Anders Vik

• Weldemichael, Tsigereda; Khan, Md. Abdul Hye; Adams, Yahaya; Mishra, Abhishek; Goorani, Samaneh & Vik, Anders [Vis alle 8 forfattere av denne artikkelen] (2026). 8,9-EET analogs protect glomerular cells from doxorubicin-induced toxicity. Frontiers in Pharmacology. 17. doi: 10.3389/fphar.2026.1913312. Fulltekst i vitenarkiv Vis sammendrag

  Introduction Doxorubicin (DOX) is an anthracycline chemotherapeutic whose clinical utility is limited by dose-dependent nephrotoxicity that contributes to acute and chronic kidney injury. Podocytes are essential components of the glomerular filtration barrier and are particularly vulnerable to DOX-induced oxidative stress, cytoskeletal disruption, loss of adhesion, and apoptosis. Therapeutic strategies that protect podocytes without compromising anticancer efficacy therefore represent an important unmet need. This study investigated the protective mechanisms and translational potential of 8,9-epoxyeicosatrienoic acid (8,9-EET) analogs against DOX-induced podocyte injury. Methods Nineteen 8,9-EET analogs were screened in cultured podocytes exposed to DOX. Protective effects were evaluated by assessing cell viability, caspase-3/7 activation, reactive oxygen species (ROS) generation, and focal adhesion integrity using confocal immunofluorescence analysis of vinculin. Selected analogs were also evaluated in DU145 prostate cancer and HCC1806 breast cancer cells to determine whether podocyte protection altered the anticancer activity of DOX. Results and Discussion Several 8,9-EET analogs significantly improved podocyte viability and attenuated DOX-induced apoptosis, as demonstrated by reduced caspase-3/7 activation. DOX markedly disrupted focal adhesion complexes, decreasing vinculin number and area, whereas co-treatment with selected analogs preserved vinculin-associated focal adhesion integrity. Effective analogs also significantly reduced DOX-induced ROS generation, consistent with attenuation of oxidative stress. Importantly, selected analogs protected podocytes without compromising DOX anticancer activity in either DU145 or HCC1806 cells, supporting separation of renoprotective effects from the desired cytotoxic action of DOX. These findings identify selected 8,9-EET analogs as promising podocyte-protective agents against DOX-induced injury. Their protective effects were associated with reduced oxidative stress and apoptosis and preservation of focal adhesion architecture, suggesting coordinated maintenance of podocyte structural integrity and survival. Preservation of DOX anticancer activity in prostate and breast cancer cells further supports the translational potential of these compounds as adjunctive therapies during anthracycline chemotherapy. Collectively, targeting epoxy lipid signaling with 8,9-EET analogs may provide a strategy to limit chemotherapy-associated podocyte injury and preserve renal function without diminishing antitumor efficacy. These results support preclinical evaluation of lead analogs, including their pharmacological properties, renal protective efficacy, and therapeutic compatibility with DOX in relevant models. These findings warrant defining efficacy, safety, dosing, and translational feasibility in vivo .

• Shahmohammadi, Niayesh; Khan, Falguni; Jang, Haneol; Kim, Il-Hwan; Lee, Donghee & Wallen, Joseph [Vis alle 10 forfattere av denne artikkelen] (2026). EpOME functionally antagonises prostaglandin signalling in Spodoptera exigua via a specific GPCR conserved across metazoans. Nature Communications. doi: 10.1038/s41467-026-77858-6. Fulltekst i vitenarkiv
• Khan, Falguni; Song, Taegeun; Vik, Anders; Shahmohammadi, Niayesh & Kim, Yonggyun (2026). Chemical Modifications of an Insect Immune Resolvin, EpOME, to a Broad-Spectrum Lepidopteran-Specific Insecticide. Insects. 17(6), s. 588–588. doi: https:/www.mdpi.com/2075-4450/17/6/588. Fulltekst i vitenarkiv
• Bathen, Mina; Sigurjónsson, Svanur; Malterud, Karl Egil; Hasselstrøm, Daniel Haga; Gani, Osman & Vik, Anders [Vis alle 9 forfattere av denne artikkelen] (2026). A modular semi-synthetic approach to form a DHA-like polyunsaturated ether lipid with 15-lipoxygenase-1 substrate activity. Organic and biomolecular chemistry. ISSN 1477-0520. doi: 10.1039/d6ob00245e. Fulltekst i vitenarkiv Vis sammendrag

  In this work a docosahexaenoic acid-like-methoxylated ether lipid was synthesised using a novel semi-synthetic approach, from natural docosahexaenoic acid and commercially available (2′ S )-epichlorohydrin and (2 R )-solketal.

• Misra, Abhisek; Bourg, Marcus de; Mohammad, Rawand Salam; Khan, Md Abdul Hye; Weldemichael, Tsigereda & Jr., Donald J. Johann, [Vis alle 11 forfattere av denne artikkelen] (2025). EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage. Biomolecules. 15(9). doi: https:/www.mdpi.com/2218-273X/15/9/1324. Fulltekst i vitenarkiv
• Shahmohammadi, Niayesh; Haraji, Shiva; Khan, Falguni; Sørskår, Åshild Moi; Danielsen, Parastoo Ebrahimi & Vik, Anders [Vis alle 7 forfattere av denne artikkelen] (2025). Antagonistic control of intracellular signals by EpOMEs in hemocytes induced by PGE2 and their chemical modification for a potent insecticide. PLOS ONE. 20(5). doi: 10.1371/journal.pone.0320488. Fulltekst i vitenarkiv
• Bourg, Marcus de; Mishra, Abhishek; Mohammad, Rawand S.; Morisseau, Christophe; Hammock, Bruce D. & Imig, John D. [Vis alle 7 forfattere av denne artikkelen] (2025). Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death. Molecules. ISSN 1431-5157. 30, s. 1445–1445. doi: 10.3390/molecules30071445. Fulltekst i vitenarkiv
• Reinertsen, Amalie Føreid; Vik, Anders & Hansen, Trond Vidar (2024). Biology and Total Synthesis of n-3 Docosapentaenoic Acid-Derived Specialized Pro-Resolving Mediators. Molecules. ISSN 1431-5157. 29(12). doi: 10.3390/molecules29122833. Fulltekst i vitenarkiv
• Hrithik, Md Tafim Hossain; Shahmohammadi, Niayesh; Gahyeon, Jin; Lee, Dong-Hee; Singh, Nalin & Vik, Anders [Vis alle 8 forfattere av denne artikkelen] (2024). Insect immune resolution with EpOME/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity. Insect Biochemistry and Molecular Biology. ISSN 0965-1748. 168. doi: 10.1016/j.ibmb.2024.104104. Fulltekst i vitenarkiv
• Esmaeily, Mojtaba; Cha, Wook Hyun; Lee, Dae-Weon; Kwon, Minji; Lee, Dong-Hee & Vik, Anders [Vis alle 7 forfattere av denne artikkelen] (2024). EpOME mediates the immune resolution and its alkoxide analog enhances the virulence of microbial insecticides against the legume pod borer, Maruca vitrata. Pesticide Biochemistry and Physiology. ISSN 0048-3575. 205. doi: 10.1016/j.pestbp.2024.106155. Fulltekst i vitenarkiv
• Balta, Maria; Schreurs, Olaf Joseph Franciscus; Hansen, Trond Vidar; Tungen, Jørn Eivind; Vik, Anders & Glaab, Enrico [Vis alle 10 forfattere av denne artikkelen] (2022). Expression and function of resolvin RvD1n-3 DPA receptors in oral epithelial cells. European Journal of Oral Sciences. ISSN 0909-8836. 130:e12883(4), s. 1–10. doi: 10.1111/eos.12883. Fulltekst i vitenarkiv Vis sammendrag

  Chronic inflammatory responses can inflict permanent damage to host tissues. Specialized pro-resolving mediators downregulate inflammation but also can have other functions. The aim of this study was to examine whether oral epithelial cells express the receptors FPR2/ALX and DRV1/GPR32, which bind RvD1n-3 DPA, a recently described pro-resolving mediator derived from omega-3 docosapentaenoic acid (DPA), and whether RvD1n-3 DPA exposure induced significant responses in these cells. Gingival biopsies were stained using antibodies to FPR2/ALX and DRV1/GPR32. Expression of FPR2/ALX and DRV1/GPR32 was examined in primary oral epithelial cells by qRT-PCR, flow cytometry, and immunofluorescence. The effect of RvD1n-3 DPA on intracellular calcium mobilization and transcription of beta-defensins 1 and 2, and cathelicidin was evaluated by qRT-PCR. FPR2/ALX and DRV1/GPR32 were expressed by gingival keratinocytes in situ. In cultured oral epithelial cells, FPR2/ALX was detected on the cell surface, whereas FPR2/ALX and DRV1/GPR32 were detected intracellularly. Exposure to RvD1n-3 DPA induced intracellular calcium mobilization, FPR2/ALX internalization, DRV1/GPR32 translocation to the nucleus, and significantly increased expression of genes coding for beta-defensin 1, beta-defensin 2, and cathelicidin. This shows that the signal constituted by RvD1n-3 DPA is recognized by oral keratinocytes and that this can strengthen the antimicrobial and regulatory potential of the oral epithelium.

• Singh, Nalin; Vik, Anders; Lybrand, Daniel B.; Morisseau, Christophe & Hammock, Bruce D. (2021). New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation. Chemical Research in Toxicology. ISSN 0893-228X. 34(12), s. 2579–2591. doi: 10.1021/acs.chemrestox.1c00347. Fulltekst i vitenarkiv Vis sammendrag

  The usage of cisplatin, a highly potent chemotherapeutic, is limited by its severe nephrotoxicity. Arachidonic acid (ARA)-derived epoxyeicosatrienoic acids (EETs) and soluble epoxide hydrolase (sEH) inhibitors were shown to ameliorate this dose-limiting side effect, but both approaches have some pharmacological limitations. Analogues of EETs are an alternative avenue with unique benefits, but the current series of analogues face concerns regarding their structure and mimetic functionality. Hence, in this study, regioisomeric mixtures of four new ARA alkyl ethers were synthesized, characterized, and assessed as EET analogues against the concentration- and time-dependent toxicities of cisplatin in porcine proximal tubular epithelial cells. All four ether groups displayed bioisostere activity, ranging from marginal for methoxy- (1), good for n-propoxy- (4), and excellent for ethoxy- (2) and i-propoxy- (3). Compounds 2 and 3 displayed cytoprotective effects comparable to that of an EET regioisomeric mixture (5) against high, acute cisplatin exposures but were more potent against low to moderate, chronic exposures. Compounds 2 and 3 (and 5) acted through stabilization of the mitochondrial transmembrane potential and attenuation of reactive oxygen species, leading to reduced phosphorylation of mitogen-activated protein kinases p38 and JNK and decreased activation of caspase-9 and caspase-3. This study demonstrates that alkoxy- groups are potent and more metabolically stable bioisostere alternatives to the epoxide within EETs that enable sEH-independent activity. It also illustrates the potential of ether-based mimics of EETs and other epoxy fatty acids as promising nephroprotective agents to tackle the clinically relevant side effect of cisplatin without compromising its antineoplastic function.

• Vik, Anders & Hansen, Trond Vidar (2021). Stereoselective syntheses and biological activities of E-series resolvins. Organic and biomolecular chemistry. ISSN 1477-0520. 19(4), s. 705–721. doi: 10.1039/d0ob02218g. Fulltekst i vitenarkiv Vis sammendrag

  Recent research efforts focusing on the many mechanisms participating in the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators. These endogenous molecules include the lipoxins, resolvins, protectins and maresins, collectively coined specialized pro-resolving mediators (SPMs). SPMs are oxygenated polyunsaturated fatty acids biosynthesized by lipoxygenases and cyclooxygenases enzymes. These chemically sensitive molecules are produced in nano- to pico-gram amounts in vivo and exhibit potent anti-inflammatory and pro-resolving bioactions. In addition, SPMs clear bacterial infections, reduce pain and display bioactivities towards host defense, organ protection and tissue remodeling. Altogether, these bioactions and the need for synthetic SPMs for determination of absolute configuration and in vivo experiments have spurred a great interest in the synthetic and biomolecular communities. This review covers reported stereoselective total syntheses and outlines the most significant bioactions of the E-series resolvins.

• Nesman, Jannicke Irina; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar (2020). Stereoselective Synthesis of the Specialized Pro-resolving and Anti-inflammatory Mediator Resolvin E1. Tetrahedron. ISSN 0040-4020. 76(3), s. 130821–130821. doi: 10.1016/j.tet.2019.130821. Fulltekst i vitenarkiv
• Paluchova, Veronika; Vik, Anders; Cajka, Tomas; Brezinova, Maria; Brejchova, Krisyna & Bugajev, Viktor [Vis alle 15 forfattere av denne artikkelen] (2020). Triacylglycerol‐Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13‐DHAHLA) with Anti‐Inflammatory Properties in Mice. Molecular Nutrition & Food Research. ISSN 1613-4125. 64(11), s. 1901238–1901238. doi: 10.1002/mnfr.201901238. Fulltekst i vitenarkiv
• Hansen, Trond Vidar; Vik, Anders & Serhan, Charles N. (2019). The Protectin Family of Specialized Pro-Resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes. Frontiers in Pharmacology. 9. doi: 10.3389/fphar.2018.01582. Fulltekst i vitenarkiv Vis sammendrag

  A western type diet and lifestyle play an important role in the development of chronic diseases, yet little insight into the precise cellular and biomolecular mechanisms has emerged. It is known that an unbalanced diet may result in obesity and diabetes. Sufficient amounts and proper balance of omega-6 and omega-3 polyunsaturated fatty acids is key for maintenance of health. The resolution of inflammation is now held to be a biosynthetically actively driven process precisely regulated and controlled by a superfamily of specialized pro-resolving mediators. Specialized pro-resolving mediators are biosynthesized from both omega-6 and omega-3 polyunsaturated fatty acids and are resolution agonists acting on distinct G-coupled protein receptors. These mediators display potent anti-inflammatory and pro-resolving bioactions with EC50-values in the low nanomolar to picomolar range. The protectin family of specialized pro-resolving mediators is biosynthesized from the two omega-3 polyunsaturated fatty acids docosahexaenoic acid and n-3 docosapentaenoic acid. All of the protectins display interesting bioactions as anti-inflammatory and pro-resolving agents. This review covers the bioactions, G-coupled protein receptors pharmacology, biosynthesis and medicinal chemistry of the protectin family of specialized pro-resolving mediators with an emphasis on obesity and anti-diabetic effects. In order to enable drug development and medicinal chemistry efforts against these diseases, stereoselective total organic synthesis of each of these mediators is required for confirmation of structure, stereochemical biosynthesis and their functions. We provide an overview of our ongoing efforts and the current knowledge.

• Tungen, Jørn Eivind; Gerstmann, Lisa; Vik, Anders; Mateis, Roberta de; Colas, Romain A. & Dalli, Jesmond [Vis alle 10 forfattere av denne artikkelen] (2019). Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n−3  DPA. Chemistry - A European Journal. ISSN 0947-6539. 25(6), s. 1476–1480. doi: 10.1002/chem.201806029. Fulltekst i vitenarkiv Vis sammendrag

  New drugs that can resolve inflammation without immunosuppressive effects are at the medicinal chemistry frontier. Pro‐resolving endogenously formed small molecules, that is, the resolvins, are excellent candidates displaying such bioactions. The first total synthesis of the specialized pro‐resolving mediator RvD1n−3 DPA has been achieved using the underutilized sp3–sp3 Negishi cross coupling reaction and an alkyne hydrosilylation–protodesilylation protocol. Biological evaluations revealed that this novel mediator displays low nanomolar pro‐resolving properties and potently activates the human DRV1/GPR32 receptor. As such, this endogenous natural product is a lead compound for the development of novel immunoresolvents.

• Vik, Anders; Hansen, Trond Vidar & Kuda, Ondrej (2019). Synthesis of both enantiomers of the docosahexaenoic acid ester of 13-hydroxyoctadecadienoic acid (13-DHAHLA). Tetrahedron Letters. ISSN 0040-4039. 60(52), s. 151331–151332. doi: 10.1016/j.tetlet.2019.151331. Fulltekst i vitenarkiv Vis sammendrag

  Recently, several different classes of endogenous lipids have been reported that display antidiabetic and anti-inflammatory effects. Due to their minute presence in human samples, access to synthetic material of each enantiomer becomes necessary for exact structural elucidation and extensive biological evaluation. Herein we report the multi-milligram synthesis of both enantiomers of the docosahexaenoic acid ester of 13-hydroxyoctadecadienoic acid (13-DHAHLA) from commercially available starting materials.

• Tungen, Jørn Eivind; Kristianslund, Renate; Vik, Anders & Hansen, Trond Vidar (2019). Organoselenium Accelerated Bromolactonization Reaction. Journal of Organic Chemistry. ISSN 0022-3263. 84(18), s. 11373–11381. doi: 10.1021/acs.joc.9b01294. Fulltekst i vitenarkiv Vis sammendrag

  A highly efficient and regioselective bromolactonization protocol is reported. The quantitative formation of synthetically versatile bromolactones occurs in the presence of only 0.1 mol % of an organoselenium compound, coined DECAD herein, within 90 min. DECAD is conveniently prepared on multigram scale from cheap racemic camphor. The presented protocol was easy to scale up and performed equally well on gram scale. Investigation of the mechanism revealed that DECAD forms a selenonium ylene in situ.

• Vik, Anders & Hansen, Trond Vidar (2018). Synthetic manipulations of polyunsaturated fatty acids as a convenient strategy for the synthesis of bioactive compounds. Organic and biomolecular chemistry. ISSN 1477-0520. 16(48), s. 9319–9333. doi: 10.1039/c8ob02586j. Fulltekst i vitenarkiv
• Pistorius, Kimberly; Souza, Patricia R.; Matteis, Roberta De; Austin-Williams, Shani; Primdahl, Karoline Gangestad & Vik, Anders [Vis alle 11 forfattere av denne artikkelen] (2018). PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function. Cell Chemical Biology. ISSN 2451-9456. 25(6), s. 749–760. doi: 10.1016/j.chembiol.2018.04.017. Fulltekst i vitenarkiv
• Stepniewski, Tomasz Maciej; Torrens-Fontanals, Mariona; Rodríguez-Espigares, Ismael; Giorgino, Toni; Primdahl, Karoline Gangestad & Vik, Anders [Vis alle 9 forfattere av denne artikkelen] (2018). Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 26(12), s. 3580–3587. doi: 10.1016/j.bmc.2018.05.036. Fulltekst i vitenarkiv
• Al-Kazaale, Nora; Tran, Phuong Dan Dinh; Haidari, Farhad; Solum, Eirik Johansson; Liekens, Sandra & Vervaeke, Peter [Vis alle 10 forfattere av denne artikkelen] (2018). Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol. Steroids. ISSN 0039-128X. 136, s. 47–55. doi: 10.1016/j.steroids.2018.05.002. Fulltekst i vitenarkiv
• Kristianslund, Renate; Vik, Anders & Hansen, Trond Vidar (2018). A convenient synthesis of phenols. Synthetic Communications. ISSN 0039-7911. 48(21), s. 2809–2814. doi: 10.1080/00397911.2018.1496263. Fulltekst i vitenarkiv Vis sammendrag

  Anilines are rapidly, often within 60 minutes, converted into the corresponding phenols in up to 87% isolated yield. The presented experimentally simple protocol display broad compatibility with a variety of functional groups, and in particular, well suited for the preparation of methyl-substituted phenols. Such phenols are not easily available by other synthetic approaches. The formation of phenolic radical coupling products was not observed even for activated anilines using this open flask method.

• Sæther, Thomas; Paulsen, Steinar M; Tungen, Jørn Eivind; Vik, Anders; Aursnes, Marius & Holen, Torgeir [Vis alle 8 forfattere av denne artikkelen] (2018). Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects. European Journal of Medicinal Chemistry. ISSN 0223-5234. 155, s. 736–753. doi: 10.1016/j.ejmech.2018.06.034. Fulltekst i vitenarkiv Vis sammendrag

  Obesity and associated disorders such as metabolic syndrome and type 2 diabetes (T2D) have reached epidemic proportions. Several natural products have been reported as Peroxisome Proliferator-Activated Receptor (PPAR) agonists, functioning as lead compounds towards developing new anti-diabetic drugs due to adverse side effects of existing PPAR drugs. We recently isolated and identified (7E)-9-oxohexadec-7-enoic acid (1) and (10E)-9-oxohexadec-10-enoic acid (2) from the marine algae Chaetoceros karianus. Herein we report the total synthesis, pharmacological characterization, and biological evaluations of these naturally occurring oxo-fatty acids (oFAs). The syntheses of 1 and 2 afforded sufficient material for extensive biological evaluations. Both oFAs show an appreciable dose-dependent activation of PPARα and -γ, with EC50 values in the micromolar range, and an ability to regulate important PPAR target genes in hepatocytes and adipocytes. Moreover, both 1 and 2 are able to drive adipogenesis when evaluated in the Simpson-Golabi-Behmel syndrome (SGBS) pre-adipocyte cell model, but with lowered expression of adipocyte markers and reduced lipid accumulation compared to the drug rosiglitazone. This seems to be caused by a transient upregulation of PPARγ and C/EBPα expression. Importantly, whole transcriptome analysis shows that both compounds induce anti-diabetic gene programs in adipocytes by upregulating insulin-sensitizing adipokines and repressing pro-inflammatory cytokines.

• Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; Souza, Patricia R De; Colas, Romain A.; Dalli, Jesmond & Hansen, Trond Vidar [Vis alle 7 forfattere av denne artikkelen] (2017). Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA. Organic and biomolecular chemistry. ISSN 1477-0520. 15(40), s. 8606–8613. doi: 10.1039/c7ob02113e. Fulltekst i vitenarkiv Vis sammendrag

  PD1n-3 DPA is a specialized pro-resolving lipid mediator that displays potent anti-inflammatory properties and pro-resolving bioactivities. Such naturally occurring compounds are of current interest in biomolecular chemistry and drug discovery. To investigate the involvement of an epoxide intermediate in the biosynthesis of PD1n-3 DPA from n-3 docosapentaenoic acid, the epoxy acid 16(S),17(S)-epoxy-PDn-3 DPA, herein named ePDn-3 DPA, was prepared by stereoselective total synthesis. The synthetic material of ePDn-3 DPA allowed investigations of its role in the biosynthesis of PD1n-3 DPA. The obtained results establish that the biosynthesis of PD1n-3 DPA in neutrophils occurs with ePDn-3 DPA as the intermediate, and that 15-LOX produces ePDn-3 DPA from n-3 docosapentaenoic acid. Furthermore, support for the involvement of a hydrolytic enzyme in the biosynthetic conversion of ePDn-3 DPA to PD1n-3 DPA was found. In addition, ePDn-3 DPA was found to regulate the formation of the potent neutrophil chemoattractant LTB4 with equal potencies to that obtained with PD1n-3 DPA.

• Vik, Anders; Dalli, Jesmond & Hansen, Trond Vidar (2017). Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 27(11), s. 2259–2266. doi: 10.1016/j.bmcl.2017.03.079. Fulltekst i vitenarkiv Vis sammendrag

  Several novel oxygenated polyunsaturated lipid mediators biosynthesized from n-3 docosapentaenoic acid were recently isolated from murine inflammatory exudates and human primary cells. These compounds belong to a distinct family of specialized pro-resolving mediators, and display potent in vivo anti-inflammatory and pro-resolution effects. The endogenously formed specialized pro-resolving mediators have attracted a great interest as lead compounds in drug discovery programs towards the development of new classes of drugs that dampen inflammation without interfering with the immune response. Detailed information on the chemical structures, cellular functions and distinct biosynthetic pathways of specialized pro-resolving lipid mediators is a central aspect of these biological actions. Herein, the isolation, structural elucidation, biosynthetic pathways, total synthesis and bioactions of the n-3 docosapentaenoic acid derived mediators PD1n-3 DPA and MaR1n-3 DPA are discussed. In addition, a brief discussion of a novel family of mediators derived from n-3 docosapentaenoic acid, termed 13-series resolvins is included.

• Gansbeke, Koen van; Solum, Eirik Johansson; Liekens, Sandra; Vik, Anders & Hansen, Trond Vidar (2017). Regioselective monoalkylation of 17β-estradiol for the synthesis of cytotoxic estrogens. Steroids. ISSN 0039-128X. 124, s. 54–59. doi: 10.1016/j.steroids.2017.06.001. Fulltekst i vitenarkiv Vis sammendrag

  The regioselective synthesis of estrogens and their derivatives continues to be of interest. Most reported syntheses require multistep protocols associated with poor overall yield and lack of regioselectivity. New preparative protocols are still desired. Herein, 11 2-alkylated 17β-estradiol analogs were synthesized in a highly regioselective manner. The products were obtained using a convenient, one pot and high-yielding protocol. The anti-proliferative activity of the compounds was tested in human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human dermal microvascular endothelial (HMEC-1) cells.

• Vik, Anders & Hansen, Trond Vidar (2016). Fatty Acids and their Derivatives. I Zografos, Alexandros L. (Red.), From Biosynthesis to Total Synthesis: Strategies and Tactics for Natural Products. John Wiley & Sons. ISSN 9781118751732. s. 130–161. Fulltekst i vitenarkiv
• Tungen, Jørn Eivind; Aursnes, Marius & Vik, Anders (2016). Synthesis of Ieodomycin D. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. ISSN 0936-5214. 27(17), s. 2497–2499. doi: 10.1055/s-0035-1562776. Fulltekst i vitenarkiv
• Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Colas, Romain A.; Serhan, Charles N. & Dalli, Jesmond [Vis alle 8 forfattere av denne artikkelen] (2016). Synthesis of 13(R)‐Hydroxy‐7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R‐HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. Journal of natural products. ISSN 0163-3864. 79, s. 2693–2702. doi: 10.1021/acs.jnatprod.6b00634. Fulltekst i vitenarkiv Vis sammendrag

  Specialized pro-resolving lipid mediators are biosynthesized during the resolution phase of acute inflammation from n-3 polyunsaturated fatty acids. Recently, the isolation and identification of the four novel mediators denoted 13-series resolvins, namely, RvT1 (1), RvT2 (2), RvT3 (3) and RvT4 (4), were reported, which showed potent bioactions characteristic for specialized pro-resolving lipid mediators. Herein, based on results from LC/MS-MS metabololipidomics and the stereoselective synthesis of 13(R)-hydroxy-7Z,10Z,13R,14E,16Z,19Z docosapentaenoic acid (13R-HDPA, 5), we provide direct evidence that the four novel mediators 1−4 are all biosynthesized from the pivotal intermediate 5. The UV and LC/MS-MS results from synthetic 13R-HDPA (5) matched those from endogenously and biosynthetically produced material obtained from in vivo infectious exudates, endothelial cells, and human recombinant COX-2 enzyme. Stereochemically pure 5 was obtained with the use of a chiral pool starting material that installed the configuration at the C-13 atom as R. Two stereoselective Z-Wittig reactions and two Z-selective reductions of internal alkynes afforded the geometrically pure alkene moieties in 5. Incubation of 5 with isolated human neutrophils gave all four RvTs. The results presented herein provide new knowledge on the biosynthetic pathways and the enzymatic origin of RvTs 1−4.

• Kaupang, Åsmund; Kase, Eili Tranheim; Vo, Cecilie Xuan Trang; Amundsen, Marthe; Vik, Anders & Hansen, Trond Vidar (2016). Synthesis of 5-trifluoromethyl-2-sulfonylpyridine PPARβ/δ antagonists: Effects on the affinity and selectivity towards PPARβ/δ. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 24(2), s. 247–260. doi: 10.1016/j.bmc.2015.12.012. Fulltekst i vitenarkiv
• Primdahl, Karoline Gangestad; Stenstrøm, Yngve H.; Hansen, Trond Vidar & Vik, Anders (2016). Synthesis of 5-(S)-HETE, 5-(S)-HEPE and (+)-zooxanthellactone: Three hydroxylated polyunsaturated fatty acid metabolites. Chemistry and Physics of Lipids. ISSN 0009-3084. 196, s. 1–4. doi: 10.1016/j.chemphyslip.2015.12.005. Fulltekst i vitenarkiv
• Solum, Eirik Johansson; Akselsen, Øyvind Wilhelm; Vik, Anders & Hansen, Trond Vidar (2015). Synthesis and pharmacological effects of the anti-cancer agent 2-methoxyestradiol. Current pharmaceutical design. ISSN 1381-6128. 21(38), s. 5453–5466. doi: 10.2174/1381612821666151002112511. Fulltekst i vitenarkiv
• Kaupang, Åsmund; Hildonen, Siri; Halvorsen, Trine Grønhaug; Mortén, Magnus; Vik, Anders & Hansen, Trond Vidar (2015). Involvement of covalent interactions in the mode of action of PPARβ/δ antagonists. RSC Advances. 5(93), s. 76483–76490. doi: 10.1039/c5ra15707b. Fulltekst i vitenarkiv
• Solum, Eirik Johansson; Cheng, Jing-Jy; Sylte, Ingebrigt; Vik, Anders & Hansen, Trond Vidar (2015). Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis. RSC Advances. 5(41), s. 32497–32504. doi: 10.1039/c5ra03570h. Fulltekst i vitenarkiv Vis sammendrag

  The synthesis, cytotoxicity, inhibition of tubulin polymerization and anti-angiogenic effects of 10 analogs of 2-methoxyestradiol are reported. These efforts revealed that the analog with a 4-pyridine ring in the 17-position, in combination with 2-ethyl- and 3-sulfamate substituents on the steroid A-ring, is the most interesting anti-cancer agent. This compound showed potent inhibitory effects against angiogenesis (IC50 = 0.1 ± 0.02 μM) and selective cytotoxic effects towards the CEM, H460 and HT-29 cancer cell lines, with no cytotoxicity observed against the healthy VERO cell line. The most interesting analog also displayed inhibition of tubulin polymerization (IC50 = 4.3 μM) almost as potent as 2-methoxyestradiol (IC50 = 3.5 μM). Molecular modeling experiments showed that this analog interacts within the colchicine-binding site of β-tubulin via multiple bonding with several amino acids. These observations provide support that the cytotoxic and anti-angiogenic effects observed for this novel analog are, at least in part, mediated by binding to tubulin.

• Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; Aursnes, Marius; Hansen, Trond Vidar & Vik, Anders (2015). An efficient total synthesis of leukotriene B4. Organic and biomolecular chemistry. ISSN 1477-0520. 13(19), s. 5412–5417. doi: 10.1039/c5ob00473j. Fulltekst i vitenarkiv
• Aursnes, Marius; Tungen, Jørn Eivind; Vik, Anders; Dalli, J. & Hansen, Trond Vidar (2014). Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. Organic and biomolecular chemistry. ISSN 1477-0520. 12(3), s. 432–437. doi: 10.1039/c3ob41902a. Fulltekst i vitenarkiv
• Aursnes, Marius; Tungen, Jørn Eivind; Vik, Anders; Colas, Romain; Cheng, Chien-Yee C. & Dalli, Jesmond [Vis alle 8 forfattere av denne artikkelen] (2014). Total synthesis of the lipid mediator PD1n-3 DPA: Configurational assignments and anti-inflammatory and pro-resolving actions. Journal of natural products. ISSN 0163-3864. 77(4), s. 910–916. doi: 10.1021/np4009865. Fulltekst i vitenarkiv
• Jakobsen, Martin Gjerde; Vik, Anders & Hansen, Trond Vidar (2014). Stereoselective synthesis of zooxanthellactone. Tetrahedron Letters. ISSN 0040-4039. 55(17), s. 2842–2844. doi: 10.1016/j.tetlet.2014.03.085. Fulltekst i vitenarkiv
• Solum, Eirik Johansson; Cheng, Jing-Jy; Sørvik, Irene Beate; Paulsen, Ragnhild Elisabeth; Vik, Anders & Hansen, Trond Vidar (2014). Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: Inhibitors of tubulin and angiogenesis. European Journal of Medicinal Chemistry. ISSN 0223-5234. 85, s. 391–398. doi: 10.1016/j.ejmech.2014.08.002. Fulltekst i vitenarkiv
• Solum, Eirik Johansson; Vik, Anders & Hansen, Trond Vidar (2014). Synthesis, cytotoxic effects and tubulin polymerization inhibition of 1,4-disubstituted 1,2,3-triazole analogs of 2-methoxyestradiol. Steroids. ISSN 0039-128X. 87, s. 46–53. doi: 10.1016/j.steroids.2014.05.020. Fulltekst i vitenarkiv
• Tungen, Jørn Eivind; Aursnes, Marius; Vik, Anders; Ramon, Sesquile; Colas, Romain A. & Dalli, Jesmond [Vis alle 8 forfattere av denne artikkelen] (2014). Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. Journal of natural products. ISSN 0163-3864. 77(10), s. 2241–2247. doi: 10.1021/np500498j. Fulltekst i vitenarkiv
• Mohamed, Yasser Mahmoud Ali; Vik, Anders; Hofer, Tim; Andersen, Jeanette hammer & Hansen, Trond Vidar (2013). Polyunsaturated fatty acid-derived chromones exhibiting potent antioxidant activity. Chemistry and Physics of Lipids. ISSN 0009-3084. 170, s. 41–45. doi: 10.1016/j.chemphyslip.2013.03.003. Fulltekst i vitenarkiv
• Jakobsen, Martin Gjerde; Vik, Anders & Hansen, Trond Vidar (2012). Concise syntheses of three ω-3 polyunsaturated fatty acids. Tetrahedron Letters. ISSN 0040-4039. 53(44), s. 5837–5839. doi: 10.1016/j.tetlet.2012.08.009. Fulltekst i vitenarkiv
• Vik, Anders & Hansen, Trond Vidar (2011). Synthesis of a polyunsaturated amino ketone isolated from a Guangxi sponge of the genus Haliclona. Tetrahedron Letters. ISSN 0040-4039. 52(10), s. 1060–1061. doi: 10.1016/j.tetlet.2010.12.089. Fulltekst i vitenarkiv
• Vik, Anders; Hansen, Trond Vidar; Holmeide, Anne Kristin & Skattebøl, Lars (2010). Synthesis of juniperonic acid. Tetrahedron Letters. ISSN 0040-4039. 51(21), s. 2852–2854. doi: 10.1016/j.tetlet.2010.03.085. Fulltekst i vitenarkiv Vis sammendrag

  Synthesis of juniperonic acid ((all-Z)-5,11,14,17-eicosatetraenoic acid), has been achieved in eight steps and in 19% overall yield starting from eicosapentaenoic acid.

• Vik, Anders; Proszenyak, Agnes; Vermeersch, Marieke; Cos, Paul; Maes, Louis & Gundersen, Lise-Lotte (2009). Screening of Agelasine D and Analogs for Inhibitory Activity against Pathogenic Protozoa; Identification of Hits for Visceral Leishmaniasis and Chagas Disease. Molecules. ISSN 1431-5157. 14(1), s. 279–288. doi: 10.3390/molecules14010279. Fulltekst i vitenarkiv Vis sammendrag

  There is an urgent need for novel and improved drugs against several tropical diseases caused by protozoa. The marine sponge (Agelas sp.) metabolite agelasine D, as well as other agelasine analogs and related structures were screened for inhibitory activity against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei and T. cruzi, as well as for toxicity against MRC-5 fibroblast cells. Many compounds displayed high general toxicity towards both the protozoa and MRC-5 cells. However, three compounds exhibited more selective inhibitory activity against L. donovani (IC50 <0.5 μg/mL) while two others displayed IC50 <1 μg/mL against T. cruzi in combination with relatively low toxicity against MRC-5 cells. According to criteria set up by the WHO Special Programme for Research & Training in Tropical Diseases (TDR), these compounds could be classified as hits for leishmaniasis and for Chagas disease, respectively. Identification of the hits as well as other SAR data from this initial screening will be valuable for design of more potent and selective potential drugs against these neglected tropical diseases.

• Sjögren, Martin; Dahlström, Mia; Hedner, Erik; Jonsson, Per R.; Vik, Anders & Gundersen, Lise-Lotte [Vis alle 7 forfattere av denne artikkelen] (2008). Antifouling activity of the sponge metabolite agelasine D and synthesized analogs on Balanus improvisus. Biofouling (Print). ISSN 0892-7014. 24(4), s. 251–258. doi: 10.1080/08927010802072753. Fulltekst i vitenarkiv Vis sammendrag

  This study reports a screening study for antifouling (AF) activity of the natural compound agelasine D isolated from marine sponges of the genus Agelas and 20 synthesised analogs of agelasines and agelasimines. Agelasine D, together with two of the analogs, ie AV1003A and AKB695, displayed a strong inhibitory effect on settlement of Balanus improvisus cypris larvae. Agelasine D had an EC50 value of 0.11 μM while the two analogs AV1033A and AKB695 had EC50 values of 0.23 and 0.3 μM, respectively. None of these three compounds affected larval mortality as was the case with several of the analogs tested. Moreover, the effect of AV1033A and AKB695 was reversible. When cyprids after 24 h exposure to the compounds were transferred to fresh seawater, the settlement frequency compared with the controls was completely recovered. The properties of the agelasine D analogs AV1003A and AKB695 make them highly attractive candidates as AF agents in future marine coatings.

• Vik, Anders & Gundersen, Lise-Lotte (2007). Synthetic studies directed towards asmarines; construction of the tetrahydrodiazepinopurine moiety by ring closing metathesis. Tetrahedron Letters. ISSN 0040-4039. 48, s. 1931–1934. doi: 10.1016/j.tetlet.2007.01.090. Fulltekst i vitenarkiv

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• Bathen, Mina; Sigurjónsson, Svanur; Vik, Anders; Guðmundsson, Haraldur Gunnar; Haraldsson, Guðmundur Gunnar & Hansen, Trond Vidar (2026). Synthesis of n-3 Polyunsaturated Docosahexaenoic Acid-Like Methoxylated Ether Lipid. Fulltekst i vitenarkiv
• The, Daniel; Reinertsen, Amalie Føreid; Vik, Anders & Hansen, Trond Vidar (2025). Synthetic Studies Towards RvD1 Analogs. Fulltekst i vitenarkiv
• Bathen, Mina; Vik, Anders & Hansen, Trond Vidar (2024). Synthetic studies towards 4S,5S-dihydroxy docosapentaenoic acid. Fulltekst i vitenarkiv
• Bathen, Mina; Vik, Anders & Hansen, Trond Vidar (2024). Synthetic efforts towards 4S,5S-dihydroxy docosapentaenoic acid. Fulltekst i vitenarkiv
• Bathen, Mina; Vik, Anders & Hansen, Trond Vidar (2024). Synthetic studies towards 4S,5S-dihydroxy docosapentaenoic acid. Fulltekst i vitenarkiv
• Bourg, Marcus de; Mohammad, Rawand S. & Vik, Anders (2023). Epoxy fatty acid mimics: A potential treatment for renal failure. Fulltekst i vitenarkiv
• Haatveit, Åsmund Stenvik; Bathen, Mina; Hansen, Trond Vidar & Vik, Anders (2023). Synthetic studies toward 4S,5S-dihydroxy docosapentaenoic acid. Fulltekst i vitenarkiv
• Bathen, Mina; Haatveit, Åsmund Stenvik; Vik, Anders & Hansen, Trond Vidar (2023). Synthetic studies towards 4S,5S-dihydroxy docosapentaenoic acid. Fulltekst i vitenarkiv
• Nsowah, Samuel Kwame Opoku; Vik, Anders & Hansen, Trond Vidar (2023). Synthesis of New Analogs of 2-Methoxyestradiol. Fulltekst i vitenarkiv
• Bourg, Marcus de; Vik, Anders & Mohammad, Rawand S. (2022). Epoxy fatty acid mimics: A potential treatment for renal failure. Fulltekst i vitenarkiv
• Vik, Anders; Halvorsen, Trine Grønhaug; Primdahl, Karoline Gangestad; Hansen, Trond Vidar; Wangensteen, Helle & Reubsaet, Leon [Vis alle 7 forfattere av denne artikkelen] (2022). Grunnkurs i farmasøytisk kjemi på UiO moderniseres kontinuerlig. Norsk Farmaceutisk Tidsskrift (NFT). ISSN 0029-1935. s. 33–34. Fulltekst i vitenarkiv
• Bourg, Marcus de; Mohammas, Rawand S. & Vik, Anders (2021). Epoxy fatty acid mimics: a potential treatment for renal failure. Fulltekst i vitenarkiv
• Reinertsen, Amalie Føreid; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar (2019). Synthetic Studies Towards an Analogue of RvD1n-3 DPA. Fulltekst i vitenarkiv Vis sammendrag

  Specialized pro-resolving lipid mediators (SPMs) are biosynthesized from n-3 polyunsaturated fatty acids during the resolution phase of acute inflammation.1,2 These molecules are shown to limit further neutrophil recruitment to the inflammatory sites, accelerate the termination of inflammation, shorten the resolution time in vivo and increase the clearance of bacteria and apoptotic cells.2 The SPMs have attracted a great interest as lead compounds in drug discovery programs towards the development of new classes of drugs that dampen inflammation without interfering with the immune response. In 2013, the SPM RvD1n-3 DPA was reported.1 RvD1n-3 DPA displays potent in vivo anti-inflammatory and pro-resolution effects in the low nanomolar range.1 This SPM is an excellent biotemplate for the development of new, small molecular anti-inflammatory drugs and immunoresolvents.3,4 Such simpler analogues are currently in development in our group. 1. Dalli, J.; Colas, R. A.; Serhan, C. N. Sci. Rep. 2013, 3, 1940. 2. Serhan, C. N.; Petasis, N. A. Chem. Rev. 2011, 111, 5922. 3. (a) Serhan, N. A. Nature 2014, 510, 92. (b) Fullerton, J. N.; Gilroy, D.W. Nat. Rev. Drug Discov. 2016, 15, 551. 4. (a) Serhan, C. N, FASEB J. 2017, 31, 1273. (b) Serhan, C. N.; Chiang, N. Curr. Opin. Pharmacol. 2013, 13, 632.

• Rasmussen, Jeanne Sønderskov; Tungen, Jørn Eivind; Vik, Anders; Hansen, Trond Vidar & Stenstrøm, Yngve H. (2019). Synthetic Studies Towards MaR2n-3 DPA. Fulltekst i vitenarkiv Vis sammendrag

  In the last two decades it has been known that specialized pro-resolving mediators (SPMs), biosynthesized from n-3 PUFAs, play an important role in stimulating the return of inflamed tissue to homeostasis.1 There has therefore been a great interest in using these endogenously formed SPMs as lead compounds in drug discovery programs towards the development of new classes of anti-inflammatory drugs. Our group has synthesized MaR1n-3 DPA2 as well as several other SPMs.3 The poster will present our initial synthetic efforts towards the n-3 DPA derived SPM MaR2n-3 DPA (1). 1. Serhan, C. N. Nature 2014, 510, 92–101. 2. Tungen, J. E.; Aursnes, M.; Dalli, J.; Arnardottir, H.; Serhan, C. N.; Hansen, T. V. Chem. Eur. J. 2014, 20, 14575–14578.

• Kristianslund, Renate; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar (2019). An Organoselenium Accelerated Bromolactonization Reaction. Fulltekst i vitenarkiv
• Vik, Anders; Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Colas, Romain A. & Serhan, Charles Nicholas [Vis alle 8 forfattere av denne artikkelen] (2019). Biosynthetic Studies of RvT1-4: A Novel Class of Specialized Pro-resolving and Anti-inflammatory Mediators. Fulltekst i vitenarkiv
• Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; Souza, Patrica R. S De; Colas, Romain A.; Dalli, Jesmond & Hansen, Trond Vidar [Vis alle 7 forfattere av denne artikkelen] (2019). Stereocontrolled Synthesis and Investigation of The Biosynthetic Transformations of 16(S),17(S)-epoxy-PDn-3 DPA. Fulltekst i vitenarkiv
• Tungen, Jørn Eivind; Gerstmann, Lisa; Vik, Anders; Kalesse, Markus; Dalli, Jesmond & Chiang, Nan [Vis alle 8 forfattere av denne artikkelen] (2019). Stereoselective Synthesis and Biological Evaluations of RvD1n-3 DPA. Fulltekst i vitenarkiv
• Nesman, Jannicke Irina; Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; Vik, Anders; Dalli, Jesmond & Hansen, Trond Vidar (2019). Total Synthesis and Biological Evaluations of 22-OH PD1n-3 DPA. Fulltekst i vitenarkiv
• Johnsen, Lars-Inge Gammelsæter; Bero, Rawan; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar (2019). Synthetic studies towards 10-keto-DeH-PD1. Fulltekst i vitenarkiv
• Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; Souza, Patricia R.S De; Colas, Romain A.; Dalli, Jesmond & Hansen, Trond Vidar [Vis alle 7 forfattere av denne artikkelen] (2018). Stereocontrolled Synthesis and Investigation of the Biosynthetic Transformations of 16(S),17(S)-epoxy-PDn-3 DPA. Fulltekst i vitenarkiv
• Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Colas, Romain A.; Serhan, Charles Nicholas & Dalli, Jesmond [Vis alle 8 forfattere av denne artikkelen] (2017). Biosynthetic Studies of RvT1-4: A Novel Class of Specialized Pro-resolving and Anti-inflammatory Mediators. Fulltekst i vitenarkiv
• Vik, Anders; Aursnes, Marius; Tungen, Jørn Eivind; Colas, Romain A.; Cheng, Chien-Yee C. & Dalli, Jesmond [Vis alle 8 forfattere av denne artikkelen] (2017). Biosynthesis and the Anti-inflammatory and Pro-resolving Effects of the Novel Lipid Mediator Protectin D1n-3 DPA. Fulltekst i vitenarkiv
• Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Serhan, Charles Nicholas; Dalli, Jesmond & Hansen, Trond Vidar [Vis alle 7 forfattere av denne artikkelen] (2017). Synthesis of 13R‑HDPA and Its Biosynthetic Conversion to the 13-Series Resolvins. Fulltekst i vitenarkiv
• al-Kazaale, Nora; Solum, Eirik Johansson; Vik, Anders & Hansen, Trond Vidar (2017). Synthesis of New Analogs of 2-Methoxyestradiol as Potential Anticancer Agents. Fulltekst i vitenarkiv
• Aursnes, Marius; Primdahl, Karoline Gangestad; Hansen, Trond Vidar & Vik, Anders (2017). Synthetic Studies Towards the 13-series Resolvin Member RvT3. Fulltekst i vitenarkiv
• Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Colas, Romain A.; Dalli, Jesmond & Hansen, Trond Vidar [Vis alle 7 forfattere av denne artikkelen] (2016). Synthesis of 13-(R)-HDPA. Fulltekst i vitenarkiv
• Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; Aursnes, Marius; Hansen, Trond Vidar & Vik, Anders (2016). Total Synthesis of Leukotriene B4. Fulltekst i vitenarkiv
• Kristianslund, Renate; Aursnes, Marius; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar (2016). Organocatalytic enantioselective iodolactonization of allenoic acids. Fulltekst i vitenarkiv
• Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar M & Sylte, Ingebrigt [Vis alle 8 forfattere av denne artikkelen] (2016). Anti-diabetic activity from marine lipids: new anti-diabetic drugs. Fulltekst i vitenarkiv
• Primdahl, Karoline Gangestad; Aursnes, Marius; Tungen, Jørn Eivind; Hansen, Trond Vidar & Vik, Anders (2015). Total synthesis of leukotriene B4. Fulltekst i vitenarkiv
• Sæther, Thomas; Moldes-Anaya, Angel; Tungen, Jørn Eivind; Vik, Anders; Paulsen, Steinar Martin & Sylte, Ingebrigt [Vis alle 8 forfattere av denne artikkelen] (2015). Anti-diabetic activity from marine lipids: new anti-diabetic drugs. Fulltekst i vitenarkiv
• Aursnes, Marius; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar (2015). Synthesis, Anti-inflammatory and Pro-resolving Activities of 22-OH-PD1, a Mono-Hydroxylated Metabolite of Protectin D1. Fulltekst i vitenarkiv
• Vik, Anders (2015). Synthesis of Specialized Pro-resolving Lipid Mediators. Fulltekst i vitenarkiv
• Kaupang, Åsmund; Hildonen, Siri; Halvorsen, Trine Grønhaug; Mortén, Magnus; Vik, Anders & Hansen, Trond Vidar (2015). Investigations on the covalent antagonistic modulation of PPARβ/δ. Fulltekst i vitenarkiv
• Solum, Eirik Johansson; Vik, Anders & Hansen, Trond Vidar (2013). Synthesis of analogs of 2-methoxyestradiol as potent anticancer agents. Fulltekst i vitenarkiv
• Solum, Eirik Johansson; Vik, Anders & Hansen, Trond Vidar (2013). Synthesis of analogs of 2-methoxyestradiol as potential anticancer agents. Fulltekst i vitenarkiv
• Aursnes, Marius; Tungen, Jørn Eivind; Vik, Anders & Hansen, Trond Vidar (2013). Total synthesis of Protectin D1. Fulltekst i vitenarkiv
• Kaupang, Åsmund; Laitinen, Tuomo; Vik, Anders; Poso, Antti & Hansen, Trond Vidar (2013). Molecular modelling and synthesis of putative high-affinity inhibitors of hPPARδ. Fulltekst i vitenarkiv
• Aursnes, Marius; Vik, Anders & Hansen, Trond Vidar (2012). Synthetic Studies Towards Protectin D1. Fulltekst i vitenarkiv
• Mohamed, Yasser Mahmoud Ali; Vik, Anders & Hansen, Trond Vidar (2012). Synthesis of lipophilic antioxidants. Fulltekst i vitenarkiv
• Gundersen, Lise-Lotte; Kania, Jindrich; Odden, Hege Hortemo; Proszenyak, Agnes & Vik, Anders (2011). Synthesis directed towards Agelasines and Asmarines; Marine Antibiotics. Fulltekst i vitenarkiv
• Jakobsen, Martin Gjerde; Vik, Anders & Hansen, Trond Vidar (2011). Synthetic Studies Towards Resolvin D1. Fulltekst i vitenarkiv
• Vik, Anders; Hansen, Trond Vidar; Skattebøl, Lars & Holmeide, Anne Kristin (2011). Synthesis of juniperonic acid. Fulltekst i vitenarkiv
• Vik, Anders; Hansen, Trond Vidar; Holmeide, Anne Kristin & Skattebøl, Lars (2010). Synthesis of juniperonic acid. Fulltekst i vitenarkiv
• Sjögren, Martin; Dahlström, Mia; Göransson, Ulf; Hedner, Erik; Jonsson, Per R. & Bohlin, Lars [Vis alle 8 forfattere av denne artikkelen] (2009). Antifouling activity of the sponge metabolite agelasine D. Fulltekst i vitenarkiv
• Vik, Anders; Proszenyak, Agnes; Vermeersch, Marieke; Cos, Paul; Maes, Louis & Gundersen, Lise-Lotte (2009). Screening of agelasine analogs; Identification of hits for visceral leishmaniasis and Chagas disease. Fulltekst i vitenarkiv
• Bakkestuen, Anne Kristin; Charnock, Colin; Cos, Paul; Gundersen, Lise-Lotte; Maes, Louis & Proszenyak, Agnes [Vis alle 10 forfattere av denne artikkelen] (2009). Synthetic studies directed towards antimicrobial agelasines. Fulltekst i vitenarkiv
• Vik, Anders; James, Anthony & Gundersen, Lise-Lotte (2008). Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro. Fulltekst i vitenarkiv
• Vik, Anders & Gundersen, Lise-Lotte (2007). Synthetic studies directed towards Asmarines: Construction of the 7-membered ring by RCM. Fulltekst i vitenarkiv

Se alle arbeider i NVA