Kirsten Sandvig

• Øverbye, Anders; Torgersen, Maria Lyngaas; Sønstevold, Tonje; Iversen, Tore Geir; Mørch, Ýrr Asbjørg & Skotland, Tore [Vis alle 7 forfattere av denne artikkelen] (2021). Cabazitaxel-loaded poly(alkyl cyanoacrylate) nanoparticles: Toxicity and changes in the proteome of breast, colon and prostate cancer cells. Nanotoxicology. ISSN 1743-5390. 15(7), s. 865–884. doi: 10.1080/17435390.2021.1924888. Fulltekst i vitenarkiv
• Rudolph, Michael J.; Poon, Amanda Y.; Kavaliauskiene, Simona; Myrann, Anne-Grethe; Reynolds-Peterson, Claire & Davis, Simon A. [Vis alle 9 forfattere av denne artikkelen] (2021). Structural Analysis of Toxin-Neutralizing, Single-Domain Antibodies that Bridge Ricin's A-B Subunit Interface. Journal of Molecular Biology (JMB). ISSN 0022-2836. 433(15), s. 1–20. doi: 10.1016/j.jmb.2021.167086.
• Sandvig, Kirsten; Kavaliauskiene, Simona & Skotland, Tore (2021). The Protein Toxins Ricin and Shiga Toxin as Tools to Explore Cellular Mechanisms of Internalization and Intracellular Transport. Toxins. ISSN 2072-6651. 13(6). doi: 10.3390/toxins13060377. Fulltekst i vitenarkiv
• Pandya, Abhilash D.; Iversen, Tore Geir; Moestue, Siver Andreas; Grinde, Maria Tunset; Mørch, Ýrr Asbjørg & Snipstad, Sofie [Vis alle 13 forfattere av denne artikkelen] (2021). Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft. Nanomaterials. ISSN 2079-4991. 11(5). doi: 10.3390/nano11051140. Fulltekst i vitenarkiv
• Skotland, Tore; Iversen, Tore Geir & Sandvig, Kirsten (2021). Cellular uptake of nanoparticles: Involvement of caveolae? Precision Nanomedicine (PRNANO). ISSN 2639-9431. 4(2), s. 782–786. doi: 10.33218/001c.22201. Fulltekst i vitenarkiv
• Valsalakumari, Remya; Yadava, Sunil Kumar; Szwed, Marzena; Pandya, Abhilash D.; Mælandsmo, Gunhild Mari & Torgersen, Maria Lyngaas [Vis alle 10 forfattere av denne artikkelen] (2021). Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells. . International Journal of Pharmaceutics. ISSN 0378-5173. 597(120217). doi: 10.1016/j.ijpharm.2021.120217. Fulltekst i vitenarkiv
• Skotland, Tore & Sandvig, Kirsten (2021). Transport of nanoparticles across the endothelial cell layer. Nano Today. ISSN 1748-0132. 36. doi: 10.1016/j.nantod.2020.101029. Fulltekst i vitenarkiv
• Tsjokajev, Ahmad; Røberg-Larsen, Hanne; Wilson, Steven Ray Haakon; Anne Berit Dyve, Lingelem; Skotland, Tore & Sandvig, Kirsten [Vis alle 7 forfattere av denne artikkelen] (2020). Mass spectrometry-based measurements of cyclic adenosine monophosphate in cells, simplified using reversed phase liquid chromatography with a polar characterized stationary phase. Journal of chromatography. B. ISSN 1570-0232. 1160, s. 1–6. doi: 10.1016/j.jchromb.2020.122384. Fulltekst i vitenarkiv
• Sønstevold, Tonje; Engedal, Nikolai; Mørch, Ýrr Asbjørg; Iversen, Tore Geir; Skotland, Tore & Sandvig, Kirsten [Vis alle 7 forfattere av denne artikkelen] (2020). Structural Variants of poly(alkylcyanoacrylate) Nanoparticles Differentially Affect LC3 and Autophagic Cargo Degradation. Journal of Biomedical Nanotechnology. ISSN 1550-7033. 16(4), s. 432–445. doi: 10.1166/jbn.2020.2906. Fulltekst i vitenarkiv Vis sammendrag

  Nanoparticle drug carriers trigger a variety of cellular stress responses, including ER stress and antioxidant responses, but may also affect the intracellular degradative pathway autophagy. This can impose profound effects on drug delivery, cellular treatment responses, and nanoparticle cytotoxicity. We recently demonstrated that even small variations in the alkyl side chains of poly(alkylcyanoacrylate) (PACA) drug carrier nanoparticles, namely butyl (PBCA), ethylbutyl (PEBCA), or octyl (POCA), differentially induce ER stress and redox imbalance in human cell lines. Here, we systematically investigate how these PACA variants affect autophagy. Interestingly, treatment with PEBCA or POCA particles led to intracellular accumulation of the autophagosome marker LC3-II, but via different mechanisms. PEBCA induced an integrated stress response-and ATF4-mediated increase in LC3B mRNA, whereas POCA blocked autophagic degradation of LC3-II and long-lived proteins in bulk. PBCA also increased LC3B mRNA via the integrated stress response and ATF4, but unlike PEBCA, it inhibited LC3 lipidation and autophagic cargo degradation. Our data demonstrate that even subtle variations in NP structure can have profoundly different impacts on autophagy, and that careful monitoring of autophagic flux and cargo degradation is critical for drawing accurate conclusions. Our findings have important implications for the choice of PACA monomer in different therapeutic settings.

• Torgersen, Maria Lyngaas; Judge, Peter J.; Bada Juarez, Juan F.; Pandya, Abhilash D.; Fusser, Markus & Davies, Charlie W. [Vis alle 12 forfattere av denne artikkelen] (2020). Physicochemical characterization, toxicity and in vivo biodistribution studies of a discoidal, lipid-based drug delivery vehicle: Lipodisq nanoparticles containing doxorubicin. Journal of Biomedical Nanotechnology. ISSN 1550-7033. 16(4), s. 419–431. doi: 10.1166/jbn.2020.2911. Fulltekst i vitenarkiv
• Lingelem, Anne Berit Dyve; Kavaliauskiene, Simona; Halsne, Ruth; Klokk, Tove Irene; Surma, Michal A. & Klose, Christian [Vis alle 8 forfattere av denne artikkelen] (2020). Diacylglycerol Kinase and Phospholipase D Inhibitors Alter the Cellular Lipidome and Endosomal Sorting Towards the Golgi Apparatus. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. doi: 10.1007/s00018-020-03551-6. Fulltekst i vitenarkiv
• Skotland, Tore; Sagini, Krizia; Sandvig, Kirsten & Llorente, Alicia (2020). An emerging focus on lipids in extracellular vesicles. Advanced Drug Delivery Reviews. ISSN 0169-409X. 159, s. 308–321. doi: 10.1016/j.addr.2020.03.002. Fulltekst i vitenarkiv
• Skotland, Tore; Kavaliauskiene, Simona & Sandvig, Kirsten (2020). The role of lipid species in membranes and cancer-related changes. Cancer Metastasis Review. ISSN 0167-7659. 39, s. 343–360. doi: 10.1007/s10555-020-09872-z. Fulltekst i vitenarkiv
• Pandya, Abhilash D.; Øverbye, Anders; Saharia, Priyanka; Gaware, Vivek S.; Høgset, Håkon & Masson, Már [Vis alle 11 forfattere av denne artikkelen] (2020). Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer. Biomacromolecules. ISSN 1525-7797. 21, s. 1489–1498. doi: 10.1021/acs.biomac.0c00061. Fulltekst i vitenarkiv
• Szwed, Marzena; Torgersen, Maria Lyngaas; Kumari, Remya Valsala; Yadava, Sunil Kumar; Pust, Sascha & Iversen, Tore Geir [Vis alle 9 forfattere av denne artikkelen] (2020). Biological response and cytotoxicity induced by lipid nanocapsules . Journal of Nanobiotechnology. ISSN 1477-3155. 18(5). doi: 10.1186/s12951-019-0567-y. Fulltekst i vitenarkiv
• Pandya, Abhilash D.; Jäger, Eliézer; Fam, Shahla Bagheri; Höcherl, Anita; Jäger, Alessandro & Sincari, Vladimir [Vis alle 12 forfattere av denne artikkelen] (2019). Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy. International Journal of Nanomedicine. ISSN 1176-9114. 14, s. 6269–6285. doi: 10.2147/IJN.S208938. Fulltekst i vitenarkiv
• Skotland, Tore & Sandvig, Kirsten (2019). The role of PS 18:0/18:1 in membrane function. Nature Communications. ISSN 2041-1723. 10(1), s. 1–10. doi: 10.1038/s41467-019-10711-1. Fulltekst i vitenarkiv
• Sowa-Rogozińska, Natalia; Sominska, Hanna; Nowakowska-Gołacka, Jowita; Sandvig, Kirsten & Słomińska-Wojewódzka, Monika (2019). Intracellular transport and cytotoxicity of the protein toxin ricin. Toxins. ISSN 2072-6651. 11:350(6), s. 1–37. doi: 10.3390/toxins11060350. Fulltekst i vitenarkiv
• Szwed, Marzena; Sønstevold, Tonje; Øverbye, Anders; Engedal, Nikolai; Grallert, Beata & Mørch, Ýrr Asbjørg [Vis alle 11 forfattere av denne artikkelen] (2019). Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death. Nanotoxicology. ISSN 1743-5390. 13(6), s. 761–782. doi: 10.1080/17435390.2019.1576238. Fulltekst i vitenarkiv
• Skotland, Tore; Hessvik, Nina Pettersen; Sandvig, Kirsten & Llorente Martinez, Alicia (2019). Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology. Journal of Lipid Research. ISSN 0022-2275. 60, s. 9–18. doi: 10.1194/jlr.R084343. Fulltekst i vitenarkiv
• Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F. & Kildal, Wanja [Vis alle 16 forfattere av denne artikkelen] (2018). Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft. Journal of Controlled Release. ISSN 0168-3659. 293, s. 183–192. doi: 10.1016/j.jconrel.2018.11.029. Fulltekst i vitenarkiv
• Sandvig, Kirsten; Kavaliauskiene, Simona & Skotland, Tore (2018). Clathrin-independent endocytosis: an increasing degree of complexity. Histochemistry and Cell Biology. ISSN 0948-6143. 150, s. 107–118. doi: 10.1007/s00418-018-1678-5. Fulltekst i vitenarkiv
• Sulheim, Einar; Iversen, Tore Geir; To, Vu; Klinkenberg, Geir; Sletta, Håvard & Schmid, Ruth [Vis alle 12 forfattere av denne artikkelen] (2017). Cytotoxicity of poly(Alkyl cyanoacrylate) nanoparticles. International Journal of Molecular Sciences. ISSN 1661-6596. 18(11). doi: 10.3390/ijms18112454. Fulltekst i vitenarkiv
• Taubenschmid, Jasmin; Stadlmann, Johannes; Jost, Markus; Klokk, Tove Irene; Rillahan, Cory D. & Leibbrandt, Andreas [Vis alle 16 forfattere av denne artikkelen] (2017). A vital sugar code for ricin toxicity. Cell Research. ISSN 1001-0602. 27(11), s. 1351–1364. doi: 10.1038/cr.2017.116.
• Øverbye, Anders; Holsæter, Ann Mari; Fusser, Markus; Skalko-Basnet, Natasa; Iversen, Tore Geir & Torgersen, Maria Lyngaas [Vis alle 12 forfattere av denne artikkelen] (2017). Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. OncoTarget. ISSN 1949-2553. 8(44), s. 76921–76934. doi: 10.18632/oncotarget.20217. Fulltekst i vitenarkiv
• Vestad, Beate; Llorente, Alicia; Neurauter, Axl; Phuyal, Santosh; Kierulf, Bente & Kierulf, Peter [Vis alle 10 forfattere av denne artikkelen] (2017). Size and concentration analyses of extracellular vesicles by nanoparticle tracking analysis: a variation study. Journal of Extracellular Vesicles. ISSN 2001-3078. 6(1), s. 1–11. doi: 10.1080/20013078.2017.1344087. Fulltekst i vitenarkiv
• Simm, Roger; Kvalvaag, Audun Sverre Myrset; van Deurs, Bo; Lindback, Toril & Sandvig, Kirsten (2017). Benzyl alcohol induces a reversible fragmentation of the Golgi apparatus and inhibits membrane trafficking between endosomes and the trans-Golgi network. Experimental Cell Research. ISSN 0014-4827. 357(1), s. 67–78. doi: 10.1016/j.yexcr.2017.04.025.
• Skotland, Tore; Sandvig, Kirsten & Llorente, Alicia (2017). Lipids in exosomes: Current knowledge and the way forward. Progress in lipid research. ISSN 0163-7827. 66, s. 30–41. doi: 10.1016/j.plipres.2017.03.001. Fulltekst i vitenarkiv
• Hardes, Kornelia; Ivanova, Teodora; Thaa, Bastian; McInerney, Gerald M; Klokk, Tove Irene & Sandvig, Kirsten [Vis alle 9 forfattere av denne artikkelen] (2017). Elongated and shortened peptidomimetic inhibitors of the proprotein furin. ChemMedChem. ISSN 1860-7179. 12(8), s. 613–620. doi: 10.1002/cmdc.201700108.
• Ailte, Ieva; Anne Berit Dyve, Lingelem; Kvalvaag, Audun Sverre Myrset; Kavaliauskiene, Simona; Brech, Andreas & Koster, Gerbrand [Vis alle 10 forfattere av denne artikkelen] (2017). Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis. Traffic : the International Journal of Intracellular Transport. ISSN 1398-9219. 18(3), s. 176–191. doi: 10.1111/tra.12468. Fulltekst i vitenarkiv
• Kavaliauskiene, Simona; Anne Berit Dyve, Lingelem; Skotland, Tore & Sandvig, Kirsten (2017). Protection against Shiga Toxins. Toxins. ISSN 2072-6651. 9(2). doi: 10.3390/toxins9020044. Fulltekst i vitenarkiv
• Manna, Dipankar; Pust, Sascha; Torgersen, Maria Lyngaas; Cordara, Gabriele; Kunzler, Markus & Krengel, Ute [Vis alle 7 forfattere av denne artikkelen] (2017). Polyporus squamosus lectin 1a (PSL1a) exhibits cytotoxicity in mammalian cells by disruption of focal adhesions, inhibition of protein synthesis and induction of apoptosis. PLOS ONE. ISSN 1932-6203. 12(1). doi: 10.1371/journal.pone.0170716. Fulltekst i vitenarkiv
• Skotland, Tore; Ekroos, Kim; Kauhanen, Dimple; Simolin, Helena; Seierstad, Therese & Berge, Viktor [Vis alle 8 forfattere av denne artikkelen] (2017). Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers. European Journal of Cancer. ISSN 0959-8049. 70, s. 122–132. doi: 10.1016/j.ejca.2016.10.011.
• Ling, Wang; Skotland, Tore; Berge, Viktor; Sandvig, Kirsten & Llorente, Alicia (2017). Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 98, s. 80–85. doi: 10.1016/j.ejps.2016.09.023.
• Torgersen, Maria Lyngaas; Klokk, Tove Irene; Kavaliauskiene, Simona; Klose, Christian; Simons, Kai & Skotland, Tore [Vis alle 7 forfattere av denne artikkelen] (2016). The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. OncoTarget. ISSN 1949-2553. 7(52), s. 86871–86888. doi: 10.18632/oncotarget.13508.
• Kavaliauskiene, Simona; Torgersen, Maria Lyngaas; Lingelem , Anne Berit Dyve; Klokk, Tove Irene; Lintonen, Tuulia & Simolin, Helena [Vis alle 9 forfattere av denne artikkelen] (2016). Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport. OncoTarget. ISSN 1949-2553. 7(48), s. 79885–79900. doi: 10.18632/oncotarget.13089.
• Hessvik, Nina Pettersen; Øverbye, Anders; Brech, Andreas; Torgersen, Maria Lyngaas; Jakobsen, Ida Seim & Sandvig, Kirsten [Vis alle 7 forfattere av denne artikkelen] (2016). PIKfyve inhibition increases exosome release and induces secretory autophagy. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 73(24), s. 4717–4737. doi: 10.1007/s00018-016-2309-8.
• Skotland, Tore; Ekroos, Kim; Kavaliauskiene, Simona; Bergan, Jonas; Kauhanen, Dimple & Lintonen, Tuulia [Vis alle 7 forfattere av denne artikkelen] (2016). Determining the turnover of glycosphingolipid species by stable-isotope tracer lipidomics. Journal of Molecular Biology (JMB). ISSN 0022-2836. 428(24), s. 4856–4866. doi: 10.1016/j.jmb.2016.06.013.
• Hjelseth, Ieva Ailte; Lingelem , Anne Berit Dyve; Kavaliauskiene, Simona; Bergan, Jonas; Kvalvaag, Audun Sverre Myrset & Myrann, Anne-Grethe [Vis alle 8 forfattere av denne artikkelen] (2016). Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding. Scientific Reports. ISSN 2045-2322. 6. doi: 10.1038/srep30336.
• Asp, Nagham Theres; Kvalvaag, Audun Sverre Myrset; Sandvig, Kirsten & Pust, Sascha (2016). Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins. OncoTarget. ISSN 1949-2553. 7(18), s. 25443–25460. doi: 10.18632/oncotarget.8327.
• Herrera, Cristina; Klokk, Tove Irene; Cole, Richard; Sandvig, Kirsten & Mantis, Nicholas J (2016). A bispecific antibody promotes aggregation of ricin toxin on cell surfaces and alters dynamics of toxin internalization and trafficking. PLOS ONE. ISSN 1932-6203. 11:0156893(6). doi: 10.1371/journal.pone.0156893.
• Róg, Tomasz; Orłowski, Adam; Llorente, Alicia; Skotland, Tore; Sylvänne, Tuulia & Kauhanen, Dimple [Vis alle 9 forfattere av denne artikkelen] (2016). Data including GROMACS input files for atomistic molecular dynamics simulations of mixed, asymmetric bilayers including molecular topologies, equilibrated structures, and force field for lipids compatible with OPLS-AA parameters. Data in Brief. ISSN 2352-3409. 7, s. 1171–1174. doi: 10.1016/j.dib.2016.03.067.
• Yermakova, Anastasiya; Klokk, Tove Irene; O'Hara, Joanne M.; Cole, Richard; Sandvig, Kirsten & Mantis, Nicholas J. (2016). Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport. Scientific Reports. ISSN 2045-2322. 6. doi: 10.1038/srep22721.
• Klokk, Tove Irene; Kavaliauskiene, Simona & Sandvig, Kirsten (2016). Cross-linking of glycosphingolipids at the plasma membrane: Consequences for intracellular signaling and traffic. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 73(6), s. 1301–1316. doi: 10.1007/s00018-015-2049-1.
• Rog, Tomasz; Orlowski, Adam; Llorente, Alicia; Skotland, Tore; Sylvänne, Tuulia & Kauhanen, Dimple [Vis alle 9 forfattere av denne artikkelen] (2016). Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner. Biochimica et Biophysica Acta - Biomembranes. ISSN 0005-2736. 1858(2), s. 281–288. doi: 10.1016/j.bbamem.2015.12.003.
• Kymre, Linn Furebotten; Simm, Roger; Skotland, Tore & Sandvig, Kirsten (2015). Different roles of the C-terminal end of Stx1A and Stx2A for AB5 complex integrity and retrograde transport of Stx in HeLa cells. Pathogens and Disease. ISSN 2049-632X. 73(9), s. 1–9. doi: 10.1093/femspd/ftv083.
• Øverbye, Anders; Skotland, Tore; Koehler, Christian; Thiede, Bernd; Seierstad, Therese & Berge, Viktor [Vis alle 8 forfattere av denne artikkelen] (2015). Identification of prostate cancer biomarkers in urinary exosomes. OncoTarget. ISSN 1949-2553. 6(30), s. 30357–30376. doi: 10.18632/oncotarget.4851.
• Kavaliauskiene, Simona; Skotland, Tore; Sylvänne, Tuulia; Simolin, Helena; Klokk, Tove Irene & Torgersen, Maria Lyngaas [Vis alle 10 forfattere av denne artikkelen] (2015). Novel actions of 2-deoxy-D-glucose: Protection against Shiga toxins and changes in cellular lipids. Biochemical Journal. ISSN 0264-6021. 470, s. 23–37. doi: 10.1042/BJ20141562.
• Skotland, Tore; Iversen, Tore Geir; Torgersen, Maria Lyngaas & Sandvig, Kirsten (2015). Cell-penetrating peptides: Possibilities and challenges for drug delivery in vitro and in vivo. Molecules. ISSN 1420-3049. 20(7), s. 13313–13323. doi: 10.3390/molecules200713313.
• Sandvig, Kirsten; Lingelem, Anne Berit Dyve; Skotland, Tore & Bergan, Jonas (2015). Shiga toxins: Properties and action on cells. I Alouf, Joseph E; Ladant, Daniel & Popoff, Michel R (Red.), The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition. Elsevier. ISSN 978-0-12-800188-2. s. 267–286.
• Slominska-Wojewodzka, Monika & Sandvig, Kirsten (2015). The role of lectin-carbohydrate interactions in the regulation of ER-associated protein degradation. Molecules. ISSN 1420-3049. 20(6), s. 9816–9846. doi: 10.3390/molecules20069816.
• Lingelem, Anne Berit Dyve; Hjelseth, Ieva Ailte; Simm, Roger; Torgersen, Maria Lyngaas & Sandvig, Kirsten (2015). Geldanamycin enhances retrograde transport of Shiga toxin in HEp-2 cells. PLOS ONE. ISSN 1932-6203. 10:e0129214(5). doi: 10.1371/journal.pone.0129214.
• Hardes, Kornelia; Becker, Gero L.; Lu, Yinghui; Dahms, Sven O.; Köhler, Susanne & Beyer, Wolfgang [Vis alle 14 forfattere av denne artikkelen] (2015). Novel furin inhibitors with potent anti-infectious activity. ChemMedChem. ISSN 1860-7179. 10(7), s. 1218–1231. doi: 10.1002/cmdc.201500103.
• Phuyal, Santosh; Skotland, Tore; Hessvik, Nina Pettersen; Simolin, Helena; Øverbye, Anders & Brech, Andreas [Vis alle 10 forfattere av denne artikkelen] (2015). The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells. Journal of Biological Chemistry. ISSN 0021-9258. 290, s. 4225–4237. doi: 10.1074/jbc.M114.593962.
• Sokołowska, Iwona; Piłka, Ewa S.; Sandvig, Kirsten; Węgrzyn, Grzegorz & Słomińska-Wojewódzka, Monika (2015). Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells. BMC Cell Biology. ISSN 1471-2121. 16(1). doi: 10.1186/s12860-015-0047-7.
• Holland, Petter; Torgersen, Maria Lyngaas; Sandvig, Kirsten & Simonsen, Anne (2014). LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis. Traffic : the International Journal of Intracellular Transport. ISSN 1398-9219. 15(12), s. 1390–1405. doi: 10.1111/tra.12227.
• Bergan, Jonas; Skotland, Tore; Anne Berit Dyve, Lingelem; Simm, Roger; Spilsberg, Bjørn & Lindback, Toril [Vis alle 10 forfattere av denne artikkelen] (2014). The ether lipid precursor hexadecylglycerol protects against Shiga toxins. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 71, s. 4285–4300. doi: 10.1007/s00018-014-1624-1.
• Cordara, Gabriele; Winter, Harry C.; Goldstein, Irwin J.; Krengel, Ute & Sandvig, Kirsten (2014). The fungal chimerolectin MOA inhibits protein and DNA synthesis in NIH/3T3 cells and may induce BAX-mediated apoptosis. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 447(4), s. 586–589. doi: 10.1016/j.bbrc.2014.04.043.
• Asp, Nagham; Pust, Sascha & Sandvig, Kirsten (2014). Flotillin depletion affects ErbB protein levels in different human breast cancer cells. BBA - Molecular Cell Research. ISSN 0167-4889. 1843(9), s. 1987–1996. doi: 10.1016/j.bbamcr.2014.04.013.
• Yermakova, Anastasiya; Klokk, Tove Irene; Cole, Richard; Sandvig, Kirsten & Mantis, Nicholas J (2014). Antibody-mediated inhibition of ricin toxin retrograde transport. mBio. ISSN 2161-2129. 5(2). doi: 10.1128/mBio.00995-13.
• Phuyal, Santosh; Hessvik, Nina Pettersen; Skotland, Tore; Sandvig, Kirsten & Llorente, Alicia (2014). Regulation of exosome release by glycosphingolipids and flotillins. The FEBS Journal. ISSN 1742-464X. 281(9), s. 2214–2227. doi: 10.1111/febs.12775.
• Kavaliauskiene, Simona; Nymark, Carl-Martin; Bergan, Jonas; Simm, Roger; Sylvänne, Tuulia & Simolin, Helena [Vis alle 9 forfattere av denne artikkelen] (2014). Cell density-induced changes in lipid composition and intracellular trafficking. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 71(6), s. 1097–1116. doi: 10.1007/s00018-013-1441-y.
• Kvalvaag, Audun Sverre Myrset; Pust, Sascha & Sandvig, Kirsten (2014). Vps11, a subunit of the tethering complexes HOPS and CORVET, is involved in regulation of glycolipid degradation and retrograde toxin transport. Communicative & Integrative Biology. ISSN 1942-0889. 7. doi: 10.4161/cib.28129.
• Sandvig, Kirsten; Bergan, Jonas; Kavaliauskiene, Simona & Skotland, Tore (2014). Lipid requirements for entry of protein toxins into cells. Progress in lipid research. ISSN 0163-7827. 54(1), s. 1–13. doi: 10.1016/j.plipres.2014.01.001.
• Slominska-Wojewodska, Monika; Pawlik, A; Sokolowska, Iwona; Antoniewicz, J; Wegrzyn, Grzegorz & Sandvig, Kirsten (2014). The role of EDEM2 versus EDEM1 in ricin transport fro the endoplasmic reticulum to the cytosol. Biochemical Journal. ISSN 0264-6021. 457(3), s. 485–496. doi: 10.1042/BJ20130155.
• Pust, Sascha; Klokk, Tove Irene; Musa, Nagham; Jenstad, Monica; Risberg, Bjørn Åke & Erikstein, Bjørn K [Vis alle 11 forfattere av denne artikkelen] (2013). Flotillins as regulators of ErbB2 levels in breast cancer. Oncogene. ISSN 0950-9232. 32(29), s. 3443–3451. doi: 10.1038/onc.2012.357.
• Bergan, Jonas; Skotland, Tore; Sylvänne, Tuulia; Simolin, Helena; Ekroos, Kim & Sandvig, Kirsten (2013). The ether lipid precursor hexadecylglycerol causes major changes in the lipidome of HEp-2 cells. PLOS ONE. ISSN 1932-6203. 8(9). doi: 10.1371/journal.pone.0075904.
• Llorente, Alicia; Skotland, Tore; Sylvänne, Tuulia; Kauhanen, Dimple; Rog, Tomasz & Orlowski, Adam [Vis alle 9 forfattere av denne artikkelen] (2013). Molecular lipidomics of exosomes released by PC-3 prostate cancer cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1831(7), s. 1302–1309. doi: 10.1016/j.bbalip.2013.04.011.
• Slominska-Wojewodska, Monika & Sandvig, Kirsten (2013). Ricin and ricin-containing immunotoxins: insights into intracellular transport and mechanism of action in vitro. Antibodies. ISSN 2073-4468. 2, s. 485–496. doi: 10.3390/antib2020236.
• Hessvik, Nina Pettersen; Sandvig, Kirsten & Llorente, Alicia (2013). Exosomal miRNA as biomarkers for prostate cancer. Frontiers in Genetics. ISSN 1664-8021. s. 1–9. doi: 10.3389/fgene.2013.00036.
• Sandvig, Kirsten; Skotland, Tore; Van Deurs, Bo & Klokk, Tove Irene (2013). Retrograde transport of protein toxins through the Golgi apparatus. Histochemistry and Cell Biology. ISSN 0948-6143. 140(3), s. 317–326. doi: 10.1007/s00418-013-1111-z.
• Kvalvaag, Audun Sverre Myrset; Pust, Sascha; Sundet, Kristine Ingrid; Simm, Roger; Sandvig, Kirsten & Engedal, Kim Nikolai (2013). The ERM Proteins Ezrin and Moesin Regulate Retrograde Shiga Toxin Transport. Traffic : the International Journal of Intracellular Transport. ISSN 1398-9219. 14(7), s. 839–852. doi: 10.1111/tra.12077.
• Gregers, Tone Fredsvik; Skånland, Sigrid Strand; Waelchli, Sebastien; Bakke, Oddmund & Sandvig, Kirsten (2013). BiP Negatively Affects Ricin Transport. Toxins. ISSN 2072-6651. 5(5), s. 969–982. doi: 10.3390/toxins5050969.
• Iversen, Tore Geir; Frerker, Nadine & Sandvig, Kirsten (2012). Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism. Journal of Nanobiotechnology. ISSN 1477-3155. 10. doi: 10.1186/1477-3155-10-33.
• Ilina, Polina; Hyvonen, Zanna; Saura, Maeva; Sandvig, Kirsten; Yliperttula, Marjo & Ruponen, Marika (2012). Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems. Journal of Controlled Release. ISSN 0168-3659. 163(3), s. 385–395. doi: 10.1016/j.jconrel.2012.09.016.
• Bergan, Jonas; Lingelem, Anne Berit Dyve; Simm, Roger; Skotland, Tore & Sandvig, Kirsten (2012). Shiga toxins. Toxicon. ISSN 0041-0101. 60(6), s. 1085–1107. doi: 10.1016/j.toxicon.2012.07.016.
• Iversen, Tore Geir; Frerker, Nadine & Sandvig, Kirsten (2012). Cellular uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism. Journal of Nanobiotechnology. ISSN 1477-3155. 10. doi: 10.1186/1477-3155-10-33.
• Becker, G.L.; Lu, Y.; Hardes, K.; Strehlow, B.; Levesque, C. & Lindberg, I. [Vis alle 11 forfattere av denne artikkelen] (2012). Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases. Journal of Biological Chemistry. ISSN 0021-9258. 287(26), s. 21992–22003. doi: 10.1074/jbc.M111.332643.
• Hessvik, Nina Pettersen; Phuyal, Santosh; Brech, Andreas; Sandvig, Kirsten & Llorente, Alicia (2012). Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms. ISSN 1874-9399. 1819(11-12), s. 1154–1163. doi: 10.1016/j.bbagrm.2012.08.016.
• Sandvig, Kirsten & Llorente, Alicia (2012). Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3. Molecular & Cellular Proteomics. ISSN 1535-9476. 11(7). doi: 10.1074/mcp.M111.012914.
• Tcatchoff, Lionel; Andersson, Sofia; Utskarpen, Audrun; Klokk, Tove Irene; Skånland, Sigrid Strand & Pust, Sascha [Vis alle 8 forfattere av denne artikkelen] (2012). Annexin A1 and A2: Roles in Retrograde Trafficking of Shiga Toxin. PLOS ONE. ISSN 1932-6203. 7(7). doi: 10.1371/journal.pone.0040429.

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• Torgersen, Maria Lyngaas; Szwed, Marzena; Sønstevold, Tonje; Øverbye, Anders; Engedal, Nikolai & Grallert, Beata [Vis alle 11 forfattere av denne artikkelen] (2018). Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death.
• Rodriguez, Marta; Bajo-Santos, Cristina; Hessvik, Nina Pettersen; Lorenz, Susanne; Fromm, Bastian & Berge, Viktor [Vis alle 9 forfattere av denne artikkelen] (2017). Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes. Molecular Cancer. ISSN 1476-4598. 16:156, s. 1–6. doi: 10.1186/s12943-017-0726-4. Vis sammendrag

  The aim of this study was to identify microRNAs in urinary exosomes that are differently expressed in prostate cancer patients and healthy donors. For this purpose, RNA was extracted from urinary exosomes from 20 prostate cancer patients and 9 healthy males and the microRNAs were analyzed by next generation sequencing. Interestingly, 5 microRNAs - miR-196a-5p, miR-34a-5p, miR-143-3p, miR-501-3p and miR-92a-1-5p - were significantly downregulated in exosomes from prostate cancer patients. Furthermore, RT-qPCR analysis of an independent cohort of 28 prostate cancer patients and 19 healthy males confirmed that miR-196a-5p and miR-501-3p were downregulated in prostate cancer samples. These results suggest that specific microRNAs in urinary exosomes might serve as non-invasive biomarkers for prostate cancer. In particular, miR-196a-5p and miR-501-3p are promising biomarkers that need to be further studied in large patient cohorts.

• Sulheim, Einar; Iversen, Tore Geir; To, Vu; Klinkenberg, Geir; Sletta, Håvard & Schmid, Ruth [Vis alle 12 forfattere av denne artikkelen] (2017). Cytotoxicity of Poly (alkyl cyanoacrylate) Nanoparticles.
• Manna, Dipankar; Krengel, Ute & Sandvig, Kirsten (2016). Structure-function characterization and cytotoxicity studies of fungal chimerolections. NBS-nytt. ISSN 0801-3535.
• Manna, Dipankar; Cordara, Gabriele; Sandvig, Kirsten & Krengel, Ute (2016). I Robot- Biological nanomachines for fungal defense.
• Øverbye, Anders; Holsæter, Ann Mari; Skalko-Basnet, Natasa; Tore-Geir, Iversen; Torgersen, Maria Lyngaas & Sønstevold, Tonje [Vis alle 8 forfattere av denne artikkelen] (2016). Biodegradable nanoparticles in cancer diagnosis and therapy (NANOCAN):Ceramide modulation of liposomal doxorubicin.
• Manna, Dipankar; Cordara, Gabriele; Pust, Sascha; Goldstein, Irwin J; Winter, Harry C. & Krengel, Ute [Vis alle 7 forfattere av denne artikkelen] (2015). PSL1a: a new member in the growing family of fungal chimerolectin.
• Skotland, Tore; Iversen, Tore Geir & Sandvig, Kirsten (2014). Development of nanoparticles for clinical use. Nanomedicine. ISSN 1743-5889. 9(9), s. 1295–1299. doi: 10.2217/NNM.14.81.
• O'Hara, Joanne; Klokk, Tove Irene; Sandvig, Kirsten & Mantis, Nicholas (2012). RTA-specific monoclonal antibodies neutralize ricin toxin intracellularly. Journal of Immunology. ISSN 0022-1767. 188.
• Kvalvaag, Audun Sverre Myrset & Sandvig, Kirsten (2015). Shiga toxin: Uptake and transport in cancer cells. Akademika Publishing.
• Seim Jakobsen, Ida; Llorente, Alicia & Sandvig, Kirsten (2014). Exosome release: Role of PIKfyve and ERM proteins. Reprosentralen, UIO.
• Svensson, Karin; Klokk, Tove Irene & Sandvig, Kirsten (2014). The role of evectin-2 and its binding partner PS in toxin transport. Reprosentralen, UIO.
• Sandvig, Kirsten; Simm, Roger & Kymre, LInn (2014). Structure-function relationship of Shiga toxins. Role of the A-subunit in complex stability and endocytosis. Reprosentralen, UIO.
• Phuyal, Santosh; Llorente, Alicia & Sandvig, Kirsten (2014). Composition and cellular release of exosomes from cancer cells. Akademika publishing.
• Asp, Nagham; Sandvig, Kirsten; Pust, Sascha & Klokk, Tove Irene (2014). Regulation of ErbB2 and ErbB3 Growth factor receptors in human breast cancer. Akademika Publishing.
• Cordara, Gabriele; Krengel, Ute & Sandvig, Kirsten (2013). Structure-function studies on the Marasmius oreades agglutinin (MOA), a cytotoxic protease. Akademika Publishing.
• Sandvig, Kirsten & Bergan, Jonas (2013). Investigation of membrane dynamics in cancer cells by following Shiga toxin. Faculty of Mathematics and Natural Sciences, University of Oslo.
• Sandvig, Kirsten & Gargul, Anne Grete (2013). In vitro studies of nanosized iron oxide particles. Reprosentralen Universitetet i Oslo.
• Lingelem, Anne Berit Dyve & Sandvig, Kirsten (2012). Intracellular transport of Shiga toxin and ricin. Unipub forlag.

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