanczyk; Bremer, Sara; Bergan, Stein; Midtvedt, Karsten; Skottheim, Ine Blankenberg; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2013). Farmakokinetisk betydning av sekvensvarianter i CYP3A4, POR og PPAR-alpha.
• Jensen, Ben Andre; Hermann, Monica; Reubsaet, Leon & Christensen, Hege Staaland (2013). Utvikling av kvantitativ proteomikkmetodefor P-glykoprotein i mononukleære celler fra perifert blod.
• Jensen, Ben Andre; Reubsaet, Leon; Christensen, Hege Staaland; Åsberg, Anders & Hermann, Monica (2013). Utvikling av kvantitativ proteomikkmetode for måling av P-glykoprotein i lymfocytter isolert fra pasienter.
• Hotvedt, Tor Arne; Fleischer, Phillip; Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (2012). Cytokiners effekt på CYP3A4-mediert metabolisme av midazolam i THLE-celler.
• Robertsen, Ida; Falck, Pål; Næss, Nina Kaajal; Andreassen, Arne K.; Gullestad, Lars; Christensen, Hege Staaland & Åsberg, Anders (2012). Endomyovardial, intralymphocyte and whole blood concentrations of cyclosporine A in heart transplant recipients.
• Amundsen, Rune; Åsberg, Anders; Ohm, IK & Christensen, Hege Staaland (2011). Ciklosporin og takrolimus som hemmere av CYP3A4 og CYP3A5.
• Christensen, Hege Staaland; Amundsen, Rune & Åsberg, Anders (2011). Mechanisms involved in the pharmacokinetic interaction between atorvastatin and cyclosporine A.
• Huynh, C; Nordeng, Marit; Skottheim, Ine Blankenberg; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2011). Individuell variasjon i P-glykoprotein uttrykk i ulike deler av mage- og tarmsystemet.
• Jensstuen, Ågot K; Robertsen, Ida; Amundsen, Rune & Christensen, Hege Staaland (2011). CYP3A4-mediert metabolisme av cyklosporin i insektsmikrosomer.
• Amundsen, Rune; Christensen, Hege Staaland; Zabihyan, B & Åsberg, Anders (2010). Cyclosporin A, men ikke takrolimus, hemmer OATP1B1-mediert opptak av atorvastatin.
• Amundsen, Rune; Christensen, Hege Staaland; Zabihyan, Behnaz & Åsberg, Anders (2010). Cyclosporine A, but not tacrolimus, shows relevant inhibition of OATP1B1-mediated transport of atorvastatin.
• Lund, Cathrine; Christensen, Hege Staaland; Frøyshov, Sten & Jacobsen, Dag (2010). Toxicokinetics of Diltiazem and Three Metabolites During Acute Life-Threatening Poisoning. Clinical Toxicology.  ISSN 1556-3650.  48(3), s 281- 281
• Nguyen, Maria; Barsett, Hilde & Christensen, Hege Staaland (2010). Hemming av CYP3A4-metabolisme av ulike bærekstrakter.
• Ohm, IK; Amundsen, Rune & Christensen, Hege Staaland (2010). Cyclosporin A som hemmer av CYP3A4 og CYP3A5.
• Vist, Solveig; Skottheim, Ine Blankenberg; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2010). Uttrykk av CYP3A4 og CYP3A5 i parrede prøver fra GI-traktus og lever fra overvektige personer.
• Christensen, Hege Staaland; Hestad, Anette L; Molden, Espen & Mathiesen, Liv (2009). Effect of NADPH-cytochrome P450 oxidoreductase on CYP3A5-mediated metabolism of midazolam.
• Amundsen, Rune; Zabihyan, Behnaz; Christensen, Hege Staaland & Åsberg, Anders (2009). CYCLOSPORINE A, BUT NOT TACROLIMUS, INHIBITS OATP1B1 MEDIATED TRANSPORT OF ATORVASTATIN. Journal of clinical pharmacology.  ISSN 0091-2700.  49(9), s 1112- 1112
• Amundsen, Rune; Zabihyan, Behnaz; Christensen, Hege Staaland & Åsberg, Anders (2009). CYCLOSPORINE A, BUT NOT TACROLIMUS, INHIBITS OATP1B1 MEDIATED TRANSPORT OF ATORVASTATIN.
• Skottheim, Ine Blankenberg; Kjartan, Stormark; Christensen, Hege Staaland; Jacobsen, Gunn Signe; Hjelmesæth, Jøran; Jensen, Trond; Reubsaet, Jan Leo; Sandbu, Rune & Åsberg, Anders (2009). Signifikant endret biotilgjengelighet av atorvastatin etter gastrisk bypass i sykelig overvektige pasienter.
• Bakken, Vibeke; Rudberg, Ida; Hermann, Monica; Molden, Espen & Christensen, Hege Staaland (2008). Metabolisme av quetiapin via CYP3A4 og CYP3A5 in vitro.
• Christensen, Hege Staaland (2008). From drug interactions in patients to in vitro drug metabolism studies.
• Skottheim, Ine Blankenberg; Christensen, Hege Staaland; Stormark, Kjartan; Hjelmesæth, Jøran; Jacobsen, Gunn Signe; Sandbu, Rune & Åsberg, Anders (2008). GASTRIC BYPASS SURGERY IN MORBIDLY OBESE PATIENTS ALTERS ATORVASTATIN ACID BIOAVAILABILITY.
• Skottheim, Ine Blankenberg; Stormark, Kjartan; Christensen, Hege Staaland; Hjelmesæth, Jøran; Åsberg, Anders; Jacobsen, Gunn Signe & Sandbu, Rune (2008). Significantly altered bioavailability of atorvastatin acid following laparoscopic gastric bypass in morbidly obese patients.
• Christensen, Hege Staaland; Postvoll, Lillian W; Mathiesen, Liv; Johannesen, Siri & Molden, Espen (2007). Different CYP3A4 enzyme kinetics of midazolam in different microsomal preparations.
• Christensen, Hege Staaland; Postvoll, Lillian W; Mathiesen, Liv; Johannesen, Siri & Molden, Espen (2007). Different microsomal preparations exhibit different CYP3A4 enzyme kinetics of midazolam.
• Christensen, Hege Staaland (2007). Visjoner for framtidens forskning innen farmasøytisk biovitenskap.
• Skottheim, Ine Blankenberg; Stormark, Kjartan; Åsberg, Anders; Christensen, Hege Staaland; Hjælmeseth, Jøran; Nergård, Bent Johnny; Hofsø, Dag & Sandbu, Rune (2007). Legemiddelabsorpsjon etter bariatrisk kirurgi.
• Christensen, Hege Staaland (2006). Fortrengning fra plasmaproteiner: Ekstrapolering av legemiddelinteraksjoner fra in vitro data.
• Christensen, Hege Staaland (2006). In vitro-in vivo extrapolation of metabolism based drug-drug interactions.
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2005). Plasma protein binding displacement: prediction and implications for extrapolation of metabolic drug-drug interactions from in vitro data.
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2005). Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data. Drug metabolism reviews (Softcover ed.).  ISSN 0360-2532.  37, s 19- 19
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2005). Prediksjon av fortrengning fra plasmaproteiner og betydningen for in vitro-in vivo ekstrapolering av legemiddel-interaksjoner.
• Åsberg, Anders; Lemahieu, Wim P D; Hermann, Monica; Holdaas, Hallvard; Hartmann, Anders; Verbeke, K; Christensen, Hege Staaland; Vanrenterghem, Yves; Reubsaet, Jan Leo & Maes, Bart (2005). The mechanisms of the pharmacokinetic interaction between calcineurin inhibitors and statins.
• Christensen, Hege Staaland; Baker, M; Tucker, G & Rostami-Hodjegan, A (2005). Plasma protein binding displacement: Prediction and implications for extrapolation of metabolic drug-drug interactions from in vitro data. Journal of clinical pharmacology.  ISSN 0091-2700.  45
• Åsberg, Anders; Hermann, Monica; Christensen, Hege Staaland; Reubsaet, Jan Leo; Holdaas, Hallvard & Hartmann, Anders (2004). Several-fold higher systemic exposure of atorvastatin and meabolites n cyclosporine treated renal transplant recipients compared with healthy volunteers.
• Åsberg, Anders; Hermann, Monica; Christensen, Hege Staaland; Reubsaet, Jan Leo; Holdaas, Hallvard & Hartmann, Anders (2004). The substantially higher levels of atorvastatin and metabolites in cyclosporine A treated renal transplant recipients are mostly due to an effect on the acid forms compared to lactone forms.
• Hermann, Monica; Åsberg, Anders; Christensen, Hege Staaland; Holdaas, Hallvard; Hartmann, Anders & Reubsaet, Jan Leo (2004). Substantially elevated levels of atorvastatin and metabolites in cyclosporine-treated renal transplant recipients. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  76, s 388- 391
• Arnesen, Petter; Molden, Espen; Malterud, Karl Egil & Christensen, Hege Staaland (2003). Substanser i rødvin hemmer CYP3A4-mediert legemiddelmetabolisme.
• Hermann, Monica; Åsberg, Anders; Reubsaet, Leon; Christensen, Hege Staaland & Hartmann, Anders (2003). Kraftig økning i systemisk eksponering av atorvastatin og metabolitter ved samtidig inntak av cyclosporin hos nyretransplanterte pasienter.
• Kase, Eili Tranheim; Hermann, Monica; Molden, Espen & Christensen, Hege Staaland (2003). Metabolism of cyclosporine A in microsomes isolated from CYP 3A4 transfected liver epithelial cells.
• Molden, Espen; Johansen, Per Wiik; Bøe, Grethe Helen; Bergan, Stein; Christensen, Hege Staaland; Rugstad, Hans Erik; Reubsaet, Jan Leo; Rootwelt, Helge & Lehne, Gustav (2002). Disposition of diltiazem and metabolites in relation to CYP2D6 genotype.
• Bøe, Grethe Helen; Molden, Espen; Christensen, Hege Staaland & Reubsaet, Jan Leo (2002). Development of a LC/MS method for analyzing diltiazem and seven metabolites in human plasma.
• Christensen, Hege Staaland (2002). Problembasert læring - noe for ditt fag?.
• Wangensteen, Helle; Molden, Espen; Christensen, Hege Staaland & Malterud, Karl Egil (2002). Epoxybergamottin - a CYP3A4 inhibitor in grapefruit peel.
• Wangensteen, Helle; Molden, Espen; Christensen, Hege Staaland & Malterud, Karl Egil (2002). Epoxybergamottin - en CYP3A4 inhibitor isolert fra grapefruktskall.
• Bøe, Grethe Helen; Molden, Espen & Christensen, Hege Staaland (2001). Optimisation of a HPLC-method for quantification of diltiazem and five of its metabolites.
• Molden, Espen & Christensen, Hege Staaland (2001). Concentration dependent interference of desacetyl-diltiazem on formation of morfine from codein in vitro.
• Wangensteen, Helle; Malterud, Karl Egil; Molden, Espen; Skari, Karl Prestkvern & Christensen, Hege Staaland (2001). Isolation of compounds in grapefruit juice responsible for inhibition og CYP3A4.
• Christensen, Hege Staaland (2000). Individuell variasjon i diltiazems metabolisme.
• Åsberg, Anders; Sæther, Stig; Christensen, Hege Staaland; Berg, Knut Joachim. & Hartmann, Anders (1999). Acute effects of grape fruit juice administration on microemulsion formulated cyclosporine. A pharmacokinetics and plasmea endothelin-1 in renal transplant recipients.

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