Hege Christensen

• Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Wegler, Christine; Angeles, Philip Carlo Soriano; Hjelmesæth, Jøran; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Åsberg, Anders; Andersson, Tommy B & Christensen, Hege Staaland (2019). A comparative analysis of cytochrome P450 activities in paired liver and small intestinal samples from patients with obesity. Drug Metabolism And Disposition.  ISSN 0090-9556.  48(1), s 8- 17 . doi: 10.1124/dmd.119.087940
• Hjelmesæth, Jøran; Åsberg, Anders; Andersson, Shalini; Sandbu, Rune; Robertsen, Ida; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Hertel, Jens Kristoffer; Skovlund, Eva; Heijer, Maria; Ek, Anna-Lena; Krogstad, Veronica; Karlsen, Tor-Ivar; Christensen, Hege Staaland; Andersson, Tommy B & Karlsson, Cecilia (2018). Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for an open, non-randomised, three-armed single centre study (COCKTAIL). BMJ Open.  ISSN 2044-6055.  8:e021878(5), s 1- 10 . doi: 10.1136/bmjopen-2018-021878 Fulltekst i vitenarkiv.
• Krogstad, Veronica; Vethe, Nils Tore; Robertsen, Ida; Hasvold, Grete; Ose, Anne-Marthe Due; Hermann, Monica; Andersen, Anders Mikal; Chan, Wai Joe; Skauby, Morten Heier; Svensson, My Hanna Sofia; Åsberg, Anders & Christensen, Hege Staaland (2018). Determination of Tacrolimus Concentration and Protein Expression of P-Glycoprotein in Single Human Renal Core Biopsies. Therapeutic Drug Monitoring.  ISSN 0163-4356.  40(3), s 292- 300 . doi: 10.1097/FTD.0000000000000510
• Hermann, Monica; Robertsen, Ida & Christensen, Hege Staaland (2015). Immunologisk aktivitet og biologiske legemidler påvirker legemiddelmetabolisme og -transport. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  123(6), s 22- 25
• Robertsen, Ida; Vethe, Nils Tore; Midtvedt, Karsten; Falck, Pål; Christensen, Hege Staaland & Åsberg, Anders (2015). Closer to the site of action: everolimus concentrations in peripheral blood mononuclear cells correlate well with whole blood concentrations. Therapeutic Drug Monitoring.  ISSN 0163-4356.  37(5), s 675- 680 . doi: 10.1097/FTD.0000000000000185
• Lunde, Ingrid; Bremer, Sara; Midtvedt, Karsten; Mohebi, Beata Urbanczyk; Husvegg, Miriam Dahl; Bergan, Stein; Åsberg, Anders & Christensen, Hege Staaland (2014). The influence of CYP3A, PPARA and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  70(6), s 685- 693 . doi: 10.1007/s00228-014-1656-3
• Bräunlich, Paula Marie; Christensen, Hege Staaland; Johannesen, Siri; Slimestad, Rune; Wangensteen, Helle; Malterud, Karl Egil & Barsett, Hilde (2013). In Vitro Inhibition of Cytochrome P450 3A4 by Aronia melanocarpa Constituents. Planta Medica.  ISSN 0032-0943.  79(2), s 137- 141 . doi: 10.1055/s-0032-1328055
• Darwich, AS; Pade, D; Rowland-Yeo, K; Jamei, M; Åsberg, Anders; Christensen, Hege Staaland; Ashcroft, DM & Rostami-Hodjegan, Amin (2013). Application of an in silico physiologically based pharmacokinetic model to simulate oral drug bioavailability of atorvastatin and cyclosporine post bariatric surgery. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  2, s E47 . doi: 10.1038/psp.2013.23
• Jakobsen, Gunn Signe; Skottheim, Ine Blankenberg; Sandbu, Rune; Christensen, Hege Staaland; Røislien, Jo; Åsberg, Anders & Hjelmesæth, Jøran (2013). Long-term effects of gastric bypass and duodenal switch on systemic exposure of atorvastatin. Surgical Endoscopy.  ISSN 0930-2794.  27(6), s 2094- 2101 . doi: 10.1007/s00464-012-2716-3
• Robertsen, Ida; Falck, Pål; Andreassen, Arne K.; Næss, Nina Kaajal; Lunder, Niclas; Christensen, Hege Staaland; Gullestad, Lars & Åsberg, Anders (2013). Endomyocardial, intralymphocyte and whole blood concentrations of ciclosporin A in heart transplant recipients. Transplantation Research.  ISSN 2047-1440.  2(5) . doi: 10.1186/2047-1440-2-5
• Ulvestad, Maria; Skottheim, Ine Blankenberg; Jakobsen, Gunn Signe; Bremer, Sara; Molden, Espen; Åsberg, Anders; Hjelmesæth, Jøran; Andersson, Tommy B; Sandbu, Rune & Christensen, Hege Staaland (2013). Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  93(3), s 275- 282 . doi: 10.1038/clpt.2012.261
• Amundsen, Rune; Åsberg, Anders; Ohm, Ingrid Kristine & Christensen, Hege Staaland (2012). Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro. Drug Metabolism And Disposition.  ISSN 0090-9556.  40(4), s 655- 661 . doi: 10.1124/dmd.111.043018
• Christensen, Hege Staaland & Hermann, Monica (2012). Immunological response as a source to variability in drug metabolism and transport. Frontiers in Pharmacology.  ISSN 1663-9812.  3(8), s 1- 10
• Christensen, Hege Staaland; Hestad, Anette Leirvik; Molden, Espen & Mathiesen, Liv (2011). CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity. Xenobiotica.  ISSN 0049-8254.  41(1), s 1- 5 . doi: 10.3109/00498254.2010.523734
• Amundsen, Rune; Christensen, Hege Staaland; Zabihyan, Behnaz & Åsberg, Anders (2010). Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin. Drug Metabolism And Disposition.  ISSN 0090-9556.  38(9), s 1499- 1504 . doi: 10.1124/dmd.110.032268
• Skottheim, IB; Jakobsen, Gunn Signe; Stormark, Kjartan; Christensen, H; Hjelmesæth, Jøran; Jenssen, Trond Geir; Åsberg, Anders & Sandbu, Rune (2010). Significant Increase in Systemic Exposure of Atorvastatin After Biliopancreatic Diversion With Duodenal Switch. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  87(6), s 699- 705 . doi: 10.1038/clpt.2010.32
• Christensen, Hege Staaland; Mathiesen, Liv; Postvoll, Lillian Wåge; Winther, Bjørn & Molden, Espen (2009). Different Enzyme Kinetics of Midazolam in Recombinant CYP3A4 Microsomes from Human and Insect Sources. Drug Metabolism and Pharmacokinetics.  ISSN 1347-4367.  24(3), s 261- 268
• Bakken, Gry Vibeke; Rudberg, Ida; Christensen, Hege Staaland; Molden, Espen; Refsum, Helge & Hermann, Monica (2009). Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome b5. Drug Metabolism And Disposition.  ISSN 0090-9556.  37(2), s 254- 258 . doi: 10.1124/dmd.108.023291
• Skottheim, IB; Stormark, KM; Stormark, Kjartan; Christensen, H; Jakobsen, GS; Hjelmesæth, Jøran; Hjelmesæth, Jøran; Jenssen, Trond Geir; Reubsaet, JLE; Sandbu, R & Åsberg, Anders (2009). Significantly Altered Systemic Exposure to Atorvastatin Acid Following Gastric Bypass Surgery in Morbidly Obese Patients. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  86(3), s 311- 318 . doi: 10.1038/clpt.2009.82
• Waade, RB; Christensen, Hege Staaland; Rudberg, Ida; Refsum, H & Hermann, Monica (2009). Influence of Comedication on Serum Concentrations of Aripiprazole and Dehydroaripiprazole. Therapeutic Drug Monitoring.  ISSN 0163-4356.  31(2), s 233- 238
• Christensen, Hege Staaland & Åsberg, Anders (2008). Interaksjon mellom næringsmidler og legemidler. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.  (3), s 16- 21
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2006). Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data. Journal of Pharmaceutical Sciences.  ISSN 0022-3549.  95(12), s 2778- 2787
• Hermann, Monica; Kase, Eili Tranheim; Molden, Espen & Christensen, Hege Staaland (2006). Evaluation of microsomal incubation conditions on CYP3A4-mediated metabolism of cyclosporine A by a statistical experimental design. Current drug metabolism.  ISSN 1389-2002.  7, s 265- 271
• Hermann, Monica; Christensen, Hege Staaland & Reubsaet, Jan Leo (2005). Determination of atorvastatin and metabolites in human plasma with solid-phase extraction followed by LC-tandem MS. Analytical and Bioanalytical Chemistry.  ISSN 1618-2642.  382, s 1242- 1249
• Molden, Espen; Bøe, Grethe Helen; Christensen, Hege Staaland & Reubsaet, Leon (2003). High-performance liquid chromatography - mass spectrometry analysis of diltiazem and 11 of its phase I metabolites. Journal of Pharmaceutical and Biomedical Analysis.  ISSN 0731-7085.  33, s 275- 285
• Wangensteen, Helle; Molden, Espen; Christensen, Hege Staaland & Malterud, Karl Egil (2003). Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  58, s 663- 668
• Christensen, Hege Staaland; Åsberg, Anders; Holmboe, Aase-Britt & Berg, Knut Joachim. (2002). Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  58, s 515- 520
• Hermann, Monica; Åsberg, Anders; Reubsaet, Jan Leo; Berg, Knut Joachim.; Sæther, Stig & Christensen, Hege Staaland (2002). Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients. International journal of clinical pharmacology and therapeutics.  ISSN 0946-1965.  40, s 451- 456
• Molden, Espen; Johansen, Per Wiik; Bøe, Grethe Helen; Bergan, Stein; Christensen, Hege Staaland; Rugstad, Hans Erik; Rootwelt, Helge; Reubsaet, Jan Leo & Lehne, Gustav (2002). Pharmacokinetics of diltiazem and its metabolites in relation to CYP2D6 genotype. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  72, s 333- 342
• Hermann, Monica; Christensen, Hege Staaland & Reubsaet, Jan Leo (2002). Evaluation of essential parameters in the chromatographic determination of cyclosporin A and metabolites using a D-optimal design. Journal of Pharmaceutical and Biomedical Analysis.  ISSN 0731-7085.  30, s 1263- 1276
• Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (2002). Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared to CYP3A4. Drug Metabolism And Disposition.  ISSN 0090-9556.  30, s 1- 3
• Molden, Espen; Christensen, Hege Staaland & Sund, Reidar Bredo (2000). Extensive metabolism of diltiazem and P-glycoprotein-mediated efflux of desacetyl-diltiazem (M1) by rat jejunum in vitro. Drug Metabolism And Disposition.  ISSN 0090-9556.  28(2), s 107- 109
• Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (2000). CYP2D6 is involved in O-demethylation of diltiazem. An in vitro study with transfected human liver cells. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  56, s 575- 579
• Christensen, Hege Staaland; Carlsen, E; Åsberg, Anders; Schram, Lita & Berg, Knut Joachim. (1999). A simple and sensitive high-performance liquid chromatography assay of diltiazem and main metabolites in renal transplanted patients. Clinica Chimica Acta.  ISSN 0009-8981.  283(1-2), s 63- 75 Vis sammendrag

  A sensitive and specific reversed-phase high-performance liquid chromatographic method was developed for determination of the benzothiazepine calcium channel blocker diltiazem and three of its main metabolites in human plasma. A solid-phase extraction method (C18) is described for isolating diltiazem and the metabolites N-demethyl- diltiazem (M(A)), deacetyldiltiazem (M1) and N-demethyl-deacetyl- diltiazem (M2) from human plasma spiked with trans-diltiazem as internal standard. Chromatographic analysis of the eluate was accomplished using a reversed-phase column (C8) and a mobile phase consisting of acetonitrile, potassium dihydrogen phosphate-buffer (pH 2.9), triethylamine and methanol (280:598:2:90 v/v/v/v). The limit of detection was 5 ng/ml for diltiazem and 2.5 ng/ml for the metabolites (UV detection). Recoveries were > 75% for all substances. Precision analysis indicated a coefficient of variation below 5% for both diltiazem and metabolites at plasma concentrations ranging from 30 to 120 ng/ml for diltiazem and from 15 to 60 ng/ml for the metabolites. The accuracy was < 3% for diltiazem at all concentrations investigated. Metabolites showed an accuracy of < 7% at higher concentrations, however at low concentration the accuracy was < 16%. A pilot study has been performed in order to study whether the method was applicable to patients and volunteers. Plasma samples from renal transplanted patients treated with cyclosporin A and healthy volunteers did not show any interference by cyclosporin A with the determination of diltiazem and metabolites.

• Åsberg, Anders; Christensen, Hege Staaland; Hartmann, Anders; Calson, E.; Molden, Espen & Berg, Knut Joachim. (1999). Pharmacokinetic between microemulsion formulated cyklosporine A and diltiazem in renal transplant recipients. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  55, s 383- 387
• Åsberg, Anders; Christensen, Hege Staaland; Hartmann, Anders; Carlsen, E; Molden, Espen & Berg, Knut Joachim. (1999). Pharmacokinetic interactions between microemulsion formulated cyclosporine A and diltiazem in renal transplant recipients. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  55, s 383- 387
• Christensen, Hege Staaland (1999). Legemidler og næringsstoffer, I: Gunn Elin Bjørneboe & Christian A Drevon (red.),  Mat og Medisin.  Høyskoleforlaget, Oslo.  Kap.40.

Se alle arbeider i Cristin

• Ose, Anne M; Krogstad, Veronica; Hasvold, Grete; Robertsen, Ida; Egeland, Erlend Johannessen; Hermann, Monica; Skauby, Morten Heier; Åsberg, Anders & Christensen, Hege Staaland (2017). Optimalisering av metode for kvantifisering av CYP3A5 og P_glykoprotein i små nyrebiopsier.
• Vu, Martin; Krogstad, Veronica; Johnson, Line Kristin; Angeles, Philip Carlo S; Hasvold, Grete; Hermann, Monica; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B; Hjelmesæth, Jøran; Åsberg, Anders; Christensen, Hege Staaland & Robertsen, Ida (2017). Effect of low calorie diet on the absolute bioavailability of midazolam in patients with severe obesity.
• Le, Peter Huy Vo; Robertsen, Ida; Åsberg, Anders; Christensen, Hege Staaland & Hermann, Monica (2016). Utvikling av en sensitiv LC-MS/MS-metode for å kvantifisere midazolam og metabolitter i pasienter med sykelig overvekt før og etter gastrisk bypass-operasjon.
• Myhrer, Marthe; Krogstad, Veronica; Christensen, Hege Staaland; Reubsaet, Leon & Hermann, Monica (2015). Kvantifisering av P-glykoprotein i lymfocytter ved bruk av LC-MS/MS.
• Ulvmoen, Anders; Robertsen, Ida; Åsberg, Anders; Christensen, Hege Staaland & Hermann, Monica (2015). Utvikling av en sensitiv LC-MS/MS-metode for å kvantifisere midazolam og metabolitter in vitro og i sykelig overvektige pasienter.
• Ahlsen, Kathrine; Robertsen, Ida; Midtvedt, Karsten; Åsberg, Anders & Christensen, Hege Staaland (2014). Aktivitet av P-glykoprotein i mononukleære celler fra perifert blod.
• Ho, Giang Thanh Thi; Braünlich, Marie; Wangensteen, Helle; Malterud, Karl Egil; Økstad, Ole Andreas Løchen; Christensen, Hege Staaland; Johannesen, Siri; Slimestad, Rune & Barsett, Hilde (2014). Spennende helseeffekter av aroniabær.
• Lilleengen, Anniken; Lunde, Ingrid; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2014). CYP3A4-aktivitet ex vivo i individuelle humane intestinale mikrosomer.
• Barsett, Hilde; Bräunlich, Paula Marie; Wangensteen, Helle; Malterud, Karl Egil; Christensen, Hege Staaland; Johannesen, Siri; Ho, Giang Thanh Thi; Vo, L.V. & Slimestad, Rune (2013). Bioactive compounds in Aronia melanocarpa berries.
• Bjøringsøy, Stine Karen; Barsett, Hilde & Christensen, Hege Staaland (2013). Ekstrakter av hageblåbær, skogsblåbær, tranebær og tyttebær hemmer CYP3A4 in vitro.
• Bräunlich, Paula Marie; Christensen, Hege Staaland; Johannesen, Siri; Ho, Giang Thanh Thi; Wangensteen, Helle & Barsett, Hilde (2013). Complement fixing Activity and in vitro inhibition of cytochrome P450 3A4 by Aronia melanocarpa constituents.
• Dahl, Miriam; Lunde, Ingrid; Mohebi, Beata Urbanczyk; Bremer, Sara; Bergan, Stein; Midtvedt, Karsten; Skottheim, Ine Blankenberg; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2013). Farmakokinetisk betydning av sekvensvarianter i CYP3A4, POR og PPAR-alpha.
• Jensen, Ben Andre; Hermann, Monica; Reubsaet, Leon & Christensen, Hege Staaland (2013). Utvikling av kvantitativ proteomikkmetodefor P-glykoprotein i mononukleære celler fra perifert blod.
• Jensen, Ben Andre; Reubsaet, Leon; Christensen, Hege Staaland; Åsberg, Anders & Hermann, Monica (2013). Utvikling av kvantitativ proteomikkmetode for måling av P-glykoprotein i lymfocytter isolert fra pasienter.
• Hotvedt, Tor Arne; Fleischer, Phillip; Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (2012). Cytokiners effekt på CYP3A4-mediert metabolisme av midazolam i THLE-celler.
• Robertsen, Ida; Falck, Pål; Næss, Nina Kaajal; Andreassen, Arne K.; Gullestad, Lars; Christensen, Hege Staaland & Åsberg, Anders (2012). Endomyovardial, intralymphocyte and whole blood concentrations of cyclosporine A in heart transplant recipients.
• Amundsen, Rune; Åsberg, Anders; Ohm, IK & Christensen, Hege Staaland (2011). Ciklosporin og takrolimus som hemmere av CYP3A4 og CYP3A5.
• Christensen, Hege Staaland; Amundsen, Rune & Åsberg, Anders (2011). Mechanisms involved in the pharmacokinetic interaction between atorvastatin and cyclosporine A.
• Huynh, C; Nordeng, Marit; Skottheim, Ine Blankenberg; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2011). Individuell variasjon i P-glykoprotein uttrykk i ulike deler av mage- og tarmsystemet.
• Jensstuen, Ågot K; Robertsen, Ida; Amundsen, Rune & Christensen, Hege Staaland (2011). CYP3A4-mediert metabolisme av cyklosporin i insektsmikrosomer.
• Amundsen, Rune; Christensen, Hege Staaland; Zabihyan, B & Åsberg, Anders (2010). Cyclosporin A, men ikke takrolimus, hemmer OATP1B1-mediert opptak av atorvastatin.
• Amundsen, Rune; Christensen, Hege Staaland; Zabihyan, Behnaz & Åsberg, Anders (2010). Cyclosporine A, but not tacrolimus, shows relevant inhibition of OATP1B1-mediated transport of atorvastatin.
• Lund, Cathrine; Christensen, Hege Staaland; Frøyshov, Sten & Jacobsen, Dag (2010). Toxicokinetics of Diltiazem and Three Metabolites During Acute Life-Threatening Poisoning. Clinical Toxicology.  ISSN 1556-3650.  48(3), s 281- 281
• Nguyen, Maria; Barsett, Hilde & Christensen, Hege Staaland (2010). Hemming av CYP3A4-metabolisme av ulike bærekstrakter.
• Ohm, IK; Amundsen, Rune & Christensen, Hege Staaland (2010). Cyclosporin A som hemmer av CYP3A4 og CYP3A5.
• Vist, Solveig; Skottheim, Ine Blankenberg; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2010). Uttrykk av CYP3A4 og CYP3A5 i parrede prøver fra GI-traktus og lever fra overvektige personer.
• Christensen, Hege Staaland; Hestad, Anette L; Molden, Espen & Mathiesen, Liv (2009). Effect of NADPH-cytochrome P450 oxidoreductase on CYP3A5-mediated metabolism of midazolam.
• Amundsen, Rune; Zabihyan, Behnaz; Christensen, Hege Staaland & Åsberg, Anders (2009). CYCLOSPORINE A, BUT NOT TACROLIMUS, INHIBITS OATP1B1 MEDIATED TRANSPORT OF ATORVASTATIN. Journal of clinical pharmacology.  ISSN 0091-2700.  49(9), s 1112- 1112
• Amundsen, Rune; Zabihyan, Behnaz; Christensen, Hege Staaland & Åsberg, Anders (2009). CYCLOSPORINE A, BUT NOT TACROLIMUS, INHIBITS OATP1B1 MEDIATED TRANSPORT OF ATORVASTATIN.
• Skottheim, Ine Blankenberg; Kjartan, Stormark; Christensen, Hege Staaland; Jacobsen, Gunn Signe; Hjelmesæth, Jøran; Jensen, Trond; Reubsaet, Jan Leo; Sandbu, Rune & Åsberg, Anders (2009). Signifikant endret biotilgjengelighet av atorvastatin etter gastrisk bypass i sykelig overvektige pasienter.
• Bakken, Vibeke; Rudberg, Ida; Hermann, Monica; Molden, Espen & Christensen, Hege Staaland (2008). Metabolisme av quetiapin via CYP3A4 og CYP3A5 in vitro.
• Christensen, Hege Staaland (2008). From drug interactions in patients to in vitro drug metabolism studies.
• Skottheim, Ine Blankenberg; Christensen, Hege Staaland; Stormark, Kjartan; Hjelmesæth, Jøran; Jacobsen, Gunn Signe; Sandbu, Rune & Åsberg, Anders (2008). GASTRIC BYPASS SURGERY IN MORBIDLY OBESE PATIENTS ALTERS ATORVASTATIN ACID BIOAVAILABILITY.
• Skottheim, Ine Blankenberg; Stormark, Kjartan; Christensen, Hege Staaland; Hjelmesæth, Jøran; Åsberg, Anders; Jacobsen, Gunn Signe & Sandbu, Rune (2008). Significantly altered bioavailability of atorvastatin acid following laparoscopic gastric bypass in morbidly obese patients.
• Christensen, Hege Staaland; Postvoll, Lillian W; Mathiesen, Liv; Johannesen, Siri & Molden, Espen (2007). Different CYP3A4 enzyme kinetics of midazolam in different microsomal preparations.
• Christensen, Hege Staaland; Postvoll, Lillian W; Mathiesen, Liv; Johannesen, Siri & Molden, Espen (2007). Different microsomal preparations exhibit different CYP3A4 enzyme kinetics of midazolam.
• Christensen, Hege Staaland (2007). Visjoner for framtidens forskning innen farmasøytisk biovitenskap.
• Skottheim, Ine Blankenberg; Stormark, Kjartan; Åsberg, Anders; Christensen, Hege Staaland; Hjælmeseth, Jøran; Nergård, Bent Johnny; Hofsø, Dag & Sandbu, Rune (2007). Legemiddelabsorpsjon etter bariatrisk kirurgi.
• Christensen, Hege Staaland (2006). Fortrengning fra plasmaproteiner: Ekstrapolering av legemiddelinteraksjoner fra in vitro data.
• Christensen, Hege Staaland (2006). In vitro-in vivo extrapolation of metabolism based drug-drug interactions.
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2005). Plasma protein binding displacement: prediction and implications for extrapolation of metabolic drug-drug interactions from in vitro data.
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2005). Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data. Drug metabolism reviews (Softcover ed.).  ISSN 0360-2532.  37, s 19- 19
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2005). Prediksjon av fortrengning fra plasmaproteiner og betydningen for in vitro-in vivo ekstrapolering av legemiddel-interaksjoner.
• Åsberg, Anders; Lemahieu, Wim P D; Hermann, Monica; Holdaas, Hallvard; Hartmann, Anders; Verbeke, K; Christensen, Hege Staaland; Vanrenterghem, Yves; Reubsaet, Jan Leo & Maes, Bart (2005). The mechanisms of the pharmacokinetic interaction between calcineurin inhibitors and statins.
• Christensen, Hege Staaland; Baker, M; Tucker, G & Rostami-Hodjegan, A (2005). Plasma protein binding displacement: Prediction and implications for extrapolation of metabolic drug-drug interactions from in vitro data. Journal of clinical pharmacology.  ISSN 0091-2700.  45
• Åsberg, Anders; Hermann, Monica; Christensen, Hege Staaland; Reubsaet, Jan Leo; Holdaas, Hallvard & Hartmann, Anders (2004). Several-fold higher systemic exposure of atorvastatin and meabolites n cyclosporine treated renal transplant recipients compared with healthy volunteers.
• Åsberg, Anders; Hermann, Monica; Christensen, Hege Staaland; Reubsaet, Jan Leo; Holdaas, Hallvard & Hartmann, Anders (2004). The substantially higher levels of atorvastatin and metabolites in cyclosporine A treated renal transplant recipients are mostly due to an effect on the acid forms compared to lactone forms.
• Hermann, Monica; Åsberg, Anders; Christensen, Hege Staaland; Holdaas, Hallvard; Hartmann, Anders & Reubsaet, Jan Leo (2004). Substantially elevated levels of atorvastatin and metabolites in cyclosporine-treated renal transplant recipients. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  76, s 388- 391
• Arnesen, Petter; Molden, Espen; Malterud, Karl Egil & Christensen, Hege Staaland (2003). Substanser i rødvin hemmer CYP3A4-mediert legemiddelmetabolisme.
• Hermann, Monica; Åsberg, Anders; Reubsaet, Leon; Christensen, Hege Staaland & Hartmann, Anders (2003). Kraftig økning i systemisk eksponering av atorvastatin og metabolitter ved samtidig inntak av cyclosporin hos nyretransplanterte pasienter.
• Kase, Eili Tranheim; Hermann, Monica; Molden, Espen & Christensen, Hege Staaland (2003). Metabolism of cyclosporine A in microsomes isolated from CYP 3A4 transfected liver epithelial cells.
• Molden, Espen; Johansen, Per Wiik; Bøe, Grethe Helen; Bergan, Stein; Christensen, Hege Staaland; Rugstad, Hans Erik; Reubsaet, Jan Leo; Rootwelt, Helge & Lehne, Gustav (2002). Disposition of diltiazem and metabolites in relation to CYP2D6 genotype.
• Bøe, Grethe Helen; Molden, Espen; Christensen, Hege Staaland & Reubsaet, Jan Leo (2002). Development of a LC/MS method for analyzing diltiazem and seven metabolites in human plasma.
• Christensen, Hege Staaland (2002). Problembasert læring - noe for ditt fag?.
• Wangensteen, Helle; Molden, Espen; Christensen, Hege Staaland & Malterud, Karl Egil (2002). Epoxybergamottin - a CYP3A4 inhibitor in grapefruit peel.
• Wangensteen, Helle; Molden, Espen; Christensen, Hege Staaland & Malterud, Karl Egil (2002). Epoxybergamottin - en CYP3A4 inhibitor isolert fra grapefruktskall.
• Bøe, Grethe Helen; Molden, Espen & Christensen, Hege Staaland (2001). Optimisation of a HPLC-method for quantification of diltiazem and five of its metabolites.
• Molden, Espen & Christensen, Hege Staaland (2001). Concentration dependent interference of desacetyl-diltiazem on formation of morfine from codein in vitro.
• Wangensteen, Helle; Malterud, Karl Egil; Molden, Espen; Skari, Karl Prestkvern & Christensen, Hege Staaland (2001). Isolation of compounds in grapefruit juice responsible for inhibition og CYP3A4.
• Christensen, Hege Staaland (2000). Individuell variasjon i diltiazems metabolisme.
• Åsberg, Anders; Sæther, Stig; Christensen, Hege Staaland; Berg, Knut Joachim. & Hartmann, Anders (1999). Acute effects of grape fruit juice administration on microemulsion formulated cyclosporine. A pharmacokinetics and plasmea endothelin-1 in renal transplant recipients.
• Halvorsen, Trine Grønhaug; Christensen, Hege Staaland; Nordbø, Kirsten; Johnsen, Einar Broch & Krogh, Mette (1999). Automated Determination of Citalopram and N-desmethylcitalopram with On-line Dialysis and High-Performance Liquid Chromatography. Vis sammendrag

  An automated method for determination of citalopram and N-desmethylcitalopram is described. The procedure combines on-line dialysis and trace enrichment prior to high-performance liquid chromatography (HPLC). An existing method for determination of citalopram and its four metabolites was modified and optimalised. Proteins and particles were removed by dialysis before trace enrichment on a C8 column. Separation was performed on a C18 analytical column, and the analytes were subsequently detected with a fluorescence detector at an excitation wavelength of 249 nm and an emission wavelength of 302 nm. The correlation coeffisient were 0.994 or above. Automated determination of the total concentration of citalopram and N-desmethylcitalopram in plasma by the automated dialysis-HPLC was shown to be an accurate and reproducible method. The sample throughput was 70 samples in 24 h. In a minor clinical study, blood samples from eight patients treated with citalopram were analysed using the method. The aim of this study was to examine the correlation between adverse effects/interactions of citalopram and plasma drug concentration. A correlation between citalopram dose and plasma concentration was found. No correlation between adverse effects and plasma drug concentration was observed.

• Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (1999). O-Demethylation of diltiazem by CYP2D6 in transfected human liver cells. Vis sammendrag

  The calcium channel blocker diltiazem is subjected to complex metabolism including desacetylation, N-demethylation and O-demethylation. The CYP3A subfamily, mainly represented by the isoenzyme CYP3A4 in humans, is formerly shown to catalyse the N-demethylation of diltiazem (Pichard et al. 1990). In a previous interaction study between diltiazem and cyclosporine A in renal transplanted patients, it was speculated that CYP2D6 might be involved in the metabolism of diltazem (Åsberg et al. 1999). The aim of the present study was to see if the polymorphic CYP2D6 is involved in the O-demethylation of diltiazem. To study this tranfected human liver epithelal cells (THLE) expressing high levels of CYP2D6 (T5-2D6) were used. Diltiazem was substantially O-demethylated in incubations with T5-2D6 cells and no sign of N-demethylated metabolites were observed. O-Demethylation was inhibited by the quinidine (CYP2D6 inhibitor) but not erythromycin (CYP3A4 inhibitor). These results demonstrate that O-demethylation of diltiazem is mediated by CYP2D6. The pharmacokinetics of diltiazem show large inter-individual variability. This might be due to phenotypic variabilty in CYP3A4 expression (10-40 fold) and gentic polymorpfism of CYP2D6. It is known that about 5-10 % of Caucasians (white Europeans) have minor CYP2D6 activity due to genetic mutations (poor metaboliseres) indicating that this part of the population lack the ability to O-demethylate diltiazem. Dissimilarities in metabolic status might also reflect differences in susceptibility to drug interactions within patients treated with diltiazem.

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