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Solberg, Rigmor
(2023).
Drugs and new pharmacological targets in the treatment of osteoporosis .
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Alrawaf, Firas; Nilsen, Hilde; Lunde, Ngoc Nguyen; Morland, Cecilie & Solberg, Rigmor
(2022).
The cysteine protease legumain in Parkinson’s disease.
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Antobreh, Alfreda Serwah; Lunde, Ngoc Nguyen; Nilsen, Hilde & Solberg, Rigmor
(2022).
Effects of conditioned media from skeletal muscle cells on metabolism and regulation of the cysteine protease legumain in differentiating osteoblasts.
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Ciyow, Nasra; Bosnjak, Tatjana; Nilsen, Hilde; Lunde, Ngoc Nguyen; Johansen, Harald Thidemann & Solberg, Rigmor
(2020).
Effekt av teriparatid på differensiering og regulering av cysteinproteaser i osteoblaster.
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Olsen, Kristine Løkke; Johansen, Harald Thidemann; Nilsen, Hilde; Solberg, Rigmor & Berg, Kristian
(2020).
Effekt av cysteinproteasen legumain på celleviabilitet etter fotodynamisk terapi.
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Mohanachandran, Arthii; Bosnjak, Tatjana; Nilsen, Hilde; Lunde, Ngoc Nguyen; Solberg, Rigmor & Johansen, Harald Thidemann
(2020).
Differensiering av RAW264.7 til osteoklaster og karakterisering av cysteinproteaser i osteoklaster.
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Solberg, Rigmor
(2019).
The proteolytic enzyme legumain: Structure and functions.
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Bosnjak, Tatjana; Solberg, Rigmor; Arnekleiv, Guro L.; Nilsen, Hilde; Jafari, Abbas & Bassatne, A.
[Vis alle 9 forfattere av denne artikkelen]
(2019).
Vitamin D3 upregulates legumain in the early phase of osteoblast differentiation
.
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Awale, Mustafa; Bosnjak, Tatjana; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann
(2019).
Effekten av kjønnshormoner på differensiering av stamceller til osteoblaster og regulering av cysteinproteasene legumain og cathepsin B.
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Lunde, Ngoc Nguyen Dieu; Holm, Sverre; Dahl, Tuva Børresdatter; Elyouncha, Inass; Sporsheim, Bjørnar & Gregersen, Ida
[Vis alle 12 forfattere av denne artikkelen]
(2018).
Plasma and plaques from patients with carotid atherosclerosis have increased levels of legumain
.
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Solberg, Rigmor
(2018).
Hvordan settes positive dopinganalyser i medisinsk/farmakologisk sammenheng, og hvordan omsettes dette til dom?
-
Bosnjak, Tatjana; Hemati, Paya Diana; Solberg, Rigmor & Johansen, Harald Thidemann
(2018).
Cysteine proteases as Targets for Proton Pump Inhibitors (PPIs).
-
Lunde, Ngoc Nguyen Dieu; Gregersen, Ida; Holm, Sverre; Michelsen, Annika; Sporsheim, Bjørnar & Espevik, Terje
[Vis alle 9 forfattere av denne artikkelen]
(2018).
Platelet-derived legumain, a cysteine protease
involved in atherosclerosis
.
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Abbas, Iram; Nilsen, Hilde; Johansen, Harald Thidemann & Solberg, Rigmor
(2018).
Deksametason hemmer differensiering av humane mesenkymale stamceller til osteoblaster og regulerer cysteinproteasene legumain og cathepsin B.
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Gjonbalaj, Nora; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann
(2018).
Effekt av inflammasjon på regulering av cysteinproteasene legumain og cathepsin B under differensiering av humane mesenkymale stamceller til osteoblaster.
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Solberg, Rigmor; Bosnjak, Tatjana; Nilsen, Hilde; Jafari, Abbas; Kassem, Moustapha & Johansen, Harald Thidemann
(2017).
Regulation of legumain and cysteine cathepsins during differentiation of human bone marrow stromal cells towards osteoblasts.
-
Bosnjak, Tatjana; Hemati, Paya Diana; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann
(2017).
Legumain as a target for proton pump inhibitors (PPIs): Importance for off-target
effects of PPIs?
-
Lunde, Ngoc Nguyen Dieu; Holm, Sverre; Dahl, Tuva B.; Elyoncha, Inass; Sporsheim, Bjørnar & Gregersen, Ida
[Vis alle 12 forfattere av denne artikkelen]
(2017).
Plasma and plaques from patients with carotid atherosclerosis have increased levels
of legumain.
-
Arnekleiv, Guro L.; Nilsen, Hilde; Lunde, Ngoc Nguyen Dieu; Solberg, Rigmor & Johansen, Harald Thidemann
(2017).
Effekt av vitamin D3 på uttrykk, aktivitet og sekresjon av cysteinproteasen legumain studert i ulike cellemodeller.
-
Hemati, Paya Diana; Bosnjak, Tatjana; Nilsen, Hilde; Lunde, Ngoc Nguyen Dieu; Johansen, Harald Thidemann & Solberg, Rigmor
(2017).
The Proton Pump Inhibitor Lansoprazole Inhibits Protease Activity of Legumain.
-
Røsjø, Bjarne & Solberg, Rigmor
(2016).
Desillusjonert over dopingbruken i idretten.
[Internett].
titan.uio.no.
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Lunde, Ngoc Nguyen Dieu; Dahl, Tuva Børresdatter; Abdukadir, Nuriddin; Halvorsen, Bente; Solberg, Rigmor & Johansen, Harald Thidemann
(2016).
Increased secretion of legumain from pro-inflammatory M1 compared to M2 macrophages
.
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Abdukadir, Nuriddin; Lunde, Ngoc Nguyen Dieu; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann
(2016).
Regulering av cysteinproteaser ved differensiering av monocytter til makrofager.
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Larsen, Kristina Broe Bodin; Johansen, Harald Thidemann; Solberg, Rigmor & Lunde, Ngoc Nguyen Dieu
(2016).
Betydning av glykosylering for internalisering og aktivering av prolegumain i humane tykktarmskreftceller.
-
Solberg, Rigmor; Rut, Wioletta; Lunde, Ngoc Nguyen Dieu; Kasperkiewicz, Paulina; Snipas, Scott J. & Mihelic, Marko
[Vis alle 11 forfattere av denne artikkelen]
(2016).
New Selective Probes to Inhibit and Image Legumain in Living Cells.
-
Solberg, Rigmor & Johansen, Harald Thidemann
(2016).
Involvement of the cysteine protease legumain in human health and disease.
-
Johansen, Harald Thidemann; Elyouncha, Inass; Lunde, Ngoc Nguyen Dieu; Williams, Rich; Solberg, Rigmor & Nilsen, Hilde
[Vis alle 7 forfattere av denne artikkelen]
(2015).
Opposing effects of glucose on legumain and cysteine cathepsins
.
-
Solberg, Rigmor; Poreba, Marcin; Rut, Wioletta; Kasperkiewicz, Paulina; Snipas, Scott & Turk, Boris
[Vis alle 8 forfattere av denne artikkelen]
(2015).
Novel legumain-specific activity based probes binds and inhibits legumain in living cells.
-
Lunde, Ngoc Nguyen Dieu; Nilsen, Hilde; Damgaard, Ingrid; Kasem, Roya; Solberg, Rigmor & Haugen, Mads Haugland
[Vis alle 7 forfattere av denne artikkelen]
(2015).
Importance of glycosylation for legumain and cystatin E/M functions.
-
Solberg, Rigmor
(2015).
Novel legumain specific cell-permeable activity based probes.
-
Berven, Lise; Solberg, Rigmor & Samuelsen, Anne Berit C.
(2014).
Effects of alginates on legumain Activity in RAW 264.7 cells and on prolegumain autoactivation.
Planta Medica.
ISSN 0032-0943.
80(16),
s. 1358–1358.
doi:
10.1055/s-0034-1394502.
-
Smith, Robert; Johansen, Harald Thidemann; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild & Thoresen, G. Hege
[Vis alle 7 forfattere av denne artikkelen]
(2013).
Simvastatin inhibits legumain activity and processing in human myotubes.
-
-
Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde & Solberg, Rigmor
(2013).
Effects and interplay of legumain and cystatin E/M on migration and invasion of macrophages.
-
Johansen, Harald Thidemann; Solberg, Rigmor; Nilsen, Hilde & Smith, Robert
(2013).
Effects and interplay of legumain and cystatin E/M om migration and invasion of macrophages.
-
Tina, Elvestrand; Åstrand, Ove Alexander; Smith, Robert; Rongved, Pål; Nilsen, Hilde & Solberg, Rigmor
[Vis alle 7 forfattere av denne artikkelen]
(2013).
Cellular effects of a colchicine-prodrug cleaved by legumain.
-
Voreland, Anette; Smith, Robert; Thoresen, G. Hege; Johansen, Harald Thidemann & Solberg, Rigmor
(2013).
The cysteine protease legumain is downregulated by simvastatin in primary human skeletal muscle cells.
-
Ånonsen, Kjersti Bergh; Nilsen, Hilde; Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor
(2013).
Regulering av legumain i samspillet mellom makrofager og kreftceller.
-
Berven, Lise; Johansen, Harald Thidemann; Solberg, Rigmor; Kolset, Svein Olav & Samuelsen, Anne Berit C.
(2012).
INTERACTIONS BETWEEN PROLEGUMAIN AND GLYCOSAMINOGLYCANS.
-
Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland & Pettersen, Solveig
[Vis alle 9 forfattere av denne artikkelen]
(2012).
SECRETION, INTERNALIZATION AND INTERPLAY OF LEGUMAIN AND CYSTATIN E/M.
-
Jacobsen, Linn Løkken; Smith, Robert; Thoresen, G. Hege; Solberg, Rigmor & Johansen, Harald Thidemann
(2012).
Are the cysteine proteases legumain and cathepsins involved in statin-induced myotoxicity?
-
Tran, Anny T.; Smith, Robert; Solberg, Rigmor & Johansen, Harald Thidemann
(2012).
Effects of atorvastatin on regulation of protease activities in macrophages.
-
Haugen, Mads Haugland; Mælandsmo, Gunhild; Johansen, Harald Thidemann; Solberg, Rigmor; Pettersen, Solveig & Boye, Kjetil
[Vis alle 7 forfattere av denne artikkelen]
(2011).
Nuclear activity of the cysteine protease legumain in colorectal carcinoma.
-
Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland & Pettersen, Solveig J.
[Vis alle 7 forfattere av denne artikkelen]
(2011).
SUBCELLULAR LOCALIZATION, INTERPLAY AND SECRETION OF LEGUMAIN AND CYSTATIN E/M IN HEK 293 CELLS.
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Johansen, Harald Thidemann; Smith, Robert; Tewolde, Eyassu; Nilsen, Hilde & Solberg, Rigmor
(2011).
ATORVASTATIN INHIBITS LEGUMAIN ACTIVITY IN AND PROLEGUMAIN SECRETION FROM HUMAN ACTIVATED MACROPHAGES.
-
Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor
(2011).
Cellular localization and interplay between legumain and its endogenous inhibitor cystatin E/M.
-
Haugen, Mads Haugland; Johansen, Harald Thidemann; Solberg, Rigmor; Flatmark, Kjersti & Mælandsmo, Gunhild M
(2009).
Expression and activity of the cysteine protease legumain in colorectal carcinoma cell lines.
-
Briggs, Jon; Haugen, Mads Haugland; Johansen, Harald Thidemann; Riker, Adam I; Abrahamson, Magnus & Fodstad, Øystein
[Vis alle 8 forfattere av denne artikkelen]
(2009).
Cystatin E/M suppresses legumain activity and invasion of human melanoma.
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Solberg, Rigmor; Almlöf, Maria; Nilsen, Hilde; Ali, Zana Abdullrahman; Abrahamson, Magnus & Johansen, Harald Thidemann
(2009).
Asparaginyl endopeptidase activity is upregulated during differentiation of monocytes to macrophages but only partly mediated by legumain.
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Ben Omar, Sakina; Johansen, Harald Thidemann; Aukrust, Pål; Halvorsen, Bente & Solberg, Rigmor
(2008).
Lysosomal cysteine proteases in atherosclerosis: Do inflammatory modulators regulate expression and activity?
-
Almlöf, Maria; Solberg, Rigmor & Johansen, Harald Thidemann
(2007).
Regulation of cystein proteases in monocytes/macrophages and in tumorigenesis.
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Solberg, Rigmor; Nilsen, Hilde; Johansen, Harald Thidemann; Mælandsmo, Gunhild M. & Briggs, Jon
(2007).
SCREENING OF THE EXPRESSIONS OF LEGUMAIN AND ITS SPECIFIC INHIBITOR CYSTATIN M IN VARIOUS MELANOMA CELLS.
-
Almlöf, Maria; Solberg, Rigmor; Nilsen, Hilde & Johansen, Harald Thidemann
(2006).
Legumain expression and activity is highly increased as monocytes differentiate toward macrophages.
-
Almlöf, Maria; Elenjord, Renate; Solberg, Rigmor; Winberg, Jan-Olof; Loennechen, Thrina & Johansen, Harald Thidemann
(2006).
Malignant osteosarcoma cells express higher levels of legumain compared to non-malignant cells.
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Almlöf, Maria; Elenjord, Renate; Solberg, Rigmor; Winberg, Jan Olof; Loennechen, Thrina & Johansen, Harald Thidemann
(2006).
The expression and activity of legumain is highly increased in malignant osteosarcoma cells compared to non-malignant cells.
-
Solberg, Rigmor
(2005).
FRM 2410 - Formulering og bruk av legemidler.
Norges apotekerforenings tidsskrift.
ISSN 0802-8400.
113(2),
s. 104–105.
-
Brekke, Stian; Rønning, Camilla; Värn, Christine; Aas, Vigdis; Thoresen, G. Hege & Solberg, Rigmor
(2005).
Moxonidine exhibits direct effects on human skeletal muscle cells.
-
Värn, Christine; Aas, Vigdis; Endresen, Marit JR & Solberg, Rigmor
(2004).
Moxonidine enhances glucose uptake in human skeletal muscle cells.
-
Barsett, Hilde & Solberg, Rigmor
(2004).
New curriculum for master of pharmacy, School of Pharmacy, University of Oslo, Norway.
-
Yaqub, Sheraz; Solhaug, Vigdis; Vang, Torkel; Solberg, Rigmor; Aasen, Ansgar Oddne & Tasken, Kjetil
[Vis alle 7 forfattere av denne artikkelen]
(2002).
A Human Whole Blood Model Of LPS-Mediated Suppresion Of T-Cell Activation.
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Rustan, Arild; Solberg, Rigmor; Reseland, Janne Elin; Andersen, Merethe H; Drevon, Christian A & Aas, Vigdis
(2002).
FATTY ACIDS MODULATE LEPTIN AND LEPTIN RECEPTOR (OB-RB) GENE EXPRESSION AND LEPTIN SECRETION IN CULTURED HUMAN SKELETAL MUSCLE CELLS.
Vis sammendrag
Leptin is a hormone primarily secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function. Leptin stimulates oxidation of fatty acids and uptake of glucose, and prevents accumulation of lipids in nonadipose tissues. Inducible leptin expression in skeletal muscle cells (L6 rat cells) in response to insulin and glucosamine has been reported (Wang et al., Nature 1998, 393: 684-8). Based on this observation, we examined if leptin is present in skeletal muscle cells from human biopsies, and also if leptin and its receptor (OB-RB) could be modulated by hormones, fatty acids and other energy substrates.
Leptin was expressed in differentiated myotubes, and both expression (mRNA) and secretion were changed after incubation with 0.1-0.6 mM of fatty acids for 24 and 48 h. Oleate (OA) and eicosapentaenoic acid (EPA 20:5 n-3) increased leptin secretion to the culture medium, with the strongest effect of OA after 48 h incubation. We also observed that incubation with palmitate (PA), OA and EPA for 24 and 48 h increased leptin mRNA expression, whereas the leptin receptor (OB-RB) mRNA expression was reduced 40-50 % by EPA. Moreover, the effect of these fatty acids on basal and insulin-stimulated glucose metabolism was also examined. Preincubation with PA and OA (0.6 mM for 24 h) induced insulin resistance assessed by decreased insulin-stimulated 2-deoxy-glucose transport, when compared to fatty acid-free controls. EPA on the other hand, did not reduce insulin-stimulated glucose transport, and caused a 2-fold increase in basal as well as insulin-stimulated glucose transport.
We have for the first time demonstrated leptin expression in human skeletal muscle cells. Furthermore, this is the first documentation of regulation of OB-RB in any tissue examined. The physiological effect of fatty acids on the leptin axis in muscle cells needs further studies. We focus on how fatty acids affect leptin, OB-RB and their signalling pathways in glucose and lipid metabolism.
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Wang, Jacob Edward; Warris, A.; Ellingsen, Espen Alme; Jørgensen, Pål Foyn; Flo, T. H. & Espevik, T
[Vis alle 9 forfattere av denne artikkelen]
(2001).
Involvement of CD 14 and toll-like receptors in signaling by Aspergillus hypae.
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Samuelsen, Anne Berit C.; Berven, Lise; Solberg, Rigmor; Johansen, Harald Thidemann & Truong, Hong Hoa Thi
(2012).
Effekt av alginat på legumain, en protease involvert i kreftutvikling.
Universitetet i Oslo.
-
Samuelsen, Anne Berit C.; Berven, Lise; Solberg, Rigmor; Johansen, Harald Thidemann & Nguyen, Nga Thi
(2011).
Studier av alginats effekt på prolegumain og cellesekresjon av matriksmetalloproteaser.
Universitetet i Bergen.