Hege Christensen

• Kvitne, Kine Eide; Åsberg, Anders; Johnson, Line Kristin; Wegler, Christine; Hertel, Jens Kristoffer & Artursson, Per [Vis alle 14 forfattere av denne artikkelen] (2022). Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity. Clinical and Translational Science (CTS). ISSN 1752-8054. doi: 10.1111/cts.13394. Fulltekst i vitenarkiv
• Hovd, Markus Herberg; Mariussen, Espen; Uggerud, Hilde Thelle; Lashkarivand, Aslan; Christensen, Hege & Ringstad, Geir [Vis alle 7 forfattere av denne artikkelen] (2022). Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders. Fluids and Barriers of the CNS. ISSN 2045-8118. 19(1), s. 1–14. doi: 10.1186/s12987-022-00352-w. Fulltekst i vitenarkiv Vis sammendrag

  Background Quantitative measurements of cerebrospinal fluid to blood clearance has previously not been established for neurological diseases. Possibly, variability in cerebrospinal fluid clearance may affect the underlying disease process and may possibly be a source of under- or over-dosage of intrathecally administered drugs. The aim of this study was to characterize the cerebrospinal fluid to blood clearance of the intrathecally administered magnetic resonance imaging contrast agent gadobutrol (Gadovist, Bayer Pharma AG, GE). For this, we established a population pharmacokinetic model, hypothesizing that cerebrospinal fluid to blood clearance differs between cerebrospinal fluid diseases. Methods Gadobutrol served as a surrogate tracer for extra-vascular pathways taken by several brain metabolites and drugs in cerebrospinal fluid. We estimated cerebrospinal fluid to blood clearance in patients with different cerebrospinal fluid disorders, i.e. symptomatic pineal and arachnoid cysts, as well as tentative spontaneous intracranial hypotension due to cerebrospinal fluid leakage, idiopathic intracranial hypertension, or different types of hydrocephalus (idiopathic normal pressure hydrocephalus, communicating- and non-communicating hydrocephalus). Individuals with no verified cerebrospinal fluid disturbance at clinical work-up were denoted references. Results Population pharmacokinetic modelling based on 1,140 blood samples from 161 individuals revealed marked inter-individual variability in pharmacokinetic profiles, including differences in absorption half-life (time to 50% of tracer absorbed from cerebrospinal fluid to blood), time to maximum concentration in blood and the maximum concentration in blood as well as the area under the plasma concentration time curve from zero to infinity. In addition, the different disease categories of cerebrospinal fluid diseases demonstrated different profiles. Conclusions The present observations of considerable variation in cerebrospinal fluid to blood clearance between individuals in general and across neurological diseases, may suggest that defining cerebrospinal fluid to blood clearance can become a useful diagnostic adjunct for work-up of cerebrospinal fluid disorders. We also suggest that it may become useful for assessing clearance capacity of endogenous brain metabolites from cerebrospinal fluid, as well as measuring individual cerebrospinal fluid to blood clearance of intrathecal drugs.

• Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine & Johnson, Line Kristin [Vis alle 19 forfattere av denne artikkelen] (2022). Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range. European Journal of Clinical Pharmacology. ISSN 0031-6970. 78(8), s. 1289–1299. doi: 10.1007/s00228-022-03336-9. Fulltekst i vitenarkiv
• Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin; Kringen, Marianne K. & Hovd, Markus Herberg [Vis alle 19 forfattere av denne artikkelen] (2022). Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity. British Journal of Clinical Pharmacology. ISSN 0306-5251. 88(9), s. 4121–4133. doi: 10.1111/bcp.15349. Fulltekst i vitenarkiv
• Wegler, Christine; Wisniewski, Jacek R.; Robertsen, Ida; Christensen, Hege; Hertel, Jens Kristoffer & Hjelmesæth, Jøran Sture [Vis alle 10 forfattere av denne artikkelen] (2022). Drug disposition protein quantification in matched human jejunum and liver from donors with obesity. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 111(5), s. 1142–1154. doi: 10.1002/cpt.2558. Fulltekst i vitenarkiv Vis sammendrag

  Mathematical models, such as physiologically based pharmacokinetic (PBPK) models, are used to predict e.g., drug disposition and toxicity. However, populations differ in the abundance of proteins involved in these processes. To improve the building and refinement of such models, they must take into account these inter-individual variabilities. In this study, we used global proteomics to characterize the protein composition of jejunum and liver from 37 donors with obesity enrolled in the COCKTAIL study. Liver protein levels from the 37 donors were further compared with those from donors without obesity. We quantified thousands of proteins and could present the expression of several drug-metabolizing enzymes, for the first time, in jejunum, many of which belong to the cytochrome P450 (e.g., CYP2U1) and the amine oxidase [flavin-containing] (e.g., MAOA) families. Although we show that many metabolizing enzymes had greater expression in liver, others had higher expression in jejunum (such as, MAOA and CES2), indicating the role of the small intestine in extrahepatic drug metabolism. We further show that proteins involved in drug disposition are not correlated in the two donor-matched tissues. These proteins also do not correlate with physiological factors such as BMI, age, and inflammation status in either tissue. Furthermore, the majority of these proteins are not differently expressed in donors with or without obesity. Nonetheless, inter-individual differences were considerable, with implications for personalized prediction models and systems pharmacology.

• Skauby, Ragnhild Kristine Heier; Bergan, Stein; Andersen, Anders Mikal; Vethe, Nils Tore & Christensen, Hege (2021). In vitro assessments predict that CYP3A4 contributes to a greater extent than CYP3A5 to prednisolone clearance. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 129(6), s. 427–436. doi: 10.1111/bcpt.13645.
• Wegler, Christine; Matsson, Pär; Krogstad, Veronica; Urdzik, Jozef; Christensen, Hege & Andersson, Tommy B. [Vis alle 7 forfattere av denne artikkelen] (2021). Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes. Molecular Pharmaceutics. ISSN 1543-8384. 18(4), s. 1792–1805. doi: 10.1021/acs.molpharmaceut.1c00053. Fulltekst i vitenarkiv
• Kvitne, Kine Eide; Robertsen, Ida; Skovlund, Eva; Christensen, Hege Staaland; Krogstad, Veronica & Wegler, Christine [Vis alle 18 forfattere av denne artikkelen] (2021). Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity – a non-randomized three-armed controlled trial. Clinical and Translational Science (CTS). ISSN 1752-8054. doi: 10.1111/cts.13142. Fulltekst i vitenarkiv
• Eide, Per Kristian; Mariussen, Espen; Uggerud, Hilde Thelle; Pripp, Are Hugo; Lashkarivand, Aslan & Hassel, Bjørnar [Vis alle 8 forfattere av denne artikkelen] (2021). Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood. JCI Insight. ISSN 2379-3708. 6(9), s. 1–13. doi: 10.1172/jci.insight.147063. Fulltekst i vitenarkiv
• Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria & Hjelmesæth, Jøran [Vis alle 15 forfattere av denne artikkelen] (2020). Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes . Journal of Pharmaceutical Sciences. ISSN 0022-3549. 110(1), s. 432–437. doi: 10.1016/j.xphs.2020.10.027. Fulltekst i vitenarkiv
• Egeland, Erlend Johannessen; Witczak, Bartlomiej J; Zare, Hasse Khiabani; Christensen, Hege Staaland; Åsberg, Anders & Robertsen, Ida (2020). Chronic Inhibition of CYP3A is Temporarily Reduced by Each Hemodialysis Session in Patients With End‐Stage Renal Disease. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 108(4), s. 866–873. doi: 10.1002/cpt.1875.
• Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Wegler, Christine & Angeles, Philip Carlo Soriano [Vis alle 13 forfattere av denne artikkelen] (2019). A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity. Drug Metabolism And Disposition. ISSN 0090-9556. 48(1), s. 8–17. doi: 10.1124/DMD.119.087940.
• Krogstad, Veronica; Vethe, Nils Tore; Robertsen, Ida; Hasvold, Grete; Ose, Anne-Marthe Due & Hermann, Monica [Vis alle 12 forfattere av denne artikkelen] (2018). Determination of Tacrolimus Concentration and Protein Expression of P-Glycoprotein in Single Human Renal Core Biopsies. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(3), s. 292–300. doi: 10.1097/FTD.0000000000000510.
• Hjelmesæth, Jøran; Åsberg, Anders; Andersson, Shalini; Sandbu, Rune; Robertsen, Ida & Johnson, Line Kristin [Vis alle 16 forfattere av denne artikkelen] (2018). Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for an open, non-randomised, three-armed single centre study (COCKTAIL). BMJ Open. ISSN 2044-6055. 8:e021878(5), s. 1–10. doi: 10.1136/bmjopen-2018-021878. Fulltekst i vitenarkiv
• Hermann, Monica; Robertsen, Ida & Christensen, Hege Staaland (2015). Immunologisk aktivitet og biologiske legemidler påvirker legemiddelmetabolisme og -transport. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 123(6), s. 22–25.
• Robertsen, Ida; Vethe, Nils Tore; Midtvedt, Karsten; Falck, Pål; Christensen, Hege Staaland & Åsberg, Anders (2015). Closer to the site of action: everolimus concentrations in peripheral blood mononuclear cells correlate well with whole blood concentrations. Therapeutic Drug Monitoring. ISSN 0163-4356. 37(5), s. 675–680. doi: 10.1097/FTD.0000000000000185.
• Lunde, Ingrid; Bremer, Sara; Midtvedt, Karsten; Mohebi, Beata Urbanczyk; Husvegg, Miriam Dahl & Bergan, Stein [Vis alle 8 forfattere av denne artikkelen] (2014). The influence of CYP3A, PPARA and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 70(6), s. 685–693. doi: 10.1007/s00228-014-1656-3.
• Bräunlich, Paula Marie; Christensen, Hege Staaland; Johannesen, Siri; Slimestad, Rune; Wangensteen, Helle & Malterud, Karl Egil [Vis alle 7 forfattere av denne artikkelen] (2013). In Vitro Inhibition of Cytochrome P450 3A4 by Aronia melanocarpa Constituents. Planta Medica. ISSN 0032-0943. 79(2), s. 137–141. doi: 10.1055/s-0032-1328055.
• Jakobsen, Gunn Signe; Skottheim, Ine Blankenberg; Sandbu, Rune; Christensen, Hege Staaland; Røislien, Jo & Åsberg, Anders [Vis alle 7 forfattere av denne artikkelen] (2013). Long-term effects of gastric bypass and duodenal switch on systemic exposure of atorvastatin. Surgical Endoscopy. ISSN 0930-2794. 27(6), s. 2094–2101. doi: 10.1007/s00464-012-2716-3.
• Darwich, AS; Pade, D; Rowland-Yeo, K; Jamei, M; Åsberg, Anders & Christensen, Hege Staaland [Vis alle 8 forfattere av denne artikkelen] (2013). Application of an in silico physiologically based pharmacokinetic model to simulate oral drug bioavailability of atorvastatin and cyclosporine post bariatric surgery. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 2. doi: 10.1038/psp.2013.23.
• Robertsen, Ida; Falck, Pål; Andreassen, Arne K.; Næss, Nina Kaajal; Lunder, Niclas & Christensen, Hege Staaland [Vis alle 8 forfattere av denne artikkelen] (2013). Endomyocardial, intralymphocyte and whole blood concentrations of ciclosporin A in heart transplant recipients. Transplantation Research. ISSN 2047-1440. 2(5). doi: 10.1186/2047-1440-2-5.
• Ulvestad, Maria; Skottheim, Ine Blankenberg; Jakobsen, Gunn Signe; Bremer, Sara; Molden, Espen & Åsberg, Anders [Vis alle 10 forfattere av denne artikkelen] (2013). Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 93(3), s. 275–282. doi: 10.1038/clpt.2012.261.
• Amundsen, Rune; Åsberg, Anders; Ohm, Ingrid Kristine & Christensen, Hege Staaland (2012). Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro. Drug Metabolism And Disposition. ISSN 0090-9556. 40(4), s. 655–661. doi: 10.1124/dmd.111.043018.
• Christensen, Hege Staaland & Hermann, Monica (2012). Immunological response as a source to variability in drug metabolism and transport. Frontiers in Pharmacology. ISSN 1663-9812. 3(8), s. 1–10. doi: 10.3389/fphar.2012.00008.
• Christensen, Hege Staaland; Hestad, Anette Leirvik; Molden, Espen & Mathiesen, Liv (2011). CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity. Xenobiotica. ISSN 0049-8254. 41(1), s. 1–5. doi: 10.3109/00498254.2010.523734.
• Amundsen, Rune; Christensen, Hege Staaland; Zabihyan, Behnaz & Åsberg, Anders (2010). Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin. Drug Metabolism And Disposition. ISSN 0090-9556. 38(9), s. 1499–1504. doi: 10.1124/dmd.110.032268.
• Skottheim, IB; Jakobsen, Gunn Signe; Stormark, Kjartan; Christensen, H; Hjelmesæth, Jøran & Jenssen, Trond Geir [Vis alle 8 forfattere av denne artikkelen] (2010). Significant Increase in Systemic Exposure of Atorvastatin After Biliopancreatic Diversion With Duodenal Switch. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 87(6), s. 699–705. doi: 10.1038/clpt.2010.32.
• Bakken, Gry Vibeke; Rudberg, Ida; Christensen, Hege Staaland; Molden, Espen; Refsum, Helge & Hermann, Monica (2009). Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome b5. Drug Metabolism And Disposition. ISSN 0090-9556. 37(2), s. 254–258. doi: 10.1124/dmd.108.023291.
• Waade, RB; Christensen, Hege Staaland; Rudberg, Ida; Refsum, H & Hermann, Monica (2009). Influence of Comedication on Serum Concentrations of Aripiprazole and Dehydroaripiprazole. Therapeutic Drug Monitoring. ISSN 0163-4356. 31(2), s. 233–238.
• Christensen, Hege Staaland; Mathiesen, Liv; Postvoll, Lillian Wåge; Winther, Bjørn & Molden, Espen (2009). Different Enzyme Kinetics of Midazolam in Recombinant CYP3A4 Microsomes from Human and Insect Sources. Drug Metabolism and Pharmacokinetics (DMPK). ISSN 1347-4367. 24(3), s. 261–268.
• Skottheim, IB; Stormark, KM; Stormark, Kjartan; Christensen, H; Jakobsen, GS & Hjelmesæth, Jøran [Vis alle 11 forfattere av denne artikkelen] (2009). Significantly Altered Systemic Exposure to Atorvastatin Acid Following Gastric Bypass Surgery in Morbidly Obese Patients. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 86(3), s. 311–318. doi: 10.1038/clpt.2009.82.
• Christensen, Hege Staaland & Åsberg, Anders (2008). Interaksjon mellom næringsmidler og legemidler. Norsk tidsskrift for ernæring (NTFE). ISSN 1503-5034. s. 16–21.
• Hermann, Monica; Kase, Eili Tranheim; Molden, Espen & Christensen, Hege Staaland (2006). Evaluation of microsomal incubation conditions on CYP3A4-mediated metabolism of cyclosporine A by a statistical experimental design. Current drug metabolism. ISSN 1389-2002. 7, s. 265–271.
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2006). Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data. Journal of Pharmaceutical Sciences. ISSN 0022-3549. 95(12), s. 2778–2787.
• Hermann, Monica; Christensen, Hege Staaland & Reubsaet, Jan Leo (2005). Determination of atorvastatin and metabolites in human plasma with solid-phase extraction followed by LC-tandem MS. Analytical and Bioanalytical Chemistry. ISSN 1618-2642. 382, s. 1242–1249.
• Wangensteen, Helle; Molden, Espen; Christensen, Hege Staaland & Malterud, Karl Egil (2003). Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel. European Journal of Clinical Pharmacology. ISSN 0031-6970. 58, s. 663–668.
• Molden, Espen; Bøe, Grethe Helen; Christensen, Hege Staaland & Reubsaet, Leon (2003). High-performance liquid chromatography - mass spectrometry analysis of diltiazem and 11 of its phase I metabolites. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 33, s. 275–285.
• Molden, Espen; Johansen, Per Wiik; Bøe, Grethe Helen; Bergan, Stein; Christensen, Hege Staaland & Rugstad, Hans Erik [Vis alle 9 forfattere av denne artikkelen] (2002). Pharmacokinetics of diltiazem and its metabolites in relation to CYP2D6 genotype. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 72, s. 333–342.
• Christensen, Hege Staaland; Åsberg, Anders; Holmboe, Aase-Britt & Berg, Knut Joachim. (2002). Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers. European Journal of Clinical Pharmacology. ISSN 0031-6970. 58, s. 515–520.
• Hermann, Monica; Christensen, Hege Staaland & Reubsaet, Jan Leo (2002). Evaluation of essential parameters in the chromatographic determination of cyclosporin A and metabolites using a D-optimal design. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 30, s. 1263–1276.
• Hermann, Monica; Åsberg, Anders; Reubsaet, Jan Leo; Berg, Knut Joachim.; Sæther, Stig & Christensen, Hege Staaland (2002). Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients. International Journal of Clinical Pharmacology and Therapeutics. ISSN 0946-1965. 40, s. 451–456.
• Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (2002). Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared to CYP3A4. Drug Metabolism And Disposition. ISSN 0090-9556. 30, s. 1–3.

Se alle arbeider i Cristin

• Christensen, Hege Staaland; Damsa, Crina I. & Henriksen, Lise Toft (2021). Kollegaveiledning for PBL-veiledere i farmasiutdanning. I Wittek, Anne Line & de Lange, Thomas (Red.), Kollegaveiledning i høyere utdanning. Universitetsforlaget. ISSN 9788215048420.
• Ose, Anne M; Krogstad, Veronica; Hasvold, Grete; Robertsen, Ida; Egeland, Erlend Johannessen & Hermann, Monica [Vis alle 9 forfattere av denne artikkelen] (2017). Optimalisering av metode for kvantifisering av CYP3A5 og P_glykoprotein i små nyrebiopsier.
• Vu, Martin; Krogstad, Veronica; Johnson, Line Kristin; Angeles, Philip Carlo S; Hasvold, Grete & Hermann, Monica [Vis alle 13 forfattere av denne artikkelen] (2017). Effect of low calorie diet on the absolute bioavailability of midazolam in patients with severe obesity.
• Le, Peter Huy Vo; Robertsen, Ida; Åsberg, Anders; Christensen, Hege Staaland & Hermann, Monica (2016). Utvikling av en sensitiv LC-MS/MS-metode for å kvantifisere midazolam og metabolitter i pasienter med sykelig overvekt før og etter gastrisk bypass-operasjon.
• Myhrer, Marthe; Krogstad, Veronica; Christensen, Hege Staaland; Reubsaet, Leon & Hermann, Monica (2015). Kvantifisering av P-glykoprotein i lymfocytter ved bruk av LC-MS/MS.
• Ulvmoen, Anders; Robertsen, Ida; Åsberg, Anders; Christensen, Hege Staaland & Hermann, Monica (2015). Utvikling av en sensitiv LC-MS/MS-metode for å kvantifisere midazolam og metabolitter in vitro og i sykelig overvektige pasienter.
• Ho, Giang Thanh Thi; Braünlich, Marie; Wangensteen, Helle; Malterud, Karl Egil; Økstad, Ole Andreas Løchen & Christensen, Hege Staaland [Vis alle 9 forfattere av denne artikkelen] (2014). Spennende helseeffekter av aroniabær.
• Ahlsen, Kathrine; Robertsen, Ida; Midtvedt, Karsten; Åsberg, Anders & Christensen, Hege Staaland (2014). Aktivitet av P-glykoprotein i mononukleære celler fra perifert blod.
• Lilleengen, Anniken; Lunde, Ingrid; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2014). CYP3A4-aktivitet ex vivo i individuelle humane intestinale mikrosomer.
• Jensen, Ben Andre; Reubsaet, Leon; Christensen, Hege Staaland; Åsberg, Anders & Hermann, Monica (2013). Utvikling av kvantitativ proteomikkmetode for måling av P-glykoprotein i lymfocytter isolert fra pasienter.
• Dahl, Miriam; Lunde, Ingrid; Mohebi, Beata Urbanczyk; Bremer, Sara; Bergan, Stein & Midtvedt, Karsten [Vis alle 10 forfattere av denne artikkelen] (2013). Farmakokinetisk betydning av sekvensvarianter i CYP3A4, POR og PPAR-alpha.
• Bräunlich, Paula Marie; Christensen, Hege Staaland; Johannesen, Siri; Ho, Giang Thanh Thi; Wangensteen, Helle & Barsett, Hilde (2013). Complement fixing Activity and in vitro inhibition of cytochrome P450 3A4 by Aronia melanocarpa constituents.
• Barsett, Hilde; Bräunlich, Paula Marie; Wangensteen, Helle; Malterud, Karl Egil; Christensen, Hege Staaland & Johannesen, Siri [Vis alle 9 forfattere av denne artikkelen] (2013). Bioactive compounds in Aronia melanocarpa berries.
• Hotvedt, Tor Arne; Fleischer, Phillip; Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (2012). Cytokiners effekt på CYP3A4-mediert metabolisme av midazolam i THLE-celler.
• Robertsen, Ida; Falck, Pål; Næss, Nina Kaajal; Andreassen, Arne K.; Gullestad, Lars & Christensen, Hege Staaland [Vis alle 7 forfattere av denne artikkelen] (2012). Endomyovardial, intralymphocyte and whole blood concentrations of cyclosporine A in heart transplant recipients.
• Huynh, C; Nordeng, Marit; Skottheim, Ine Blankenberg; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2011). Individuell variasjon i P-glykoprotein uttrykk i ulike deler av mage- og tarmsystemet.
• Jensstuen, Ågot K; Robertsen, Ida; Amundsen, Rune & Christensen, Hege Staaland (2011). CYP3A4-mediert metabolisme av cyklosporin i insektsmikrosomer.
• Amundsen, Rune; Åsberg, Anders; Ohm, IK & Christensen, Hege Staaland (2011). Ciklosporin og takrolimus som hemmere av CYP3A4 og CYP3A5.
• Christensen, Hege Staaland; Amundsen, Rune & Åsberg, Anders (2011). Mechanisms involved in the pharmacokinetic interaction between atorvastatin and cyclosporine A.
• Vist, Solveig; Skottheim, Ine Blankenberg; Sandbu, Rune; Åsberg, Anders & Christensen, Hege Staaland (2010). Uttrykk av CYP3A4 og CYP3A5 i parrede prøver fra GI-traktus og lever fra overvektige personer.
• Amundsen, Rune; Christensen, Hege Staaland; Zabihyan, B & Åsberg, Anders (2010). Cyclosporin A, men ikke takrolimus, hemmer OATP1B1-mediert opptak av atorvastatin.
• Ohm, IK; Amundsen, Rune & Christensen, Hege Staaland (2010). Cyclosporin A som hemmer av CYP3A4 og CYP3A5.
• Amundsen, Rune; Christensen, Hege Staaland; Zabihyan, Behnaz & Åsberg, Anders (2010). Cyclosporine A, but not tacrolimus, shows relevant inhibition of OATP1B1-mediated transport of atorvastatin.
• Lund, Cathrine; Christensen, Hege Staaland; Frøyshov, Sten & Jacobsen, Dag (2010). Toxicokinetics of Diltiazem and Three Metabolites During Acute Life-Threatening Poisoning. Clinical Toxicology. ISSN 1556-3650. 48(3), s. 281–281.
• Amundsen, Rune; Zabihyan, Behnaz; Christensen, Hege Staaland & Åsberg, Anders (2009). CYCLOSPORINE A, BUT NOT TACROLIMUS, INHIBITS OATP1B1 MEDIATED TRANSPORT OF ATORVASTATIN. Journal of clinical pharmacology. ISSN 0091-2700. 49(9), s. 1112–1112.
• Christensen, Hege Staaland; Hestad, Anette L; Molden, Espen & Mathiesen, Liv (2009). Effect of NADPH-cytochrome P450 oxidoreductase on CYP3A5-mediated metabolism of midazolam.
• Skottheim, Ine Blankenberg; Kjartan, Stormark; Christensen, Hege Staaland; Jacobsen, Gunn Signe; Hjelmesæth, Jøran & Jensen, Trond [Vis alle 9 forfattere av denne artikkelen] (2009). Signifikant endret biotilgjengelighet av atorvastatin etter gastrisk bypass i sykelig overvektige pasienter.
• Amundsen, Rune; Zabihyan, Behnaz; Christensen, Hege Staaland & Åsberg, Anders (2009). CYCLOSPORINE A, BUT NOT TACROLIMUS, INHIBITS OATP1B1 MEDIATED TRANSPORT OF ATORVASTATIN.
• Skottheim, Ine Blankenberg; Christensen, Hege Staaland; Stormark, Kjartan; Hjelmesæth, Jøran; Jacobsen, Gunn Signe & Sandbu, Rune [Vis alle 7 forfattere av denne artikkelen] (2008). GASTRIC BYPASS SURGERY IN MORBIDLY OBESE PATIENTS ALTERS ATORVASTATIN ACID BIOAVAILABILITY.
• Christensen, Hege Staaland (2008). From drug interactions in patients to in vitro drug metabolism studies.
• Skottheim, Ine Blankenberg; Stormark, Kjartan; Christensen, Hege Staaland; Hjelmesæth, Jøran; Åsberg, Anders & Jacobsen, Gunn Signe [Vis alle 7 forfattere av denne artikkelen] (2008). Significantly altered bioavailability of atorvastatin acid following laparoscopic gastric bypass in morbidly obese patients.
• Bakken, Vibeke; Rudberg, Ida; Hermann, Monica; Molden, Espen & Christensen, Hege Staaland (2008). Metabolisme av quetiapin via CYP3A4 og CYP3A5 in vitro.
• Skottheim, Ine Blankenberg; Stormark, Kjartan; Åsberg, Anders; Christensen, Hege Staaland; Hjælmeseth, Jøran & Nergård, Bent Johnny [Vis alle 8 forfattere av denne artikkelen] (2007). Legemiddelabsorpsjon etter bariatrisk kirurgi.
• Christensen, Hege Staaland (2007). Visjoner for framtidens forskning innen farmasøytisk biovitenskap.
• Christensen, Hege Staaland; Postvoll, Lillian W; Mathiesen, Liv; Johannesen, Siri & Molden, Espen (2007). Different CYP3A4 enzyme kinetics of midazolam in different microsomal preparations.
• Christensen, Hege Staaland; Postvoll, Lillian W; Mathiesen, Liv; Johannesen, Siri & Molden, Espen (2007). Different microsomal preparations exhibit different CYP3A4 enzyme kinetics of midazolam.
• Christensen, Hege Staaland (2006). In vitro-in vivo extrapolation of metabolism based drug-drug interactions.
• Christensen, Hege Staaland (2006). Fortrengning fra plasmaproteiner: Ekstrapolering av legemiddelinteraksjoner fra in vitro data.
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2005). Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data. Drug metabolism reviews (Softcover ed.). ISSN 0360-2532. 37, s. 19–19.
• Christensen, Hege Staaland; Baker, M; Tucker, G & Rostami-Hodjegan, A (2005). Plasma protein binding displacement: Prediction and implications for extrapolation of metabolic drug-drug interactions from in vitro data. Journal of clinical pharmacology. ISSN 0091-2700. 45.
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2005). Prediksjon av fortrengning fra plasmaproteiner og betydningen for in vitro-in vivo ekstrapolering av legemiddel-interaksjoner.
• Åsberg, Anders; Lemahieu, Wim P D; Hermann, Monica; Holdaas, Hallvard; Hartmann, Anders & Verbeke, K [Vis alle 10 forfattere av denne artikkelen] (2005). The mechanisms of the pharmacokinetic interaction between calcineurin inhibitors and statins.
• Christensen, Hege Staaland; Baker, Mark; Tucker, Geoffery T. & Rostami-Hodjegan, Amin (2005). Plasma protein binding displacement: prediction and implications for extrapolation of metabolic drug-drug interactions from in vitro data.
• Hermann, Monica; Åsberg, Anders; Christensen, Hege Staaland; Holdaas, Hallvard; Hartmann, Anders & Reubsaet, Jan Leo (2004). Substantially elevated levels of atorvastatin and metabolites in cyclosporine-treated renal transplant recipients. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 76, s. 388–391.
• Åsberg, Anders; Hermann, Monica; Christensen, Hege Staaland; Reubsaet, Jan Leo; Holdaas, Hallvard & Hartmann, Anders (2004). The substantially higher levels of atorvastatin and metabolites in cyclosporine A treated renal transplant recipients are mostly due to an effect on the acid forms compared to lactone forms.
• Åsberg, Anders; Hermann, Monica; Christensen, Hege Staaland; Reubsaet, Jan Leo; Holdaas, Hallvard & Hartmann, Anders (2004). Several-fold higher systemic exposure of atorvastatin and meabolites n cyclosporine treated renal transplant recipients compared with healthy volunteers.
• Hermann, Monica; Åsberg, Anders; Reubsaet, Leon; Christensen, Hege Staaland & Hartmann, Anders (2003). Kraftig økning i systemisk eksponering av atorvastatin og metabolitter ved samtidig inntak av cyclosporin hos nyretransplanterte pasienter.
• Arnesen, Petter; Molden, Espen; Malterud, Karl Egil & Christensen, Hege Staaland (2003). Substanser i rødvin hemmer CYP3A4-mediert legemiddelmetabolisme.
• Kase, Eili Tranheim; Hermann, Monica; Molden, Espen & Christensen, Hege Staaland (2003). Metabolism of cyclosporine A in microsomes isolated from CYP 3A4 transfected liver epithelial cells.
• Christensen, Hege Staaland (2002). Problembasert læring - noe for ditt fag?
• Molden, Espen; Johansen, Per Wiik; Bøe, Grethe Helen; Bergan, Stein; Christensen, Hege Staaland & Rugstad, Hans Erik [Vis alle 9 forfattere av denne artikkelen] (2002). Disposition of diltiazem and metabolites in relation to CYP2D6 genotype.
• Wangensteen, Helle; Molden, Espen; Christensen, Hege Staaland & Malterud, Karl Egil (2002). Epoxybergamottin - en CYP3A4 inhibitor isolert fra grapefruktskall.
• Wangensteen, Helle; Molden, Espen; Christensen, Hege Staaland & Malterud, Karl Egil (2002). Epoxybergamottin - a CYP3A4 inhibitor in grapefruit peel.
• Bøe, Grethe Helen; Molden, Espen; Christensen, Hege Staaland & Reubsaet, Jan Leo (2002). Development of a LC/MS method for analyzing diltiazem and seven metabolites in human plasma.
• Molden, Espen & Christensen, Hege Staaland (2001). Concentration dependent interference of desacetyl-diltiazem on formation of morfine from codein in vitro.
• Jensen, Ben Andre; Hermann, Monica; Reubsaet, Leon & Christensen, Hege Staaland (2013). Utvikling av kvantitativ proteomikkmetodefor P-glykoprotein i mononukleære celler fra perifert blod. Universitetet i Oslo.
• Bjøringsøy, Stine Karen; Barsett, Hilde & Christensen, Hege Staaland (2013). Ekstrakter av hageblåbær, skogsblåbær, tranebær og tyttebær hemmer CYP3A4 in vitro. Universitetet i Oslo.
• Nguyen, Maria; Barsett, Hilde & Christensen, Hege Staaland (2010). Hemming av CYP3A4-metabolisme av ulike bærekstrakter. Universitetet i Oslo.

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