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Bathen, Mina; Vik, Anders & Hansen, Trond Vidar
(2024).
Synthetic efforts towards 4S,5S-dihydroxy docosapentaenoic acid.
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de Bourg, Marcus; Mohammad, Rawand S. & Vik, Anders
(2023).
Epoxy fatty acid mimics: A potential treatment for renal failure.
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Haatveit, Åsmund Stenvik; Bathen, Mina; Hansen, Trond Vidar & Vik, Anders
(2023).
Synthetic studies toward 4S,5S-dihydroxy docosapentaenoic acid.
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Bathen, Mina; Haatveit, Åsmund Stenvik; Vik, Anders & Hansen, Trond Vidar
(2023).
Synthetic studies towards 4S,5S-dihydroxy docosapentaenoic acid
.
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Nsowah, Samuel Kwame Opoku; Vik, Anders & Hansen, Trond Vidar
(2023).
Synthesis of New Analogs of 2-Methoxyestradiol.
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de Bourg, Marcus; Vik, Anders & Mohammad, Rawand S.
(2022).
Epoxy fatty acid mimics:
A potential treatment for renal failure.
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Vik, Anders; Halvorsen, Trine Grønhaug; Primdahl, Karoline Gangestad; Hansen, Trond Vidar; Wangensteen, Helle & Reubsaet, Leon
[Vis alle 7 forfattere av denne artikkelen]
(2022).
Grunnkurs i farmasøytisk kjemi på UiO moderniseres kontinuerlig.
Norsk Farmaceutisk Tidsskrift.
ISSN 0029-1935.
s. 33–34.
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de Bourg, Marcus; Mohammas, Rawand S. & Vik, Anders
(2021).
Epoxy fatty acid mimics: a potential treatment for renal failure.
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Vik, Anders; Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Colas, Romain A. & Serhan, Charles Nicholas
[Vis alle 8 forfattere av denne artikkelen]
(2019).
Biosynthetic Studies of RvT1-4: A Novel Class of Specialized Pro-resolving and Anti-inflammatory Mediators.
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Tungen, Jørn Eivind; Gerstmann, Lisa; Vik, Anders; Kalesse, Markus; Dalli, Jesmond & Chiang, Nan
[Vis alle 8 forfattere av denne artikkelen]
(2019).
Stereoselective Synthesis and Biological Evaluations
of RvD1n-3 DPA
.
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Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; De Souza, Patrica R. S; Colas, Romain A.; Dalli, Jesmond & Hansen, Trond Vidar
[Vis alle 7 forfattere av denne artikkelen]
(2019).
Stereocontrolled Synthesis and Investigation of The Biosynthetic Transformations of 16(S),17(S)-epoxy-PDn-3 DPA.
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Sønderskov Rasmussen, Jeanne; Tungen, Jørn Eivind; Vik, Anders; Hansen, Trond Vidar & Stenstrøm, Yngve H.
(2019).
Synthetic Studies Towards MaR2n-3 DPA.
Vis sammendrag
In the last two decades it has been known that specialized pro-resolving mediators (SPMs), biosynthesized from n-3 PUFAs, play an important role in stimulating the return of inflamed tissue to homeostasis.1 There has therefore been a great interest in using these endogenously formed SPMs as lead compounds in drug discovery programs towards the development of new classes of anti-inflammatory drugs.
Our group has synthesized MaR1n-3 DPA2 as well as several other SPMs.3 The poster will present our initial synthetic efforts towards the n-3 DPA derived SPM MaR2n-3 DPA (1).
1. Serhan, C. N. Nature 2014, 510, 92–101.
2. Tungen, J. E.; Aursnes, M.; Dalli, J.; Arnardottir, H.; Serhan, C. N.; Hansen, T. V. Chem. Eur. J. 2014, 20, 14575–14578.
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Føreid Reinertsen, Amalie; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar
(2019).
Synthetic Studies Towards an Analogue of RvD1n-3 DPA.
Vis sammendrag
Specialized pro-resolving lipid mediators (SPMs) are biosynthesized from n-3 polyunsaturated fatty acids during the resolution phase of acute inflammation.1,2 These molecules are shown to limit further neutrophil recruitment to the inflammatory sites, accelerate the termination of inflammation, shorten the resolution time in vivo and increase the clearance of bacteria and apoptotic cells.2 The SPMs have attracted a great interest as lead compounds in drug discovery programs towards the development of new classes of drugs that dampen inflammation without interfering with the immune response.
In 2013, the SPM RvD1n-3 DPA was reported.1 RvD1n-3 DPA displays potent in vivo anti-inflammatory and pro-resolution effects in the low nanomolar range.1 This SPM is an excellent biotemplate for the development of new, small molecular anti-inflammatory drugs and immunoresolvents.3,4 Such simpler analogues are currently in development in our group.
1. Dalli, J.; Colas, R. A.; Serhan, C. N. Sci. Rep. 2013, 3, 1940.
2. Serhan, C. N.; Petasis, N. A. Chem. Rev. 2011, 111, 5922.
3. (a) Serhan, N. A. Nature 2014, 510, 92. (b) Fullerton, J. N.; Gilroy, D.W. Nat. Rev. Drug Discov. 2016, 15, 551.
4. (a) Serhan, C. N, FASEB J. 2017, 31, 1273. (b) Serhan, C. N.; Chiang, N. Curr. Opin. Pharmacol. 2013, 13, 632.
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Nesman, Jannicke Irina; Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; Vik, Anders; Dalli, Jesmond & Hansen, Trond Vidar
(2019).
Total Synthesis and Biological Evaluations of 22-OH PD1n-3 DPA.
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Johnsen, Lars-Inge Gammelsæter; Bero, Rawan; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar
(2019).
Synthetic studies towards 10-keto-DeH-PD1.
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Kristianslund, Renate; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar
(2019).
An Organoselenium Accelerated Bromolactonization Reaction.
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Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; De Souza, Patricia R.S; Colas, Romain A.; Dalli, Jesmond & Hansen, Trond Vidar
[Vis alle 7 forfattere av denne artikkelen]
(2018).
Stereocontrolled Synthesis and Investigation of the
Biosynthetic Transformations of 16(S),17(S)-epoxy-PDn-3 DPA
.
-
Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Colas, Romain A.; Serhan, Charles Nicholas & Dalli, Jesmond
[Vis alle 8 forfattere av denne artikkelen]
(2017).
Biosynthetic Studies of RvT1-4: A Novel Class of Specialized Pro-resolving and Anti-inflammatory Mediators
.
-
Vik, Anders; Aursnes, Marius; Tungen, Jørn Eivind; Colas, Romain A.; Cheng, Chien-Yee C. & Dalli, Jesmond
[Vis alle 8 forfattere av denne artikkelen]
(2017).
Biosynthesis and the Anti-inflammatory and Pro-resolving Effects of the Novel Lipid Mediator Protectin D1n-3 DPA
.
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Aursnes, Marius; Primdahl, Karoline Gangestad; Hansen, Trond Vidar & Vik, Anders
(2017).
Synthetic Studies Towards the 13-series Resolvin Member RvT3.
-
al-Kazaale, Nora; Solum, Eirik Johansson; Vik, Anders & Hansen, Trond Vidar
(2017).
Synthesis of New Analogs of 2-Methoxyestradiol
as Potential Anticancer Agents.
-
Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Serhan, Charles Nicholas; Dalli, Jesmond & Hansen, Trond Vidar
[Vis alle 7 forfattere av denne artikkelen]
(2017).
Synthesis of 13R‑HDPA and Its Biosynthetic Conversion to the 13-Series Resolvins.
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Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar M & Sylte, Ingebrigt
[Vis alle 8 forfattere av denne artikkelen]
(2016).
Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
-
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Kristianslund, Renate; Aursnes, Marius; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar
(2016).
Organocatalytic enantioselective iodolactonization of allenoic acids
.
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Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; Aursnes, Marius; Hansen, Trond Vidar & Vik, Anders
(2016).
Total Synthesis of Leukotriene B4.
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Kaupang, Åsmund; Hildonen, Siri; Halvorsen, Trine Grønhaug; Mortén, Magnus; Vik, Anders & Hansen, Trond Vidar
(2015).
Investigations on the covalent antagonistic modulation of PPARβ/δ.
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Vik, Anders
(2015).
Synthesis of Specialized Pro-resolving Lipid Mediators.
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Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar Martin & Sylte, Ingebrigt
[Vis alle 8 forfattere av denne artikkelen]
(2015).
Anti-diabetic activity from marine lipids: new anti-diabetic drugs.
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Aursnes, Marius; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar
(2015).
Synthesis, Anti-inflammatory and Pro-resolving Activities of 22-OH-PD1, a Mono-Hydroxylated Metabolite of Protectin D1.
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Primdahl, Karoline Gangestad; Aursnes, Marius; Tungen, Jørn Eivind; Hansen, Trond Vidar & Vik, Anders
(2015).
Total synthesis of leukotriene B4.
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Solum, Eirik Johansson; Vik, Anders & Hansen, Trond Vidar
(2013).
Synthesis of analogs of 2-methoxyestradiol as potent anticancer agents.
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Aursnes, Marius; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar
(2013).
Total synthesis of Protectin D1.
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Solum, Eirik Johansson; Vik, Anders & Hansen, Trond Vidar
(2013).
Synthesis of analogs of 2-methoxyestradiol as potential anticancer agents.
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Kaupang, Åsmund; Laitinen, Tuomo; Vik, Anders; Poso, Antti & Hansen, Trond Vidar
(2013).
Molecular modelling and synthesis of putative high-affinity inhibitors of hPPARδ.
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Mohamed, Yasser Mahmoud Ali; Vik, Anders & Hansen, Trond Vidar
(2012).
Synthesis of lipophilic antioxidants.
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Aursnes, Marius; Vik, Anders & Hansen, Trond Vidar
(2012).
Synthetic Studies Towards Protectin D1.
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Jakobsen, Martin Gjerde; Vik, Anders & Hansen, Trond Vidar
(2011).
Synthetic Studies Towards Resolvin D1.
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Vik, Anders; Hansen, Trond Vidar; Skattebøl, Lars & Holmeide, Anne Kristin
(2011).
Synthesis of juniperonic acid.
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Gundersen, Lise-Lotte; Kania, Jindrich; Odden, Hege Hortemo; Proszenyak, Agnes & Vik, Anders
(2011).
Synthesis directed towards Agelasines and Asmarines; Marine Antibiotics.
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Vik, Anders; Hansen, Trond Vidar; Holmeide, Anne Kristin & Skattebøl, Lars
(2010).
Synthesis of juniperonic acid.
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Bakkestuen, Anne Kristin; Charnock, Colin; Cos, Paul; Gundersen, Lise-Lotte; Maes, Louis & Proszenyak, Agnes
[Vis alle 10 forfattere av denne artikkelen]
(2009).
Synthetic studies directed towards antimicrobial agelasines.
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Vik, Anders; Proszenyak, Agnes; Vermeersch, Marieke; Cos, Paul; Maes, Louis & Gundersen, Lise-Lotte
(2009).
Screening of agelasine analogs; Identification of hits for visceral leishmaniasis and Chagas disease.
-
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Vik, Anders; James, Anthony & Gundersen, Lise-Lotte
(2008).
Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro.
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Vik, Anders & Gundersen, Lise-Lotte
(2007).
Synthetic studies directed towards Asmarines: Construction of the 7-membered ring by RCM.
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Vik, Anders & Gundersen, Lise-Lotte
(2007).
Synthetic studies directed towards Asmarines: Construction of the 7-membered ring by RCM.
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Vik, Anders; Hedner, Erik; Charnock, Colin; Samuelsen, Ørjan; Larsson, Rolf & Gundersen, Lise-Lotte
[Vis alle 7 forfattere av denne artikkelen]
(2006).
Improved Synthesis of Agelasine D and Evaluation of Antibacterial and Cytotoxic Activity.
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Vik, Anders; Hedner, Erik; Charnock, Colin; Larsson, Rolf; Gundersen, Lise-Lotte & Bohlin, Lars
(2006).
Synthesis of agelasine and agelasimine analogs and evaluation of antibacterial and cytotoxic effects.
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Vik, Anders; Hedner, Erik; Charnock, Collin; Larsson, Rolf; Gundersen, Lise-Lotte & Bohlin, Lars
(2006).
Synthesis of agelasine and agelasimine analogs and evaluation of antibacterial and cytotoxic effects.
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Vik, Anders; Bakkestuen, Anne Kristin; Gundersen, Lise-Lotte & Utenova, Bibigul t.
(2005).
Synthesis and Bioactivities of Agelasines and Analogs.
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Vik, Anders & Gundersen, Lise-Lotte
(2005).
Synthesis and Bioactivities if Agelasines and Analogs.
-