Stig Pedersen-Bjergaard

Professor - Seksjon for farmasøytisk kjemi

English version of this page

E-post stig.pedersen-bjergaard@farmasi.uio.no

Telefon +47 22856576

Rom 206

Brukernavn

Besøksadresse Sem Sælands vei 3 Farmasibygningen 0371 OSLO

Postadresse Postboks 1068 Blindern 0316 OSLO

Pressebilde Last ned visittkort

Forskning

Vår forskning er innenfor fagområdet farmasøytisk analytisk kjemi, og har fokus på utvikling av nye konsept for mikroekstraksjon. Vi arbeider med teknikkene elektromembran ekstraksjon (EME) og væske-fase mikroekstraksjon (LPME). EME og LPME kan benyttes til å isolere og oppkonsentrere legemidler, legemiddelmetabolitter, endogene metabolitter og peptider fra humane blod, urin og spyttprøver.

Vår forskning er konseptuell, delvis grunnleggende og delvis anvendt, og omfatter følgende:

Verifiseringsforsøk
Utvikling av teori for massetransport
Utvikling av utstyr (blant annet 96-brønn og mikrochip teknologi)
Utvikling av illustrative farmasøytiske og biomedisinske anvendelser
Kommersialisering

Vår forskning er motivert av forventningene om at neste generasjon analytisk kjemi i stor grad vil være basert på mikroekstraksjonsteknikker for prøveopparbeidelse.

Undervisning

Undervisningen er innenfor farmasøytisk analytisk kjemi og er fokusert på følgende tema

Kjemisk analyse av farmasøytiske råvarer
Kjemisk analyse av farmasøytiske preparat
Bestemmelse av legemidler i biologiske prøver
Generell analytisk kjemi

Er forfatter av to internasjonale lærebøker (Wiley) innen farmasøytisk analytisk kjemi og bioanalyse.

Bakgrunn

Professor (20 % stilling), Institut for Farmaci, Københavns Universitet, Danmark, fra 2008
Professor, Farmasøytisk Institutt, Universitetet i Oslo (2000-)
Førsteamanuensis, Farmasøytisk Institutt, Universitetet i Oslo (1996-2000)
Dr.scient., Kjemisk institutt, Universitetet i Oslo, 1995
Sivilingeniør, Danmarks Tekniske Universitet, 1990

Verv

Contributing Editor Trends in Analytical Chemistry
Associate Editor Journal of Pharmaceutical Analysis
Editor International Journal of Analytical Chemistry

Emneord: Farmasi, Legemidler, Kjemi, Livsvitenskap - life science, Legemiddelanalyse, Bioanalyse, Prøveopparbeidelse, Mikroekstraksjon

Hansen, Frederik & Pedersen-Bjergaard, Stig (2021). Electromembrane extraction of streptomycin from biological fluids. Journal of Chromatography A. ISSN 0021-9673. 1639 . doi: 10.1016/j.chroma.2021.461915
Abdel-Rehim, Mohamed; Pedersen-Bjergaard, Stig; Abdel-Rehim, Abbi; Lucena, Rafael; Moein, Mohammad Mahdi; Cardenas, Soledad & Miro, Manuel (2020). Microextraction approaches for bioanalytical applications: An overview. Journal of Chromatography A. ISSN 0021-9673. 1616 . doi: 10.1016/j.chroma.2019.460790
Bavlovic Piskackova, Hana; Øiestad, Elisabeth Leere; Vanova, Nela; Lengvarska, Julia; Štěrbová-Kovaříková, Petra & Pedersen-Bjergaard, Stig (2020). Electromembrane extraction of anthracyclines from plasma: Comparison with conventional extraction techniques. Talanta: The International Journal of Pure and Applied Analytical Chemistry. ISSN 0039-9140. 223 . doi: 10.1016/j.talanta.2020.121748
Dong, Ying; Li, Jing; Pedersen-Bjergaard, Stig & Huang, Chuixiu (2020). Unidirectional solute transfer using a Janus membrane. Journal of Membrane Science. ISSN 0376-7388. 596, s 1- 7 . doi: 10.1016/j.memsci.2019.117723
Drobnjak, Milena; Hansen, Frederik; Øiestad, Elisabeth Leere; Løvli, Trond; Trones, Roger; Martinsen, Ørjan Grøttem & Pedersen-Bjergaard, Stig (2020). Electromembrane extraction with vials of conducting polymer. LC GC North America. ISSN 1527-5949. 38, s 435- 439
Fashi, Armin; Cheraghi, Mahdi; Ebadipur, Hossein; Ebadipur, Hasan; Zamani, Abbasali; Badiee, Hamid & Pedersen-Bjergaard, Stig (2020). Exploiting agarose gel modified with glucose-fructose syrup as a green sorbent in rotating-disk sorptive extraction technique for the determination of trace malondialdehyde in biological and food samples. Talanta: The International Journal of Pure and Applied Analytical Chemistry. ISSN 0039-9140. 217 . doi: 10.1016/j.talanta.2020.121001
Hansen, Frederik; Jaghl, Mohamad Fadi; Øiestad, Elisabeth Leere; Jensen, Henrik; Pedersen-Bjergaard, Stig & Huang, Chuixiu (2020). Impact of ion balance in electromembrane extraction. Analytica Chimica Acta. ISSN 0003-2670. 1124, s 129- 136 . doi: 10.1016/j.aca.2020.05.039
Hansen, Frederik; Jensen, Henrik & Pedersen-Bjergaard, Stig (2020). Electromembrane extraction using sacrificial electrodes. Analytical Chemistry. ISSN 0003-2700. 92(7), s 5595- 5603 . doi: 10.1021/acs.analchem.0c00626
Hansen, Frederik; Kuban, Pavel; Øiestad, Elisabeth Leere & Pedersen-Bjergaard, Stig (2020). Electromembrane extraction of highly polar bases from biological samples – Deeper insight into bis(2-ethylhexyl) phosphate as ionic carrier. Analytica Chimica Acta. ISSN 0003-2670. 1115, s 23- 32 . doi: 10.1016/j.aca.2020.04.027
Hansen, Frederik; Santigosa-Murillo, Elia; Payan, Maria Ramos; Munoz, Maria; Øiestad, Elisabeth Leere & Pedersen-Bjergaard, Stig (2020). Electromembrane extraction using deep eutectic solvents as the liquid membrane. Analytica Chimica Acta. ISSN 0003-2670. 1143, s 109- 116 . doi: 10.1016/j.aca.2020.11.044
Hansen, Frederik; Øiestad, Elisabeth Leere & Pedersen-Bjergaard, Stig (2020). Bioanalysis of pharmaceuticals using liquid-phase microextraction combined with liquid chromatography–mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 189, s 1- 12 . doi: 10.1016/j.jpba.2020.113446
Khan, Wajid Ali; Arain, Muhammad Balal; Yamini, Yadollah; Shah, Nasrullah; Kazi, Tasneem Gul; Pedersen-Bjergaard, Stig & Tajik, Mohammad (2020). Hollow fiber-based liquid phase microextraction followed by analytical instrumental techniques for quantitative analysis of heavy metal ions and pharmaceuticals. Journal of Pharmaceutical Analysis. ISSN 2095-1779. 10(2), s 109- 122 . doi: 10.1016/j.jpha.2019.12.003
Restan, Magnus Saed; Ramsrud, Sindre Bergstrøm; Jensen, Henrik & Pedersen-Bjergaard, Stig (2020). Influence of acid‐base dissociation equilibria during electromembrane extraction. Journal of Separation Science. ISSN 1615-9306. 43, s 3120- 3128 . doi: 10.1002/jssc.202000391
Restan, Magnus Saed; Skjærvø, Øystein; Martinsen, Ørjan Grøttem & Pedersen-Bjergaard, Stig (2020). Towards exhaustive electromembrane extraction under stagnant conditions. Analytica Chimica Acta. ISSN 0003-2670. 1104, s 1- 9 . doi: 10.1016/j.aca.2020.01.058
Restan, Magnus Saed; Skottvoll, Frøydis Sved; Jensen, Henrik & Pedersen-Bjergaard, Stig (2020). Electromembrane extraction of sodium dodecyl sulfate from highly concentrated solutions. The Analyst. ISSN 0003-2654. 145, s 4957- 4963 . doi: 10.1039/d0an00622j
Ask, Kristine Skoglund; Lid, Marthe; Øiestad, Elisabeth Leere; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2019). Liquid-phase microextraction in 96-well plates - calibration and accurate quantification of pharmaceuticals in human plasma samples. Journal of Chromatography A. ISSN 0021-9673. 1602, s 117- 123 . doi: 10.1016/j.chroma.2019.06.013
Hansen, Frederik & Pedersen-Bjergaard, Stig (2019). Emerging extraction strategies in analytical chemistry. Analytical Chemistry. ISSN 0003-2700. 92(1), s 2- 15 . doi: 10.1021/acs.analchem.9b04677
Lin, Ann; Skottvoll, Frøydis Sved; Rayner, Simon; Pedersen-Bjergaard, Stig; Sullivan, Gareth; Krauss, Stefan; Wilson, Steven Ray Haakon & Harrison, Sean (2019). 3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry. Electrophoresis. ISSN 0173-0835. 41, s 56- 64 . doi: 10.1002/elps.201900170 Fulltekst i vitenarkiv.
Pedersen-Bjergaard, Stig (2019). Analytical microextraction – Present status and future directions. TrAC. Trends in analytical chemistry. ISSN 0165-9936. 118, s 770- 770 . doi: 10.1016/j.trac.2019.07.004
Pedersen-Bjergaard, Stig (2019). Electromembrane extraction – looking into the future. Analytical and Bioanalytical Chemistry. ISSN 1618-2642. 411(9), s 1687- 1693 . doi: 10.1007/s00216-018-1512-x
Restan, Magnus Saed; Pedersen, Morten E.; Jensen, Henrik & Pedersen-Bjergaard, Stig (2019). Electromembrane Extraction of Unconjugated Fluorescein Isothiocyanate from Solutions of Labeled Proteins Prior to Flow Induced Dispersion Analysis. Analytical Chemistry. ISSN 0003-2700. 91(10), s 6702- 6708 . doi: 10.1021/acs.analchem.9b00730
Rezazadeh, Maryam; Seidi, Shahram; Lid, Marthe; Pedersen-Bjergaard, Stig & Yamini, Yadollah (2019). The modern role of smartphones in analytical chemistry. TrAC. Trends in analytical chemistry. ISSN 0165-9936. 118, s 548- 555 . doi: 10.1016/j.trac.2019.06.019
Roman-Hidalgo, Cristina; Santigosa-Murillo, Elia; Ramos-Payan, Maria; Petersen, Nickolaj Jacob; Kutter, Jörg P. & Pedersen-Bjergaard, Stig (2019). On-chip electromembrane extraction of acidic drugs. Electrophoresis. ISSN 0173-0835. 40(18-19), s 2514- 2521 . doi: 10.1002/elps.201900024
Vårdal, Linda; Øiestad, Elisabeth Leere; Gjelstad, Astrid; Jensen, Henrik & Pedersen-Bjergaard, Stig (2019). Electromembrane extraction with solvent modification of the acceptor solution: improved mass transfer of drugs of abuse from human plasma. Bioanalysis. ISSN 1757-6180. 11(8), s 755- 771 . doi: 10.4155/bio-2018-0308
Wan, Libin; Lin, Bin; Zhu, Ruiqin; Huang, Chuixiu; Pedersen-Bjergaard, Stig & Shen, Xiantao (2019). Liquid-Phase Microextraction or Electromembrane Extraction?. Analytical Chemistry. ISSN 0003-2700. 91, s 8267- 8273 . doi: 10.1021/acs.analchem.9b00946
Ask, Kristine Skoglund; Øiestad, Elisabeth Leere; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2018). Dried blood spots and parallel artificial liquid membrane extraction – A simple combination of microsampling and microextraction. Analytica Chimica Acta. ISSN 0003-2670. 1009, s 56- 64 . doi: 10.1016/j.aca.2018.01.024
Drouin, Nicolas; Kuban, Pavel; Rudaz, Serge; Pedersen-Bjergaard, Stig & Schappler, Julie (2018). Electromembrane extraction: Overview of the last decade. TrAC. Trends in analytical chemistry. ISSN 0165-9936. 113, s 357- 363 . doi: 10.1016/j.trac.2018.10.024
Dvorak, Milos; Seip, Knut Fredrik; Pedersen-Bjergaard, Stig & Kuban, Pavel (2018). Semi-automated set-up for exhaustive micro-electromembrane extractions of basic drugs from biological fluids. Analytica Chimica Acta. ISSN 0003-2670. 1005, s 34- 42 . doi: 10.1016/j.aca.2017.11.081
Fuchs, David; Hidalgo, Cristina Román; Ramos Payán, Maria; Petersen, Nickolaj Jacob; Jensen, Henrik; Kutter, Jörg P. & Pedersen-Bjergaard, Stig (2018). Continuous electromembrane extraction coupled with mass spectrometry – Perspectives and challenges. Analytica Chimica Acta. ISSN 0003-2670. 999, s 27- 36 . doi: 10.1016/j.aca.2017.09.027
Hansen, Frederik A; Sticker, Drago; Kutter, Jorg P; Petersen, Nickolaj Jacob & Pedersen-Bjergaard, Stig (2018). Nanoliter-Scale Electromembrane Extraction and Enrichment in a Microfluidic Chip. Analytical Chemistry. ISSN 0003-2700. 90(15), s 9322- 9329 . doi: 10.1021/acs.analchem.8b01936
Huang, Chuixiu; Shen, Xiantao; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2018). Investigation of alternative supported liquid membranes in electromembrane extraction of basic drugs from human plasma. Journal of Membrane Science. ISSN 0376-7388. 548, s 176- 183 . doi: 10.1016/j.memsci.2017.11.001
Lin, Bin; Wan, Libin; Sun, Xiaojie; Huang, Chuixiu; Pedersen-Bjergaard, Stig & Shen, Xiantao (2018). Electromembrane extraction of high level substances: A novel approach for selective recovery of templates in molecular imprinting. Journal of Membrane Science. ISSN 0376-7388. 568, s 30- 39 . doi: 10.1016/j.memsci.2018.09.056
Olsen, Katharina Norgren; Ask, Kristine Skoglund; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2018). Parallel artificial liquid membrane extraction of psychoactive analytes: a novel approach in therapeutic drug monitoring. Bioanalysis. ISSN 1757-6180. 10(6), s 385- 395 . doi: 10.4155/bio-2017-0250
Vårdal, Linda; Wong, Gladys; Øiestad, Åse Marit Leere; Pedersen-Bjergaard, Stig; Gjelstad, Astrid & Øiestad, Elisabeth Leere (2018). Rapid determination of designer benzodiazepines, benzodiazepines, and Z-hypnotics in whole blood using parallel artificial liquid membrane extraction and UHPLC-MS/MS. Analytical and Bioanalytical Chemistry. ISSN 1618-2642. 410(20), s 4967- 4978 . doi: 10.1007/s00216-018-1147-y
Vårdal, Linda; Øiestad, Elisabeth Leere; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2018). Electromembrane extraction of substances with weakly basic properties: A fundamental study with benzodiazepines. Bioanalysis. ISSN 1757-6180. 10(10), s 769- 781 . doi: 10.4155/bio-2018-0030
Fernández, Elena; Vårdal, Linda; Vidal, Lorena; Canals, Antonio; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2017). Complexation-mediated electromembrane extraction of highly polar basic drugs – a fundamental study with catecholamines in urine as model system. Analytical and Bioanalytical Chemistry. ISSN 1618-2642. 409, s 4215- 4223 . doi: 10.1007/s00216-017-0370-2
Gjelstad, Astrid; Andresen, Alf Terje; Dahlgren, Anders; Gundersen, Thomas Erik & Pedersen-Bjergaard, Stig (2017). High-throughput liquid-liquid extraction in 96-well format: Parallel artificial liquid membrane extraction. LC GC North America. ISSN 1527-5949. 35(3), s 192- 196
Gjelstad, Astrid; Andresen, Alf Terje; Dahlgren, Anders; Gundersen, Thomas Erik & Pedersen-Bjergaard, Stig (2017). High-throughput liquid-liquid extraction in 96-well format: Parallel artificial liquid membrane extraction. LC GC Europe. ISSN 1471-6577. 30(1), s 10- 17 Fulltekst i vitenarkiv.
Huang, Chuixiu; Chen, Zhiliang; Gjelstad, Astrid; Pedersen-Bjergaard, Stig & Shen, Xiantao (2017). Electromembrane extraction. TrAC. Trends in analytical chemistry. ISSN 0165-9936. 95, s 47- 56 . doi: 10.1016/j.trac.2017.07.027
Huang, Chuixiu; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2017). Electromembrane extraction with alkylated phosphites and phosphates as supported liquid membranes. Journal of Membrane Science. ISSN 0376-7388. 526, s 18- 24 . doi: 10.1016/j.memsci.2016.11.049
Khajeh, Mostafa; Pedersen-Bjergaard, Stig; Bohlooli, Mousa; Barkhordar, Afsaneh & Ghaffari-Moghaddam, Mansour (2017). Maghemite nanoparticle-decorated hollow fiber electromembrane extraction combined with dispersive liquid-liquid microextraction for the determination of thymol from Carum copticum. Journal of the Science of Food and Agriculture. ISSN 0022-5142. 97(5), s 1517- 1523 . doi: 10.1002/jsfa.7894
Pedersen-Bjergaard, Stig; Huang, Chuixiu & Gjelstad, Astrid (2017). Electromembrane extraction – Recent trends and where to go. Journal of Pharmaceutical Analysis. ISSN 2095-1779. 7(3), s 141- 147 . doi: 10.1016/j.jpha.2017.04.002 Fulltekst i vitenarkiv.
Pilarova, Veronika; Sutani, Mumtaz; Ask, Kristine Skoglund; Novakova, Lucie; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2017). One-step extraction of polar drugs from plasma by parallel artificial liquid membrane extraction. Journal of chromatography. B. ISSN 1570-0232. 1043, s 25- 32 . doi: 10.1016/j.jchromb.2016.09.019
Restan, Magnus Saed; Jensen, Henrik; Shen, Xiantao; Huang, Chuixiu; Martinsen, Ørjan Grøttem; Kubáň, Pavel; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2017). Comprehensive study of buffer systems and local pH effects in electromembrane extraction. Analytica Chimica Acta. ISSN 0003-2670. 984, s 116- 123 . doi: 10.1016/j.aca.2017.06.049
Rye, Torstein Kige; Fuchs, David; Pedersen-Bjergaard, Stig & Petersen, Nickolaj Jacob (2017). Direct coupling of electromembrane extraction to mass spectrometry – Advancing the probe functionality toward measurements of zwitterionic drug metabolites. Analytica Chimica Acta. ISSN 0003-2670. 983, s 121- 129 . doi: 10.1016/j.aca.2017.05.038
Vårdal, Linda; Askildsen, Hilde- Merete; Gjelstad, Astrid; Øiestad, Elisabeth Leere; Edvardsen, Hilde Marie Erøy & Pedersen-Bjergaard, Stig (2017). Parallel artificial liquid membrane extraction of new psychoactive substances in plasma and whole blood. Journal of chromatography. B. ISSN 1570-0232. 1048, s 77- 84 . doi: 10.1016/j.jchromb.2017.02.010 Fulltekst i vitenarkiv.
Vårdal, Linda; Gjelstad, Astrid; Huang, Chuixiu; Øiestad, Elisabeth Leere & Pedersen-Bjergaard, Stig (2017). Efficient discrimination and removal of phospholipids during electromembrane extraction from human plasma samples. Bioanalysis. ISSN 1757-6180. 9(8), s 631- 641 . doi: 10.4155/bio-2017-0027
Ask, Kristine Skoglund; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2016). Dried blood spots on carboxymethyl cellulose sheets: Rapid sample preparation based on dissolution and precipitation. Chromatographia. ISSN 0009-5893. 79, s 509- 514 . doi: 10.1007/s10337-016-3039-7
Ask, Kristine Skoglund; Turgay, Bardakci; Parmer, Marthe Petrine; Halvorsen, Trine Grønhaug; Øiestad, Elisabeth Leere; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2016). Parallel artificial liquid membrane extraction as an efficient tool for removal of phospholipids from human plasma. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 129, s 229- 236 . doi: 10.1016/j.jpba.2016.07.011
Fuchs, David; Gabel-Jensen, Charlotte; Jensen, Henrik; Rand, Kasper D.; Pedersen-Bjergaard, Stig; Honoré Hansen, Steen & Petersen, Nickolaj Jacob (2016). Direct coupling of a flow-flow electromembrane extraction probe to LC-MS. Analytica Chimica Acta. ISSN 0003-2670. 905, s 93- 99 . doi: 10.1016/j.aca.2015.12.014
Fuchs, David; Pedersen-Bjergaard, Stig; Jensen, Henrik; Rand, Kasper D.; Honoré Hansen, Steen & Petersen, Nickolaj Jacob (2016). Fully automated electro membrane extraction autosampler for LC-MS systems allowing soft extractions for high-throughput applications. Analytical Chemistry. ISSN 0003-2700. 88(13), s 6797- 6804 . doi: 10.1021/acs.analchem.6b01243
Huang, Chuixiu; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2016). Organic solvents in electromembrane extraction: recent insights. Analitical chemistry (Tel Aviv, 1993). ISSN 0793-0135. 35(4), s 169- 183 . doi: 10.1515/revac-2016-0008
Huang, Chuixiu; Jensen, Henrik; Seip, Knut Fredrik; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2016). Mass transfer in electromembrane extraction - The link between theory and experiments. Journal of Separation Science. ISSN 1615-9306. 39(1), s 188- 197 . doi: 10.1002/jssc.201500905
Huang, Chuixiu; Seip, Knut Fredrik; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2016). Electromembrane extraction of polar basic drugs from plasma with pure bis(2-ethylhexyl) phosphite as supported liquid membrane. Analytica Chimica Acta. ISSN 0003-2670. 934, s 80- 87 . doi: 10.1016/j.aca.2016.06.002
Kuban, Pavel; Seip, Knut Fredrik; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2016). Micro-electromembrane extraction using multiple free liquid membranes and acceptor solutions – Towards selective extractions of analytes based on their acid-base strength. Analytica Chimica Acta. ISSN 0003-2670. 943, s 64- 73 . doi: 10.1016/j.aca.2016.09.022
Poole, Colin; Mester, Zoltan; Miro, Manuel; Pedersen-Bjergaard, Stig & Pawliszyn, Janusz (2016). Extraction for analytical scale sample preparation (IUPAC Technical Report). Pure and Applied Chemistry. ISSN 0033-4545. 88(7), s 649- 687 . doi: 10.1515/pac-2015-0705
Poole, Colin; Mester, Zoltan; Miro, Manuel; Pedersen-Bjergaard, Stig & Pawliszyn, Janusz (2016). Glossary of terms used in extraction (IUPAC Recommendations 2016). Pure and Applied Chemistry. ISSN 0033-4545. 88(5), s 517- 558 . doi: 10.1515/pac-2015-0903
Fuchs, David; Jensen, Henrik; Pedersen-Bjergaard, Stig; Gabel-Jensen, Charlotte; Honoré Hansen, Steen & Petersen, Nickolaj Jacob (2015). Real time extraction kinetics of electro membrane extraction verified by comparing drug metabolism profiles obtained from a flow-flow electro membrane extraction-mass spectrometry system with LC-MS. Analytical Chemistry. ISSN 0003-2700. 87, s 5775- 5781 . doi: 10.1021/acs.analchem.5b00981
Gjelstad, Astrid; Pedersen-Bjergaard, Stig & Seip, Knut Fredrik (2015). Electromembrane extraction as a rapid and selective miniaturized sample preparation technique for biological fluids. Bioanalysis. ISSN 1757-6180. 7(17), s 2203- 2209 . doi: 10.4155/bio.15.150
Huang, Chuixiu; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2015). Exhaustive extraction of peptides by electromembrane extraction. Analytica Chimica Acta. ISSN 0003-2670. 853(1), s 328- 334 . doi: 10.1016/j.aca.2014.10.017
Huang, Chuixiu; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2015). Selective electromembrane extraction based on isoelectric point: Fundamental studies with angiotensin II antipeptide as model analyte. Journal of Membrane Science. ISSN 0376-7388. 481, s 115- 123 . doi: 10.1016/j.memsci.2015.02.006
Huang, Chuixiu; Gjelstad, Astrid; Seip, Knut Fredrik; Jensen, Henrik & Pedersen-Bjergaard, Stig (2015). Exhaustive and stable electromembrane extraction of acidic drugs from human plasma. Journal of Chromatography A. ISSN 0021-9673. 1425, s 81- 87 . doi: 10.1016/j.chroma.2015.11.052
Huang, Chuixiu; Seip, Knut Fredrik; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2015). Electromembrane extraction for pharmaceutical and biomedical analysis - Quo vadis. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 113, s 97- 107 . doi: 10.1016/j.jpba.2015.01.038
Huang, Chuixiu; Seip, Knut Fredrik; Gjelstad, Astrid; Shen, Xiantao & Pedersen-Bjergaard, Stig (2015). Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Step: Simultaneous Group Separation of Acidic and Basic Drugs. Analytical Chemistry. ISSN 0003-2700. 87(13), s 6951- 6957 . doi: 10.1021/acs.analchem.5b01610
Khajeh, Mostafa; Pedersen-Bjergaard, Stig; Barkhordar, Afsaneh & Bohlooli, Mousa (2015). Application of hollow cylindrical wheat stem for electromembrane extraction of thorium in water samples. Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy. ISSN 1386-1425. 137, s 328- 332 . doi: 10.1016/j.saa.2014.08.103
Pedersen-Bjergaard, Stig (2015). Analysis of small-molecule drugs in biological fluids, In Steen Honoré Hansen & Stig Pedersen-Bjergaard (ed.), Bioanalysis of pharmaceuticals : sample preparation, separation techniques and mass spectrometry. Wiley-Blackwell. ISBN 978-111871682-3. s 207 - 259
Pedersen-Bjergaard, Stig; Gjelstad, Astrid & Halvorsen, Trine Grønhaug (2015). Sample preparation, In Steen Honoré Hansen & Stig Pedersen-Bjergaard (ed.), Bioanalysis of pharmaceuticals : sample preparation, separation techniques and mass spectrometry. Wiley-Blackwell. ISBN 978-111871682-3. s 73 - 121
Petersen, Nickolaj Jacob; Jensen, Henrik & Pedersen-Bjergaard, Stig (2015). On-chip electromembrane extraction for monitoring drug metabolism in real time by electrospray ionization mass spectrometry. Methods in molecular biology. ISSN 1064-3745. 1274, s 171- 182 . doi: 10.1007/978-1-4939-2353-3_15
Roldán-Pijuán, Mercedes; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2015). Parallel artificial liquid membrane extraction of acidic drugs from human plasma. Analytical and Bioanalytical Chemistry. ISSN 1618-2642. 407(10), s 2811- 2819 . doi: 10.1007/s00216-015-8505-9
Seip, Knut Fredrik; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2015). The potential of electromembrane extraction for bioanalytical applications. Bioanalysis. ISSN 1757-6180. 7(4), s 463- 480 . doi: 10.4155/bio.14.303
Dugstad, Helene bonkerud; Petersen, Nickolaj Jacob; Jensen, Henrik; Gabel-Jensen, Charlotte; Honoré Hansen, Steen & Pedersen-Bjergaard, Stig (2014). Development and characterization of a small electromembrane extraction probe coupled with mass spectrometry for real-time and online monitoring of in vitro drug metabolism. Analytical and Bioanalytical Chemistry. ISSN 1618-2642. 406(2), s 421- 429 . doi: 10.1007/s00216-013-7378-z
Eibak, Lars Erik; Parmer, Marthe Petrine; Rasmussen, Knut Einar; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2014). Parallel electromembrane extraction in a multiwell plate. Analytical and Bioanalytical Chemistry. ISSN 1618-2642. 406(2), s 431- 440 . doi: 10.1007/s00216-013-7345-8

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Pedersen-Bjergaard, Stig; Gammelgaard, Bente & Halvorsen, Trine Grønhaug (2019). Introduction to Pharmaceutical Analytical Chemistry, 2nd Edition. Wiley-Blackwell. ISBN 9781119362722.
Hansen, Steen Honoré & Pedersen-Bjergaard, Stig (ed.) (2015). Bioanalysis of pharmaceuticals : sample preparation, separation techniques and mass spectrometry. Wiley-Blackwell. ISBN 978-111871682-3. 318 s.

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Skottvoll, Frøydis Sved; Harrison, Sean; Hansen, Frederik; Pedersen-Bjergaard, Stig; Sullivan, Gareth; Bogen, Inger Lise; Lundanes, Elsa & Wilson, Steven Ray Haakon (2020). Liver mini-organ analyses using liquid chromatography mass spectrometry. Vis sammendrag
Organoids (self-organized multi-cellular tissue derived from e.g. patient-derived stem cells) are emerging in vitro 3D representations of human organ functionality, predicted to have a game-changing impact on drug discovery, disease modeling and personalized medicine [1]. Integrating the organoids in a microfluidic chip (i.e. organoids-on-a-chip) would allow for controllable perfusion of nutrients and manipulation of the organoids by the addition of e.g. drugs [2]. Coupling the organoid-on-a-chip online to liquid chromatography mass spectrometry (LC-MS) would enable real-time measurements of the biochemical processes that occur on-chip. However, limited sample sizes, complex matrices and the presence of low abundant analytes also create analytical challenges [3]. Moreover, the organoids are still at the developmental stage, thus fundamental questions on the functionality of the developed organoids remain to be answered. Liver organoid functionality was assessed by protein characterization of adult liver tissue and liver organoids using nanoLC-MS/MS. The proteins identified from the liver organoids covered 70-84% (1003 proteins) of the liver protein expression from adult liver tissue derived from five patients. The proteins that were shared between the adult liver tissue and liver organoids could also relate to central liver pathways (e.g. amino acid biosynthesis and glycolysis). The sample preparation technique electromembrane extraction (i.e. electrophoretic separation across an oil membrane, EME) has shown to have on-chip analytical potential [4] and was thus used in the study of heroin drug metabolism in liver organoids. Multi-well EME (100 µL solutions) allowed for simple and repeatable monitoring of heroin metabolism kinetics without interference from cell medium components (e.g. albumin). The EME extracts were also compatible with different analytical approaches (LC-MS, nanoLC-MS, capillary electrophoresis-UV). Hence, the hyphenation of EME with nanoLC-MS would be a natural next step. References 1. Method of the Year 2017: Organoids. Nature Methods. Vol. 15 (2018) 1-1. 2. Park, S.E., A. Georgescu, and D. Huh, Organoids-on-a-chip. Science. Vol. 364 (2019) 960. 3. Lin, A., F. Sved Skottvoll, S. Rayner, S. Pedersen-Bjergaard, G. Sullivan, S. Krauss, S. Ray Wilson, and S. Harrison, 3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry. ELECTROPHORESIS. Vol. 0 (2019). 4. Hansen, F.A., D. Sticker, J.P. Kutter, N.J. Petersen, and S. Pedersen-Bjergaard, Nanoliter-Scale Electromembrane Extraction and Enrichment in a Microfluidic Chip. Analytical Chemistry. Vol. 90 (2018) 9322-9329.
Pedersen-Bjergaard, Stig (2019). In-vitro drug metabolism monitoring by micro-chip electromembrane extraction coupled with mass spectrometry.
Pedersen-Bjergaard, Stig (2018). Liquid-phase microextraction – recent trends and perspectives.
Pedersen-Bjergaard, Stig (2018). Microextraction based on electrical fields – combining partition and electrophoresis.
Skjærvø, Øystein; Pilarova, Veronika; Khalikova, Maria; Reubsaet, Leon; Halvorsen, Trine Grønhaug; Gjelstad, Astrid; Øiestad, Elisabeth Leere; Lundanes, Elsa; Wilson, Steven Ray Haakon & Pedersen-Bjergaard, Stig (2018). Those Who Can, Teach: Pharma Stars. The Analytical Scientist. ISSN 2051-4077. 1118, s 40- 45
Skjærvø, Øystein; Pilarova, Veronika; Khalikova, Maria; Reubsaet, Leon; Halvorsen, Trine Grønhaug; Gjelstad, Astrid; Øiestad, Elisabeth Leere; Lundanes, Elsa; Wilson, Steven Ray Haakon & Pedersen-Bjergaard, Stig (2018). Those Who Can, Teach: Pharma Stars. The Analytical Scientist. ISSN 2051-4077. 1118, s 40- 45
Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2017). Liquid-phase microextraction (LPME) – From conceptual development and into routine laboratories.
Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2017). Microextraction through supported liquid membranes – Tuning the extraction chemistry for biomedical and pharmaceutical applications.
Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2017). Recent trends in drug analysis using liquid-phase microextraction.
Pedersen-Bjergaard, Stig; Gjelstad, Astrid & Rasmussen, Knut Einar (2017). Arrested development – Given ongoing challenges in sample preparation and lack of novel alternatives, is it time to give liquid-phase microextraction (LPME) a second chance?. The Analytical Scientist. ISSN 2051-4077. 49, s 46- 49
Ask, Kristine Skoglund; Øiestad, Elisabeth Leere; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2016). Parallel Artificial Liquid Membrane Extraction - En ny metode for fjerning av fosfolipider.
Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2016). Parallel Artificial Liquid Membrane Extraction as a Selective, Single-step Sample Preparation Method of Human Plasma Prior to LC-MS.
Kuban, Pavel; Boceka, Petr; Seip, Knut Fredrik; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2016). Multiple phase micro-electromembrane extraction for selective pretreatment of raw biological samples.
Pedersen-Bjergaard, Stig (2016). Liquid-phase microextraction – recent trends and where to go?.
Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2016). Drug analysis using liquid-phase microextraction – recent trends and where to go.
Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2016). Liquid-phase microextraction – recent trends and where to go?.
Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2016). Parallel artificial liquid membrane extraction as an efficient tool for removal of phospholipids from human plasma.
Ask, Kristine Skoglund; Halvorsen, Trine Grønhaug; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2015). Phospholipid removal from human plasma samples by Parallel Artificial Liquid Membrane Extraction.
Huang, Chuixiu; Seip, Knut Fredrik; Gjelstad, Astrid; Shen, Xiantao & Pedersen-Bjergaard, Stig (2015). Combination of electromembrane extraction and liquid-phase microextraction in a single step: simultaneous extraction of acidic drugs and basic drugs.
Lund, Hilde Marie Erøy; Øiestad, Elisabeth Leere; Christophersen, Asbjørg S.; Gjerde, Hallvard & Pedersen-Bjergaard, Stig (2015). Using biological samples to study the use of alcohol and drugs in cohorts. Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo.. 1594.
Pedersen-Bjergaard, Stig (2015). Introduction, In Steen Honoré Hansen & Stig Pedersen-Bjergaard (ed.), Bioanalysis of pharmaceuticals : sample preparation, separation techniques and mass spectrometry. Wiley-Blackwell. ISBN 978-111871682-3. Introduction. s 1 - 7
Seip, Knut Fredrik & Pedersen-Bjergaard, Stig (2015). Microextraction across artificial liquid membranes in 96-well format – A new approach to sample preparation for liquid chromatography.
Vårdal, Linda; Øiestad, Elisabeth Leere; Seip, Knut Fredrik; Gjelstad, Astrid & Pedersen-Bjergaard, Stig (2015). Development of Stable, Selective, and Efficient Artificial Liquid Membranes for Electromembrane Extraction (EME).
Ask, Kristine Skoglund; Pedersen-Bjergaard, Stig & Gjelstad, Astrid (2014). Dried Blood Spots på vannløselige polymere.
Eibak, Lars Erik; Pedersen-Bjergaard, Stig; Rasmussen, Knut Einar & Gjelstad, Astrid (2014). Ekstraksjon av legemidler fra plasma, urin og fullblod ved bruk av elektriske felt.
Eibak, Lars Erik; Pedersen-Bjergaard, Stig; Rasmussen, Knut Einar & Gjelstad, Astrid (2014). Water Soluble Biopolymers as Sampling Medium for Dried Blod Spot Analysis.

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Publisert 3. nov. 2010 15:42 - Sist endret 11. apr. 2019 08:24

Stig Pedersen-Bjergaard

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