The brain has a remarkable ability to adapt to changing environments, but the mechanisms underlying these processes remain elusive.
The Fyhn group works to identify the neural fingerprint that reflects
learning of sensory experiences in cortical circuits, from structural
changes of synapses to changes in the population code of neural
ensembles in behaving animals. To achieve this, we use large scale
extracellular recordings of populations of neurons and transcranial
two-photon laser scanning microscopy to identify structural and
functional changes of identified neurons. A better understanding of
the mechanisms underlying basic cortical plasticity and function will
untangle how experience modifies cortical circuits to form long-lasting
memories. It will also have a significant impact on our understanding
of both normal and diseased brain function.
Marianne Fyhn is director of Centre for Integrative Neuroplasticity
(CINPLA). CINPLA is a strategic research initiative at the MN Faculty
at UiO, aiming to reveal mechanisms underlying the brain’s ability
to change and learn from experiences. By integrating experimental
methods with physics-based computational modelling and analysis,
we work to develop a creative and inspiring consortium aiming to
deliver groundbreaking research and develop an interdisciplinary and
high-quality educational program in Neuroscience at the faculty.