New publication on knockout of Aggrecan in PV neurons

Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function

By Hafting
Published Feb. 2, 2025
 
Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrapping parvalbumin-expressing inhibitory neurons.
  • Knockout of ACAN in PV+ cells inhibit formation of WFA positive perineuronal nets (PNNs) around PV+ cells.
  • ACAN KO mice show lower level of anxiety-related behavior. In the morris watermaze they employ bolder search strategy, but long-term memory is the same.
  • The absence of WFA+ labeled PNNs had little to no impact on memory processing or the intrinsic physiological properties of PV+ interneurons in V1.
  • Our discoveries could put into question the role of PNNs in memory processing, and challenge the notion that PV+ neurons are reliant on PNNs as a facilitator.

Authors

Sverre Grødem, Elise H. Thompson, Malin Røe, Guro H. Vatne,  Ingeborg Nymoen,  Alessio Buccino, Tarjei Madland, Torkel Hafting,  Marianne Fyhn, Kristian K. Lensjø
 
Source: Molecular Psychiatry (22 January 2025)
DOI: https://doi.org/10.1038/s41380-025-02894-5
 
Read the full paper at Nature
Published Feb. 2, 2025 9:32 PM - Last modified Feb. 3, 2025 10:29 AM
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