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Beshkov, Kosio; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute Tomas
(2023).
Topological Structure of Population Activity in Mouse Visual Cortex Encodes Densely Sampled Visual Scene Rotations.
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Beshkov, Kosio; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute Tomas
(2023).
Topological Structure of Population Activity in Mouse Visual Cortex Encodes Densely Sampled Visual Scene Rotations.
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Banono, Nancy Saana; Gawel, Kinga Aurelia; Mäki-Marttunen, Tuomo; van der Ent, Wietske; Kukula-Koch, Wirginia & Fyhn, Marianne
[Vis alle 10 forfattere av denne artikkelen]
(2023).
Novel zebrafish model for studying neurodevelopment in Timothy syndrome.
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Elle Lepperød, Mikkel; Stöber, Tristan; Hafting, Torkel; Fyhn, Marianne & Kording, Konrad
(2022).
Inferring causal connectivity from pairwise recordings and optogenetics.
bioRxiv.
ISSN 2692-8205.
doi:
10.1101/463760.
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Schøyen, Vemund Sigmundson; Pettersen, Markus Borud; Holzhousen, Konstantin; Fyhn, Marianne; Malthe-Sørenssen, Anders & Elle Lepperød, Mikkel
(2022).
Coherently Remapping Toroidal Cells But Not Grid Cells are Responsible for Path Integration in Virtual Agents.
bioRxiv.
ISSN 2692-8205.
doi:
10.1101/2022.08.18.504379.
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Schlegel, Ulrike; Hjallar, Viktor A.; Lensjø, Kristian; Uggerud, Ida Margrethe; Bjaalie, Jan G. & Hvoslef-Eide, Martha
[Vis alle 8 forfattere av denne artikkelen]
(2022).
Mapping of parahippocampal and visual neural networks in mice: Preliminary evidence for feedback projections from perirhinal cortex to visual areas.
Vis sammendrag
Feedback projections from higher-order processing areas to lower-order areas within the visual system havebeen observed in several species. While much is known about the function of feedforward connections in thevisual processing pathway, feedback connections are not as well studied. They are thought to cause behaviorssuch as (selective) attention or expectations, but the exact mechanism and underlying neural connectivity isstill unknown. The perirhinal cortex (PRH) forms the intersection between perceptual and mnemonic areas ofthe visual processing pathway. Evidence from rats, monkeys and humans suggests that it is involved in bothobject memory and perceptual tasks, which is reflected in its connectivity. PRH forms numerous feedforwardand feedback projections with other areas of the visual processing pathway. However, little is known about thefunction and organization of feedback projections from PRH, and other parahippocampal regions, to visualareas in mice. Given the widespread availability of genetic and molecular tools, novel opportunities toinvestigate the function of these feedback projections would be enabled by mapping them in mice. Here wepresent preliminary data from anterograde and retrograde tract tracing experiments showing feedbackprojections from PRH, and other parahippocampal regions, to visual areas. We have found first evidence forfeedback projections from PRH to lower-order visual areas that were assumed to be exclusive to higher-developed animals such as monkeys or humans. Further, we have identified feedback projections from otherparahippocampal regions with specific subregional distribution.
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Banono, Nancy Saana; van der Ent, Wietske; Gawel, Kinga Aurelia; Marttunen, Tuomo; Kukula, Wirginia Koch & Fyhn, Marianne
[Vis alle 9 forfattere av denne artikkelen]
(2022).
Zebrafish larvae with cacna1c mutations display both shared and distinct phenotypes.
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Thon, Sarah Kriebel; Christensen, Ane Charlotte; Fjeldstad, Maria P; Schøyen, Vemund Sigmundson; Olsen, Elise Reppe & Lepperød, Mikkel Elle
[Vis alle 8 forfattere av denne artikkelen]
(2022).
Social and spatial codes in hippocampus CA2 and entorhinal cortex.
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Engebretsen, Solveig; Goodwin, Morten; Fyhn, Marianne & Jemterud, Torkild
(2022).
Abels tårn.
[Radio].
NRK P2.
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Banono, Nancy Saana; van der Ent, Wietske; Gawel, Kinga Aurelia; Mäki-Marttunen, Tuomo; Kukula-Koch, Wirginia & Einevoll, Gaute
[Vis alle 9 forfattere av denne artikkelen]
(2021).
Functional characterisation of cacna1c mutations in zebrafish larvae.
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Sørensen, Christina; Qureshi, Tayyaba; Fyhn, Marianne; Hafting, Torkel & Chaudhry, Farrukh Abbas
(2021).
GABA er essensielt for normal hjerneutvikling og synaptisk plastisitet.
NBS-nytt.
ISSN 0801-3535.
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Iannella, Nicolangelo Libero; Prydz, Kristian; Malthe-Sørensen, Anders; Einevoll, Gaute & Fyhn, Marianne
(2020).
A framework for modelling neuronal-ECM signalling.
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Fyhn, Marianne; Malthe-Sørenssen, Anders; Mørken, Knut Martin; Nederbragt, Alexander Johan; Odden, Tor Ole & Sundnes, Joakim
(2019).
Beregningsorientering og utdanningsutvikling.
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Fyhn, Marianne & Einevoll, Gaute
(2019).
Hjernen digitaliseres - hvordan moderne datateknologi brukes til å forstå biologiske mekanismer i hjernen.
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Iannella, Nicolangelo Libero; Prydz, Kristian; Malthe-Sørensen, Anders; Einevoll, Gaute & Fyhn, Marianne
(2019).
A new framework for modelling neural-ECM signaling.
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Iannella, Nicolangelo Libero; Prydz, Kristian; Malthe-Sørensen, Anders; Einevoll, Gaute & Fyhn, Marianne
(2019).
A new framework for modelling neural-ECM signalling and interaction.
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Håberg, Asta & Fyhn, Marianne
(2019).
Hvor god stendsans har du?
[Radio].
NRK P1.
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Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel
[Vis alle 7 forfattere av denne artikkelen]
(2019).
Stable orientation tuning in the freely moving rat: Movement-robust orientation-selective neurons in the deep layers of the primary visual cortex.
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Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel
[Vis alle 7 forfattere av denne artikkelen]
(2019).
Stable orientation tuning in the freely moving rat: Movement-robust orientation-selective neurons in the deep layers of the primary visual cortex.
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Hagen, Espen; Stasik, Alexander Johannes; Billeh, Yazan N.; Siegle, Joshua H.; Dai, Kael & Rimehaug, Atle Eskeland
[Vis alle 14 forfattere av denne artikkelen]
(2019).
Comparing spikes and the local field potential (LFP) in V1 between experimental data and a comprehensive biophysical model.
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Hagen, Espen; Stasik, Alexander Johannes; Billeh, Yazan; Siegle, Joshua H.; Dai, Kael & Rimehaug, Atle Eskeland
[Vis alle 14 forfattere av denne artikkelen]
(2019).
Comparing spikes and the local field potential (LFP) in V1 between experimental data and a comprehensive biophysical model.
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Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Stöber, Tristan Manfred & Einevoll, Gaute
[Vis alle 8 forfattere av denne artikkelen]
(2018).
Stable orientation tuning in the freely moving rat: Movement-robust orientation-selective neurons in the deep layers of the primary visual cortex.
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Hazen, Jennifer; Wigestrand, Mattis B; Aasebø, Ida Elisabeth Jørgensen; Tully, Annabelle; Dinh, Tovy & Lepperød, Mikkel
[Vis alle 8 forfattere av denne artikkelen]
(2018).
Lateral hypothalamic area projection neurons contribute to an innate freezing response.
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Grødem, Sverre; Sandvik, Guro Katrine; Hazen, Jennifer; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne
(2018).
A CRISPR-Cas9 platform for genetic perturbations of brain extracellular matrix regulators in vivo
.
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Lensjø, Kristian Kinden; Rowlands, Daire; Dinh, Tovy; Thompson, Elise Holter; Andrews, Melissa & Hafting, Torkel
[Vis alle 9 forfattere av denne artikkelen]
(2018).
Conditional knock-out of the Acan gene removes perineuronal nets in adult mice and induces life-long brian plasticity.
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Dragly, Svenn-Arne; Mobarhan, Milad; Lepperød, Mikkel Elle; Tennøe, Simen; Stasik, Alexander Johannes & Fyhn, Marianne
[Vis alle 8 forfattere av denne artikkelen]
(2018).
Exdir
An alternative to HDF5 that uses Numpy files for data, YAML for metadata and simple directories to define the hierarchy.
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Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel
[Vis alle 7 forfattere av denne artikkelen]
(2018).
Stable orientation tuning in the freely moving rat: Movement-robust orientation selective neurons in the deep layers of the primary visual cortex.
-
Aasebø, Ida Elisabeth Jørgensen; Røe, Malin Benum; Mobarhan, Milad; Lensjø, Kristian Kinden; Stöber, Tristan Manfred & Einevoll, Gaute
[Vis alle 8 forfattere av denne artikkelen]
(2018).
Orientation selectivity in the freely moving rat: Movement-robust orientation-selectivity (MROS) of units in the deep layers of the rat visual cortex
.
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Røe, Malin Benum; Aasebø, Ida Elisabeth Jørgensen; Mobarhan, Milad; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel
[Vis alle 7 forfattere av denne artikkelen]
(2018).
Movement-resistant orientation selectivity of cells in the deep layers of the rat visual cortex.
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Christensen, Ane Charlotte; Fyhn, Marianne & Hafting, Torkel
(2017).
The role of perineuronal nets in spatial representations.
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Fyhn, Marianne; Kristensen, Solveig; Mørken, Knut Martin; Sølna, Hanne; Tellefsen, Cathrine Wahlstrøm & Villanger, Ilan Dehli
(2017).
Helhetlig fokus på utdanningsutvikling.
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Mobarhan, Milad; Halnes, Geir; Martínez-Cañada, Pablo; Hafting, Torkel; Fyhn, Marianne & Einevoll, Gaute
(2017).
Firing-rate Based Network Modeling of the dLGN Circuit: Effects of Cortical Feedback on Spatiotemporal Response Properties of Relay Cells
.
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Dragly, Svenn-Arne; Mobarhan, Milad; Solbrå, Andreas Våvang; Tennøe, Simen; Hafreager, Anders & Malthe-Sørenssen, Anders
[Vis alle 9 forfattere av denne artikkelen]
(2017).
Neuronify: An Educational Simulator for Neural Circuits.
Vis sammendrag
Neurons are cells in the brain that are able to rapidly change the electric field across their cell membrane. These changes allow neurons to communicate with each other and is the basis for the complex computations in the brain. Understanding how neurons communicate and the properties of neuronal networks is essential for neuroscience students. Traditionally, students draw networks with pen and paper and qualitatively deduce features of the network by analyzing the static drawings. Here, we present Neuronify, an app that allows students to draw the same networks on a computer or mobile device and run dynamic simulations without programming. The students can test their analysis by running the network and check their predictions against the outcome.
Educational software (apps) can improve science education by providing an interactive way of learning about complicated topics that are hard to explain with text and static illustrations. Such software is readily available in many areas of natural science such as physics and electrical engineering. However, few educational apps are available for simulation of neural networks. Neuronify allows the user to easily create and explore neural networks in a plug-and-play simulation environment. The user can drag and drop network elements such as neurons, electrical stimulation tools and recording devices. The components can then easily be connected to one another.
Building intuition for how neurons and neural networks behave has been a top priority in designing Neuronify. We aim to provide a low entry point to simulation-based neuroscience. Most undergraduate students do not have the computational experience to create their own neural simulator. Neuronify offers them an opportunity to build and experiment with neural networks in a graphical and easy-to-understand interface. By playing around with the networks, the students can develop a good understanding of their properties.
To facilitate the use of Neuronify in teaching, a set of premade common network motifs is provided, performing functions such as input summation and detection of direction of stimulus movement. Neuronify is developed in C++ and QML using the cross-platform application framework Qt. It has been downloaded more than 30,000 times since its launch and is available on smart phones (Android, iOS), tablet computers as well personal computers (Windows, Mac, Linux).
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Buccino, Alessio Paolo; Ness, Torbjørn Vefferstad; Einevoll, Gaute; Cauwenberghs, Gert; Fyhn, Marianne & Hafting, Torkel
[Vis alle 7 forfattere av denne artikkelen]
(2017).
Classification of Neural Cell-types from Extracellular Signatures on Multi-Electrode Arrays using Deep Learning
.
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Aasebø, Ida E. J.; Mobarhan, Milad; Røe, Malin Benum; Lensjø, Kristian Kinden; Einevoll, Gaute & Hafting, Torkel
[Vis alle 7 forfattere av denne artikkelen]
(2017).
Movement-resistant orientation-selective units in the deep layers of the visual cortex.
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Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel; Malthe-Sørenssen, Anders & Fyhn, Marianne
(2017).
The perineuronal nets in the lateral secondary visual cortex are essential for remote visual fear memory.
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Dinh, Tovy; Lensjø, Kristian Kinden; Lanton, Rune Alexander; Dick, Gunnar; Fyhn, Marianne & Hafting, Torkel
(2017).
Increased ocular dominance plasticity in adult visual cortex after genetic knock out of aggrecan, an essential component of perineuronal nets.
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Blackstad, Jan Sigurd; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne
(2016).
Involvement of perineuronal nets in spatial information transfer between the entorhinal cortex and hippocampus.
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Blackstad, Jan Sigurd; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne
(2016).
Involvement of perineuronal nets in spatial information transfer between the entorhinal cortex and hippocampus.
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Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel; Fyhn, Marianne & Malthe-Sørenssen, Anders
(2016).
The perineuronal nets in the lateral secondary visual cortex are essential for remote visual memory.
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Wigestrand, Mattis B; Aasebø, Ida E. J.; Tully, Annabelle; Lepperød, Mikkel Elle; Hafting, Torkel & Fyhn, Marianne
(2016).
Lateral hypothalamic outputs control innate defensive responses.
Vis sammendrag
When facing a threat, animals display defensive behaviors that are critical for survival. The hypothalamus is believed to mediate such defensive responses, but the prevailing view includes a medial/lateral separation, where medial hypothalamus is thought to influence defensive responses, while the lateral hypothalamic area (LHA) regulates feeding and arousal. Here we identify two distinct neural populations in the LHA with surprising survival functions in rats. The two neural populations, defined by their output projections to either the periaqueductal gray (PAG) or the lateral habenula (LHb) have distinct anatomical placements along the anterior-posterior axis of the LHA and express distinct biochemical markers. Optogenetic stimulation of the two LHA populations robustly induced opposite active- or passive defensive responses. Further, chemogenetic silencing of LHA and optogenetic silencing of the LHA-PAG projection disrupted innate defensive responses to a predator-like looming shadow. Using single-unit recordings in the downstream LHb and PAG, we show that the LHA-LHb projection is largely excitatory, while the LHA-PAG projection is mainly inhibitory. We are currently using a miniaturized microscope to image the calcium activity of the two LHA populations during threat processing in behaving rats. Overall, our findings identify a novel LHA circuit that is critical for appropriate defensive responses to innate visual threats. The location of the LHA defense circuits, intermingled within circuitry that governs feeding, suggests that this circuit may provide rapid cross-talk between circuits that govern foraging- and anti-predator behaviors.
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Lepperød, Mikkel Elle; Wigestrand, Mattis B; Frey, Mina Martine; Lensjø, Kristian Kinden; Einevoll, Gaute & Solstad, Trygve
[Vis alle 8 forfattere av denne artikkelen]
(2016).
On the role of input-specific perturbations of medial septal projections to the grid cell network.
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Røe, Malin Benum; Aasebø, Ida E. J.; Lensjø, Kristian Kinden; Hafting, Torkel & Fyhn, Marianne
(2016).
Orientation selective cells in layer six of the primary visual cortex are resistant to the animal's movement.
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Bjerke, Line; Wigestrand, Mattis B; Aasebø, Ida E. J.; Fyhn, Marianne & Hafting, Torkel
(2016).
Inhibitory outputs from lateral hypothalamus to paraqueductal grey control innate defensive behavior.
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Thompson, Elise Holter; Lensjø, Kristian Kinden; Wigestrand, Mattis B; Hafting, Torkel & Fyhn, Marianne
(2016).
The perineuronal nets in the lateral secondary visual cortex and their impact on remote visual fear memory.
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Lensjø, Kristian Kinden; Lepperød, Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne
(2016).
Removal of perineuronal nets affects information processing and plasticity in the primary visual cortex.
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Lepperød, Mikkel Elle; Wigestrand, Mattis B; Lensjø, Kristian Kinden; Frey, M.M.; Dragly, Svenn-Arne & Einevoll, Gaute
[Vis alle 9 forfattere av denne artikkelen]
(2016).
Grid cell network resilient to input-specific medial septum perturbations.
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Lepperød, Mikkel Elle; Wigestrand, Mattis B; Frey, M.M.; Lensjø, Kristian Kinden; Einevoll, Gaute & Solstad, Trygve
[Vis alle 8 forfattere av denne artikkelen]
(2016).
Role of input-specific perturbations of medial septal projections to the grid cell network.
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Wigestrand, Mattis B; Aasebø, Ida E. J.; Tully, Annabelle; Dinh, Vy To; Lepperød, Mikkel Elle & Hafting, Torkel
[Vis alle 7 forfattere av denne artikkelen]
(2016).
Lateral hypothalamic outputs control innate defensive responses.
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Hobbi Mobarhan, Milad; Einevoll, Gaute; Geir, Halnes; Vervaeke, Koen Gerard Alois & Fyhn, Marianne
(2015).
Roles of cortical feedback in lateral geniculate nucleus.
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Lepperød, Mikkel Elle; Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute
(2015).
Building an entorhinal cortex network.
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Aasebø, Ida E. J.; Hafting, Torkel; Stavrinou, Maria; Sandra, Nøkkevangen; Lepperød, Bjørn Mikkel Elle & Fyhn, Marianne
(2015).
Temporal processing in the visual cortex in the awake and anesthetized rat.
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Lensjø, Kristian Kinden; Lepperød, Bjørn Mikkel Elle; Dick, Gunnar; Hafting, Torkel & Fyhn, Marianne
(2015).
Removal of perineuronal nets in the visual cortex leads to a reduced inhibition and mimics critical period plasticity
.
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Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Lepperød, Bjørn Mikkel Elle; Fyhn, Marianne & Hafting, Torkel
(2015).
The role of extracellular matrix molecules for spatial representations and plasticity in
entorhinal cortex.
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Fyhn, Marianne
(2014).
PNNs in the cortex, hippocampus and medial entorhinal cortex
.
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Hafting, Torkel; Lensjø, Kristian Kinden; Christensen, Ane Charlotte; Dick, Gunnar & Fyhn, Marianne
(2014).
Perineuronal nets, plasticity and information-processing in visual cortex, medial entorhinal cortex and hippocampus.
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Aasebø, Ida E. J.; Norheim, Eivind Skjønsberg; Lensjø, Kristian Kinden; Fyhn, Marianne & Fyhn, Torkel Hafting
(2013).
The effect of anesthesia on activity and modulation of visually responsive neurons in cortical and subcortical areas.
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Lensjø, Kristian Kinden; Dick, Gunnar; Fyhn, Torkel Hafting & Fyhn, Marianne
(2013).
Cortical processing in awake, behaving rats after removal of perineuronal nets.
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Bonnevie, Tora; Dunn, Benjamin Adric; Fyhn, Marianne; Hafting, Torkel; Derdikman, Dori Moshe & Kubie, J. L.
[Vis alle 9 forfattere av denne artikkelen]
(2012).
702.12/DDD28 - Entorhinal grid cells require excitatory drive from the hippocampus.
SFN Abstract Viewer/Itinerary Planner.
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Bonnevie, Tora; Fyhn, Marianne; Hafting, Torkel; Derdikman, Dori Moshe; Moser, Edvard Ingjald & Moser, May-Britt
(2011).
Preserved spatial correlation structure in grid cells after hippocampal inactivation.
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Bonnevie, Tora; Fyhn, Marianne; Hafting, Torkel; Derdikman, Dori Moshe; Moser, Edvard Ingjald & Moser, May-Britt
(2010).
Hippocampal contribution to maintenance of entorhinal grid fields.
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Bonnevie, Tora; Fyhn, Marianne; Hafting, Torkel; Derdikman, Dori Moshe; Moser, Edvard Ingjald & Moser, May-Britt
(2010).
Hippocampal contribution to maintenance of entorhinal grid fields.
Society for Neuroscience : Abstracts.
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Banono, Nancy Saana; Esguerra, Camila; Fyhn, Marianne & Andreassen, Ole
(2021).
Functional analysis of psychiatric risk genes in zebrafish (Danio rerio): a focus on the L-type voltage-gated calcium channel subtypes CaV1.2 and CaV1.3.
Universitetet i Oslo.
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Aasebø, Ida Elisabeth Jørgensen; Fyhn, Marianne; Hafting, Torkel & Einevoll, Gaute
(2018).
Behavioural state and neuronal activity: how the freely moving paradigm can uncover novel response characteristics.
Universitetet i Oslo.
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